Detailed information for compound 1476489

Basic information

Technical information
  • TDR Targets ID: 1476489
  • Name: [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]- furan-2-ylmethanone
  • MW: 346.396 | Formula: C19H23FN2O3
  • H donors: 0 H acceptors: 1 LogP: 3.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)OCCCCN1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C19H23FN2O3/c20-16-5-7-17(8-6-16)24-14-2-1-9-21-10-12-22(13-11-21)19(23)18-4-3-15-25-18/h3-8,15H,1-2,9-14H2
  • InChiKey: ANCGVVKQRRYNLM-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]-(2-furyl)methanone
  • [4-[4-(4-fluorophenoxy)butyl]-1-piperazinyl]-(2-furyl)methanone
  • [4-[4-(4-fluorophenoxy)butyl]piperazin-1-yl]-furan-2-yl-methanone
  • STOCK1S-63092

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.1044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.007 0.242
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.1044
Schistosoma mansoni hypothetical protein 0.0073 0.0254 0.0597
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0141 0.0608
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0161 0.0797
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0039 0.1044
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0373 0.047
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0161 0.0339
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0161 0.0339
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0141 0.3785
Brugia malayi MAP kinase sur-1 0.0052 0.0141 0.0698
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.3645 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Loa Loa (eye worm) hypothetical protein 0.0125 0.0533 0.2299
Echinococcus granulosus tar DNA binding protein 0.0064 0.0205 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Brugia malayi TAR-binding protein 0.0064 0.0205 0.1016
Echinococcus granulosus geminin 0.0513 0.2622 0.7164
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0402 0.2021 0.5497
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0457 0.232 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni alpha glucosidase 0.0037 0.006 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0694
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0141 0.0284
Brugia malayi hypothetical protein 0.0125 0.0533 0.2639
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni hypothetical protein 0.0513 0.2622 0.7164
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Giardia lamblia Hypothetical protein 0.0056 0.0161 0.0648
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.006 0.0058
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0141 0.3785
Loa Loa (eye worm) hypothetical protein 0.005 0.0132 0.0569
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0373 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0161 0.0339
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.1028 0.1392
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Onchocerca volvulus Huntingtin homolog 0.0125 0.0533 0.136
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.1158 0.1575
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0161 0.4319
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.007 0.392
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.4319
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Brugia malayi hypothetical protein 0.0308 0.1519 0.7514
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0161 0.0339
Trypanosoma brucei unspecified product 0.0027 0.0005 0.014
Trypanosoma brucei protein kinase, putative 0.0052 0.0141 0.3785
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0039 0.1868
Leishmania major DNA polymerase kappa, putative 0.0039 0.007 0.187
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0532 0.272 0.2691
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0161 0.0339
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Loa Loa (eye worm) PDE1B protein 0.0056 0.0161 0.0694
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.007 0.0085
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0056 0.0161 0.0797
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.007 0.0085
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Leishmania major hypothetical protein, conserved 0.0056 0.0161 0.4319
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.1028 0.1392
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0056 0.0161 0.0339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0141 0.3785
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0362 0.1807 0.7787
Entamoeba histolytica hypothetical protein 0.0073 0.0254 1
Brugia malayi MH2 domain containing protein 0.0362 0.1807 0.894
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0373 0.1607
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Echinococcus multilocularis dna polymerase eta 0.0064 0.0207 0.0466
Brugia malayi hypothetical protein 0.0073 0.0254 0.1257
Loa Loa (eye worm) glutathione reductase 0.0095 0.0373 0.1607
Echinococcus multilocularis geminin 0.0513 0.2622 0.7164
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0207 0.0892
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0755 0.3254
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei unspecified product 0.0027 0.0005 0.014
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0141 0.3785
Loa Loa (eye worm) MH2 domain-containing protein 0.0362 0.1807 0.7787
Trypanosoma brucei trypanothione reductase 0.0095 0.0373 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0141 0.3785
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Giardia lamblia hypothetical protein 0.0056 0.0161 0.0648
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0141 0.3785
Plasmodium vivax glutathione reductase, putative 0.0095 0.0373 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.0205 0.0885
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0039 0.0143
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.007 0.0085
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.007 0.187
Schistosoma mansoni hypothetical protein 0.0034 0.0047 0.0021
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0161 0.0797
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1354 0.7142 1
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.3645 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.007 0.0043
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0039 0.1044
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.007 0.392
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0113 0.0557
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0039 0.1044
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0254 0.0597
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.006 0.0221
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0254 0.0597
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.007 0.0043
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0039 0.1044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Mycobacterium tuberculosis Probable reductase 0.0217 0.1028 0.1392
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0207 0.555
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0039 0.0143
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0161 0.0339
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0402 0.2021 0.871
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0532 0.272 0.2768
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0532 0.272 0.2691
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Giardia lamblia DINP protein human, muc B family 0.0039 0.007 0.0252
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0005 0.014
Trichomonas vaginalis MYB, putative 0.0028 0.0012 0.0047
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.006 0.3272
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.1158 0.1575
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0161 0.0797
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0205 0.0885
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0141 0.0284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0254 0.0597
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.006 0.3272
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0161 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.006 0.0297
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0113 0.0204
Loa Loa (eye worm) hypothetical protein 0.0308 0.1519 0.6545
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0012 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0113 0.0485
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0039 0.1044
Brugia malayi glutathione reductase 0.0095 0.0373 0.1845
Echinococcus multilocularis dna polymerase kappa 0.0039 0.007 0.0085
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0207 0.1024
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0457 0.232 0.8531
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Schistosoma mansoni alpha-glucosidase 0.0143 0.0631 0.1641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0113 0.0204
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0207 0.555
Echinococcus granulosus dna polymerase kappa 0.0039 0.007 0.0085
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0039 0.1044
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Leishmania major cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0161 0.0339
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.1158 0.1575
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0161 0.4319
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.1028 0.1392
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0064 0.0234
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0039 0.1044
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0132 0.0654
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0141 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0056 0.0161 0.0339
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0141 0.3785
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.006 0.202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0457 0.232 0.6326
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.1609
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0532 0.272 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0141 0.0561
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0064 0.1705
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0028 0.0012 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0161 0.0339
Trypanosoma brucei glucosidase, putative 0.0037 0.006 0.1609
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Loa Loa (eye worm) hypothetical protein 0.0457 0.232 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.006 0.1609
Plasmodium falciparum glutathione reductase 0.0033 0.0039 0.1044
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0402 0.2021 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.006 0.202
Plasmodium falciparum thioredoxin reductase 0.0095 0.0373 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0141 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.1609
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0039 0.0193
Schistosoma mansoni alpha-glucosidase 0.0143 0.0631 0.1641
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Plasmodium falciparum glutathione reductase 0.0095 0.0373 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium falciparum thioredoxin reductase 0.0033 0.0039 0.1044
Leishmania major hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.007 0.0345
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0039 0.1044
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0039 0.1868
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.1028 0.1392
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0039 0.1044
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0205 0.0885
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0161 0.4319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0113 0.0204
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0039 0.1044
Leishmania major DNA polymerase eta, putative 0.0038 0.0064 0.1705
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0056 0.0161 0.4319
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0402 0.2021 0.5497
Leishmania major trypanothione reductase 0.0095 0.0373 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Brugia malayi Thioredoxin reductase 0.0095 0.0373 0.1845
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0161 0.4319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044
Trypanosoma brucei unspecified product 0.0039 0.007 0.187
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.007 0.0301
Loa Loa (eye worm) hypothetical protein 0.0125 0.0533 0.2299
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0141 0.8675
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0161 0.4319
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0161 0.0339
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0755 0.3736
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.007 0.187
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0141 0.0284
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0373 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.007 0.187
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0039 0.1044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0373 0.0926
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1354 0.7142 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0205 0.1016
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0457 0.232 0.6326
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.007 0.0085
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0132 0.0654
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.006 0.3272
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0161 0.0592
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0161 0.0339
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0039 0.0119
Echinococcus granulosus microtubule associated protein 2 0.0704 0.3645 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0161 0.0339
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0755 0.1986
Echinococcus granulosus dna polymerase eta 0.0064 0.0207 0.0466
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0028 0.0012 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0132 0.0569
Toxoplasma gondii thioredoxin reductase 0.0095 0.0373 0.1371
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0161 0.0339
Loa Loa (eye worm) hypothetical protein 0.0056 0.0161 0.0694
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0205 0.0461
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.007 0.0031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.1028 0.1392
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0161 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.006 0.0259
Schistosoma mansoni DNA polymerase eta 0.0064 0.0207 0.0466
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0373 0.0926
Onchocerca volvulus Huntingtin homolog 0.0125 0.0533 0.136
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0161 0.4319
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.006 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0205 0.0461
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.006 0.3272
Leishmania major DNA polymerase eta, putative 0.0064 0.0207 0.555
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.1158 0.0213
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.007 0.187
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.007 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0113 0.0204
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0056 0.0161 0.4319
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.006 0.3272
Schistosoma mansoni hypothetical protein 0.0513 0.2622 0.7164
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0141 0.0284
Onchocerca volvulus 0.0308 0.1519 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0161 0.4319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0113 0.0204
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1886 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0047 0.023
Brugia malayi RNA binding protein 0.0064 0.0205 0.1016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0039 0.1044

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.