Detailed information for compound 1493425

Basic information

Technical information
  • TDR Targets ID: 1493425
  • Name: [2-(cyclohexyl-methylamino)-2-oxoethyl] 2-chl oropyridine-3-carboxylate
  • MW: 310.776 | Formula: C15H19ClN2O3
  • H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)COC(=O)c1cccnc1Cl)C1CCCCC1
  • InChi: 1S/C15H19ClN2O3/c1-18(11-6-3-2-4-7-11)13(19)10-21-15(20)12-8-5-9-17-14(12)16/h5,8-9,11H,2-4,6-7,10H2,1H3
  • InChiKey: XIXITZPKWPOVAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(cyclohexyl-methyl-amino)-2-oxo-ethyl] 2-chloropyridine-3-carboxylate
  • 2-chloro-3-pyridinecarboxylic acid [2-(cyclohexyl-methylamino)-2-oxoethyl] ester
  • 2-chloronicotinic acid [2-(cyclohexyl-methyl-amino)-2-keto-ethyl] ester
  • T0512-7329
  • Oprea1_465131
  • ZINC03620322
  • Oprea1_241420
  • Enamine_004896

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cpg binding protein 0.003 0.02 0.0589
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0448 0.1089
Leishmania major carbonic anhydrase family protein, putative 0.0495 0.4112 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0951 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0311 0.0755
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0175 0.079
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0214 0.0078
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.0951 0.4319
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0137 0.0618
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0137 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0311 0.0755
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0457 0.1109
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0231 0.1891 0.224
Echinococcus multilocularis cpg binding protein 0.003 0.02 0.0243
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0119 0.0951 0.4319
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.8193 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.0755
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0953 0.7968 1
Trichomonas vaginalis conserved hypothetical protein 0.1194 1 1
Entamoeba histolytica carbonic anhydrase, putative 0.0495 0.4112 1
Echinococcus multilocularis RUN 0.0023 0.0135 0.0164
Plasmodium falciparum carbonic anhydrase 0.0027 0.0175 0.7304
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0565
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0495 0.4112 1
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0175 0.0423
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0161 0.0474
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0137 0.0442
Schistosoma mansoni hypothetical protein 0.0372 0.3076 0.7481
Onchocerca volvulus Putative sulfate transporter 0.02 0.163 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0135 0.0436
Loa Loa (eye worm) hypothetical protein 0.0023 0.0135 0.0436
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0411 0.1332
Schistosoma mansoni cpg binding protein 0.0029 0.0186 0.0451
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0005 0.0005
Leishmania major GTP-binding protein, putative 0.0026 0.0161 0.039
Echinococcus granulosus carbonic anhydrase 0.0027 0.0175 0.0514
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0137 0.033
Loa Loa (eye worm) glutaminase 0.0268 0.22 0.715
Schistosoma mansoni cpg binding protein 0.003 0.02 0.0485
Schistosoma mansoni hypothetical protein 0.0023 0.0135 0.0327
Entamoeba histolytica Ran family GTPase 0.0026 0.0161 0.039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0411 0.05
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0214 0.2241
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0472 0.3923 0.4835
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0135 0.108 0.1317
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0161 0.0521
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0137 0.0137
Brugia malayi glutaminase DH11.1 0.0268 0.22 1
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.0755
Trichomonas vaginalis glutaminase, putative 0.0268 0.22 0.22
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0137 0.143
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0137 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.0448 0.1455
Echinococcus granulosus importin subunit beta 1 0.0035 0.0239 0.0703
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0253 0.2079 0.2481
Onchocerca volvulus 0.006 0.0448 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.1194 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0137 0.0166
Brugia malayi hypothetical protein 0.0043 0.0311 0.1412
Mycobacterium ulcerans glutaminase 0.0268 0.22 0.2092
Brugia malayi RNA, U transporter 1 0.0099 0.0779 0.3541
Loa Loa (eye worm) glutaminase 2 0.0268 0.22 0.715
Schistosoma mansoni rab6-interacting 0.0023 0.0135 0.0327
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0239 0.2504
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.0951 1
Schistosoma mansoni carbonic anhydrase 0.0495 0.4112 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0161 0.0729
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0161 1
Schistosoma mansoni ap endonuclease 0.0023 0.0137 0.033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0135 0.0164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0311 0.0918
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0161 0.1689
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0402 1
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.0755
Entamoeba histolytica hypothetical protein 0.0043 0.0311 0.0755
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0135 0.0164
Schistosoma mansoni hypothetical protein 0.0027 0.0175 0.0423
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0214 0.0946
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0239 0.5928
Schistosoma mansoni ran 0.0026 0.0161 0.039
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0175 0.0423
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0175 0.079
Trypanosoma brucei carbonic anhydrase-like protein 0.0119 0.0951 1
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0175 0.0423
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0214 0.895
Toxoplasma gondii exonuclease III APE 0.0023 0.0137 0.3385
Echinococcus granulosus carbonic anhydrase II 0.0119 0.0951 0.2809
Echinococcus granulosus carbonic anhydrase 0.0027 0.0175 0.0514
Schistosoma mansoni lipoxygenase 0.0094 0.0739 0.1795
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0239 0.2504
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0183 0.0183
Onchocerca volvulus 0.0029 0.0186 0.0343
Leishmania major carbonic anhydrase-like protein 0.0119 0.0951 0.231
Brugia malayi hypothetical protein 0.0023 0.0135 0.061
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0135 0.0397
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0161 0.6744
Trichomonas vaginalis ran, putative 0.0026 0.0161 0.0161
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0239 0.029
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0137 0.0402
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0005
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0175 0.079
Plasmodium falciparum importin beta, putative 0.0035 0.0239 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0411 0.1212
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0135 0.0397
Plasmodium vivax importin-beta 2, putative 0.0035 0.0239 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0135 0.5644
Echinococcus multilocularis snurportin 1 0.0372 0.3076 0.3754
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0161 0.6744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0997
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0175 0.0212
Schistosoma mansoni lipoxygenase 0.0135 0.108 0.2625
Echinococcus granulosus RUN 0.0023 0.0135 0.0397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0565
Mycobacterium ulcerans carbonic anhydrase 0.0495 0.4112 0.403
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0183 0.0183
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0183 0.0183
Schistosoma mansoni glutaminase 0.0268 0.22 0.5349
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0137 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0997
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0005 0.0013
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0175 0.079
Schistosoma mansoni ran 0.0026 0.0161 0.039
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0214 0.0946
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0951 0.231
Schistosoma mansoni loxhd1 0.0023 0.0135 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0411 0.0997
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0411 0.1864
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.0773
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.0951 0.3088
Schistosoma mansoni importin beta-1 0.0035 0.0239 0.0578
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0137 0.5711
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0135 0.5644
Brugia malayi CXXC zinc finger family protein 0.0029 0.0186 0.0844
Brugia malayi Doublecortin family protein 0.0023 0.0135 0.061
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0175 0.0565
Plasmodium vivax sulfate transporter, putative 0.0032 0.0214 0.895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0005 0.0011
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0175 0.0212
Schistosoma mansoni rab6-interacting 0.0023 0.0135 0.0327
Echinococcus granulosus carbonic anhydrase 0.0027 0.0175 0.0514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0175 0.0565
Echinococcus multilocularis tumor protein p63 0.0408 0.3382 0.4127
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0161 0.3998
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0175 0.079
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0135 0.0164
Echinococcus multilocularis carbonic anhydrase II 0.0119 0.0951 0.1159
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0161 0.0196
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0137 0.5711
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0135 0.0436
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0135 0.108 0.3192
Schistosoma mansoni ap endonuclease 0.0023 0.0137 0.033
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0214 0.5305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0411 0.1212
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0214 0.0078
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0214 0.0078
Schistosoma mansoni carbonic anhydrase 0.0027 0.0175 0.0423
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.0023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3076 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0161 0.0302
Loa Loa (eye worm) carbonic anhydrase 3 0.0119 0.0951 0.3088
Entamoeba histolytica hypothetical protein 0.0028 0.0183 0.0444
Brugia malayi hypothetical protein 0.0023 0.0135 0.061
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.0951 0.231
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0175 0.0212
Leishmania major importin beta-1 subunit, putative 0.0028 0.0183 0.0444
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0161 0.0302
Onchocerca volvulus 0.02 0.163 1
Echinococcus granulosus snurportin 1 0.0372 0.3076 0.9095
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0183 0.0572
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0186 0.0603
Echinococcus granulosus tumor protein p63 0.0408 0.3382 1
Schistosoma mansoni cpg binding protein 0.003 0.02 0.0485
Chlamydia trachomatis sulfate transporter 0.0032 0.0214 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0019 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0311 0.0379
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0135 0.0397
Toxoplasma gondii hypothetical protein 0.0027 0.0175 0.433
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0005 0.0013
Brugia malayi Importin beta-1 subunit 0.0035 0.0239 0.1081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0411 0.05
Schistosoma mansoni polycystin 1-related 0.0023 0.0135 0.0327
Trichomonas vaginalis hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) histone methyltransferase 0.0009 0.002 0.0062

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0034 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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