Detailed information for compound 1490355

Basic information

Technical information
  • TDR Targets ID: 1490355
  • Name: N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)qui nazolin-4-amine
  • MW: 397.467 | Formula: C22H27N3O4
  • H donors: 1 H acceptors: 2 LogP: 3.86 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOc1cc2c(ncnc2cc1OCCOC)Nc1cccc(c1)CC
  • InChi: 1S/C22H27N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h5-7,12-15H,4,8-11H2,1-3H3,(H,23,24,25)
  • InChiKey: NUQUOVYZADJDTI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
  • [6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethylphenyl)amine
  • KBioSS_002494

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0178 0.0234
Trypanosoma brucei unspecified product 0.0026 0.0398 0.0902
Schistosoma mansoni lamin 0.0027 0.041 0.0879
Brugia malayi glutathione reductase 0.0047 0.1107 0.1456
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.1107 0.1456
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0303 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0178 0.0234
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0282 0.9259 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0046 0.0105
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0178 0.0234
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.077 0.1746
Echinococcus granulosus FTZ F1 alpha 0.002 0.0178 0.0234
Entamoeba histolytica hypothetical protein 0.0036 0.0719 0.6467
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Brugia malayi hypothetical protein 0.0036 0.0719 0.0946
Echinococcus multilocularis lamin dm0 0.0027 0.041 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0178 0.0234
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0178 0.0381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0287 1
Schistosoma mansoni hypothetical protein 0.0036 0.0719 0.1542
Entamoeba histolytica hypothetical protein 0.0036 0.0719 0.6467
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.3601 0.3858
Mycobacterium tuberculosis Probable peptidase 0.0057 0.1442 0.1515
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1112 0.1462
Schistosoma mansoni amine oxidase 0.0021 0.0224 0.0481
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.3188 0.341
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0046 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0224 0.2024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0178 0.0381
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0178 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0398 0.0902
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.2339 0.5016
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0178 0.0234
Mycobacterium ulcerans oxidoreductase 0.0021 0.0224 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0178 0.0234
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.1112 0.1071
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0178 0.0234
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.1112 0.2629
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0224 0.2024
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.1107 0.2512
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0224 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0809 0.0766
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Leishmania major DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1112 0.1462
Onchocerca volvulus 0.0047 0.1112 0.2522
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0178 0.0381
Mycobacterium ulcerans dehydrogenase 0.0021 0.0224 0.0179
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.1107 0.1152
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.1112 0.1071
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0057 0.1442 0.3271
Trypanosoma brucei prolyl oligopeptidase, putative 0.0057 0.1442 0.3271
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0178 0.0234
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0287 0.3675
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.1684 0.382
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.1684 0.382
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1112 0.1071
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0224 0.0295
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0224 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0178 0.0234
Schistosoma mansoni lamin 0.0027 0.041 0.0879
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0634 0.0638
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1112 0.2522
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Onchocerca volvulus 0.0082 0.2339 0.5306
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0142 0.4408 0.9455
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0057 0.1442 0.1515
Plasmodium vivax glutathione reductase, putative 0.0047 0.1107 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0809 0.7276
Schistosoma mansoni DNA polymerase eta 0.0063 0.1684 0.3612
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0809 0.1835
Schistosoma mansoni amine oxidase 0.0021 0.0224 0.0481
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0178 0.0234
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0178 0.0234
Echinococcus granulosus dna polymerase kappa 0.0038 0.0809 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0398 0.0902
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0224 0.2024
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0046 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0178 0.0234
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0224 0.0295
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.3601 0.3858
Plasmodium falciparum glutathione reductase 0.0047 0.1107 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0178 0.0234
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0719 0.0946
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.07 0.6324
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.114 0.1499
Echinococcus granulosus prolyl endopeptidase 0.0142 0.4408 0.5797
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0224 0.2024
Brugia malayi intermediate filament protein 0.0027 0.041 0.0539
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.1112 1
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0809 0.1835
Echinococcus multilocularis prolyl endopeptidase 0.0142 0.4408 0.5797
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0178 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0634 0.0638
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0178 0.0234
Schistosoma mansoni survival motor neuron protein 0.0048 0.114 0.2445
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0224 0.2024
Plasmodium falciparum thioredoxin reductase 0.0016 0.0046 0.0417
Brugia malayi nuclear receptor NHR-88 0.002 0.0178 0.0234
Entamoeba histolytica hypothetical protein 0.0023 0.0287 0.2577
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0046 0.0417
Onchocerca volvulus 0.0027 0.041 0.0929
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0224 0.0193
Loa Loa (eye worm) hypothetical protein 0.0027 0.041 0.0539
Brugia malayi prolyl oligopeptidase family protein 0.0142 0.4408 0.5797
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1112 0.2522
Brugia malayi steroid hormone receptor 0.002 0.0178 0.0234
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0178 0.0234
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0719 0.1542
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0224 0.0481
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0287 1
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0224 0.0508
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0224 0.0508
Toxoplasma gondii prolyl endopeptidase 0.0142 0.4408 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.1112 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0178 0.0234
Loa Loa (eye worm) glutathione reductase 0.0047 0.1107 0.1456
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0057 0.1442 0.3606
Echinococcus multilocularis musashi 0.0027 0.041 0.0539
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.3188 0.341
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0719 0.0946
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Leishmania major trypanothione reductase 0.0047 0.1107 0.2512
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0046 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Trypanosoma brucei oligopeptidase b 0.0057 0.1442 0.3271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0046 0.0061
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.1112 0.1157
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Loa Loa (eye worm) hypothetical protein 0.0234 0.7605 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0178 0.0234
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0178 0.0234
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0057 0.1442 0.3271
Loa Loa (eye worm) intermediate filament protein 0.0027 0.041 0.0539
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.1107 0.1456
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0142 0.4408 0.9455
Echinococcus granulosus intermediate filament protein 0.0027 0.041 0.0539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0178 0.0234
Loa Loa (eye worm) hypothetical protein 0.0047 0.1112 0.1462
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0224 0.0508
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.3601 0.3858
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0809 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0046 0.0417
Echinococcus multilocularis lamin 0.0027 0.041 0.0539
Leishmania major UDP-galactopyranose mutase 0.0021 0.0224 0.0508
Onchocerca volvulus 0.0021 0.0224 0.0508
Trypanosoma brucei trypanothione reductase 0.0047 0.1107 0.2512
Brugia malayi nuclear hormone receptor 0.002 0.0178 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Schistosoma mansoni thyroid hormone receptor 0.002 0.0178 0.0381
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0809 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0178 0.0234
Brugia malayi hypothetical protein 0.0021 0.0224 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1112 0.1071
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0809 0.0828
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.07 0.071
Onchocerca volvulus 0.002 0.0178 0.0403
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0178 0.0381
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0809 0.1835
Plasmodium falciparum thioredoxin reductase 0.0047 0.1107 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.07 0.0921
Trypanosoma cruzi prolyl endopeptidase 0.0142 0.4408 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Loa Loa (eye worm) hypothetical protein 0.0063 0.1684 0.2214
Schistosoma mansoni coup transcription factor 0.002 0.0178 0.0381
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.2339 0.3076
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0178 0.0381
Trypanosoma brucei prolyl endopeptidase 0.0142 0.4408 1
Trypanosoma cruzi oligopeptidase b 0.0057 0.1442 0.3271
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0178 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.1112 0.1157
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0224 0.0508
Onchocerca volvulus 0.0048 0.114 0.2586
Schistosoma mansoni intermediate filament proteins 0.0027 0.041 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0047 0.1112 0.1462
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0809 0.0828
Brugia malayi SWIRM domain containing protein 0.0021 0.0224 0.0295
Onchocerca volvulus Prolyl endopeptidase homolog 0.0142 0.4408 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0224 0.0295
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0809 0.0766
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0287 0.0185
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0178 0.0234
Entamoeba histolytica hypothetical protein 0.0036 0.0719 0.6467
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0224 0.0193
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0224 0.2024
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.3188 0.341
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0809 0.1064
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.7605 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0178 0.0234
Brugia malayi hypothetical protein 0.0234 0.7605 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0046 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0398 0.0902
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0809 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0178 0.0234
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0057 0.1442 0.1402
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0178 0.0381
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.1112 0.2522
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.3188 0.8776
Leishmania major DNA polymerase eta, putative 0.0063 0.1684 0.382
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0046 0.0105
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.3601 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Leishmania major oligopeptidase b 0.0057 0.1442 0.3271
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0046 0.0105
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.1107 0.1456
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0178 0.0381
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0287 0.0241
Mycobacterium ulcerans hypothetical protein 0.0047 0.1112 0.1071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0393 0.0516
Loa Loa (eye worm) hypothetical protein 0.0035 0.07 0.0921
Brugia malayi Thioredoxin reductase 0.0047 0.1107 0.1456
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0046 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0046 0.0061
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0809 0.1735
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0178 0.0234
Toxoplasma gondii thioredoxin reductase 0.0047 0.1107 0.2512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0178 0.0234
Echinococcus granulosus lamin dm0 0.0027 0.041 0.0539
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.07 0.6324
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.041 0.0539
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0046 0.0105
Echinococcus granulosus dna polymerase eta 0.0063 0.1684 0.2214
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0178 0.0381
Onchocerca volvulus 0.0018 0.0094 0.0214
Echinococcus multilocularis 0.0021 0.0224 0.0295
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0809 0.1064
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.3188 0.341
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0178 0.0234
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.2339 0.3076
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0046 0.0571
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0178 0.0403
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0178 0.0234
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0224 0.272
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.1112 0.1071
Loa Loa (eye worm) hypothetical protein 0.0035 0.07 0.0921
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0057 0.1442 0.3271
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0287 0.0261
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0127 0.3892 0.4174
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0046 0.0061
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0634 0.0638
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0287 0.2588
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0287 0.065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0178 0.0234
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.1112 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.1107 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.2339 0.3076
Schistosoma mansoni hypothetical protein 0.0048 0.114 0.2445
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0224 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0178 0.0234
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.041 0.0539
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0046 0.0417
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.2339 0.3076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0178 0.0403
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.7605 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0046 0.0105
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0046 0.0105
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.07 1
Giardia lamblia DINP protein human, muc B family 0.0038 0.0809 1
Plasmodium falciparum glutathione reductase 0.0016 0.0046 0.0417
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0178 0.0234
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0287 0.2588
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.1112 0.1071
Trypanosoma brucei unspecified product 0.0038 0.0809 0.1835
Leishmania major DNA polymerase eta, putative 0.0037 0.077 0.1746
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.1684 0.2214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0046 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0178 0.0234
Schistosoma mansoni nuclear hormone receptor 0.002 0.0178 0.0381
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Trypanosoma cruzi oligopeptidase b 0.0057 0.1442 0.3271
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0178 0.0234
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0287 0.065
Schistosoma mansoni thyroid hormone receptor 0.002 0.0178 0.0381
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0287 0.065
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0178 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.0178 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0178 0.0234
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0224 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0178 0.0234
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0046 0.0417
Onchocerca volvulus 0.0027 0.041 0.0929
Loa Loa (eye worm) hypothetical protein 0.0035 0.07 0.0921
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0178 0.0234
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0809 0.1064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0634 0.0638
Trypanosoma brucei unspecified product 0.0026 0.0398 0.0902
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0178 0.0234
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0287 0.0241
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0287 0.065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0046 0.0105
Echinococcus granulosus lamin 0.0027 0.041 0.0539
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0142 0.4408 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.077 0.1746
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0224 0.0295
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0809 0.1064
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0809 0.1835
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.1112 0.2629
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0809 0.1735
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0178 0.0381
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.3188 0.341
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0178 0.0403
Loa Loa (eye worm) hypothetical protein 0.0047 0.1112 0.1462
Loa Loa (eye worm) hypothetical protein 0.0142 0.4408 0.5797
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0809 0.1835
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0057 0.1442 0.3271
Echinococcus multilocularis dna polymerase eta 0.0063 0.1684 0.2214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0178 0.0234
Mycobacterium tuberculosis Probable reductase 0.0107 0.3188 0.341
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0046 0.0105
Loa Loa (eye worm) hypothetical protein 0.0021 0.0224 0.0295
Brugia malayi ecdysteroid receptor 0.002 0.0178 0.0234
Loa Loa (eye worm) hypothetical protein 0.0035 0.07 0.0921
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.07 0.0657
Entamoeba histolytica hypothetical protein 0.0036 0.0719 0.6467
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0046 0.0571
Loa Loa (eye worm) hypothetical protein 0.0047 0.1112 0.1462
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.1112 0.1071
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0224 0.2024

Activities

Activity type Activity value Assay description Source Reference
Activity > 40 um PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1446, AID1486, AID1520, AID1521, AID1691, AID1699, AID1797] Panel member name: irf1 Inhibition (HEL cells) ChEMBL. No reference
Activity > 40 um PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1446, AID1486, AID1520, AID1521, AID1691, AID1699, AID1797] Panel member name: JAK2V617F Inhibition ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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