Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2 receptor | Starlite/ChEMBL | No references |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | ferric reductase, putative | 0.2222 | 0.6278 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.2222 | 0.6278 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0634 | 0.1689 | 1 |
Giardia lamblia | Programmed cell death protein-like protein | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.3509 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0115 | 0.0189 | 0.0189 |
Echinococcus multilocularis | Calcium binding protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | calcyphosin protein | 0.005 | 0 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0634 | 0.1689 | 0.5 |
Trichomonas vaginalis | calcium binding protein, putative | 0.005 | 0 | 0.5 |
Toxoplasma gondii | calmodulin, putative | 0.005 | 0 | 0.5 |
Plasmodium falciparum | centrin-4 | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.3577 | 0.3577 |
Trichomonas vaginalis | caltractin, putative | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.2222 | 0.6278 | 0.5 |
Trichomonas vaginalis | caltractin, putative | 0.005 | 0 | 0.5 |
Echinococcus granulosus | calcyphosin protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | programmed cell death protein 6 | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0115 | 0.0189 | 0.0189 |
Onchocerca volvulus | Dual oxidase homolog | 0.3509 | 1 | 1 |
Echinococcus granulosus | Calcium binding protein | 0.005 | 0 | 0.5 |
Toxoplasma gondii | EF hand domain-containing protein | 0.005 | 0 | 0.5 |
Toxoplasma gondii | calcium binding protein precursor, putative | 0.005 | 0 | 0.5 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.2222 | 0.6278 | 0.5 |
Echinococcus granulosus | programmed cell death protein 6 | 0.005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 400 nM | Tested for inhibition of adenosine A1 receptor binding to rat brain | ChEMBL. | No reference |
Ki (binding) | = 400 nM | Tested for inhibition of adenosine A1 receptor binding to rat brain | ChEMBL. | No reference |
Ki (binding) | = 2700 nM | Tested for inhibition of adenosine A2 receptor binding to rat brain | ChEMBL. | No reference |
Ki (binding) | = 2700 nM | Tested for inhibition of adenosine A2 receptor binding to rat brain | ChEMBL. | No reference |
logP (ADMET) | 0 | Partition coefficient (logP) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.