Detailed information for compound 1490416

Basic information

Technical information
  • TDR Targets ID: 1490416
  • Name: N-(4-methoxyphenyl)-2-(4-phenylphenoxy)acetam ide
  • MW: 333.38 | Formula: C21H19NO3
  • H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)COc1ccc(cc1)c1ccccc1
  • InChi: 1S/C21H19NO3/c1-24-19-13-9-18(10-14-19)22-21(23)15-25-20-11-7-17(8-12-20)16-5-3-2-4-6-16/h2-14H,15H2,1H3,(H,22,23)
  • InChiKey: FUUPHAPZBZNIBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methoxyphenyl)-2-(4-phenylphenoxy)ethanamide
  • T5418336
  • Oprea1_168956

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis jumonji domain containing protein 0.0164 0.1185 0.3721
Echinococcus multilocularis PHD finger protein rhinoceros 0.0118 0.0785 0.2416
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0098 0.0072
Trichomonas vaginalis esterase, putative 0.0105 0.0676 0.0676
Brugia malayi PHD-finger family protein 0.0039 0.0097 0.006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0674 0.5598 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0149 0.1053 0.329
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0676 0.1144
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0293 0.2303 1
Echinococcus granulosus lysine specific demethylase 6a 0.0038 0.0093 0.0158
Plasmodium falciparum phd finger protein, putative 0.0118 0.0785 0.2435
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Schistosoma mansoni chromobox protein 0.0069 0.036 0.1327
Echinococcus multilocularis peregrin 0.0118 0.0785 0.2416
Echinococcus multilocularis lysine specific demethylase 6a 0.0038 0.0093 0.0158
Loa Loa (eye worm) hypothetical protein 0.007 0.0371 0.0396
Schistosoma mansoni inositol monophosphatase 0.0036 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0202 0.1515 0.1706
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0102 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.02 0.1496 0.6103
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Mycobacterium ulcerans beta-lactamase 0.0105 0.0676 0.2109
Mycobacterium ulcerans hypothetical protein 0.0105 0.0676 0.2109
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0555 0.2148
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Schistosoma mansoni phd/f-box containing protein 0.0038 0.0093 0.0204
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0371 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.7993
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0145 0.0421
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0555 0.0607
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0676 0.2061
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0102 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Mycobacterium ulcerans lipase LipD 0.0105 0.0676 0.2109
Loa Loa (eye worm) inositol-1 0.0036 0.0073 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0069 0.036 0.036
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0123 0.0098
Schistosoma mansoni protein phosphatase 2C 0.0038 0.0093 0.0204
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.036 0.0383
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0123 0.0123
Echinococcus granulosus jumonji domain containing 1A 0.0038 0.0093 0.0158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0149 0.1053 0.329
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0676 0.1144
Plasmodium vivax SET domain protein, putative 0.0149 0.1053 0.3379
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0102 0.0189
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0539 0.1613
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0038 0.0093 0.0205
Loa Loa (eye worm) beta-lactamase 0.0105 0.0676 0.0746
Giardia lamblia PHD finger protein 15 0.0118 0.0785 0.1405
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0067 0.0346 0.1266
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0143 0.1006 0.3136
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0077
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0366 0.2935 0.5208
Echinococcus granulosus Dipeptidyl peptidase 9 0.0067 0.0346 0.0982
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0067 0.0346 0.4518
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0102 0.0244
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.0077
Loa Loa (eye worm) jmjC domain-containing protein 0.0244 0.1873 0.2116
Schistosoma mansoni chromobox protein 0.0069 0.036 0.1327
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0676 0.2061
Trichomonas vaginalis chromobox protein, putative 0.0069 0.036 0.036
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Brugia malayi beta-lactamase family protein 0.0105 0.0676 0.0725
Loa Loa (eye worm) hypothetical protein 0.0118 0.0785 0.087
Schistosoma mansoni hypothetical protein 0.0118 0.0785 0.3115
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0555 0.0586
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0277 0.0758
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0366 0.2935 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0652 0.0718
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0293 0.2303 0.779
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0676 1
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0676 0.1144
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0073 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0098
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0102 0.0189
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0652 0.0698
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0386 0.311 1
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0038 0.0093 0.0333
Trichomonas vaginalis set domain proteins, putative 0.1182 1 1
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0676 0.1144
Schistosoma mansoni jumonji domain containing protein 0.0307 0.2422 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0539 0.1613
Brugia malayi Bromodomain containing protein 0.0118 0.0785 0.085
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0277 0.2082
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0366 0.2935 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Schistosoma mansoni hypothetical protein 0.0039 0.0097 0.0221
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0149 0.1053 0.329
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Onchocerca volvulus Alhambra homolog 0.0118 0.0785 0.0762
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.0097 0.0248
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.4961 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0277 0.0758
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0555 0.7993
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0277 0.0978
Giardia lamblia Fructose-bisphosphate aldolase 0.06 0.4961 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0044 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0676 0.0676
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0676 0.0746
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0555 0.1666
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0539 0.1613
Echinococcus granulosus phd:f box containing protein 0.0038 0.0093 0.0158
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0073 0.0073
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0764 0.0846
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.0097 0.0248
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0102 0.0088
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.02 0.1496 0.4733
Brugia malayi follicle stimulating hormone receptor 0.0262 0.2035 0.2284
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0676 0.2658
Onchocerca volvulus 0.0105 0.0676 0.0653
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0293 0.2303 0.407
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0764 0.0846
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0038 0.0093 0.0204
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.1 0.4019
Toxoplasma gondii ABC1 family protein 0.0105 0.0676 0.6157
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0073 0.0073
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0676 0.1144
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0067 0.0346 0.4518
Schistosoma mansoni hypothetical protein 0.007 0.0371 0.1373
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0067 0.0346 0.4518
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Brugia malayi Pre-SET motif family protein 0.1038 0.8757 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0652 0.0718
Echinococcus multilocularis chromobox protein 1 0.0069 0.036 0.1029
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0067 0.0346 0.0982
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0785 0.7265
Echinococcus granulosus chromobox protein 1 0.0069 0.036 0.1029
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0676 0.0676
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Echinococcus multilocularis phd:f box containing protein 0.0038 0.0093 0.0158
Plasmodium vivax hypothetical protein, conserved 0.0118 0.0785 0.2435
Onchocerca volvulus 0.016 0.1151 0.1128
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0102 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0676 0.0676
Echinococcus granulosus PHD finger protein rhinoceros 0.0118 0.0785 0.2416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.016 0.1151 0.4653
Echinococcus multilocularis JmjC domain containing protein 4 0.0038 0.0093 0.0158
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0038 0.0093 0.0205
Schistosoma mansoni kinase 0.0046 0.0166 0.051
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0539 0.0588
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0555 0.1666
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0676 0.2109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0555 0.7993
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0277 0.0426
Brugia malayi Inositol-1 0.0036 0.0073 0.0033
Brugia malayi prolyl oligopeptidase family protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0102 0.0189
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0555 0.0531
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0102 0.0066
Brugia malayi beta-lactamase family protein 0.0105 0.0676 0.0725
Mycobacterium tuberculosis Conserved protein 0.0105 0.0676 0.1144
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0073 0.0093
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0038 0.0093 0.0333
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0676 1
Brugia malayi PHD-finger family protein 0.0118 0.0785 0.085
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0676 0.1144
Echinococcus granulosus lysine specific demethylase 5A 0.0143 0.1 0.3117
Echinococcus multilocularis chromobox protein 1 0.0069 0.036 0.1029
Loa Loa (eye worm) hypothetical protein 0.0149 0.1053 0.1177
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0145 0.0115
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0676 0.2109
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0102 0.0244
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1038 0.8757 1
Brugia malayi jmjC domain containing protein 0.0143 0.1 0.1097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0277 0.0713
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0155 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0149 0.1053 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0118 0.0785 0.3115
Brugia malayi MH2 domain containing protein 0.0116 0.0764 0.0826
Brugia malayi jmjC domain containing protein 0.0386 0.311 0.3518
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0039 0.0097 0.0015
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0366 0.2935 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0097 0.0402
Loa Loa (eye worm) hypothetical protein 0.0039 0.0098 0.0083
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0056
Schistosoma mansoni phosphatidylserine receptor 0.0038 0.0093 0.0204
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0539 0.0568
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0102 0.0189
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.4961 1
Giardia lamblia Kinase, PLK 0.0091 0.0555 0.0932
Mycobacterium leprae Probable lipase LipE 0.0105 0.0676 0.2812
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0366 0.2935 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0676 0.1144
Toxoplasma gondii PHD-finger domain-containing protein 0.0118 0.0785 0.7265
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.02 0.1496 0.1474
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0102 0.0102
Loa Loa (eye worm) PHD-finger family protein 0.0118 0.0785 0.087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0676 0.2658
Brugia malayi beta-lactamase 0.0105 0.0676 0.0725
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Brugia malayi hypothetical protein 0.0051 0.0208 0.0188
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.0097 0.0402
Schistosoma mansoni jumonji/arid domain-containing protein 0.0143 0.1 0.4019
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0123 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0555 0.0555
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0102 0.049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0652 0.0698
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0539 0.1613
Loa Loa (eye worm) prolyl oligopeptidase 0.02 0.1496 0.1684
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0067 0.0346 0.2782
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0097 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0038 0.0093 0.0204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0676 0.0725
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0676 0.2053
Brugia malayi Pre-SET motif family protein 0.0149 0.1053 0.1158
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0102 0.006
Brugia malayi prolyl oligopeptidase family protein 0.02 0.1496 0.1665
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0102 0.049
Onchocerca volvulus 0.0105 0.0676 0.0653
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0676 0.2812
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0209
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0366 0.2935 1
Brugia malayi chromobox protein homolog 3 0.0039 0.0098 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.1053 0.4242
Echinococcus multilocularis jumonji domain containing 1A 0.0038 0.0093 0.0158
Loa Loa (eye worm) hypothetical protein 0.0105 0.0676 0.0746
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0555 0.0987
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0093 0.0158
Echinococcus granulosus JmjC domain containing protein 4 0.0038 0.0093 0.0158
Brugia malayi Heterochromatin protein 1 0.0069 0.036 0.0362
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0093 0.0158
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.2035 0.2301
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0277 0.0978
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0277 0.3381
Brugia malayi AF-10 protein 0.0039 0.0097 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0155 0.0155
Treponema pallidum fructose-bisphosphate aldolase 0.06 0.4961 0.5
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0386 0.311 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Entamoeba histolytica fatty acid elongase, putative 0.0048 0.0175 0.0209
Echinococcus granulosus jumonji domain containing protein 0.0164 0.1185 0.3721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Trypanosoma brucei polo-like protein kinase 0.0091 0.0555 0.7993
Leishmania major hypothetical protein, conserved 0.0105 0.0676 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0143 0.1 0.3117
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.4961 0.4961
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0073 0.0073
Echinococcus granulosus chromobox protein 1 0.0069 0.036 0.1029
Schistosoma mansoni inositol monophosphatase 0.0036 0.0073 0.0119
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.02 0.1496 0.4733
Echinococcus granulosus peregrin 0.0118 0.0785 0.2416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0539 0.208
Loa Loa (eye worm) hypothetical protein 0.0039 0.0097 0.0082
Onchocerca volvulus 0.0105 0.0676 0.0653
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.1 0.1116

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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