Detailed information for compound 1490416

Basic information

Technical information
  • TDR Targets ID: 1490416
  • Name: N-(4-methoxyphenyl)-2-(4-phenylphenoxy)acetam ide
  • MW: 333.38 | Formula: C21H19NO3
  • H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)COc1ccc(cc1)c1ccccc1
  • InChi: 1S/C21H19NO3/c1-24-19-13-9-18(10-14-19)22-21(23)15-25-20-11-7-17(8-12-20)16-5-3-2-4-6-16/h2-14H,15H2,1H3,(H,22,23)
  • InChiKey: FUUPHAPZBZNIBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxyphenyl)-2-(4-phenylphenoxy)ethanamide
  • T5418336
  • Oprea1_168956

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0118 0.0785 0.3115
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.02 0.1496 0.6103
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0067 0.0346 0.4518
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0676 0.2658
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0073 0.0073
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Onchocerca volvulus 0.0105 0.0676 0.0653
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0676 0.2053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.4961 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0102 0.0189
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0073 0.0093
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0097 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Giardia lamblia PHD finger protein 15 0.0118 0.0785 0.1405
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0676 0.2658
Brugia malayi Inositol-1 0.0036 0.0073 0.0033
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0555 0.0531
Trichomonas vaginalis chromobox protein, putative 0.0069 0.036 0.036
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0785 0.2435
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0221
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0067 0.0346 0.0982
Brugia malayi prolyl oligopeptidase family protein 0.02 0.1496 0.1665
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0102 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0539 0.1613
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0067 0.0346 0.4518
Echinococcus multilocularis lysine specific demethylase 5A 0.0143 0.1 0.3117
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0277 0.3381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0088
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0102 0.0189
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0366 0.2935 1
Toxoplasma gondii ABC1 family protein 0.0105 0.0676 0.6157
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0073 0.0093
Schistosoma mansoni kinase 0.0046 0.0166 0.051
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0386 0.311 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0077
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0555 0.0586
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0102 0.0102
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0555 0.7993
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0083
Echinococcus multilocularis peregrin 0.0118 0.0785 0.2416
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0123 0.0098
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0145 0.0115
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0123 0.0123
Brugia malayi jmjC domain containing protein 0.0386 0.311 0.3518
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0676 0.1144
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0366 0.2935 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Loa Loa (eye worm) PHD-finger family protein 0.0118 0.0785 0.087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0293 0.2303 0.407
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0093 0.0204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Trichomonas vaginalis chromobox protein, putative 0.0069 0.036 0.036
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0102 0.0066
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0676 0.2061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0676 0.2109
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0676 1
Brugia malayi beta-lactamase family protein 0.0105 0.0676 0.0725
Trypanosoma brucei polo-like protein kinase 0.0091 0.0555 0.7993
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0102 0.0189
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Echinococcus granulosus Dipeptidyl peptidase 9 0.0067 0.0346 0.0982
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0676 0.0676
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0102 0.049
Loa Loa (eye worm) prolyl oligopeptidase 0.02 0.1496 0.1684
Treponema pallidum fructose-bisphosphate aldolase 0.06 0.4961 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.2035 0.2301
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0145 0.0421
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0555 0.1666
Schistosoma mansoni inositol monophosphatase 0.0036 0.0073 0.0119
Brugia malayi AF-10 protein 0.0039 0.0097 0.006
Leishmania major hypothetical protein, conserved 0.0038 0.0093 0.0333
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0293 0.2303 0.779
Brugia malayi PHD-finger family protein 0.0118 0.0785 0.085
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.1 0.1116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.4961 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0098 0.0072
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0371 0.0375
Mycobacterium ulcerans hypothetical protein 0.0105 0.0676 0.2109
Onchocerca volvulus Alhambra homolog 0.0118 0.0785 0.0762
Brugia malayi Bromodomain containing protein 0.0118 0.0785 0.085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1038 0.8757 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Mycobacterium ulcerans lipase LipD 0.0105 0.0676 0.2109
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0676 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0044 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.7993
Echinococcus granulosus chromobox protein 1 0.0069 0.036 0.1029
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0093 0.0205
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0676 0.2812
Schistosoma mansoni hypothetical protein 0.007 0.0371 0.1373
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Trichomonas vaginalis esterase, putative 0.0105 0.0676 0.0676
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0676 0.0725
Leishmania major hypothetical protein, conserved 0.0105 0.0676 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0277 0.0978
Giardia lamblia Fructose-bisphosphate aldolase 0.06 0.4961 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0093 0.0158
Echinococcus multilocularis PHD finger protein rhinoceros 0.0118 0.0785 0.2416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.1 0.4019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0149 0.1053 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0155 0.0155
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0149 0.1053 0.329
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0676 0.1144
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0209
Loa Loa (eye worm) hypothetical protein 0.0118 0.0785 0.087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0093 0.0158
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0097 0.0402
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Brugia malayi hypothetical protein 0.0051 0.0208 0.0188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0093 0.0205
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0293 0.2303 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0149 0.1053 0.329
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0277 0.2082
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0676 0.1144
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0093 0.0204
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0366 0.2935 0.5208
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0143 0.1006 0.3136
Plasmodium vivax SET domain protein, putative 0.0149 0.1053 0.3379
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0676 0.0676
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0366 0.2935 1
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0093 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0539 0.1613
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0764 0.0846
Brugia malayi prolyl oligopeptidase family protein 0.0067 0.0346 0.0346
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0097 0.0015
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0102 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Schistosoma mansoni jumonji domain containing protein 0.0307 0.2422 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0155 0.0155
Onchocerca volvulus 0.0105 0.0676 0.0653
Schistosoma mansoni chromobox protein 0.0069 0.036 0.1327
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0366 0.2935 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0118 0.0785 0.2416
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.02 0.1496 0.4733
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0077
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0277 0.0978
Loa Loa (eye worm) inositol-1 0.0036 0.0073 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0539 0.0568
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0093 0.0158
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0093 0.0158
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0652 0.0698
Brugia malayi beta-lactamase family protein 0.0105 0.0676 0.0725
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0067 0.0346 0.1266
Brugia malayi chromobox protein homolog 3 0.0039 0.0098 0.0061
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0555 0.1666
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0102 0.0189
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.1 0.4019
Brugia malayi beta-lactamase 0.0105 0.0676 0.0725
Echinococcus granulosus lysine specific demethylase 5A 0.0143 0.1 0.3117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0277 0.0758
Onchocerca volvulus 0.0105 0.0676 0.0653
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0386 0.311 1
Schistosoma mansoni hypothetical protein 0.0118 0.0785 0.3115
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0652 0.0718
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0676 0.1144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.016 0.1151 0.4653
Echinococcus multilocularis chromobox protein 1 0.0069 0.036 0.1029
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0123 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Loa Loa (eye worm) hypothetical protein 0.0103 0.0652 0.0718
Schistosoma mansoni inositol monophosphatase 0.0036 0.0073 0.0119
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0093 0.0158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Loa Loa (eye worm) jmjC domain-containing protein 0.0244 0.1873 0.2116
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0102 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0102
Plasmodium falciparum phd finger protein, putative 0.0118 0.0785 0.2435
Echinococcus granulosus jumonji domain containing protein 0.0164 0.1185 0.3721
Echinococcus multilocularis chromobox protein 1 0.0069 0.036 0.1029
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Loa Loa (eye worm) beta-lactamase 0.0105 0.0676 0.0746
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0676 0.0746
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.7993
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0676 0.2109
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0676 0.1144
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0555 0.0607
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0093 0.0158
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0082
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0093 0.0158
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0093 0.0204
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0277 0.0426
Echinococcus granulosus histone lysine methyltransferase setb 0.0149 0.1053 0.329
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0097 0.0402
Brugia malayi jmjC domain containing protein 0.0143 0.1 0.1097
Brugia malayi follicle stimulating hormone receptor 0.0262 0.2035 0.2284
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0539 0.1613
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.036 0.0383
Echinococcus granulosus phd:f box containing protein 0.0038 0.0093 0.0158
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.02 0.1496 0.4733
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0093 0.0158
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0093 0.0158
Onchocerca volvulus 0.016 0.1151 0.1128
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Echinococcus granulosus chromobox protein 1 0.0069 0.036 0.1029
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0102 0.0189
Schistosoma mansoni chromobox protein 0.0069 0.036 0.1327
Giardia lamblia Kinase, PLK 0.0091 0.0555 0.0932
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0067 0.0346 0.2782
Echinococcus multilocularis jumonji domain containing protein 0.0164 0.1185 0.3721
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.02 0.1496 0.1474
Echinococcus granulosus peregrin 0.0118 0.0785 0.2416
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0102 0.0244
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Mycobacterium ulcerans beta-lactamase 0.0105 0.0676 0.2109
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0555 0.0987
Brugia malayi Heterochromatin protein 1 0.0069 0.036 0.0362
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0277 0.0758
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0097 0.0248
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0785 0.7265
Brugia malayi Pre-SET motif family protein 0.1038 0.8757 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0371 0.0396
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0102 0.0189
Loa Loa (eye worm) hypothetical protein 0.0149 0.1053 0.1177
Mycobacterium leprae Probable lipase LipE 0.0105 0.0676 0.2812
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0674 0.5598 1
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Loa Loa (eye worm) hypothetical protein 0.0202 0.1515 0.1706
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0093 0.0204
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0764 0.0846
Trichomonas vaginalis set domain proteins, putative 0.1182 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0785 0.7265
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0676 0.2061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0539 0.0588
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0022
Brugia malayi Pre-SET motif family protein 0.0149 0.1053 0.1158
Brugia malayi PHD-finger family protein 0.0039 0.0097 0.006
Brugia malayi MH2 domain containing protein 0.0116 0.0764 0.0826
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0073 0.0073
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0073 0.0073
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0676 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0652 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0555 0.2148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0676 0.1144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0676 0.1144
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0539 0.1613
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0097 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0098

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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