Detailed information for compound 1477401

Basic information

Technical information
  • TDR Targets ID: 1477401
  • Name: N-[1-[2-(cyclohexyl-methylamino)-2-oxoethyl]p iperidin-4-yl]cyclohexanecarboxamide
  • MW: 363.537 | Formula: C21H37N3O2
  • H donors: 1 H acceptors: 2 LogP: 3.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CN1CCC(CC1)NC(=O)C1CCCCC1)C1CCCCC1
  • InChi: 1S/C21H37N3O2/c1-23(19-10-6-3-7-11-19)20(25)16-24-14-12-18(13-15-24)22-21(26)17-8-4-2-5-9-17/h17-19H,2-16H2,1H3,(H,22,26)
  • InChiKey: JNZHRKDFJJNKDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-[2-(cyclohexyl-methyl-amino)-2-oxo-ethyl]-4-piperidyl]cyclohexanecarboxamide
  • N-[1-[2-(cyclohexyl-methylamino)-2-oxoethyl]-4-piperidinyl]cyclohexanecarboxamide
  • N-[1-[2-(cyclohexyl-methyl-amino)-2-keto-ethyl]-4-piperidyl]cyclohexanecarboxamide
  • N-[1-[2-(cyclohexyl-methyl-amino)-2-oxo-ethyl]piperidin-4-yl]cyclohexanecarboxamide
  • ASN 06463703

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.004 0.0272 0.0439
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0005 0.0008
Echinococcus multilocularis cysteine protease 0.0198 0.3801 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0174 0.3283 0.328
Onchocerca volvulus 0.0174 0.3283 0.8636
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.1703 0.2489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Schistosoma mansoni cathepsin F (C01 family) 0.0134 0.237 0.623
Brugia malayi cathepsin F-like cysteine proteinase 0.0064 0.0805 0.1177
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0174 0.3283 0.8636
Brugia malayi ecdysteroid receptor 0.0028 0.0005 0.0008
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.004 0.0272 0.0702
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0174 0.3283 0.8636
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.1703 0.4054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0074 0.1025 0.2478
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0333 0.6839 1
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.1703 0.4315
Loa Loa (eye worm) hypothetical protein 0.0333 0.6839 0.6837
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0198 0.3801 1
Onchocerca volvulus Cathepsin L homolog 0.0198 0.3801 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0005 0.0008
Echinococcus multilocularis nAChR subunit 0.0094 0.148 0.3885
Loa Loa (eye worm) hypothetical protein 0.0064 0.0805 0.08
Loa Loa (eye worm) cathepsin B 0.0084 0.1257 0.1252
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Schistosoma mansoni cathepsin C 0.004 0.0272 0.0702
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0174 0.3283 0.8636
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0174 0.3283 0.328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0084 0.1257 0.2792
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.004 0.0272 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Entamoeba histolytica cysteine proteinase 1, putative 0.0104 0.1703 0.4315
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Echinococcus multilocularis bromodomain containing 2 0.0074 0.1025 0.2685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Onchocerca volvulus 0.0174 0.3283 0.8636
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0174 0.3283 0.328
Giardia lamblia Cathepsin B precursor 0.004 0.0272 0.1412
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.004 0.0272 0.0439
Echinococcus multilocularis cathepsin b 0.0182 0.3458 0.9096
Onchocerca volvulus Cathepsin F homolog 0.0198 0.3801 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0005 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0198 0.3801 1
Entamoeba histolytica cysteine proteinase, putative 0.0198 0.3801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1703 0.1751
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.004 0.0272 0.0439
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0174 0.3283 0.4801
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Echinococcus multilocularis glycine receptor subunit beta 0.0174 0.3283 0.8636
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Loa Loa (eye worm) GABA receptor subunit 0.0094 0.148 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.004 0.0272 0.0439
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0399 0.0784
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1703 0.4315
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.3801 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0005 0.0008
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0094 0.148 0.2164
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Brugia malayi cathepsin F-like cysteine proteinase 0.004 0.0272 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi Cation transporter family protein 0.0174 0.3283 0.4801
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0094 0.148 0.2164
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.004 0.0272 0.0266
Onchocerca volvulus Cathepsin L homolog 0.004 0.0272 0.0702
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Brugia malayi hypothetical protein 0.008 0.1178 0.1722
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0182 0.3458 0.9096
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Echinococcus granulosus cathepsin L 0.0104 0.1703 0.4471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0182 0.3458 0.9096
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Onchocerca volvulus 0.0198 0.3801 1
Brugia malayi Cathepsin L-like precursor 0.0134 0.237 0.3466
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Onchocerca volvulus 0.0198 0.3801 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0182 0.3458 0.9096
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.237 0.6124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0174 0.3283 0.4801
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Echinococcus granulosus cathepsin l1 0.0198 0.3801 1
Plasmodium vivax vivapain-2 0.0198 0.3801 1
Echinococcus multilocularis cysteine protease 0.0198 0.3801 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0134 0.237 0.3466
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1703 0.4471
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0174 0.3283 0.4801
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.004 0.0272 0.0439
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.1703 0.4054
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0174 0.3283 0.328
Brugia malayi steroid hormone receptor 0.0028 0.0005 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0272 0.0439
Plasmodium vivax vivapain-2 0.0198 0.3801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Toxoplasma gondii cathepsin CPC1 0.004 0.0272 0.0439
Plasmodium falciparum cysteine proteinase falcipain 1 0.0104 0.1703 0.4054
Onchocerca volvulus 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.237 0.6124
Schistosoma mansoni neurotransmitter gated ion channel 0.008 0.1178 0.3088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Plasmodium vivax unspecified product 0.0064 0.0805 0.1512
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0272 0.0397
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0272 0.0266
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0005 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Entamoeba histolytica hypothetical protein 0.004 0.0272 0.0439
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0182 0.3458 0.9028
Schistosoma mansoni nAChR subunit 0.008 0.1178 0.3088
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Echinococcus multilocularis Bromodomain containing protein 0.0033 0.011 0.0274
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.008 0.1178 0.3088
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.3801 1
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Loa Loa (eye worm) ACC-1 protein 0.0174 0.3283 0.328
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.004 0.0272 0.0702
Loa Loa (eye worm) ctsf protein 0.0198 0.3801 0.3798
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0174 0.3283 0.8636
Schistosoma mansoni bromodomain-containing protein 3 brd3 0.0074 0.1025 0.2685
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Onchocerca volvulus 0.0198 0.3801 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0174 0.3283 0.328
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.1257 0.3298
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.008 0.1178 0.1173
Echinococcus granulosus bromodomain containing 2 0.0074 0.1025 0.2685
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0174 0.3283 0.8636
Brugia malayi cathepsin B-like cysteine proteinase 0.0182 0.3458 0.5056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0272 0.0439
Brugia malayi Cation transporter family protein 0.0174 0.3283 0.4801
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.1703 0.4315
Onchocerca volvulus 0.004 0.0272 0.0702
Loa Loa (eye worm) ACC-1 protein 0.0174 0.3283 0.328
Plasmodium vivax unspecified product 0.0104 0.1703 0.4054
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0174 0.3283 0.4801
Trichomonas vaginalis bromodomain-containing protein, putative 0.0074 0.1025 0.2478
Loa Loa (eye worm) hypothetical protein 0.0064 0.0805 0.08
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0104 0.1703 0.4054
Brugia malayi hypothetical protein 0.008 0.1178 0.1722
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.237 0.5946
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Onchocerca volvulus 0.0174 0.3283 0.8636
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.004 0.0272 0.0702
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0174 0.3283 0.8636
Brugia malayi cathepsin L precursor 0.004 0.0272 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi cathepsin L-like cysteine proteinase 0.004 0.0272 0.0397
Echinococcus granulosus nAChR subunit 0.0094 0.148 0.3885
Entamoeba histolytica cysteine proteinase, putative 0.0198 0.3801 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.1178 0.1722
Echinococcus granulosus cathepsin L cysteine proteinase 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.237 0.6124
Echinococcus granulosus cathepsin b 0.0182 0.3458 0.9096
Onchocerca volvulus 0.0198 0.3801 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1703 0.4471
Schistosoma mansoni cathepsin s 0.0064 0.0805 0.2107
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0094 0.148 0.3885
Onchocerca volvulus 0.0198 0.3801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.004 0.0272 0.0397
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0174 0.3283 0.4801
Toxoplasma gondii cathepsin CPL 0.0198 0.3801 1
Onchocerca volvulus 0.0094 0.148 0.3885
Echinococcus multilocularis cathepsin L cysteine protease 0.0198 0.3801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.237 0.2366
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Loa Loa (eye worm) acetylcholine receptor protein 0.008 0.1178 0.1173
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.1703 0.4471
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.3801 1
Echinococcus granulosus cathepsin L cysteine protease 0.0104 0.1703 0.4471
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.004 0.0272 0.0702
Schistosoma mansoni nAChR subunit 0.008 0.1178 0.3088
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0174 0.3283 0.8636
Giardia lamblia Hypothetical protein 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0134 0.237 0.2366
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0272 0.0397
Onchocerca volvulus Cathepsin L homolog 0.0198 0.3801 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.008 0.1178 0.1173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0005 0.0008
Echinococcus granulosus glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0272 0.0397
Echinococcus granulosus glycine receptor subunit alpha 1 0.0174 0.3283 0.8636
Giardia lamblia Cathepsin B precursor 0.0084 0.1257 1
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0005 0.0008
Leishmania major cysteine peptidase A (CPA) 0.0198 0.3801 1
Onchocerca volvulus 0.0094 0.148 0.3885
Onchocerca volvulus 0.0198 0.3801 1
Schistosoma mansoni neurotransmitter gated ion channel 0.008 0.1178 0.3088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0174 0.3283 0.8636
Onchocerca volvulus 0.008 0.1178 0.3088
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.008 0.1178 0.1722
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0198 0.3801 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Giardia lamblia Dipeptidyl-peptidase I precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) bromodomain containing protein 0.0033 0.011 0.0104
Echinococcus multilocularis cathepsin L cysteine protease 0.0198 0.3801 1
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0174 0.3283 0.8636
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0289 0.0487
Echinococcus granulosus cathepsin l cysteine peptidase 0.0198 0.3801 1
Onchocerca volvulus 0.008 0.1178 0.3088
Onchocerca volvulus Putative nachr subunit 0.0174 0.3283 0.8636
Giardia lamblia Cysteine protease 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Onchocerca volvulus 0.0033 0.011 0.0274
Echinococcus multilocularis cathepsin L 0.0104 0.1703 0.4471
Echinococcus granulosus nAChR subunit 0.0174 0.3283 0.8636
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0399 0.0784
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0198 0.3801 0.3798
Loa Loa (eye worm) hypothetical protein 0.0198 0.3801 0.3798
Onchocerca volvulus 0.0134 0.237 0.623
Giardia lamblia Cathepsin L-like protease 0.004 0.0272 0.1412
Plasmodium vivax vivapain-3 0.0104 0.1703 0.4054
Giardia lamblia Cathepsin B precursor 0.0084 0.1257 1
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Onchocerca volvulus 0.0174 0.3283 0.8636
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.1178 0.1722
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.004 0.0272 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0198 0.3801 0.5558
Giardia lamblia Cysteine protease 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Loa Loa (eye worm) hypothetical protein 0.0253 0.5036 0.5033
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1703 0.4315
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0174 0.3283 0.8636
Echinococcus multilocularis cathepsin b 0.0182 0.3458 0.9096
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.004 0.0272 0.0702
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0198 0.3801 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Schistosoma mansoni cathepsin F (C01 family) 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0094 0.148 0.2164
Trypanosoma cruzi cruzipain precursor, putative 0.0198 0.3801 1
Schistosoma mansoni cathepsin F (C01 family) 0.0198 0.3801 1
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.008 0.1178 0.1722
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0174 0.3283 0.8636
Brugia malayi Cation transporter family protein 0.0174 0.3283 0.4801
Onchocerca volvulus 0.008 0.1178 0.3088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.1703 0.1751
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0174 0.3283 0.8636
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0174 0.3283 0.4801
Loa Loa (eye worm) cysteine protease 0.0198 0.3801 0.3798
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Giardia lamblia Cysteine protease 0.004 0.0272 0.1412
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0174 0.3283 0.4801
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Brugia malayi nuclear receptor NHR-88 0.0028 0.0005 0.0008
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0805 0.1512
Echinococcus granulosus cathepsin L 0.004 0.0272 0.0702
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.008 0.1178 0.3088
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Schistosoma mansoni neurotransmitter gated ion channel 0.0094 0.148 0.3885
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0005 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.004 0.0272 0.0439
Trichomonas vaginalis bromodomain containing protein, putative 0.0046 0.0399 0.0784
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0174 0.3283 0.4801
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.1703 0.4054
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Echinococcus multilocularis nAChR subunit 0.0174 0.3283 0.8636
Giardia lamblia Hypothetical protein 0.004 0.0272 0.1412
Brugia malayi nuclear hormone receptor 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0134 0.237 0.2366
Brugia malayi hypothetical protein 0.008 0.1178 0.1722
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0399 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0272 0.0439
Giardia lamblia Cathepsin B precursor 0.0084 0.1257 1
Toxoplasma gondii cathepsin CPC2 0.004 0.0272 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.1703 0.2489
Brugia malayi Bromodomain containing protein 0.0074 0.1025 0.1498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Trypanosoma cruzi cysteine protease, putative 0.0104 0.1703 0.4054
Entamoeba histolytica papain family cysteine protease domain containing protein 0.004 0.0272 0.0439
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0174 0.3283 0.328
Giardia lamblia Cathepsin B precursor 0.004 0.0272 0.1412
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0182 0.3458 0.9096
Brugia malayi cathepsin L-like precursor 0.0134 0.237 0.3466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0005 0.0008
Echinococcus granulosus glycine receptor subunit beta 0.0174 0.3283 0.8636
Entamoeba histolytica papain family cysteine protease domain containing protein 0.004 0.0272 0.0439
Brugia malayi Cathepsin L-like precursor 0.0064 0.0805 0.1177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.008 0.1178 0.1722
Schistosoma mansoni acetylcholine receptor-related 0.008 0.1178 0.3088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Onchocerca volvulus 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0272 0.0439
Echinococcus granulosus glycine receptor subunit beta 0.0174 0.3283 0.8636
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.3801 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0174 0.3283 0.4801
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.008 0.1178 0.3088
Schistosoma mansoni cathepsin S (C01 family) 0.004 0.0272 0.0702
Loa Loa (eye worm) hypothetical protein 0.0182 0.3458 0.3454
Toxoplasma gondii cathepsin B 0.0084 0.1257 0.3109
Schistosoma mansoni nAChR subunit 0.0174 0.3283 0.8636
Echinococcus granulosus cysteine protease 0.0104 0.1703 0.4471
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0198 0.3801 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.008 0.1178 0.3088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.008 0.1178 0.3088
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Brugia malayi hypothetical protein 0.008 0.1178 0.1722
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0094 0.148 0.3885
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0005 0.0008
Entamoeba histolytica cysteine proteinase 2 0.0104 0.1703 0.4315
Echinococcus multilocularis cathepsin L 0.004 0.0272 0.0702
Brugia malayi cathepsin Z-like cysteine proteinase 0.004 0.0272 0.0397
Brugia malayi Cathepsin L-like precursor 0.0134 0.237 0.3466
Entamoeba histolytica cysteine protease, putative 0.0104 0.1703 0.4315
Loa Loa (eye worm) hypothetical protein 0.004 0.0272 0.0266
Entamoeba histolytica cysteine protease, putative 0.0198 0.3801 1
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.008 0.1178 0.1722
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.004 0.0272 0.0702
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0805 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Loa Loa (eye worm) hypothetical protein 0.0074 0.1025 0.102
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Giardia lamblia Cathepsin B precursor 0.004 0.0272 0.1412
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0064 0.0805 0.1177
Echinococcus granulosus cathepsin b 0.0182 0.3458 0.9096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.004 0.0272 0.0702
Giardia lamblia Encystation-specific protease 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Brugia malayi Bromodomain containing protein 0.0074 0.1025 0.1498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0198 0.3801 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.004 0.0272 0.0702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0272 0.0439
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0198 0.3801 1
Brugia malayi Cathepsin L-like precursor 0.0198 0.3801 0.5558
Giardia lamblia Dipeptidyl-peptidase I precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0198 0.3801 0.3798
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1703 0.4315
Entamoeba histolytica hypothetical protein 0.0094 0.148 0.3713
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0174 0.3283 0.8636
Loa Loa (eye worm) LGC-31 protein 0.0174 0.3283 0.328
Loa Loa (eye worm) hypothetical protein 0.0094 0.148 0.1476
Giardia lamblia Cysteine protease 0.004 0.0272 0.1412
Giardia lamblia Cathepsin B precursor 0.004 0.0272 0.1412
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.1703 0.4315
Giardia lamblia Cathepsin B precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0805 0.08
Loa Loa (eye worm) fibroinase 0.0198 0.3801 0.3798
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Brugia malayi hypothetical protein 0.008 0.1178 0.1722
Schistosoma mansoni cathepsin B (C01 family) 0.004 0.0272 0.0702
Onchocerca volvulus 0.0174 0.3283 0.8636
Toxoplasma gondii preprocathepsin c precursor, putative 0.004 0.0272 0.0439
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0272 0.0266
Echinococcus granulosus cathepsin l1 0.0134 0.237 0.623
Leishmania major cathepsin L-like protease 0.0198 0.3801 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0198 0.3801 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.004 0.0272 0.0439
Giardia lamblia Dipeptidyl-peptidase I precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0064 0.0805 0.08
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0174 0.3283 0.8636
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.1257 0.3109
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0174 0.3283 0.8636
Schistosoma mansoni acetylcholine receptor subunit beta 0.008 0.1178 0.3088
Giardia lamblia Cathepsin L precursor 0.004 0.0272 0.1412
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0174 0.3283 0.8636
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0094 0.148 0.2164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.004 0.0272 0.0702
Brugia malayi cathepsin Z-like cysteine proteinase 0.004 0.0272 0.0397
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0174 0.3283 0.4801
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0174 0.3283 0.4801
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.008 0.1178 0.1173
Brugia malayi fibroinase precursor 0.004 0.0272 0.0397
Giardia lamblia Cathepsin L-like protease 0.004 0.0272 0.1412
Entamoeba histolytica cysteine protease, putative 0.004 0.0272 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0005 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.3801 1
Echinococcus multilocularis glycine receptor subunit beta 0.0174 0.3283 0.8636
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0174 0.3283 0.8636
Plasmodium vivax vivapain-1 0.0104 0.1703 0.4054
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0174 0.3283 0.328
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0198 0.3801 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0399 0.0784

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.