Detailed information for compound 1499482

Basic information

Technical information
  • TDR Targets ID: 1499482
  • Name: ZINC02628358
  • MW: 301.337 | Formula: C17H19NO4
  • H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCCC1)COc1ccc2c(c1)oc(=O)cc2
  • InChi: 1S/C17H19NO4/c19-16(18-13-4-2-1-3-5-13)11-21-14-8-6-12-7-9-17(20)22-15(12)10-14/h6-10,13H,1-5,11H2,(H,18,19)
  • InChiKey: NAQFZEDEMWYGOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • T5270023

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0144 0.1635 0.553
Brugia malayi RNA binding protein 0.007 0.0722 0.2289
Schistosoma mansoni hypothetical protein 0.0078 0.0816 0.1097
Plasmodium vivax aspartyl proteinase, putative 0.0243 0.2859 0.3451
Plasmodium falciparum plasmepsin VI 0.0243 0.2859 0.3403
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0816 0.2623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0537 0.0717
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0146 0.0476
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.5
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0816 0.2623
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0816 0.1911
Loa Loa (eye worm) hypothetical protein 0.0246 0.2893 1
Brugia malayi hypothetical protein 0.01 0.1093 0.3607
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0722 0.2289
Entamoeba histolytica hypothetical protein 0.0035 0.0291 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0085 0.0102
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1021 0.1469
Echinococcus granulosus bloom syndrome protein 0.0024 0.0146 0.0323
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0049 0.0071
Toxoplasma gondii hypothetical protein 0.0033 0.0256 0.0369
Plasmodium falciparum plasmepsin IX 0.01 0.1093 0.1217
Schistosoma mansoni tar DNA-binding protein 0.007 0.0722 0.0969
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0362 0.0836
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.2893 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0722 0.0969
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0608 0.1682
Echinococcus multilocularis peregrin 0.003 0.0219 0.021
Schistosoma mansoni hypothetical protein 0.003 0.0219 0.0285
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0537 0.1249
Entamoeba histolytica hypothetical protein 0.0035 0.0291 1
Plasmodium vivax aspartyl protease, putative 0.01 0.1093 0.1281
Echinococcus multilocularis tar DNA binding protein 0.007 0.0722 0.0713
Brugia malayi Probable ClpP-like protease 0.0094 0.1021 0.3349
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.01 0.1093 0.1574
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1021 0.1469
Plasmodium vivax hypothetical protein, conserved 0.003 0.0219 0.0206
Schistosoma mansoni hypothetical protein 0.0035 0.0291 0.0383
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0243 0.2859 0.675
Schistosoma mansoni tar DNA-binding protein 0.007 0.0722 0.0969
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.1127
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.2893 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0537 0.1423
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0146 0.0476
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.02 1
Schistosoma mansoni hypothetical protein 0.0078 0.0816 0.1097
Loa Loa (eye worm) aspartyl protease 6 0.01 0.1093 0.3448
Plasmodium vivax plasmepsin IV, putative 0.0243 0.2859 0.3451
Schistosoma mansoni hypothetical protein 0.0078 0.0816 0.1097
Echinococcus multilocularis GPCR, family 2 0.0078 0.0816 0.0807
Schistosoma mansoni hypothetical protein 0.0354 0.423 0.574
Toxoplasma gondii aspartyl protease ASP3 0.01 0.1093 0.1574
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0146 0.0136
Entamoeba histolytica hypothetical protein 0.0035 0.0291 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0256 0.0181
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1635 0.5419
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 1
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0296 0.0679
Loa Loa (eye worm) TAR-binding protein 0.007 0.0722 0.2098
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.5
Onchocerca volvulus 0.01 0.1093 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.01 0.1093 0.3448
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.5
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0291 0.0667
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1021 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0722 0.0969
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0219 0.0497
Echinococcus granulosus GPCR family 2 0.0078 0.0816 0.1911
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0256 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0816 0.1911
Echinococcus granulosus peregrin 0.003 0.0219 0.0497
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.02 0.0182
Plasmodium vivax aspartyl protease, putative 0.01 0.1093 0.1281
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.1049 0.1041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0296 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0537 0.1249
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.5
Brugia malayi hypothetical protein 0.0035 0.0291 0.0758
Echinococcus granulosus tar DNA binding protein 0.007 0.0722 0.1688
Plasmodium falciparum plasmepsin VIII, putative 0.01 0.1093 0.1217
Entamoeba histolytica hypothetical protein 0.0035 0.0291 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.02 0.0288
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.1021 0.1191
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Schistosoma mansoni tar DNA-binding protein 0.007 0.0722 0.0969
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0243 0.2859 0.3874
Brugia malayi jmjC domain containing protein 0.0036 0.0296 0.0777
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0722 0.2098
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.02 0.0111
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.1932 0.6586
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1021 0.1375
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.1049 0.2464
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0537 0.1631
Brugia malayi Bromodomain containing protein 0.003 0.0219 0.0504
Loa Loa (eye worm) hypothetical protein 0.0051 0.048 0.1216
Loa Loa (eye worm) RNA binding protein 0.007 0.0722 0.2098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0537 0.0717
Loa Loa (eye worm) hypothetical protein 0.0119 0.132 0.4274
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0619 0.4744
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0197
Loa Loa (eye worm) hypothetical protein 0.0168 0.1932 0.6501
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0619 0.061
Loa Loa (eye worm) hypothetical protein 0.0094 0.1021 0.3184
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0816 0.0807
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1021 0.1012
Brugia malayi aspartic protease BmAsp-2, identical 0.01 0.1093 0.3607
Brugia malayi jmjC domain containing protein 0.0097 0.1049 0.3451
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0243 0.2859 0.9874
Loa Loa (eye worm) hypothetical protein 0.01 0.1093 0.3448
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.02 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Loa Loa (eye worm) hypothetical protein 0.0243 0.2859 0.9874
Brugia malayi PHD-finger family protein 0.003 0.0219 0.0504
Brugia malayi Pepsin A precursor 0.01 0.1093 0.3607
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0219 0.0316
Plasmodium vivax plasmepsin V, putative 0.0675 0.8185 1
Plasmodium vivax aspartyl protease, putative 0.01 0.1093 0.1281
Brugia malayi aspartic protease BmAsp-1, identical 0.01 0.1093 0.3607
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Plasmodium falciparum plasmepsin II 0.0243 0.2859 0.3403
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0291 0.0383
Plasmodium falciparum plasmepsin I 0.0243 0.2859 0.3403
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0296 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0537 0.0717
Schistosoma mansoni hypothetical protein 0.0354 0.423 0.574
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0219 0.021
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0146 0.0243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0291 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0537 0.0528
Plasmodium falciparum plasmepsin X 0.01 0.1093 0.1217
Plasmodium falciparum plasmepsin VII 0.01 0.1093 0.1217
Plasmodium falciparum plasmepsin III 0.01 0.1093 0.1217
Brugia malayi hypothetical protein 0.01 0.1093 0.3607
Schistosoma mansoni memapsin-2 (A01 family) 0.01 0.1093 0.1474
Plasmodium falciparum phd finger protein, putative 0.003 0.0219 0.0135
Loa Loa (eye worm) hypothetical protein 0.003 0.0219 0.0268
Plasmodium falciparum plasmepsin IV 0.0243 0.2859 0.3403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0816 0.244
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0619 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.02 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0537 0.0528
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0816 0.0807
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0219 0.0316
Toxoplasma gondii aspartyl protease ASP1 0.0243 0.2859 0.4115
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1021 0.2396
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0362 0.0353
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0296 0.0287
Schistosoma mansoni hypothetical protein 0.0168 0.1932 0.2614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.2893 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0243 0.2859 0.2852
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.02 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Loa Loa (eye worm) hypothetical protein 0.01 0.1093 0.3448
Toxoplasma gondii aspartyl protease ASP5 0.0574 0.6947 1
Schistosoma mansoni hypothetical protein 0.0078 0.0816 0.1097
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0804 0.108
Toxoplasma gondii aspartyl protease 0.01 0.1093 0.1574
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0219 0.0268
Brugia malayi Eukaryotic aspartyl protease family protein 0.01 0.1093 0.3607
Leishmania major hypothetical protein, conserved 0.0028 0.02 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1635 0.5419
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1021 0.5
Schistosoma mansoni cathepsin D (A01 family) 0.0608 0.7363 1
Plasmodium vivax aspartyl proteinase, putative 0.01 0.1093 0.1281
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0816 0.244
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0243 0.2859 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.1093 0.1474
Echinococcus multilocularis geminin 0.0354 0.423 0.4225
Plasmodium falciparum plasmepsin V 0.0675 0.8185 1
Schistosoma mansoni cathepsin D (A01 family) 0.0608 0.7363 1
Onchocerca volvulus 0.01 0.1093 1
Brugia malayi hypothetical protein 0.0028 0.02 0.0434
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0619 0.1444
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0219 0.0285
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0619 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0296 0.0547
Echinococcus granulosus geminin 0.0354 0.423 1
Brugia malayi TAR-binding protein 0.007 0.0722 0.2289
Giardia lamblia PHD finger protein 15 0.003 0.0219 0.5
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0243 0.2859 0.4115

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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