Detailed information for compound 1487471

Basic information

Technical information
  • TDR Targets ID: 1487471
  • Name: ZINC01038800
  • MW: 359.281 | Formula: C13H8F3N3O4S
  • H donors: 1 H acceptors: 4 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(Oc1ccc(cc1)NS(=O)(=O)c1cccc2c1non2)(F)F
  • InChi: 1S/C13H8F3N3O4S/c14-13(15,16)22-9-6-4-8(5-7-9)19-24(20,21)11-3-1-2-10-12(11)18-23-17-10/h1-7,19H
  • InChiKey: KOOGCVYXTDTARL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000850590
  • N4-[4-(trifluoromethoxy)phenyl]-2,1,3-benzoxadiazole-4-sulfonamide
  • SMR000456608

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0531 0.4135 0.4135
Echinococcus multilocularis neurogenic differentiation factor 1 0.0004 0.0003 0.0003
Echinococcus granulosus cell growth regulator with ring finger domain 0.0006 0.0022 0.0022
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Echinococcus granulosus transcription factor 12 0.0004 0.0003 0.0003
Echinococcus multilocularis Basic helix loop helix dimerisation region bHLH 0.0004 0.0003 0.0003
Trichomonas vaginalis ankyrin, putative 0.0006 0.0022 0.2335
Schistosoma mansoni Upstream stimulatory factor 0.0004 0.0003 0.0003
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0006 0.0022 0.0022
Echinococcus multilocularis 0.0006 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0068 0.226
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Echinococcus multilocularis inhibitor of apoptosis protein 0.1279 1 1
Schistosoma mansoni Mxi neural development protein 0.0004 0.0003 0.0003
Echinococcus granulosus Mxi neural development protein 0.0004 0.0003 0.0003
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0013 0.0077 1
Trichomonas vaginalis ion channel nompc, putative 0.0006 0.0022 0.2335
Onchocerca volvulus 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0006 0.0022 0.0022
Echinococcus granulosus upstream transcription factor 1 0.0004 0.0003 0.0003
Echinococcus granulosus DNA binding protein inhibitor ID 4 0.0004 0.0003 0.0003
Echinococcus granulosus transcription factor 15 0.0004 0.0003 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0248 0.1918 0.1918
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus multilocularis apoptotic protease activating factor 1 0.0273 0.2117 0.2117
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0006 0.0022 0.2335
Trichomonas vaginalis ankyrin, putative 0.0006 0.0022 0.2335
Echinococcus multilocularis transcription factor sum myogenic determinant factor 0.0004 0.0003 0.0003
Echinococcus granulosus Basic helix loop helix dimerisation region bHLH 0.0004 0.0003 0.0003
Echinococcus granulosus ring finger protein 113a 0.0006 0.0022 0.0022
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Schistosoma mansoni basic helix-loop-helix protein 0.0004 0.0003 0.0003
Schistosoma mansoni n-twist 0.0004 0.0003 0.0003
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0013 0.0077 0.1942
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Loa Loa (eye worm) twist 1 0.0004 0.0003 0.0003
Echinococcus multilocularis potassium voltage gated channel protein 0.0019 0.0122 0.0122
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0068 0.0068
Schistosoma mansoni ring finger protein 151 0.0006 0.0022 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0264 0.0264
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0008 0.0008
Schistosoma mansoni achaete-scute transcription factor-related 0.0004 0.0003 0.0003
Echinococcus granulosus achaete scute transcription factor 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Trichomonas vaginalis ankyrin, putative 0.0006 0.0022 0.2335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Entamoeba histolytica hypothetical protein 0.0043 0.0315 1
Echinococcus multilocularis DNA binding protein inhibitor ID 4 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Onchocerca volvulus 0.0004 0.0003 0.0003
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0068 0.8347
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0006 0.0022 0.2335
Echinococcus granulosus aryl hydrocarbon receptor 0.0004 0.0003 0.0003
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0013 0.0077 0.0077
Onchocerca volvulus 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Echinococcus multilocularis transcription factor HES 2 0.0004 0.0003 0.0003
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0004 0.0003 0.0003
Schistosoma mansoni zinc finger protein 0.0006 0.0022 0.0022
Brugia malayi RNA binding protein 0.0076 0.0574 0.0574
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0013 0.0077 0.0077
Echinococcus multilocularis STARP-like antigen 0.0004 0.0003 0.0003
Leishmania major eukaryotic initiation factor 4a, putative 0.0013 0.0077 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0005 0.0000000053612
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0068 0.0068
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0068 0.8347
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0006 0.0022 0.0022
Echinococcus multilocularis aryl hydrocarbon receptor 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0077 0.0077
Trichomonas vaginalis DNA helicase recq1, putative 0.0012 0.0068 0.8733
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0574 0.0574
Onchocerca volvulus Protein neuralized homolog 0.0006 0.0022 0.0022
Brugia malayi hypothetical protein 0.0273 0.2117 0.2117
Leishmania major eukaryotic initiation factor 4a, putative 0.0013 0.0077 1
Loa Loa (eye worm) histone methyltransferase 0.0005 0.0016 0.0016
Echinococcus granulosus STARP-like antigen 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Schistosoma mansoni twist 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0043 0.0315 0.0315
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1279 1 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0574 0.0574
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0016 0.0016
Plasmodium vivax RNA helicase-1, putative 0.0013 0.0077 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0013 0.0077 1
Schistosoma mansoni basic helix-loop-helix transcription factor hes-related 0.0004 0.0003 0.0003
Echinococcus granulosus microphthalmia associated transcription factor 0.0004 0.0003 0.0003
Schistosoma mansoni activator protein 4 (ap4) 0.0004 0.0003 0.0003
Treponema pallidum ATP-dependent RNA helicase 0.0013 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Schistosoma mansoni dhand 0.0004 0.0003 0.0003
Echinococcus granulosus transcription factor sum 0.0004 0.0003 0.0003
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0006 0.0022 0.0022
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0006 0.0022 0.0078
Echinococcus multilocularis RING finger protein 185 0.0006 0.0022 0.0022
Echinococcus granulosus heart and neural crest derivatives expressed 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis STARP-like antigen 0.0004 0.0003 0.0003
Loa Loa (eye worm) RecQ helicase 0.0012 0.0068 0.0068
Echinococcus granulosus bhlh factor math6 0.0004 0.0003 0.0003
Onchocerca volvulus Protein cycle homolog 0.0004 0.0003 0.0003
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Onchocerca volvulus 0.0004 0.0003 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0022 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0068 0.8347
Echinococcus multilocularis transcription factor AP 4 0.0004 0.0003 0.0003
Plasmodium vivax RING zinc finger protein, putative 0.0006 0.0022 0.029
Plasmodium vivax DNA repair protein RAD5, putative 0.0006 0.0022 0.029
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis mxi neural development protein max dimerization protein 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Brugia malayi B-box zinc finger family protein 0.0006 0.0022 0.0022
Schistosoma mansoni cpg binding protein 0.0018 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Echinococcus granulosus apoptotic protease activating factor 1 0.0273 0.2117 0.2117
Echinococcus multilocularis Basic helix loop helix dimerisation region bHLH 0.0004 0.0003 0.0003
Onchocerca volvulus Cell death protein 3 homolog 0.0273 0.2117 0.2117
Loa Loa (eye worm) RiNg Finger protein family member 0.0006 0.0022 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0005 0.0016 0.0016
Schistosoma mansoni cpg binding protein 0.0017 0.0111 0.0111
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0531 0.4135 0.4135
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Toxoplasma gondii RING zinc finger protein 0.0006 0.0022 0.0078
Brugia malayi RING finger protein 20 0.0006 0.0022 0.0022
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0013 0.0077 1
Echinococcus granulosus transcription factor hes-2 0.0004 0.0003 0.0003
Brugia malayi neurogenic differentiation factor 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Leishmania major DNA repair protein-like protein 0.0006 0.0022 0.0000000069943
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0013 0.0077 0.0077
Brugia malayi Twist related protein 0.0004 0.0003 0.0003
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0006 0.0022 0.0022
Echinococcus multilocularis ring finger protein 170 0.0006 0.0022 0.0022
Echinococcus granulosus ring finger protein 170 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0006 0.0022 0.0022
Echinococcus multilocularis cpg binding protein 0.0018 0.0118 0.0118
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix protein 1 0.0004 0.0003 0.0003
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0006 0.0022 0.2335
Schistosoma mansoni rnf5 0.0006 0.0022 0.0022
Echinococcus granulosus STARP-like antigen 0.0004 0.0003 0.0003
Echinococcus granulosus sterol regulatory element binding protein 1 0.0004 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0043 0.0315 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0043 0.0315 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0006 0.0022 0.2335
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus granulosus caspase 2 0.0273 0.2117 0.2117
Onchocerca volvulus 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0574 0.0574
Schistosoma mansoni basic helix-loop-helix transcription factor 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0006 0.0022 0.0022
Schistosoma mansoni musculin 0.0004 0.0003 0.0003
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0068 0.8347
Echinococcus multilocularis achaete scute transcription factor 0.0004 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0122 0.0122
Echinococcus granulosus mixed lineage leukemia protein mll 0.0004 0.0008 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0574 0.0574
Echinococcus granulosus STARP-like antigen 0.0004 0.0003 0.0003
Echinococcus granulosus bhlhzip transcription factor max:bigmax 0.0004 0.0003 0.0003
Schistosoma mansoni mind bomb 0.0006 0.0022 0.0022
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1279 1 1
Schistosoma mansoni inhibitor of apoptosis protein 0.1279 1 1
Echinococcus multilocularis hairy:enhancer of split related with YRPW 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni basic helix-loop-helix transcription factor hes-related 0.0004 0.0003 0.0003
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0006 0.0022 0.0056
Schistosoma mansoni neurogenic differentiation factor 0.0004 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0004 0.0003 0.0003
Echinococcus granulosus inhibitor of apoptosis protein 0.1279 1 1
Brugia malayi Neuralized family protein 0.0006 0.0022 0.0022
Echinococcus granulosus transcription factor eb 0.0004 0.0003 0.0003
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0004 0.0003 0.0003
Echinococcus multilocularis transcription factor 21 0.0004 0.0003 0.0003
Echinococcus multilocularis STARP-like antigen 0.0004 0.0003 0.0003
Schistosoma mansoni single-minded 0.0004 0.0003 0.0003
Schistosoma mansoni neurogenic differentiation factor 0.0004 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0574 0.0574
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Onchocerca volvulus 0.0004 0.0003 0.0003
Schistosoma mansoni DNA-binding protein inhibitor 0.0004 0.0003 0.0003
Schistosoma mansoni bhlhzip transcription factor max/bigmax 0.0004 0.0003 0.0003
Onchocerca volvulus 0.0006 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0004 0.0003 0.0003
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0006 0.0022 0.2335
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0006 0.0022 0.2335
Loa Loa (eye worm) hypothetical protein 0.0273 0.2117 0.2117
Entamoeba histolytica SPRY domain protein 0.0006 0.0022 0.0056
Onchocerca volvulus RING finger protein 141 homolog 0.0006 0.0022 0.0022
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0006 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0006 0.0022 0.0022
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0068 0.8733
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0068 0.1631
Schistosoma mansoni caspase-7 (C14 family) 0.0273 0.2117 0.2117
Schistosoma mansoni cpg binding protein 0.0018 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0068 0.0068
Brugia malayi Cell death protein 3 precursor 0.0273 0.2117 0.2117
Echinococcus multilocularis transcription factor 12 0.0004 0.0003 0.0003
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0004 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0122 0.0122
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.002 0.002
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1279 1 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0006 0.0022 0.032
Schistosoma mansoni zinc finger transcription factor gli2 0.0004 0.0003 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0248 0.1918 0.1918
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni paraxis 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0019 0.0122 0.0122
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Brugia malayi helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0574 0.0574
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0315 0.0315
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0016 0.0016
Echinococcus multilocularis Basic helix loop helix dimerisation region bHLH 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni peter pan-related 0.0006 0.0022 0.0022
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni peter pan-related 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Schistosoma mansoni max binding protein mnt 0.0004 0.0003 0.0003
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0013 0.0077 0.0077
Echinococcus multilocularis sterol regulatory element binding protein 1 0.0004 0.0003 0.0003
Plasmodium vivax trophozoite exported protein 1, putative 0.0006 0.0022 0.029
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Schistosoma mansoni aryl hydrocarbon receptor 0.0004 0.0003 0.0003
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0013 0.0077 0.2692
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0122
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus granulosus eukaryotic initiation factor 4A 0.0013 0.0077 0.0077
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Trypanosoma brucei DNA repair protein, putative 0.0006 0.0022 0.0000000069943
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0018 0.0115 0.0115
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0006 0.0022 0.0078
Echinococcus multilocularis microphthalmia associated transcription factor 0.0004 0.0003 0.0003
Schistosoma mansoni transcription factor hey (hesr1) 0.0004 0.0003 0.0003
Brugia malayi TAR-binding protein 0.0076 0.0574 0.0574
Echinococcus multilocularis heart and neural crest derivatives expressed 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.1279 1 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0004 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0248 0.1918 0.1918
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0068 0.8733
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0013 0.0077 1
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0013 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis twist protein 0.0004 0.0003 0.0003
Echinococcus granulosus transcription factor 21 0.0004 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0022 0.0022
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0531 0.4135 0.4135
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0006 0.0022 0.029
Schistosoma mansoni hypothetical protein 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Onchocerca volvulus 0.0004 0.0003 0.0003
Schistosoma mansoni transcription factor 0.0004 0.0003 0.0003
Onchocerca volvulus Deterin homolog 0.1279 1 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0013 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus granulosus neurogenic differentiation factor 1 0.0004 0.0003 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0111 0.0111
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1279 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0315 0.0315
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus multilocularis ring finger protein 113a 0.0006 0.0022 0.0022
Echinococcus multilocularis upstream transcription factor 1 0.0004 0.0003 0.0003
Loa Loa (eye worm) neurogenic differentiation factor 0.0004 0.0003 0.0003
Brugia malayi CXXC zinc finger family protein 0.0017 0.0111 0.0111
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0122 0.0122
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0004 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0008 0.0008
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni upstream transcription factor 1 usf1 0.0004 0.0003 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0068 0.226
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0068 0.8347
Echinococcus granulosus hairy:enhancer of split related with YRPW 0.0004 0.0003 0.0003
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0006 0.0022 0.2335
Echinococcus multilocularis transcription factor eb 0.0004 0.0003 0.0003
Echinococcus multilocularis max protein X 0.0531 0.4135 0.4135
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0574 0.0574
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0068 0.0068
Echinococcus granulosus max protein X 0.0531 0.4135 0.4135
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0068 0.0068
Brugia malayi Bloom's syndrome protein homolog 0.0012 0.0068 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0033 0.0233 1
Entamoeba histolytica hypothetical protein 0.0043 0.0315 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0022 0.0031
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0006 0.0022 0.0078
Echinococcus granulosus pancreas transcription factor 1 subunit 0.0004 0.0003 0.0003
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0006 0.0022 0.0022
Onchocerca volvulus Putative RING finger protein 207 0.0006 0.0022 0.0022
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0006 0.0022 0.2335
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0019 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0273 0.2117 0.2117
Brugia malayi transcription factor Ash2 0.0004 0.0003 0.0003
Brugia malayi Zinc finger protein 183 homolog 0.0006 0.0022 0.0022
Echinococcus multilocularis bhlh factor math6 0.0004 0.0003 0.0003
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0013 0.0077 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0006 0.0022 0.0022
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Schistosoma mansoni myogenic factor 0.0004 0.0003 0.0003
Onchocerca volvulus 0.0017 0.0111 0.0111
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0006 0.0022 0.0022
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Echinococcus granulosus cpg binding protein 0.0018 0.0118 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Loa Loa (eye worm) transcription factor Ash2 0.0004 0.0003 0.0003
Onchocerca volvulus 0.0006 0.0022 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Schistosoma mansoni neurogenic differentiation factor 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Schistosoma mansoni hypothetical protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Brugia malayi hypothetical protein 0.0004 0.0003 0.0003
Brugia malayi BETA3 protein 0.0004 0.0003 0.0003
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0574 0.0574
Echinococcus granulosus bloom syndrome protein 0.0012 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0273 0.2117 0.2117
Echinococcus multilocularis transcription factor 15 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Echinococcus multilocularis pancreas transcription factor 1 subunit 0.0004 0.0003 0.0003
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0006 0.0022 0.029
Toxoplasma gondii hypothetical protein 0.0006 0.0022 0.0078
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0574 0.0574
Echinococcus multilocularis STARP-like antigen 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0006 0.0022 0.2335
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0005 0.0000000053612
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0013 0.0077 0.0077
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0013 0.0077 0.5
Onchocerca volvulus 0.1279 1 1
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0531 0.4135 0.4135
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0013 0.0077 1
Schistosoma mansoni DNA helicase recq5 0.0012 0.0068 0.0068
Onchocerca volvulus 0.0006 0.0022 0.0022
Brugia malayi RING zinc finger protein 0.0006 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0003 0 0.5
Onchocerca volvulus 0.0004 0.0003 0.0003
Plasmodium vivax zinc finger protein, putative 0.0006 0.0022 0.029
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0022 0.0062
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0006 0.0022 0.0022
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Loa Loa (eye worm) RING finger protein 20 0.0006 0.0022 0.0022
Onchocerca volvulus 0.0273 0.2117 0.2117
Onchocerca volvulus 0.0006 0.0022 0.0022
Toxoplasma gondii hypothetical protein 0.0006 0.0022 0.0078
Schistosoma mansoni DNA helicase recq1 0.0012 0.0068 0.0068
Echinococcus granulosus RING finger protein 185 0.0006 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0004 0.0003 0.0003
Echinococcus multilocularis bloom syndrome protein 0.0012 0.0068 0.0068
Brugia malayi hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0004 0.0005 0.0000000053612
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0004 0.0003 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0315 0.0315
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0004 0.0003 0.0003
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0006 0.0022 0.2335
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0068 0.8347
Echinococcus granulosus transcription factor AP 4 0.0004 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0006 0.0022 0.0022
Brugia malayi eukaryotic initiation factor 4A 0.0013 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.1279 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Toxoplasma gondii hypothetical protein 0.0006 0.0022 0.0078
Echinococcus granulosus twist protein 0.0004 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0043 0.0315 0.0315
Onchocerca volvulus 0.0004 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0006 0.0022 0.0056
Echinococcus multilocularis caspase 2 0.0273 0.2117 0.2117
Echinococcus multilocularis bhlhzip transcription factor max:bigmax 0.0004 0.0003 0.0003
Toxoplasma gondii helicase, putative 0.0006 0.0022 0.0078
Toxoplasma gondii hypothetical protein 0.0006 0.0022 0.0078
Plasmodium falciparum eukaryotic initiation factor 4A 0.0013 0.0077 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0008 0.0008
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0006 0.0022 0.0078
Echinococcus granulosus tar DNA binding protein 0.0076 0.0574 0.0574
Loa Loa (eye worm) hypothetical protein 0.1279 1 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0068 0.0068
Onchocerca volvulus 0.0004 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Loa Loa (eye worm) helix-loop-helix protein 1 0.0004 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0006 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0022 0.2335
Onchocerca volvulus 0.0004 0.0003 0.0003
Schistosoma mansoni activator protein 4 (ap4) 0.0004 0.0003 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0022 0.0086
Entamoeba histolytica zinc finger domain containing protein 0.0006 0.0022 0.0056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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