Detailed information for compound 1486636

Basic information

Technical information
  • TDR Targets ID: 1486636
  • Name: 2,3-dimethoxy-N-[1-(3-methoxyphenyl)-5-oxopyr rolidin-3-yl]benzamide
  • MW: 370.399 | Formula: C20H22N2O5
  • H donors: 1 H acceptors: 2 LogP: 1.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N1CC(CC1=O)NC(=O)c1cccc(c1OC)OC
  • InChi: 1S/C20H22N2O5/c1-25-15-7-4-6-14(11-15)22-12-13(10-18(22)23)21-20(24)16-8-5-9-17(26-2)19(16)27-3/h4-9,11,13H,10,12H2,1-3H3,(H,21,24)
  • InChiKey: ZXXZHUFQZDHMEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,3-dimethoxy-N-[1-(3-methoxyphenyl)-5-oxo-pyrrolidin-3-yl]benzamide
  • 2,3-dimethoxy-N-[1-(3-methoxyphenyl)-5-oxo-3-pyrrolidinyl]benzamide
  • N-[5-keto-1-(3-methoxyphenyl)pyrrolidin-3-yl]-2,3-dimethoxy-benzamide
  • G856-7362
  • NCGC00136712-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0066 0.0156 0.0156
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0077 0.0225 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus g protein coupled receptor 0.0063 0.0138 0.0138
Schistosoma mansoni site-1 peptidase (S08 family) 0.0077 0.0225 0.0225
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0138 0.0138
Brugia malayi GnHR receptor homolog 0.0063 0.0138 0.0138
Echinococcus multilocularis protein will die slowly 0.0066 0.0156 0.0199
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Trypanosoma brucei subtilisin peptidase 0.0077 0.0225 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0138 0.0138
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0077 0.0225 0.0225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0063 0.0138 0.0175
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) TYRA-2 protein 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide receptor 0.0063 0.0138 0.0175
Schistosoma mansoni histamine h1 receptor 0.0063 0.0138 0.0138
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0077 0.0225 0.0225
Schistosoma mansoni neuropeptide receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus membrane bound transcription factor site 1 0.0077 0.0225 0.0225
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Giardia lamblia High cysteine membrane protein Group 2 0.0525 0.3007 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Onchocerca volvulus 0.0286 0.1524 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus 7TM GPCR rhodopsin 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Brugia malayi neuropeptide F receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0077 0.0225 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0138 0.0138
Brugia malayi RE15519p 0.0063 0.0138 0.0138
Echinococcus granulosus 7tm_1 domain containing protein 0.0063 0.0138 0.0138
Brugia malayi Hypothetical WD-repeat protein F21H12.1 in chromosome II 0.007 0.0182 0.0182
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni retinoblastoma binding protein 0.007 0.0182 0.0182
Echinococcus granulosus somatostatin receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis allatostatin A receptor 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0347 0.1901 0.3374
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0077 0.0225 0.5
Echinococcus multilocularis neuropeptide receptor A26 0.0063 0.0138 0.0175
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0063 0.0138 0.0175
Schistosoma mansoni site-1 peptidase (S08 family) 0.0077 0.0225 0.0225
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0077 0.0225 0.0225
Plasmodium vivax subtilisin-like protease 1 0.0077 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Brugia malayi G protein-coupled receptor F59B2.13 0.0063 0.0138 0.0138
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Trichomonas vaginalis WD repeat domain, putative 0.0066 0.0156 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0225 0.0398
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0176 0.0843 0.0843
Schistosoma mansoni biogenic amine (5HT) receptor 0.0063 0.0138 0.0138
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0077 0.0225 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0126 0.0532 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Echinococcus granulosus neuropeptide s receptor 0.0063 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0063 0.0138 0.0138
Echinococcus multilocularis g-protein coupled receptor 0.0063 0.0138 0.0175
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus epidermal growth factor receptor 0.0126 0.0532 0.0532
Brugia malayi Furin-like cysteine rich region family protein 0.0126 0.0532 0.0532
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0138 0.0138
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0063 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis wd40 repeat 0.007 0.0182 0.0233
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus peptide allatostatin:somatostatin 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0138 0.0138
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus serotonin receptor 0.0063 0.0138 0.0138
Brugia malayi neuroendocrine convertase 1 precursor 0.1303 0.7835 0.7835
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1524 0.2705
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0063 0.0138 0.0138
Schistosoma mansoni myosin xvIII 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Brugia malayi AKH receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis G protein coupled receptor 139 0.0241 0.1246 0.1588
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0077 0.0225 0.5
Brugia malayi larval opioid receptor 0.0063 0.0138 0.0138
Echinococcus granulosus Furin 1 0.0448 0.2526 0.2526
Brugia malayi Dopamine receptor protein 2 0.0063 0.0138 0.0138
Schistosoma mansoni biogenic amine receptor 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Echinococcus granulosus dro:myosuppressin receptor 0.0063 0.0138 0.0138
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0077 0.0225 0.5
Plasmodium falciparum subtilisin-like protease 1 0.0077 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni alpha-1 adrenergic receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0063 0.0138 0.0138
Echinococcus granulosus G protein coupled receptor 139 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Echinococcus multilocularis neuropeptides capa receptor 0.0063 0.0138 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0077 0.0225 0.0225
Loa Loa (eye worm) proprotein convertase 2 0.0448 0.2526 0.2526
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0225 0.0398
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0077 0.0225 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Brugia malayi Tachykinin-like peptides receptor 99D 0.0063 0.0138 0.0138
Plasmodium vivax subtilisin-like protease 2, putative 0.0077 0.0225 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0077 0.0225 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Echinococcus granulosus neuroendocrine convertase 2 0.1151 0.6891 0.6891
Brugia malayi Dopamine receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0347 0.1901 0.1901
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0138 0.0138
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Loa Loa (eye worm) endoprotease bli-4 0.1652 1 1
Echinococcus multilocularis neuroendocrine convertase 2 0.1151 0.6891 0.8782
Brugia malayi Pre-SET motif family protein 0.0251 0.1309 0.1309
Echinococcus multilocularis epidermal growth factor receptor 0.0126 0.0532 0.0678
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1309 0.1309
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Echinococcus multilocularis orexin receptor type 2 0.0063 0.0138 0.0175
Brugia malayi follicle stimulating hormone receptor 0.0063 0.0138 0.0138
Echinococcus granulosus g protein coupled receptor 0.0063 0.0138 0.0138
Plasmodium falciparum subtilisin-like protease 2 0.0077 0.0225 1
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0077 0.0225 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0948 0.5635 1
Echinococcus granulosus fmrfamide receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptide FF receptor 2 0.0063 0.0138 0.0138
Brugia malayi neuropeptide F receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus protein will die slowly 0.0066 0.0156 0.0156
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus multilocularis somatostatin receptor 0.0063 0.0138 0.0175
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Schistosoma mansoni furin-1 (S08 family) 0.078 0.4589 0.4589
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0077 0.0225 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0225 0.0398
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0077 0.0225 0.0225
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0948 0.5635 0.7181
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0138 0.0175
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0063 0.0138 0.0175
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0077 0.0225 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis membrane bound transcription factor site 1 0.0077 0.0225 0.0286
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis dro:myosuppressin receptor 0.0063 0.0138 0.0175
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0371 0.2051 0.3639
Brugia malayi Will die slowly protein 0.0066 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis serotonin receptor 0.0063 0.0138 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0138 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0063 0.0138 0.0175
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0138 0.0175
Brugia malayi Subtilase family protein 0.0077 0.0225 0.0225
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0225 0.0398
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus granulosus sex peptide receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Trichomonas vaginalis retinoblastoma binding protein, putative 0.007 0.0182 0.0324
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) G-protein coupled receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0063 0.0138 0.0175
Echinococcus granulosus g-protein coupled receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Leishmania major subtilisin-like serine peptidase 0.0077 0.0225 0.5
Brugia malayi Serotonin receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0063 0.0138 0.0175
Trypanosoma cruzi subtilisin peptidase 0.0077 0.0225 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0063 0.0138 0.0175
Echinococcus granulosus alpha 1A adrenergic receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0063 0.0138 0.0138
Schistosoma mansoni biogenic amine receptor 0.0063 0.0138 0.0138
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptide receptor 0.0241 0.1246 0.1246
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide receptor 0.0241 0.1246 0.1588
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0101 0.0374 0.0374
Echinococcus multilocularis G-protein coupled receptor, putative 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Plasmodium vivax subtilisin-like serine protease, putative 0.0077 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0182 0.0182
Echinococcus granulosus neuropeptide Y receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0948 0.5635 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0063 0.0138 0.0138
Brugia malayi ORL1-like opioid receptor 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptide receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis rhodopsin orphan GPCR 0.0063 0.0138 0.0175
Schistosoma mansoni biogenic amine receptor 0.0063 0.0138 0.0138
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0063 0.0138 0.0175
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Schistosoma mansoni tyrosine kinase 0.0126 0.0532 0.0532
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0138 0.0175
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0948 0.5635 0.5635
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0063 0.0138 0.0175
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0371 0.2051 0.3639
Echinococcus multilocularis sex peptide receptor 0.0063 0.0138 0.0175
Brugia malayi G-protein coupled receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1652 1 1
Brugia malayi Melatonin receptor type 1A 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0727 0.4263 0.4263
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis serotonin receptor 0.0063 0.0138 0.0175
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0077 0.0225 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Schistosoma mansoni neuropeptide receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus granulosus hypothetical protein 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0101 0.0374 0.0664
Echinococcus granulosus neuropeptides capa receptor 0.0063 0.0138 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis 0.1305 0.7847 1
Brugia malayi G-protein coupled receptor 0.0063 0.0138 0.0138
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni growth hormone secretagogue receptor 0.0063 0.0138 0.0138
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Brugia malayi Dopamine receptor protein 1 0.0063 0.0138 0.0138
Brugia malayi hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide FF receptor 2 0.0063 0.0138 0.0175
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0077 0.0225 0.0286
Schistosoma mansoni hypothetical protein 0.0063 0.0138 0.0138
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0063 0.0138 0.0138
Echinococcus granulosus g protein coupled receptor 0.0063 0.0138 0.0138
Echinococcus granulosus neuropeptide receptor A26 0.0063 0.0138 0.0138
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0063 0.0138 0.0138
Schistosoma mansoni opsin-like receptor 0.0063 0.0138 0.0138
Schistosoma mansoni opsin-like receptor 0.0063 0.0138 0.0138
Echinococcus multilocularis Furin 1 0.0448 0.2526 0.3219
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Schistosoma mansoni neuropeptide receptor 0.0241 0.1246 0.1246
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0063 0.0138 0.0175
Brugia malayi sulfakinin receptor protein 0.0063 0.0138 0.0138
Echinococcus granulosus furin 0.1652 1 1
Onchocerca volvulus 0.0077 0.0225 0.0626
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) WD40 repeat protein 0.0066 0.0156 0.0156
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Echinococcus granulosus allatostatin A receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Schistosoma mansoni neuropeptide receptor 0.0063 0.0138 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0063 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0225 0.0398
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0138 0.0175
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni adenoreceptor 0.0063 0.0138 0.0138
Onchocerca volvulus 0.0066 0.0156 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374
Toxoplasma gondii subtilisin SUB12 0.0091 0.0313 1
Brugia malayi putative neuropeptide receptor 0.0063 0.0138 0.0138
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0063 0.0138 0.0138
Echinococcus granulosus wd40 repeat 0.007 0.0182 0.0182
Plasmodium falciparum subtilisin-like protease 3 0.0077 0.0225 1
Brugia malayi proprotein convertase 2 0.1151 0.6891 0.6891
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0063 0.0138 0.0138
Brugia malayi putative neuropeptide receptor NPR1 0.0063 0.0138 0.0138
Loa Loa (eye worm) melatonin receptor type 1A 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0448 0.2526 0.2526
Echinococcus multilocularis g protein coupled receptor 0.0063 0.0138 0.0175
Echinococcus granulosus biogenic amine 5HT receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) subtilase 0.0077 0.0225 0.0225
Trichomonas vaginalis hypothetical protein 0.0347 0.1901 0.3374
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0063 0.0138 0.0138
Brugia malayi celfurPC protein 0.1305 0.7847 0.7847
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Schistosoma mansoni hypothetical protein 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) neuropeptide F receptor 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0448 0.2526 0.4483
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0063 0.0138 0.0175
Echinococcus granulosus tm gpcr rhodopsin 0.0063 0.0138 0.0138
Schistosoma mansoni opsin-like receptor 0.0063 0.0138 0.0138
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0077 0.0225 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0063 0.0138 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0182 0.0324
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Mycobacterium leprae Possible secreted protease 0.0077 0.0225 0.5
Brugia malayi Serotonin receptor 0.0063 0.0138 0.0138
Echinococcus granulosus orexin receptor type 2 0.0063 0.0138 0.0138
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0063 0.0138 0.0138
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0063 0.0138 0.0138
Brugia malayi G protein-coupled receptor 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.1652 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0063 0.0138 0.0138
Schistosoma mansoni amine GPCR 0.0063 0.0138 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0077 0.0225 0.0398
Echinococcus granulosus tachykinin peptides receptor 99D 0.0063 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0063 0.0138 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.0063 0.0138 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.1901 0.3374

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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