Detailed information for compound 1476489

Basic information

Technical information
  • TDR Targets ID: 1476489
  • Name: [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]- furan-2-ylmethanone
  • MW: 346.396 | Formula: C19H23FN2O3
  • H donors: 0 H acceptors: 1 LogP: 3.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCCCCN1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C19H23FN2O3/c20-16-5-7-17(8-6-16)24-14-2-1-9-21-10-12-22(13-11-21)19(23)18-4-3-15-25-18/h3-8,15H,1-2,9-14H2
  • InChiKey: ANCGVVKQRRYNLM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]-(2-furyl)methanone
  • [4-[4-(4-fluorophenoxy)butyl]-1-piperazinyl]-(2-furyl)methanone
  • [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]-furan-2-yl-methanone
  • STOCK1S-63092

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.1158 0.1575
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0047 0.023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0113 0.0485
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.1028 0.1392
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0161 0.0339
Echinococcus granulosus tar DNA binding protein 0.0064 0.0205 0.0461
Loa Loa (eye worm) glutathione reductase 0.0095 0.0373 0.1607
Echinococcus granulosus dna polymerase eta 0.0064 0.0207 0.0466
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0373 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0402 0.2021 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Brugia malayi MH2 domain containing protein 0.0362 0.1807 0.894
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Onchocerca volvulus Huntingtin homolog 0.0125 0.0533 0.136
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0532 0.272 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0141 0.0519
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0039 0.0119
Echinococcus multilocularis dna polymerase eta 0.0064 0.0207 0.0466
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.1609
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0254 0.0597
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.006 0.0259
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Loa Loa (eye worm) hypothetical protein 0.0125 0.0533 0.2299
Onchocerca volvulus 0.0308 0.1519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Leishmania major DNA polymerase eta, putative 0.0064 0.0207 0.555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0113 0.0204
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0039 0.1044
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0141 0.0284
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0141 0.0561
Plasmodium falciparum thioredoxin reductase 0.0095 0.0373 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Echinococcus granulosus geminin 0.0513 0.2622 0.7164
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0039 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.1028 0.1392
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.006 0.0058
Schistosoma mansoni hypothetical protein 0.0513 0.2622 0.7164
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0039 0.0143
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0205 0.0885
Trypanosoma brucei protein kinase, putative 0.0052 0.0141 0.3785
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0254 0.0597
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0141 0.3785
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma brucei trypanothione reductase 0.0095 0.0373 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0254 0.0597
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.1158 0.1575
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0039 0.1044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.006 0.3272
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0205 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0132 0.0654
Schistosoma mansoni hypothetical protein 0.0073 0.0254 0.0597
Loa Loa (eye worm) transcription factor SMAD2 0.0362 0.1807 0.7787
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0012 0.0047
Leishmania major trypanothione reductase 0.0095 0.0373 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0141 0.0284
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.007 0.0031
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.007 0.0301
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium falciparum glutathione reductase 0.0095 0.0373 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.006 0.202
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1354 0.7142 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.1028 0.1392
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.007 0.0031
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Leishmania major hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.1609
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0039 0.1868
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0207 0.555
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0113 0.0204
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0532 0.272 0.2691
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.006 0.3272
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.006 0.1609
Echinococcus granulosus dna polymerase kappa 0.0039 0.007 0.0085
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0141 0.3785
Loa Loa (eye worm) hypothetical protein 0.0308 0.1519 0.6545
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0039 0.1044
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0039 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.007 0.0043
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0161 0.0339
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Giardia lamblia hypothetical protein 0.0056 0.0161 0.0648
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0205 0.1016
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.1044
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0141 0.3785
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0132 0.0569
Echinococcus multilocularis dna polymerase kappa 0.0039 0.007 0.0085
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0039 0.1044
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.007 0.0085
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0373 0.1607
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Schistosoma mansoni alpha-glucosidase 0.0143 0.0631 0.1641
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.4319
Loa Loa (eye worm) RNA binding protein 0.0064 0.0205 0.0885
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1354 0.7142 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.1028 0.1392
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Loa Loa (eye worm) hypothetical protein 0.005 0.0132 0.0569
Brugia malayi Thioredoxin reductase 0.0095 0.0373 0.1845
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Giardia lamblia Hypothetical protein 0.0056 0.0161 0.0648
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0161 0.0339
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.007 0.187
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0161 0.4319
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0012 0.0043
Brugia malayi hypothetical protein 0.0125 0.0533 0.2639
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0141 0.3785
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0533 0.2299
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0161 0.0339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0113 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0201
Trichomonas vaginalis MYB, putative 0.0028 0.0012 0.0047
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.1158 0.1575
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0113 0.0557
Onchocerca volvulus Huntingtin homolog 0.0125 0.0533 0.136
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.1028 0.1392
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.006 0.0221
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0132 0.0654
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0039 0.0193
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Brugia malayi MAP kinase sur-1 0.0052 0.0141 0.0698
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0161 0.4319
Schistosoma mansoni alpha glucosidase 0.0037 0.006 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Brugia malayi TAR-binding protein 0.0064 0.0205 0.1016
Brugia malayi hypothetical protein 0.0308 0.1519 0.7514
Plasmodium falciparum thioredoxin reductase 0.0033 0.0039 0.1044
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0402 0.2021 0.871
Leishmania major DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0141 0.0284
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0205 0.0885
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei unspecified product 0.0027 0.0005 0.014
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.007 0.0345
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0161 0.0797
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.007 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0113 0.0204
Leishmania major hypothetical protein, conserved 0.0056 0.0161 0.4319
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.007 0.392
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0457 0.232 0.6326
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0039 0.1044
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis Probable reductase 0.0217 0.1028 0.1392
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0161 0.0339
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0207 0.0892
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.007 0.242
Leishmania major DNA polymerase eta, putative 0.0038 0.0064 0.1705
Echinococcus granulosus microtubule associated protein 2 0.0704 0.3645 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0457 0.232 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Brugia malayi glutathione reductase 0.0095 0.0373 0.1845
Loa Loa (eye worm) MH2 domain-containing protein 0.0362 0.1807 0.7787
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0161 0.0797
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Giardia lamblia DINP protein human, muc B family 0.0039 0.007 0.0252
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0039 0.1868
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0012 0.0047
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.1044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.007 0.0085
Schistosoma mansoni alpha-glucosidase 0.0143 0.0631 0.1641
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0064 0.1705
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0373 0.047
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.007 0.0043
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.1158 0.0213
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0694
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Echinococcus multilocularis geminin 0.0513 0.2622 0.7164
Trypanosoma brucei unspecified product 0.0027 0.0005 0.014
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.006 0.3272
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.006 0.3272
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0161 0.0797
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.006 0.0058
Schistosoma mansoni hypothetical protein 0.0034 0.0047 0.0021
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0039 0.1044
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0161 0.0339
Plasmodium vivax glutathione reductase, putative 0.0095 0.0373 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0373 0.0926
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0532 0.272 0.2691
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0039 0.0143
Toxoplasma gondii thioredoxin reductase 0.0095 0.0373 0.1371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0141 0.0608
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.3645 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0161 0.0339
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0064 0.0234
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0161 0.4319
Loa Loa (eye worm) hypothetical protein 0.0457 0.232 1
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0373 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0755 0.3254
Trypanosoma brucei unspecified product 0.0039 0.007 0.187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Brugia malayi hypothetical protein 0.0073 0.0254 0.1257
Schistosoma mansoni DNA polymerase eta 0.0064 0.0207 0.0466
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Trypanosoma brucei glucosidase, putative 0.0037 0.006 0.1609
Loa Loa (eye worm) PDE1B protein 0.0056 0.0161 0.0694
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0532 0.272 0.2768
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0141 0.3785
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0161 0.0339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0141 0.3785
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0141 0.3785
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.007 0.0085
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0161 0.0339
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0207 0.1024
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.3645 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0141 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0161 0.4319
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0161 0.0339
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0373 0.0926
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0161 0.0339
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.006 0.0297
Plasmodium falciparum glutathione reductase 0.0033 0.0039 0.1044
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0141 0.0284
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0457 0.232 0.8531
Brugia malayi RNA binding protein 0.0064 0.0205 0.1016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.007 0.392
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.006 0.202
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0207 0.555
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0402 0.2021 0.5497
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0402 0.2021 0.5497
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0161 0.0339
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0755 0.3736
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni hypothetical protein 0.0513 0.2622 0.7164

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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