Detailed information for compound 1497574

Basic information

Technical information
  • TDR Targets ID: 1497574
  • Name: 2-(4-pyrimidin-2-yloxyphenyl)acetonitrile
  • MW: 211.219 | Formula: C12H9N3O
  • H donors: 0 H acceptors: 3 LogP: 1.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCc1ccc(cc1)Oc1ncccn1
  • InChi: 1S/C12H9N3O/c13-7-6-10-2-4-11(5-3-10)16-12-14-8-1-9-15-12/h1-5,8-9H,6H2
  • InChiKey: VGLKSOKLHZULPY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[4-(2-pyrimidinyloxy)phenyl]acetonitrile
  • 2-(4-pyrimidin-2-yloxyphenyl)ethanenitrile
  • Oprea1_307429
  • 8N-091
  • ZINC00170275

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0169 0.374 1
Brugia malayi ABC transporter family protein 0.0161 0.3552 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0026 0.0338 0.0953
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0026 0.0338 0.0951
Entamoeba histolytica P-glycoprotein 5, putative 0.0049 0.0873 0.1876
Echinococcus multilocularis solute carrier family 22 0.0014 0.0054 0.0152
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0051 0.0915 0.3559
Loa Loa (eye worm) ABC transporter 0.0051 0.0915 0.2444
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0465 0.1698
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Plasmodium falciparum hexose transporter 0.0102 0.2135 0.2135
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0177 0.0498
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.056 0.2094
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.044 0.1237
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0051 0.0915 1
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0254 0.0715
Plasmodium falciparum multidrug resistance-associated protein 1 0.0051 0.0915 0.0914
Echinococcus granulosus solute carrier family 22 0.0014 0.0054 0.0152
Entamoeba histolytica protein kinase, putative 0.0032 0.0464 0.0636
Trichomonas vaginalis taga, putative 0.0161 0.3552 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0464 0.0412
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0464 0.1306
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Trypanosoma cruzi hexose transporter 0.0032 0.0465 0.1698
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0464 0.0464
Giardia lamblia Multidrug resistance-associated protein 1 0.0051 0.0915 0.3559
Plasmodium vivax multidrug resistance protein 1, putative 0.0161 0.3552 0.3517
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Loa Loa (eye worm) hypothetical protein 0.0161 0.3552 0.9499
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Loa Loa (eye worm) hypothetical protein 0.0161 0.3552 0.9499
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0254 0.0386
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0177 0.0498
Loa Loa (eye worm) hypothetical protein 0.0019 0.0177 0.0471
Giardia lamblia Kinase, PLK 0.0116 0.2472 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0054 0.0152
Trypanosoma brucei polo-like protein kinase 0.0116 0.2472 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.044 0.1237
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Brugia malayi ABC transporter family protein 0.0051 0.0915 0.2573
Trichomonas vaginalis ABC transporter, putative 0.0161 0.3552 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.044 0.1103
Loa Loa (eye worm) hypothetical protein 0.0026 0.0338 0.0903
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.1102 0.2997
Plasmodium falciparum ABC transporter B family member 3, putative 0.0051 0.0915 0.0914
Loa Loa (eye worm) ABC transporter 0.0051 0.0915 0.2444
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Brugia malayi hypothetical protein 0.0014 0.0054 0.015
Onchocerca volvulus Serine\/threonine kinase homolog 0.0116 0.2472 0.6912
Entamoeba histolytica P-glycoprotein-2, putative 0.0161 0.3552 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0161 0.3552 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2135 0.3252
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0177 0.0471
Brugia malayi serine/threonine-protein kinase plk-2 0.0116 0.2472 0.6958
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0051 0.0915 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.0051 0.0915 0.0914
Schistosoma mansoni protein kinase 0.0032 0.0464 0.1304
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0169 0.374 1
Toxoplasma gondii protein kinase, putative 0.0288 0.6564 1
Trichomonas vaginalis ABC transporter, putative 0.0161 0.3552 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0054 0.0143
Echinococcus granulosus multidrug resistance protein 1 0.0161 0.3552 1
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0054 0.0081
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0465 0.1698
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0054 0.015
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0161 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.1175
Echinococcus granulosus ATP binding cassette sub family B 0.0049 0.0873 0.2457
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0409 0.1152
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0161 0.3552 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3635 0.5538
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Trypanosoma brucei glucose transporter 2A 0.0032 0.0465 0.1698
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Brugia malayi P-glycoprotein-like protein 0.0051 0.0915 0.2573
Trichomonas vaginalis ABC transporter, putative 0.0161 0.3552 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0049 0.0873 0.234
Giardia lamblia Multidrug resistance-associated protein 1 0.0049 0.0873 0.3386
Schistosoma mansoni protein kinase 0.0032 0.0464 0.1304
Loa Loa (eye worm) hypothetical protein 0.0051 0.0915 0.2444
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.1355 0.372
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0012 0.0029
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0161 0.3552 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0254 0.0713
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0051 0.0915 0.2573
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0465 0.1173
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0177 0.0496
Schistosoma mansoni multidrug resistance protein 0.0049 0.0873 0.2455
Echinococcus granulosus voltage gated potassium channel 0.0026 0.0338 0.0953
Schistosoma mansoni multidrug resistance protein 0.0161 0.3552 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2135 0.6011
Trichomonas vaginalis ABC transporter, putative 0.0161 0.3552 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0161 0.3552 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0173 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.0049 0.0873 0.2332
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0177 0.0498
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0177 0.0496
Echinococcus multilocularis ATP binding cassette sub family B 0.0051 0.0915 0.2575
Trichomonas vaginalis abcb9, putative 0.0161 0.3552 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0054 0.0152
Trichomonas vaginalis CAMK family protein kinase 0.0058 0.1102 0.2997
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0177 0.0498
Echinococcus multilocularis sodium channel protein 0.008 0.1617 0.4551
Schistosoma mansoni multidrug resistance protein 0.0051 0.0915 0.2573
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0161 0.3552 0.5411
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0051 0.0915 0.3559
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0465 0.1173
Leishmania major p-glycoprotein 0.0161 0.3552 1
Echinococcus multilocularis 0.0051 0.0915 0.2575
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Echinococcus granulosus solute carrier family 22 0.0014 0.0054 0.0152
Echinococcus multilocularis multidrug resistance associated protein 1 0.0051 0.0915 0.2575
Plasmodium falciparum ABC transporter B family member 6, putative 0.0051 0.0915 0.0914
Leishmania major p-glycoprotein e 0.0051 0.0915 0.2573
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2135 0.5949
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0161 0.3552 1
Entamoeba histolytica P-glycoprotein-2 0.0161 0.3552 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0161 0.3552 0.9499
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0464 0.0706
Schistosoma mansoni sugar transporter 0.0014 0.0054 0.015
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0079 0.1587 0.4467
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Echinococcus multilocularis solute carrier family 22 0.0014 0.0054 0.0152
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0049 0.0873 0.3386
Echinococcus granulosus multidrug resistance protein 1 0.0113 0.2393 0.6737
Brugia malayi ABC transporter family protein 0.0051 0.0915 0.2573
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0177 0.0498
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0254 0.0827
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0079 0.1587 0.4242
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Toxoplasma gondii sugar transporter ST3 0.0014 0.0054 0.0081
Entamoeba histolytica ABC transporter, putative 0.0051 0.0915 0.2003
Trypanosoma cruzi polo-like protein kinase, putative 0.0116 0.2472 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0054 0.0152
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0464 0.1239
Echinococcus granulosus multidrug resistance protein 1 0.0113 0.2393 0.6737
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0177 0.0498
Schistosoma mansoni kinase 0.006 0.1138 0.3203
Schistosoma mansoni hypothetical protein 0.0102 0.2135 0.601
Echinococcus granulosus solute carrier family 22 0.0014 0.0054 0.0152
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0051 0.0915 0.246
Entamoeba histolytica P-glycoprotein 6, putative 0.0051 0.0915 0.2003
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0116 0.2472 0.6959
Entamoeba histolytica P-glycoprotein 5, putative 0.0161 0.3552 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0177 0.0351
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0464 0.0412
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0465 0.1698
Echinococcus multilocularis multidrug resistance protein 1 0.0113 0.2393 0.6737
Echinococcus multilocularis solute carrier family 22 0.0014 0.0054 0.0152
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0054 0.0152
Plasmodium vivax ABC transporter B family member 3, putative 0.0051 0.0915 0.0865
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0051 0.0915 0.3559
Schistosoma mansoni multidrug resistance protein 0.0051 0.0915 0.2573
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0051 0.0915 1
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0051 0.0915 0.2573
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0177 0.0498
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0051 0.0915 0.3559
Schistosoma mansoni sugar transporter 0.0014 0.0054 0.015
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0054 0.015
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.056 0.0853
Entamoeba histolytica P-glycoprotein-2, putative 0.0049 0.0873 0.1876
Toxoplasma gondii sugar transporter ST1 0.0014 0.0054 0.0081
Echinococcus multilocularis multidrug resistance protein 1 0.0161 0.3552 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0465 0.1173
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0051 0.0915 0.246
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0049 0.0873 0.2455
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0051 0.0915 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Brugia malayi ABC transporter transmembrane region family protein 0.0049 0.0873 0.2455
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Toxoplasma gondii ABC transporter family protein 0.0051 0.0915 0.1392
Trypanosoma brucei glucose transporter 1E 0.0032 0.0465 0.1698
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0254 0.0572
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0054 0.015
Echinococcus granulosus General substrate transporter 0.0088 0.1795 0.5052
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.056 0.0509
Entamoeba histolytica protein kinase, putative 0.0032 0.0464 0.0636
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0465 0.1306
Schistosoma mansoni glucose transport protein 0.0102 0.2135 0.601
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Schistosoma mansoni multidrug resistance protein 0.0161 0.3552 1
Schistosoma mansoni multidrug resistance protein 0.0051 0.0915 0.2573
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0161 0.3552 0.5411
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0464 0.0464
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0051 0.0915 0.2573
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Brugia malayi Sugar transporter family protein 0.0102 0.2135 0.601
Plasmodium falciparum multidrug resistance-associated protein 2 0.0051 0.0915 0.0914
Trypanosoma cruzi multidrug resistance protein E, putative 0.0051 0.0915 0.3559
Brugia malayi Cam kinase protein 1 0.0032 0.0464 0.1304
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0051 0.0915 0.2573
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0177 0.0496
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0054 0.0143
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0254 0.0678
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Brugia malayi ABC transporter 0.0051 0.0915 0.2573
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0161 0.3552 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0464 0.0464
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0161 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0051 0.0915 0.1392
Entamoeba histolytica hypothetical protein 0.0051 0.0915 0.2003
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0464 0.0706
Entamoeba histolytica ATP-binding cassette protein, putative 0.0051 0.0915 0.2003
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0049 0.0873 0.234
Schistosoma mansoni multidrug resistance protein 0.0051 0.0915 0.2573
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0079 0.1587 0.4465
Echinococcus multilocularis ATP binding cassette sub family B 0.016 0.351 0.9882
Leishmania major ABC-thiol transporter 0.0051 0.0915 0.2573
Loa Loa (eye worm) hypothetical protein 0.0049 0.0873 0.2332
Echinococcus granulosus sodium channel protein 0.008 0.1617 0.4551
Echinococcus multilocularis ATP binding cassette sub family B 0.0051 0.0915 0.2575
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0465 0.1173
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0161 0.3552 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0873 0.234
Giardia lamblia Hypothetical protein 0.0049 0.0873 0.3386
Echinococcus multilocularis multidrug resistance associated protein 7 0.0051 0.0915 0.2575
Echinococcus granulosus multidrug resistance protein 1 0.0161 0.3552 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0051 0.0915 1
Brugia malayi Sugar transporter family protein 0.0014 0.0054 0.015
Echinococcus multilocularis expressed conserved protein 0.0012 0.0001 0.0002
Leishmania major glucose transporter, lmgt3 0.0032 0.0465 0.1306
Toxoplasma gondii sugar transporter ST2 0.0014 0.0054 0.0081
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0051 0.0915 0.3559
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Leishmania major protein kinase, putative 0.0032 0.0464 0.1304
Loa Loa (eye worm) hypothetical protein 0.0025 0.0304 0.0811
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0465 0.1173
Onchocerca volvulus 0.0161 0.3552 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.044 0.0564
Echinococcus granulosus ATP binding cassette sub family B 0.0051 0.0915 0.2575
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0465 0.1698
Loa Loa (eye worm) sugar transporter 0.0014 0.0054 0.0143
Schistosoma mansoni protein kinase 0.0032 0.0464 0.1304
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0464 0.1304
Toxoplasma gondii ABC transporter, putative 0.0051 0.0915 0.1392
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0161 0.3552 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1355 0.3621
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0049 0.0873 0.234
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0173 0.0339
Entamoeba histolytica P-glycoprotein-2 0.0161 0.3552 1
Entamoeba histolytica multidrug resistance protein, putative 0.0051 0.0915 0.2003
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0464 0.0706
Toxoplasma gondii hypothetical protein 0.0169 0.374 0.5696
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0161 0.3552 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0161 0.3552 0.9499
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0254 0.0827
Brugia malayi hypothetical protein 0.0051 0.0915 0.2573
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0051 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.0051 0.0915 0.2444
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0338 0.0951
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0116 0.2472 0.6958
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0177 0.0498
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.056 0.2094
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0161 0.3552 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0465 0.1698
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0254 0.0715
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0054 0.0152
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.1748 0.492
Loa Loa (eye worm) sugar transporter 0.0102 0.2135 0.5709
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0464 0.1172
Brugia malayi multidrug resistance protein 3 0.0161 0.3552 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0161 0.3552 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0465 0.1698
Leishmania major calcium channel protein, putative,ion transporter, putative 0.008 0.1617 0.455
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Trichomonas vaginalis abcb9, putative 0.0161 0.3552 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Loa Loa (eye worm) hypothetical protein 0.0169 0.374 1
Entamoeba histolytica P-glycoprotein-1 0.0161 0.3552 1
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.056 0.2094
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0051 0.0915 0.0865
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Echinococcus granulosus ATP binding cassette sub family B 0.0051 0.0915 0.2575
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0051 0.0915 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0051 0.0915 0.2444
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3635 0.3635
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.008 0.1617 0.4551
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Leishmania major pentamidine resistance protein 1 0.0051 0.0915 0.2573
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0464 0.0412
Plasmodium vivax ABC transporter B family member 4, putative 0.0051 0.0915 0.0865
Schistosoma mansoni glucose transport protein 0.0102 0.2135 0.601
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0177 0.0496
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0054 0.015
Loa Loa (eye worm) hypothetical protein 0.0051 0.0915 0.2444
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0254 0.1098
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0254 0.2324
Plasmodium vivax multidrug resistance protein 2, putative 0.0051 0.0915 0.0865
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0254 0.2324
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0161 0.3552 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0464 0.1304
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0177 0.0498
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0051 0.0915 0.3559
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0106 0.0297
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.044 0.1239
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0177 0.0498
Echinococcus multilocularis ATP binding cassette sub family B 0.0051 0.0915 0.2575
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.056 0.1576
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0001 0.0002
Entamoeba histolytica P-glycoprotein-5 0.0161 0.3552 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.044 0.1239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Brugia malayi Sugar transporter family protein 0.0014 0.0054 0.015
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0161 0.3552 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0051 0.0915 0.3559
Echinococcus granulosus multidrug resistance associated protein 1 0.0051 0.0915 0.2575
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0051 0.0915 0.246
Plasmodium falciparum protein kinase 7 0.0288 0.6564 0.6564
Loa Loa (eye worm) hypothetical protein 0.0031 0.044 0.1175
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.016 0.351 0.9882
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.044 0.1596
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0161 0.3552 1
Brugia malayi multidrug resistance related protein 1 0.0051 0.0915 0.2573
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0254 0.0713
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0116 0.2472 0.6959
Plasmodium vivax ABC transporter B family member 6, putative 0.0051 0.0915 0.0865
Schistosoma mansoni smdr1 0.0051 0.0915 0.2573
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0051 0.0915 1
Brugia malayi hypothetical protein 0.0014 0.0054 0.015
Loa Loa (eye worm) hypothetical protein 0.016 0.351 0.9387
Plasmodium vivax ABC transporter B family member 7, putative 0.0051 0.0915 0.0865
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.056 0.1576
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0054 0.0053
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0079 0.1587 0.4467
Schistosoma mansoni glucose transporter 0.0014 0.0054 0.015
Leishmania major hypothetical protein, conserved 0.0014 0.0054 0.015
Trypanosoma cruzi polo-like protein kinase, putative 0.0116 0.2472 1
Trypanosoma brucei p-glycoprotein 0.0051 0.0915 0.3559
Echinococcus multilocularis ATP binding cassette sub family B 0.0051 0.0915 0.2575
Leishmania major glucose transporter, lmgt2 0.0032 0.0465 0.1306
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0106 0.0297
Schistosoma mansoni glucose transport protein 0.0102 0.2135 0.601
Entamoeba histolytica serine/threonine protein kinase, putative 0.0116 0.2472 0.6724
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.2472 0.6958
Trichomonas vaginalis CAMK family protein kinase 0.0116 0.2472 0.6912
Plasmodium vivax hexose transporter 0.0102 0.2135 0.2092
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0177 0.0498
Leishmania major glucose transporter, lmgt1 0.0032 0.0465 0.1306
Schistosoma mansoni sugar transporter 0.0014 0.0054 0.015
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0001 0.0002
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Entamoeba histolytica P-glycoprotein 6, putative 0.0051 0.0915 0.2003
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0051 0.0915 0.2573
Echinococcus multilocularis General substrate transporter 0.0088 0.1795 0.5052
Schistosoma mansoni sugar transporter 0.0014 0.0054 0.015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Entamoeba histolytica P-glyco protein 6, putative 0.0161 0.3552 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0254 0.0827
Echinococcus granulosus multidrug resistance protein 1 0.0161 0.3552 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0051 0.0915 0.3559
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0051 0.0915 0.2573
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0465 0.1173
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0051 0.0915 0.0865
Entamoeba histolytica ATP-binding cassette protein, putative 0.0051 0.0915 0.2003
Schistosoma mansoni multidrug resistance protein 0.0161 0.3552 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0465 0.1173
Echinococcus multilocularis multidrug resistance protein 1 0.0161 0.3552 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.1355 0.372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0177 0.0496
Brugia malayi major facilitator superfamily protein 0.0014 0.0054 0.015
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0254 0.0201
Echinococcus multilocularis voltage gated potassium channel 0.0026 0.0338 0.0953
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0464 0.0464
Brugia malayi ABC transporter transmembrane region family protein 0.0051 0.0915 0.2573
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2135 0.6011
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.044 0.1237
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0051 0.0915 0.2573
Plasmodium falciparum ABC transporter B family member 4, putative 0.0051 0.0915 0.0914
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0026 0.0338 0.0953
Brugia malayi hypothetical protein 0.0014 0.0054 0.015
Brugia malayi ABC transporter 0.0049 0.0873 0.2455
Plasmodium falciparum proline--tRNA ligase 0.0036 0.056 0.056
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0051 0.0915 0.2573
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0254 0.0253
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.044 0.3605
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3635 0.3601
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0113 0.2393 0.6687
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.1748 0.492
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0054 0.015
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0177 0.0471
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0051 0.0915 0.1392
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0177 0.0496
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0161 0.3552 1
Brugia malayi ABC transporter family protein 0.0051 0.0915 0.2573
Giardia lamblia ABC transporter, putative 0.0051 0.0915 0.3559
Plasmodium vivax CDK-related protein kinase 6, putative 0.0433 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0464 0.1239
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0051 0.0915 0.3559
Echinococcus multilocularis solute carrier family 22 0.0014 0.0054 0.0152
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0161 0.3552 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.0051 0.0915 0.0914
Schistosoma mansoni multidrug resistance protein 0.0051 0.0915 0.2573
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0177 0.0496
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0161 0.3552 1
Plasmodium falciparum multidrug resistance protein 1 0.0161 0.3552 0.3552
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0464 0.1239
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0116 0.2472 0.661
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0409 0.1152
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0161 0.3552 1
Plasmodium vivax ABC transporter B family member 5, putative 0.0051 0.0915 0.0865
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0124 0.029
Schistosoma mansoni smdr2 0.0161 0.3552 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0187 0.0381
Entamoeba histolytica ATP-binding cassette protein, putative 0.0051 0.0915 0.2003
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0464 0.0412
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0464 0.1695
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0161 0.3552 1
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0051 0.0915 0.2573
Entamoeba histolytica ATP-binding cassette protein, putative 0.0051 0.0915 0.2003
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Trichomonas vaginalis abcb9, putative 0.0161 0.3552 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0464 0.1306
Trypanosoma brucei glucose transporter, putative 0.0032 0.0465 0.1698
Echinococcus granulosus multidrug resistance associated protein 7 0.0051 0.0915 0.2575
Giardia lamblia MRP-like ABC transporter 0.0051 0.0915 0.3559
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0051 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Plasmodium falciparum multidrug resistance protein 2 0.0051 0.0915 0.0914
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0177 0.0351
Schistosoma mansoni voltage-gated potassium channel 0.0026 0.0338 0.0951
Brugia malayi ABC transporter transmembrane region family protein 0.0051 0.0915 0.2573
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.044 0.1237
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0254 0.0713
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0143
Loa Loa (eye worm) ABC transporter 0.0051 0.0915 0.2444
Brugia malayi major facilitator superfamily protein 0.0014 0.0054 0.015
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0254 0.0713
Trypanosoma brucei multidrug resistance protein E 0.0051 0.0915 0.3559
Loa Loa (eye worm) hypothetical protein 0.0169 0.374 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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