TDR Targets

Basic information

Technical information

TDR Targets ID: 1499472
Name: N-[5-(diethylsulfamoyl)-2-morpholin-4-ylpheny l]-2-ethoxypyridine-3-carboxamide
MW: 462.562 | Formula: C22H30N4O5S
H donors: 1 H acceptors: 4 LogP: 1.99 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ncccc1C(=O)Nc1cc(ccc1N1CCOCC1)S(=O)(=O)N(CC)CC
InChi: 1S/C22H30N4O5S/c1-4-26(5-2)32(28,29)17-9-10-20(25-12-14-30-15-13-25)19(16-17)24-21(27)18-8-7-11-23-22(18)31-6-3/h7-11,16H,4-6,12-15H2,1-3H3,(H,24,27)
InChiKey: QKGIICDSOVBQSM-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[5-(diethylsulfamoyl)-2-morpholino-phenyl]-2-ethoxy-pyridine-3-carboxamide
N-[5-(diethylsulfamoyl)-2-morpholinophenyl]-2-ethoxy-3-pyridinecarboxamide
N-[5-(diethylsulfamoyl)-2-morpholino-phenyl]-2-ethoxy-nicotinamide
N-[5-(diethylsulfamoyl)-2-morpholin-4-yl-phenyl]-2-ethoxy-pyridine-3-carboxamide
T0508-3356

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ectonucleotide	0.0229	0.0534	0.0363
Echinococcus granulosus	ectonucleotide	0.0229	0.0534	0.0363
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0121	0.0201	0.0249
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0121	0.0201	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.2851	0.2721
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1331	0.3938	0.3931
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0121	0.0201	0.0023
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0121	0.0201	0.0023
Onchocerca volvulus		0.0121	0.0201	0.0061
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0121	0.0201	0.0061
Brugia malayi	hypothetical protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0121	0.0201	0.0249
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0131	0.0231	0.0054
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0121	0.0201	0.0196
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0121	0.0201	0.0189
Echinococcus multilocularis	Endonuclease G	0.0163	0.0331	0.0155
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0131	0.0231	0.0054
Trypanosoma brucei	endonuclease G, putative	0.0163	0.0331	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0294	0.0283
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0121	0.0201	0.0023
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.0178	0.0173
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1331	0.3938	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0229	0.0534	0.0363
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0272	0.0666	0.0662
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0587	0.164	0.1631
Onchocerca volvulus		0.0121	0.0201	0.0061
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0131	0.0231	0.0226
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.3294	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0294	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0294	0.0283
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0121	0.0201	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0131	0.0231	0.0054
Onchocerca volvulus	4.1 G protein, putative homolog	0.0121	0.0201	0.0061
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0131	0.0231	0.022
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0131	0.0231	0.0226
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1331	0.3938	1
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0121	0.0201	0.0023
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0131	0.0231	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0121	0.0201	0.0249
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0121	0.0201	0.0196
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0121	0.0201	0.0023
Schistosoma mansoni	pcd6 interacting protein-related	0.0121	0.0201	0.0196
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1331	0.3938	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.0178	0.0167
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0272	0.0666	0.1299
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0131	0.0231	0.0054
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0131	0.0231	0.0054
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1331	0.3938	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0272	0.0666	0.0662
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0229	0.0534	0.0363
Trypanosoma cruzi	endonuclease G, putative	0.0163	0.0331	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Trypanosoma cruzi	endonuclease G, putative	0.0163	0.0331	0.1668
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0121	0.0201	0.0189
Brugia malayi	hypothetical protein	0.0121	0.0201	0.0189
Brugia malayi	hypothetical protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Onchocerca volvulus		0.0121	0.0201	0.0061
Trypanosoma brucei	endonuclease G, putative	0.0163	0.0331	0.1668
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.041	0.1093	0.2776
Loa Loa (eye worm)	hypothetical protein	0.0273	0.0669	0.0659
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0131	0.0231	0.0226
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0121	0.0201	0.0189
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1331	0.3938	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0131	0.0231	0.0054
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0121	0.0201	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Trichomonas vaginalis	pten, drome, putative	0.0121	0.0201	0.051
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0666	0.0655
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Leishmania major	endonuclease G, putative	0.0163	0.0331	0.1668
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1331	0.3938	1
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0121	0.0201	0.0249
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.3294	1	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Schistosoma mansoni	endonuclease related	0.0163	0.0331	0.0326
Onchocerca volvulus		0.0121	0.0201	0.0061
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0921	0.267	0.5
Echinococcus granulosus	Endonuclease G	0.0163	0.0331	0.0155
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0121	0.0201	0.0196
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Schistosoma mansoni	hypothetical protein	0.0587	0.164	0.1636
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.041	0.1093	0.2776
Brugia malayi	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0121	0.0201	0.0196
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1331	0.3938	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0121	0.0201	0.0023
Schistosoma mansoni	protein tyrosine phosphatase	0.0131	0.0231	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0666	0.0655
Trypanosoma cruzi	hypothetical protein, conserved	0.041	0.1093	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Onchocerca volvulus		0.0272	0.0666	0.1299
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.3294	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0131	0.0231	0.0226
Onchocerca volvulus		0.0121	0.0201	0.0061
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus multilocularis		0.0121	0.0201	0.0023
Leishmania major	tyrosine specific protein phosphatase, putative	0.0121	0.0201	0.0249
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1331	0.3938	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1331	0.3938	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.3294	1	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0272	0.0666	0.0662
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.041	0.1093	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0121	0.0201	0.0023
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0163	0.0331	0.1668
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.0178	0.0167
Schistosoma mansoni	protein tyrosine phosphatase	0.0121	0.0201	0.0196
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0121	0.0201	0.0023
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0121	0.0201	0.0189
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0121	0.0201	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0272	0.0666	0.0655
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Brugia malayi	Protein-tyrosine phosphatase	0.0283	0.0699	0.0689
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0272	0.0666	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0131	0.0231	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0229	0.0534	0.0523
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1331	0.3938	1
Onchocerca volvulus		0.1331	0.3938	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0131	0.0231	0.0054
Brugia malayi	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0163	0.0331	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Brugia malayi	Protein-tyrosine phosphatase 1	0.0121	0.0201	0.0189
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0272	0.0666	0.0662
Onchocerca volvulus		0.0587	0.164	0.3889
Echinococcus multilocularis	hypothetical protein	0.0121	0.0201	0.0023
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0131	0.0231	0.0054
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0121	0.0201	0.0023
Brugia malayi	Protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0131	0.0231	0.0054
Schistosoma mansoni	protein tyrosine phosphatase	0.0121	0.0201	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0121	0.0201	0.0196
Onchocerca volvulus		0.0121	0.0201	0.0061
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1331	0.3938	0.3931
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0121	0.0201	0.0023
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0163	0.0331	0.1668
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0272	0.0666	0.0497
Trypanosoma cruzi	hypothetical protein, conserved	0.041	0.1093	1
Brugia malayi	endonuclease G, mitochondrial precursor	0.0163	0.0331	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0121	0.0201	0.0061
Leishmania major	hypothetical protein, conserved	0.041	0.1093	1
Onchocerca volvulus		0.0161	0.0324	0.0389
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0121	0.0201	0.0061
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0163	0.0331	0.1668
Giardia lamblia	Protein tyrosine phosphatase	0.0121	0.0201	0.0061
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0121	0.0201	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0201	0.0189
Onchocerca volvulus		0.0121	0.0201	0.0061
Onchocerca volvulus		0.0121	0.0201	0.0061
Onchocerca volvulus		0.0121	0.0201	0.0061
Trypanosoma brucei	endonuclease G, putative	0.0163	0.0331	0.1668
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0587	0.164	0.1631
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0121	0.0201	0.0023
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0121	0.0201	0.0196
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0121	0.0201	0.0189
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0121	0.0201	0.0189
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.0178	0.0452

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.8184 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.1714 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.8336 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1712729

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1499472