TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.393 | Formula: C18H22N4O
H donors: 0 H acceptors: 2 LogP: 1.56 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CCn1nc2c3c1cccc3C(=O)N(C2)[C@@H]1CN2CCC1CC2
InChi: 1S/C18H22N4O/c1-2-22-15-5-3-4-13-17(15)14(19-22)10-21(18(13)23)16-11-20-8-6-12(16)7-9-20/h3-5,12,16H,2,6-11H2,1H3/t16-/m1/s1
InChiKey: JOEZRUWANPRMKY-MRXNPFEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cation transporter family protein	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	484 aa	469 aa	28.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Plasmodium falciparum	choline kinase	0.0081	0.0136	0.8637
Brugia malayi	Carboxylesterase family protein	0.0411	0.1018	0.1018
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0069	0.0104	0.6186
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Schistosoma mansoni	hypothetical protein	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0096	0.0173
Giardia lamblia	Hypothetical protein	0.0088	0.0153	1
Echinococcus multilocularis	carboxylesterase 5A	0.0411	0.1018	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0062	0.0084	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.2105	0.5557	0.5557
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0447	0.1115	1
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Brugia malayi	follicle stimulating hormone receptor	0.0037	0.0016	0.0016
Echinococcus multilocularis	calcium activated potassium channel variant	0.0088	0.0153	0.0276
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0088	0.0153	0.0153
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1018	0.1018
Loa Loa (eye worm)	integrin alpha pat-2	0.0246	0.0577	0.0577
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0069	0.0104	0.0186
Brugia malayi	Choline/ethanolamine kinase family protein	0.0081	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0067	0.0096	0.0173
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0088	0.0153	0.0153
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0067	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma cruzi	ion transport protein, putative	0.0088	0.0153	0.0131
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0069	0.0104	0.0186
Echinococcus granulosus	calcium activated potassium channel variant	0.0088	0.0153	0.0276
Mycobacterium ulcerans	ion transport protein	0.0088	0.0153	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Onchocerca volvulus		0.0036	0.0014	0.0132
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus multilocularis	small conductance calcium activated potassium	0.2105	0.5557	1
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0069	0.0104	0.6186
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0016	0.0029
Trypanosoma cruzi	Emopamil binding protein, putative	0.0422	0.1049	0.1029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Echinococcus granulosus	sex peptide receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0067	0.0096	0.0173
Echinococcus granulosus	G protein coupled receptor 139	0.0037	0.0016	0.0029
Echinococcus multilocularis	integrin alpha ps	0.0072	0.0109	0.0197
Brugia malayi	G protein-coupled receptor F59B2.13	0.0037	0.0016	0.0016
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Brugia malayi	AKH receptor	0.0037	0.0016	0.0016
Onchocerca volvulus		0.0037	0.0016	0.0151
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0088	0.0153	0.0153
Loa Loa (eye worm)	LGC-31 protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0422	0.1049	0.1029
Echinococcus granulosus	potassium channel subfamily K 8	0.0088	0.0153	0.0276
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0096	0.0096
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0069	0.0104	0.0186
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0096	0.0096
Schistosoma mansoni	jumonji domain containing protein	0.0062	0.0084	0.0151
Echinococcus multilocularis	twik family of potassium channels	0.0088	0.0153	0.0276
Echinococcus multilocularis	lysine specific demethylase 5A	0.0062	0.0084	0.0151
Schistosoma mansoni	hypothetical protein	0.0034	0.001	0.0017
Echinococcus granulosus	BC026374 protein S09 family	0.0069	0.0104	0.0186
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0121	0.0241	0.0241
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.0031	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0046	0.0046
Schistosoma mansoni	opsin-like receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.3763	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0404	0.1	0.1799
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0082	0.006
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0037	0.0016	0.0029
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Echinococcus granulosus	biogenic amine 5HT receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	dro:myosuppressin receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Echinococcus multilocularis	integrin beta 2	0.0242	0.0567	0.102
Brugia malayi	Kelch motif family protein	0.005	0.0051	0.0051
Toxoplasma gondii	ion channel protein	0.0088	0.0153	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0088	0.0153	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0154	0.0154
Echinococcus granulosus	integrin alpha ps	0.0072	0.0109	0.0197
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Onchocerca volvulus		0.0037	0.0016	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0411	0.1018	0.1018
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0067	0.0096	0.0096
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0037	0.0016	0.0016
Echinococcus multilocularis	serotonin receptor	0.0404	0.1	0.1799
Brugia malayi	jmjC domain containing protein	0.0062	0.0084	0.0084
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0074	0.0133
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0096	0.0096
Brugia malayi	Dopamine receptor	0.0037	0.0016	0.0016
Leishmania major	cathepsin L-like protease	0.0067	0.0098	0.0076
Onchocerca volvulus		0.0067	0.0096	0.0917
Onchocerca volvulus		0.0067	0.0096	0.0917
Brugia malayi	jmjC domain containing protein	0.0062	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Echinococcus granulosus	integrin alpha ps	0.0034	0.001	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0016	0.0029
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0016	0.0029
Brugia malayi	Dopamine receptor protein 2	0.0037	0.0016	0.0016
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0069	0.0104	0.0186
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Schistosoma mansoni	amine GPCR	0.0037	0.0016	0.0029
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0088	0.0153	1
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0067	0.0096	0.0173
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0016	0.0029
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0013	0.0009
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0098	0.0076
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0435	0.1083	0.1949
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	neuropeptide receptor A26	0.0037	0.0016	0.0029
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0037	0.0016	0.0151
Schistosoma mansoni	microtubule-associated protein tau	0.0728	0.1868	0.3361
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0036	0.0014	0.0025
Echinococcus multilocularis	serotonin receptor	0.0404	0.1	0.1799
Brugia malayi	Carboxylesterase family protein	0.0069	0.0104	0.0104
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0031	0.0056
Schistosoma mansoni	neuropeptide F-like receptor	0.0037	0.0016	0.0029
Brugia malayi	GnHR receptor homolog	0.0037	0.0016	0.0016
Entamoeba histolytica	hypothetical protein	0.0041	0.0026	0.0116
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0096	0.0173
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Trichomonas vaginalis	spcc417.12 protein, putative	0.0069	0.0104	0.6186
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0067	0.0096	0.0096
Plasmodium falciparum	potassium channel	0.0088	0.0153	1
Echinococcus granulosus	microtubule associated protein 2	0.0728	0.1868	0.3361
Echinococcus granulosus	neuroligin	0.0069	0.0104	0.0186
Echinococcus multilocularis	neuroligin	0.0069	0.0104	0.0186
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Echinococcus granulosus	hypothetical protein	0.0037	0.0016	0.0029
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0125	0.0253	0.0456
Brugia malayi	larval opioid receptor	0.0037	0.0016	0.0016
Echinococcus granulosus	tankyrase	0.0041	0.0026	0.0047
Brugia malayi	Integrin beta pat-3 precursor	0.0327	0.0794	0.0794
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma brucei	C-8 sterol isomerase, putative	0.3763	1	1
Onchocerca volvulus		0.0088	0.0153	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0016	0.0029
Onchocerca volvulus		0.0069	0.0104	0.0988
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	choline/ethanolamine kinase	0.0081	0.0136	0.0136
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0084	0.0151
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0088	0.0153	0.0153
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	integrin beta-2	0.0327	0.0794	0.0794
Brugia malayi	Cation transporter family protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Trypanosoma brucei	Emopamil binding protein, putative	0.0422	0.1049	0.1045
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0037	0.0016	0.0029
Schistosoma mansoni	histamine h1 receptor	0.0037	0.0016	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0067	0.0096	0.0096
Brugia malayi	Integrin alpha pat-2 precursor	0.016	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Onchocerca volvulus		0.0422	0.1049	1
Echinococcus granulosus	neuropeptide s receptor	0.0037	0.0016	0.0029
Onchocerca volvulus		0.0088	0.0153	0.1463
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0016	0.0029
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0016	0.0029
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0031	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	microtubule associated protein 2	0.0728	0.1868	0.3361
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus granulosus	choline:ethanolamine kinase	0.0081	0.0136	0.0244
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0037	0.0016	0.0029
Brugia malayi	neuropeptide F receptor	0.0037	0.0016	0.0016
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0098	0.0076
Echinococcus granulosus	serotonin receptor	0.0037	0.0016	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0037	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0088	0.0153	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0084	0.0084
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.03	0.0722	0.1299
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Onchocerca volvulus		0.0037	0.0016	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Leishmania major	hypothetical protein, conserved	0.0088	0.0153	0.0131
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0422	0.1049	0.1029
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0023	0.0041
Schistosoma mansoni	integrin beta subunit	0.0193	0.0434	0.078
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0435	0.1083	0.1949
Echinococcus granulosus	twik family of potassium channels	0.0088	0.0153	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0031	0.0009
Brugia malayi	Serotonin receptor	0.0037	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Echinococcus granulosus	acetylcholinesterase	0.0411	0.1018	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	tnks protein	0.0041	0.0026	0.0026
Echinococcus granulosus	g protein coupled receptor	0.0037	0.0016	0.0029
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.03	0.0722	0.0701
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0088	0.0153	0.0276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.0014	0.0014
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.3763	1	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0069	0.0104	0.0186
Trypanosoma brucei	Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative	0.0039	0.0022	0.0019
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	hypothetical protein	0.2105	0.5557	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0088	0.0153	0.0153
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0067	0.0096	0.0096
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0016	0.0029
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0067	0.0096	0.0096
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0037	0.0016	0.0029
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0062	0.0084	0.0151
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	potassium channel subfamily K 8	0.0088	0.0153	0.0276
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0023	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0088	0.0153	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.026	0.0613	0.1103
Onchocerca volvulus		0.0088	0.0153	0.1463
Loa Loa (eye worm)	hypothetical protein	0.03	0.0721	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0037	0.0016	0.0029
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0037	0.0016	0.0016
Echinococcus granulosus	nAChR subunit	0.0036	0.0014	0.0025
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0016	0.0016
Trypanosoma cruzi	ion transport protein, putative	0.0088	0.0153	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0812	0.2094	0.2094
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0069	0.0104	0.0186
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0031	0.0639
Loa Loa (eye worm)	G-protein coupled receptor	0.0037	0.0016	0.0016
Brugia malayi	Cation transporter family protein	0.0067	0.0096	0.0096
Schistosoma mansoni	hypothetical protein	0.0037	0.0016	0.0029
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0023	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0088	0.0153	0.0153
Schistosoma mansoni	calcium-activated potassium channel	0.2105	0.5557	1
Brugia malayi	hypothetical protein	0.0069	0.0104	0.0104
Onchocerca volvulus		0.0037	0.0016	0.0151
Brugia malayi	G-protein coupled receptor	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0016	0.0029
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	neuropeptide FF receptor 2	0.0037	0.0016	0.0029
Schistosoma mansoni	hypothetical protein	0.0037	0.0016	0.0029
Onchocerca volvulus		0.0067	0.0096	0.0917
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0088	0.0153	0.0153
Trypanosoma brucei	unspecified product	0.0036	0.0013	0.0009
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	neuropeptide receptor A26	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Echinococcus multilocularis	integrin alpha ps	0.0034	0.001	0.0017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0037	0.0016	0.0029
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0088	0.0153	0.0153
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0088	0.0153	0.0276
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0096	0.0173
Onchocerca volvulus		0.0088	0.0153	0.1463
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0069	0.0104	0.6186
Onchocerca volvulus		0.0069	0.0104	0.0988
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	carboxylesterase 5A	0.0411	0.1018	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	TWK-28 protein	0.0088	0.0153	0.0153
Onchocerca volvulus		0.0088	0.0153	0.1463
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0096	0.0096
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0069	0.0104	0.0186
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0067	0.0096	0.0096
Brugia malayi	Melatonin receptor type 1A	0.0037	0.0016	0.0016
Plasmodium vivax	potassium channel, putative	0.0088	0.0153	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0088	0.0153	0.0153
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0088	0.0153	0.0153
Entamoeba histolytica	hypothetical protein	0.0041	0.0026	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0905	0.2342	0.2342
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0067	0.0096	0.0096
Echinococcus multilocularis	integrin alpha 3	0.0122	0.0246	0.0442
Echinococcus granulosus	integrin alpha 3	0.0122	0.0246	0.0442
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0422	0.1049	0.1029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0037	0.0016	0.0016
Leishmania major	calcium/potassium channel (CAKC), putative	0.0088	0.0153	0.0131
Brugia malayi	hypothetical protein	0.0088	0.0153	0.0153
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0435	0.1083	1
Echinococcus multilocularis	neuropeptide receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0037	0.0016	0.0029
Onchocerca volvulus		0.0037	0.0016	0.0151
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0023	0.0019
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0088	0.0153	0.0153
Echinococcus granulosus	potassium channel subfamily K	0.0088	0.0153	0.0276
Echinococcus multilocularis	potassium channel subfamily K	0.0088	0.0153	0.0276
Onchocerca volvulus		0.0037	0.0016	0.0151
Loa Loa (eye worm)	cytochrome P450 family protein	0.0048	0.0046	0.0046
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0074	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Echinococcus granulosus	poly (ADP ribose) polymerase	0.017	0.0372	0.067
Onchocerca volvulus		0.0037	0.0016	0.0151
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0088	0.0153	0.015
Leishmania major	potassium channel subunit-like protein	0.0088	0.0153	0.0131
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0435	0.1083	0.1949
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Echinococcus multilocularis	neuropeptides capa receptor	0.0037	0.0016	0.0029
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0088	0.0153	0.0153
Trypanosoma brucei	DNA repair protein, putative	0.0039	0.0022	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Plasmodium vivax	choline kinase, putative	0.0081	0.0136	0.8637
Brugia malayi	Carboxylesterase family protein	0.0069	0.0104	0.0104
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0067	0.0096	0.0096
Onchocerca volvulus		0.0069	0.0104	0.0988
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Echinococcus granulosus	potassium channel subfamily K 8	0.0088	0.0153	0.0276
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0037	0.0016	0.0029
Leishmania major	ion transport protein-like protein	0.0088	0.0153	0.0131
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0037	0.0016	0.0029
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0069	0.0104	0.0186
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	neuropeptide Y receptor	0.0037	0.0016	0.0029
Onchocerca volvulus		0.0036	0.0014	0.0132
Schistosoma mansoni	ap endonuclease	0.0039	0.0023	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Echinococcus multilocularis	acetylcholinesterase	0.0411	0.1018	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0067	0.0096	0.0173
Onchocerca volvulus		0.0037	0.0016	0.0151
Toxoplasma gondii	ion channel protein	0.0088	0.0153	0.1197
Schistosoma mansoni	opsin-like receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0037	0.0016	0.0029
Loa Loa (eye worm)	ACC-1 protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Brugia malayi	neuropeptide F receptor	0.0037	0.0016	0.0016
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0016	0.0029
Brugia malayi	ORL1-like opioid receptor	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0016	0.0029
Echinococcus multilocularis	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus multilocularis	somatostatin receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0067	0.0096	0.0173
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0016	0.0029
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0088	0.0153	0.0153
Onchocerca volvulus		0.0069	0.0104	0.0988
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0014	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus multilocularis	sex peptide receptor	0.0037	0.0016	0.0029
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0031	0.0009
Schistosoma mansoni	hypothetical protein	0.0088	0.0153	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	biogenic amine 5HT receptor	0.0404	0.1	0.1799
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0088	0.0153	0.0153
Schistosoma mansoni	integrin alpha-ps	0.0072	0.0109	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	choline:ethanolamine kinase	0.0081	0.0136	0.0244
Schistosoma mansoni	amine GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0004	0.0004
Echinococcus granulosus	neuropeptide Y receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0031	0.0056
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0062	0.0084	0.0151
Entamoeba histolytica	hypothetical protein	0.0085	0.0145	0.1226
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Schistosoma mansoni	myosin xvIII	0.0037	0.0016	0.0029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0031	0.0028
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0037	0.0016	0.0016
Brugia malayi	putative neuropeptide receptor	0.0037	0.0016	0.0016
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0037	0.0016	0.0016
Onchocerca volvulus		0.0088	0.0153	0.1463
Brugia malayi	polk-prov protein	0.0032	0.0004	0.0004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Echinococcus multilocularis	neuropeptide s receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	integrin beta 2	0.0242	0.0567	0.102
Schistosoma mansoni	calcium-activated potassium channel	0.1717	0.4518	0.813
Echinococcus multilocularis	tankyrase	0.0041	0.0026	0.0047
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0067	0.0096	0.0096
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1	0.1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0411	0.1018	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Onchocerca volvulus		0.0069	0.0104	0.0988
Onchocerca volvulus		0.0067	0.0096	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0037	0.0016	0.0029
Echinococcus multilocularis	acetylcholinesterase	0.0411	0.1018	0.1832
Leishmania major	C-8 sterol isomerase-like protein	0.3763	1	1
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0085	0.0145	0.0261
Echinococcus granulosus	poly adp ribose polymerase 2	0.03	0.0722	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Echinococcus multilocularis	allatostatin A receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	fmrfamide receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0016	0.0029
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0037	0.0016	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0096	0.0173
Schistosoma mansoni	acetylcholinesterase	0.0069	0.0104	0.0186
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0031	0.0028
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Brugia malayi	G-protein coupled receptor	0.0037	0.0016	0.0016
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0088	0.0153	0.0131
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0037	0.0016	0.0029
Trypanosoma brucei	poly(adp-ribose) polymerase	0.03	0.0722	0.0718
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	twik family of potassium channels	0.0088	0.0153	0.0276
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0037	0.0016	0.0029
Schistosoma mansoni	hypothetical protein	0.0037	0.0016	0.0029
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.03	0.0722	0.1299
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0037	0.0016	0.0029
Brugia malayi	WGR domain containing protein	0.03	0.0722	0.0722
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0037	0.0016	0.0029
Onchocerca volvulus	Putative nachr subunit	0.0067	0.0096	0.0917
Echinococcus granulosus	g-protein coupled receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0088	0.0153	1
Loa Loa (eye worm)	GABA receptor subunit	0.0036	0.0014	0.0014
Echinococcus granulosus	small conductance calcium activated potassium	0.2105	0.5557	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0037	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0037	0.0016	0.0029
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0067	0.0096	0.0173
Echinococcus multilocularis	g protein coupled receptor	0.0037	0.0016	0.0029
Plasmodium vivax	potassium channel, putative	0.0088	0.0153	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0069	0.0104	0.6186
Onchocerca volvulus		0.0037	0.0016	0.0151
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Onchocerca volvulus		0.0037	0.0016	0.0151
Leishmania major	hypothetical protein, conserved	0.0088	0.0153	0.0131
Echinococcus multilocularis	glycine receptor subunit beta	0.0067	0.0096	0.0173
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0037	0.0016	0.0016
Echinococcus granulosus	fmrfamide receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	tm gpcr rhodopsin	0.0037	0.0016	0.0029
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0067	0.0096	0.0173
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	integrin alpha	0.016	0.0345	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	7TM GPCR rhodopsin	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Schistosoma mansoni	neuropeptide f receptor 76f	0.0037	0.0016	0.0029
Echinococcus multilocularis	integrin alpha ps	0.0072	0.0109	0.0197
Echinococcus granulosus	WGR domain containing protein	0.017	0.0372	0.067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0016	0.0029
Echinococcus granulosus	7tm_1 domain containing protein	0.0037	0.0016	0.0029
Echinococcus granulosus	glycine receptor subunit beta	0.0067	0.0096	0.0173
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0023	0.0023
Onchocerca volvulus		0.0088	0.0153	0.1463
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0016	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Echinococcus multilocularis	twik family of potassium channels	0.0088	0.0153	0.0276
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.03	0.0722	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0404	0.1	0.1
Echinococcus multilocularis	g-protein coupled receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0037	0.0016	0.0029
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0088	0.0153	1
Echinococcus multilocularis	orexin receptor type 2	0.0037	0.0016	0.0029
Schistosoma mansoni	growth hormone secretagogue receptor	0.0037	0.0016	0.0029
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0031	0.0009
Leishmania major	hypothetical protein, conserved	0.0422	0.1049	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0014	0.0014
Onchocerca volvulus		0.0067	0.0096	0.0917
Loa Loa (eye worm)	carboxylesterase	0.0069	0.0104	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Onchocerca volvulus	DNA ligase 3 homolog	0.0039	0.0022	0.0214
Schistosoma mansoni	integrin alpha-ps	0.0037	0.0018	0.0032
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0023	0.0084
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0215	0.0494	0.0494
Brugia malayi	hypothetical protein	0.0088	0.0153	0.0153
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0037	0.0016	0.0029
Mycobacterium ulcerans	transmembrane cation transporter	0.0088	0.0153	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0069	0.0104	0.0186
Schistosoma mansoni	amine GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	lipoxygenase	0.0058	0.0074	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Onchocerca volvulus		0.0088	0.0153	0.1463
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0088	0.0153	0.015
Schistosoma mansoni	gliotactin	0.0069	0.0104	0.0186
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0098	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	orexin receptor type 2	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	carboxylesterase	0.0411	0.1018	0.1018
Brugia malayi	excitatory GABA receptor EXP-1A	0.0067	0.0096	0.0096
Brugia malayi	WGR domain containing protein	0.0435	0.1083	0.1083
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Loa Loa (eye worm)	TYRA-2 protein	0.0037	0.0016	0.0016
Onchocerca volvulus		0.0037	0.0016	0.0151
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0085	0.0145	0.0261
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0088	0.0153	0.0153
Echinococcus granulosus	allatostatin A receptor	0.0037	0.0016	0.0029
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0037	0.0016	0.0151
Schistosoma mansoni	opsin-like receptor	0.0037	0.0016	0.0029
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0088	0.0153	0.1306
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0085	0.0145	0.0261
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	potassium channel subfamily K 8	0.0088	0.0153	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.0014	0.0014
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0023	0.5
Schistosoma mansoni	ap endonuclease	0.0039	0.0023	0.0041
Loa Loa (eye worm)	hypothetical protein	0.1923	0.5071	0.5071
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0036	0.0014	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0037	0.0016	0.0029
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	TWK-7 protein	0.0088	0.0153	0.0153
Brugia malayi	Cation transporter family protein	0.0067	0.0096	0.0096
Brugia malayi	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Onchocerca volvulus	Tankyrase homolog	0.0041	0.0026	0.025
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	melatonin receptor type 1A	0.0037	0.0016	0.0016
Echinococcus granulosus	lysine specific demethylase 5A	0.0062	0.0084	0.0151
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	calcium-activated potassium channel	0.0088	0.0153	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0016	0.0029
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Leishmania major	cathepsin L-like protease	0.0067	0.0098	0.0076
Entamoeba histolytica	hypothetical protein	0.0041	0.0026	0.0116
Schistosoma mansoni	twik family of potassium channels-related	0.0088	0.0153	0.0276
Loa Loa (eye worm)	uncoordinated protein 58	0.0088	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trypanosoma cruzi	Emopamil binding protein, putative	0.0422	0.1049	0.1029
Echinococcus granulosus	neuropeptide receptor	0.0037	0.0016	0.0029
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0088	0.0153	0.0276
Onchocerca volvulus		0.0037	0.0016	0.0151
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0023	0.0023
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0067	0.0096	0.0173
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.0153	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0034	0.001	0.001
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.005	0.0051	0.0051
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0059	0.0037
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0037	0.0016	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Brugia malayi	G protein-coupled receptor	0.0037	0.0016	0.0016
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.005	0.0051	0.0051
Echinococcus granulosus	neuropeptides capa receptor	0.0037	0.0016	0.0029
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0088	0.0153	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0036	0.0014	0.0014
Brugia malayi	Tnks protein	0.0041	0.0026	0.0026
Echinococcus granulosus	somatostatin receptor	0.0037	0.0016	0.0029
Brugia malayi	Carboxylesterase family protein	0.0069	0.0104	0.0104
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0067	0.0096	0.0096
Toxoplasma gondii	phosphotransferase enzyme family protein	0.0081	0.0136	0.1034
Entamoeba histolytica	zinc finger protein, putative	0.0041	0.0026	0.0116
Brugia malayi	Serotonin receptor	0.0037	0.0016	0.0016
Onchocerca volvulus		0.0067	0.0096	0.0917
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	amine GPCR	0.0037	0.0016	0.0029
Brugia malayi	RE15519p	0.0037	0.0016	0.0016
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.0153	0.0131
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0036	0.0014	0.0025
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0088	0.0153	0.0131
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0411	0.1018	0.1832
Entamoeba histolytica	hypothetical protein	0.0041	0.0026	0.0116
Leishmania major	cathepsin L-like protease	0.0067	0.0098	0.0076
Schistosoma mansoni	neuropeptide receptor	0.0037	0.0016	0.0029
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0037	0.0016	0.0029
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0031	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0067	0.0096	0.0173
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0037	0.0016	0.0029
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0098	0.0076
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0088	0.0153	0.0153
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0088	0.0153	0.0153
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0067	0.0096	0.0173
Schistosoma mansoni	tankyrase	0.0041	0.0026	0.0047
Schistosoma mansoni	nAChR subunit	0.0067	0.0096	0.0173
Mycobacterium ulcerans	carboxylesterase, LipT	0.0069	0.0104	0.6186
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Loa Loa (eye worm)	neuropeptide F receptor	0.0037	0.0016	0.0016
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.0031	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0026	0.0261
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0088	0.0153	0.0131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0098	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0104	0.0104
Plasmodium falciparum	potassium channel	0.0088	0.0153	1
Brugia malayi	sulfakinin receptor protein	0.0037	0.0016	0.0016
Echinococcus multilocularis	dro:myosuppressin receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0067	0.0096	0.0096
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0067	0.0096	0.0096
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	carboxylesterase	0.0069	0.0104	0.0104
Echinococcus multilocularis	nAChR subunit	0.0036	0.0014	0.0025
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Brugia malayi	hypothetical protein	0.005	0.0051	0.0051
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0037	0.0016	0.0029
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0067	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0305	0.0734	0.0734
Brugia malayi	Carboxylesterase family protein	0.0069	0.0104	0.0104
Schistosoma mansoni	adenoreceptor	0.0037	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	nAChR subunit	0.0067	0.0096	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Brugia malayi	Carboxylesterase family protein	0.0411	0.1018	0.1018
Loa Loa (eye worm)	hypothetical protein	0.03	0.0722	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0153	0.0153
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0031	0.0028
Brugia malayi	Dopamine receptor protein 1	0.0037	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Echinococcus granulosus	acetylcholinesterase	0.0411	0.1018	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0016	0.0016
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0088	0.0153	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0069	0.0104	0.0186
Schistosoma mansoni	calcium-activated potassium channel	0.0088	0.0153	0.0276
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0088	0.0153	0.0153

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.6 nM	Binding affinity to human 5HT3A receptor	ChEMBL.	21146988

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1643887

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1488860