Detailed information for compound 148619

Basic information

Technical information
  • TDR Targets ID: 148619
  • Name: disodium [(2,6-dimethylphenoxy)-oxidophosphor yl]formate
  • MW: 274.118 | Formula: C9H9Na2O5P
  • H donors: 0 H acceptors: 4 LogP: 1.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)P(=O)(Oc1c(C)cccc1C)[O-].[Na+].[Na+]
  • InChi: 1S/C9H11O5P.2Na/c1-6-4-3-5-7(2)8(6)14-15(12,13)9(10)11;;/h3-5H,1-2H3,(H,10,11)(H,12,13);;/q;2*+1/p-2
  • InChiKey: RXRPOMKANXQNMI-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • disodium [(2,6-dimethylphenoxy)-oxido-phosphoryl]formate
  • disodium [(2,6-dimethylphenoxy)-oxidanidyl-phosphoryl]methanoate
  • disodium [(2,6-dimethylphenoxy)-oxido-phosphoryl]methanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis musashi 0.0057 0.0546 0.0542
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0546 0.0542
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0169
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0159 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Echinococcus multilocularis geminin 0.038 0.4595 0.4593
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus bile acid beta glucosidase 0.0201 0.2348 0.2345
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0053 0.5
Brugia malayi hypothetical protein 0.0028 0.0178 0.0173
Echinococcus granulosus lysosomal alpha glucosidase 0.0811 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0461 0.5608 0.9182
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0072 0.0723 0.4481
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0027 0.0159 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Echinococcus multilocularis neutral alpha glucosidase AB 0.0137 0.1548 0.1544
Giardia lamblia Ceramide glucosyltransferase 0.0209 0.2447 1
Schistosoma mansoni alpha glucosidase 0.0137 0.1548 0.1683
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0027 0.0159 0.0154
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Leishmania major alpha glucosidase II subunit, putative 0.0137 0.1548 1
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0159 0.0154
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0027 0.0159 0.0154
Echinococcus multilocularis lamin 0.0057 0.0546 0.0542
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0027 0.0159 0.0154
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0211 0.0207
Loa Loa (eye worm) hypothetical protein 0.0072 0.0723 0.0718
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0723 0.4654
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.1548 1
Schistosoma mansoni hypothetical protein 0.0161 0.1845 0.2007
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0155
Echinococcus granulosus glycogen debranching enzyme 0.0125 0.1396 0.1392
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0125 0.1396 0.1392
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0053 0.0313
Loa Loa (eye worm) ceramide glucosyltransferase 0.0461 0.5608 0.5606
Echinococcus granulosus non lysosomal glucosylceramidase 0.0201 0.2348 0.2345
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0546 0.0542
Brugia malayi intermediate filament protein 0.0057 0.0546 0.0542
Echinococcus multilocularis nAChR subunit 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Schistosoma mansoni ceramide glucosyltransferase 0.0461 0.5608 0.6111
Loa Loa (eye worm) hypothetical protein 0.0177 0.2051 0.2048
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0027 0.0159 0.0154
Schistosoma mansoni hypothetical protein 0.038 0.4595 0.5006
Schistosoma mansoni hypothetical protein 0.009 0.096 0.1042
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi Cation transporter family protein 0.0027 0.0159 0.0154
Onchocerca volvulus 0.0027 0.0159 0.0252
Leishmania major glycosyl hydrolase-like protein 0.0072 0.0723 0.4481
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Echinococcus granulosus lamin 0.0057 0.0546 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Schistosoma mansoni glutaminase 0.0264 0.3139 0.3418
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0723 0.1098
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Echinococcus multilocularis lamin dm0 0.0057 0.0546 0.0542
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0173 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0631 0.0948
Trichomonas vaginalis glutaminase, putative 0.0264 0.3139 0.506
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0072 0.0723 0.4481
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0027 0.0159 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Brugia malayi excitatory GABA receptor EXP-1A 0.0027 0.0159 0.0154
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0084 0.005
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0155
Onchocerca volvulus Putative nachr subunit 0.0027 0.0159 0.0252
Loa Loa (eye worm) hypothetical protein 0.0177 0.2051 0.2048
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0723 0.1098
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Echinococcus granulosus geminin 0.038 0.4595 0.4593
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0751 0.0747
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Brugia malayi MH2 domain containing protein 0.0139 0.1571 0.1567
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0053 0.0048
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0177 0.2051 0.2232
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0084 0.0079
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Onchocerca volvulus 0.0177 0.2051 0.3353
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.0723 0.0718
Trypanosoma brucei glycosyl hydrolase-like protein 0.0072 0.0723 0.4481
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0029 0.0027
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0027 0.0159 0.0154
Echinococcus granulosus lamin dm0 0.0057 0.0546 0.0542
Loa Loa (eye worm) LGC-31 protein 0.0027 0.0159 0.0154
Trichomonas vaginalis maltase-glucoamylase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus bloom syndrome protein 0.0021 0.0084 0.0079
Brugia malayi RNA binding protein 0.0074 0.0751 0.0747
Trypanosoma brucei glucosidase, putative 0.0137 0.1548 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Onchocerca volvulus 0.0057 0.0546 0.0887
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0159 0.0154
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0751 0.0747
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Brugia malayi TAR-binding protein 0.0074 0.0751 0.0747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0494 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Trichomonas vaginalis sucrase-isomaltase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0027 0.0159 0.0154
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0027 0.0159 0.0154
Echinococcus multilocularis bile acid beta glucosidase 0.0201 0.2348 0.2345
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0027 0.0159 0.0168
Schistosoma mansoni alpha-glucosidase 0.0745 0.9175 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0057 0.0546 0.0542
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0072 0.0723 0.1177
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1571 0.1567
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Onchocerca volvulus 0.0177 0.2051 0.3353
Echinococcus granulosus neutral alpha glucosidase AB 0.0137 0.1548 0.1544
Schistosoma mansoni bile acid beta-glucosidase-related 0.0201 0.2348 0.2556
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0211 0.0207
Brugia malayi Ceramide glucosyltransferase 0.0461 0.5608 0.5606
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0165 0.1898 0.1894
Loa Loa (eye worm) glutaminase 2 0.0264 0.3139 0.3136
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.1548 1
Echinococcus granulosus ceramide glucosyltransferase 0.0461 0.5608 0.5606
Mycobacterium ulcerans glutaminase 0.0264 0.3139 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0533 0.0529
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0027 0.0159 0.0154
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0159 0.0154
Loa Loa (eye worm) RecQ helicase 0.0021 0.0084 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Onchocerca volvulus Glucosylceramidase homolog 0.0331 0.3976 0.6507
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0084 0.005
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0504 0.6152 0.615
Echinococcus multilocularis lysosomal alpha glucosidase 0.0811 1 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0811 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1571 0.1567
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Schistosoma mansoni lamin 0.0057 0.0546 0.0591
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0084 0.0079
Echinococcus granulosus tar DNA binding protein 0.0074 0.0751 0.0747
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0027 0.0159 0.0154
Schistosoma mansoni ceramide glucosyltransferase 0.0461 0.5608 0.6111
Schistosoma mansoni alpha-glucosidase 0.0745 0.9175 1
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0201 0.2348 0.2345
Entamoeba histolytica glycogen debranching enzyme, putative 0.0125 0.1396 0.9017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Echinococcus multilocularis lysosomal alpha glucosidase 0.0811 1 1
Schistosoma mansoni hypothetical protein 0.038 0.4595 0.5006
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Schistosoma mansoni bile acid beta-glucosidase-related 0.0201 0.2348 0.2556
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0173 0.0169
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0125 0.1396 0.5611
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0137 0.1548 0.2451
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0053 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.42 0.6799
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0053 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0061 0.059 0.0585
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0136 0.1528 0.1524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Brugia malayi Cation transporter family protein 0.0027 0.0159 0.0154
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0751 0.0747
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0494 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0494 0.0489
Onchocerca volvulus 0.0177 0.2051 0.3353
Echinococcus multilocularis glycogen debranching enzyme 0.0125 0.1396 0.1392
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.42 0.6799
Brugia malayi Glycosyl hydrolases family 31 protein 0.0137 0.1548 0.1544
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0494 0.0489
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0027 0.0159 0.0154
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Onchocerca volvulus 0.0027 0.0159 0.0252
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0494 0.0489
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0546 0.0542
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0137 0.1548 0.2451
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0125 0.1396 0.2202
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0159 0.0154
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0125 0.1396 0.8985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Onchocerca volvulus 0.0057 0.0546 0.0887
Onchocerca volvulus 0.0501 0.6108 1
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0159 0.0154
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0125 0.1396 0.2202
Loa Loa (eye worm) glutaminase 0.0264 0.3139 0.3136
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Schistosoma mansoni intermediate filament proteins 0.0057 0.0546 0.0591
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0053 0.5
Onchocerca volvulus 0.0027 0.0159 0.0252
Echinococcus granulosus intermediate filament protein 0.0057 0.0546 0.0542
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0053
Brugia malayi glutaminase DH11.1 0.0264 0.3139 0.3136
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0751 0.0747
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0137 0.1548 0.1544
Loa Loa (eye worm) hypothetical protein 0.0125 0.1396 0.1392
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0494 0.0489
Echinococcus multilocularis ceramide glucosyltransferase 0.0461 0.5608 0.5606
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0504 0.6152 0.615
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Brugia malayi Cation transporter family protein 0.0177 0.2051 0.2048
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0159 0.0154
Echinococcus granulosus nAChR subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0053
Schistosoma mansoni lamin 0.0057 0.0546 0.0591
Loa Loa (eye worm) RNA binding protein 0.0074 0.0751 0.0747
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0177 0.2051 0.2232
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0027 0.0159 0.0154

Activities

Activity type Activity value Assay description Source Reference
Effect (functional) 0 Evaluated for antiviral activity against cutaneous HSV-1 C42 infections in guinea pig; Active ChEMBL. 6298425
IC50 (binding) > 500 uM Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay ChEMBL. 6298425
IC50 (binding) > 500 uM Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay ChEMBL. 6298425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.