Detailed information for compound 1502785

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 244.315 | Formula: C12H12N4S
  • H donors: 2 H acceptors: 2 LogP: 2.93 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1scc(n1)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C12H12N4S/c1-2-13-12-15-11(7-17-12)8-3-4-10-9(5-8)6-14-16-10/h3-7H,2H2,1H3,(H,13,15)(H,14,16)
  • InChiKey: PYHCYHNXLIEWSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) carbonic anhydrase 3 0.0863 1 1
Schistosoma mansoni protein kinase 0.0019 0.0116 0.0089
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0116 0.0089
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0863 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.5367 0.5355
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.2169 0.2148
Schistosoma mansoni cell adhesion molecule 0.0015 0.007 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0596 0.8026
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0116 0.0089
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.2281 0.2261
Trichomonas vaginalis STE family protein kinase 0.0021 0.0144 0.0472
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0468 0.5367 0.5367
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0144 0.0117
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.007
Toxoplasma gondii hypothetical protein 0.0468 0.5367 1
Brugia malayi Protein kinase domain 0.0021 0.0144 0.0117
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.0714 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0863 1 1
Echinococcus granulosus aurora kinase A 0.007 0.0714 0.0689
Echinococcus multilocularis roundabout 2 0.0018 0.0103 0.0077
Echinococcus granulosus carbonic anhydrase 0.0468 0.5367 0.5355
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0863 1 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.0714 0.0689
Onchocerca volvulus 0.0167 0.1846 0.7943
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.0144 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0714 0.0689
Echinococcus multilocularis carbonic anhydrase 0.0468 0.5367 0.5355
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.2502 0.2482
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0596 0.0571
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.2169 0.2169
Entamoeba histolytica protein kinase, putative 0.007 0.0714 1
Brugia malayi WH1 domain containing protein 0.0019 0.0116 0.0089
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0596 0.0596
Echinococcus granulosus twitchin 0.0017 0.0089 0.0062
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.007 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0144 0.0117
Loa Loa (eye worm) hypothetical protein 0.0468 0.5367 0.5367
Brugia malayi serine/threonine protein kinase 6 0.007 0.0714 0.0689
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0116 0.0089
Schistosoma mansoni protein kinase 0.0021 0.0144 0.0117
Trichomonas vaginalis AGC family protein kinase 0.007 0.0714 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0596 0.0571
Loa Loa (eye worm) AUR protein kinase 0.007 0.0714 0.0714
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.2169 0.2148
Entamoeba histolytica protein kinase, putative 0.006 0.0596 0.8026
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.2169 0.2169
Onchocerca volvulus 0.0178 0.1977 0.8775
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.2281 0.2261
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0596 0.0571
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0468 0.5367 0.5355
Loa Loa (eye worm) AUR protein kinase 0.007 0.0714 0.0714
Schistosoma mansoni tyrosine kinase 0.002 0.0128 0.0101
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.5367 0.5355
Plasmodium falciparum carbonic anhydrase 0.0468 0.5367 1
Echinococcus multilocularis protein kinase shaggy 0.006 0.0596 0.0571
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.0714 0.0689
Entamoeba histolytica protein kinase, putative 0.0021 0.0144 0.0472
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0128 0.0101
Onchocerca volvulus 0.0175 0.1948 0.8595
Echinococcus multilocularis carbonic anhydrase 0.0468 0.5367 0.5355
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.5367 0.5355
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0596 0.8026
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0468 0.5367 0.5355
Trichomonas vaginalis AGC family protein kinase 0.007 0.0714 1
Entamoeba histolytica p21-activated kinase 0.0021 0.0144 0.0472
Schistosoma mansoni protein kinase 0.007 0.0714 0.0689
Giardia lamblia Aurora kinase 0.007 0.0714 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.2169 0.2148
Trichomonas vaginalis STE family protein kinase 0.0021 0.0144 0.0472
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0116 0.0089
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0089
Entamoeba histolytica protein kinase, putative 0.0021 0.0144 0.0472
Echinococcus multilocularis rho associated protein kinase 0.0178 0.1977 0.1955
Schistosoma mansoni hypothetical protein 0.0468 0.5367 0.5355
Brugia malayi intracellular kinase 0.006 0.0596 0.0571
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0863 1 1
Giardia lamblia Kinase, CMGC GSK 0.006 0.0596 0.7928
Trypanosoma brucei carbonic anhydrase-like protein 0.0863 1 1
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0116 0.0089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Entamoeba histolytica protein kinase, putative 0.007 0.0714 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0863 1 1
Giardia lamblia Kinase, CMGC GSK 0.006 0.0596 0.7928
Trichomonas vaginalis STE family protein kinase 0.0021 0.0144 0.0472
Entamoeba histolytica protein kinase domain containing protein 0.007 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Schistosoma mansoni carbonic anhydrase 0.0468 0.5367 0.5355
Loa Loa (eye worm) hypothetical protein 0.0468 0.5367 0.5367
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0116 0.0089
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.0714 1
Echinococcus granulosus neuroglian 0.0014 0.006 0.0034
Echinococcus multilocularis carbonic anhydrase II 0.0863 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.5367 0.5355
Schistosoma mansoni nephrin 0.0014 0.006 0.0034
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0596 0.8026
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1891 0.8232
Echinococcus granulosus carbonic anhydrase II 0.0863 1 1
Entamoeba histolytica protein kinase, putative 0.0021 0.0144 0.0472
Entamoeba histolytica protein kinase , putative 0.007 0.0714 1
Brugia malayi serine/threonine-protein kinase 6 0.007 0.0714 0.0689
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0144 0.0117
Echinococcus granulosus roundabout 2 0.0018 0.0103 0.0077
Schistosoma mansoni protein kinase 0.0021 0.0144 0.0117
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.0714 0.0248
Echinococcus granulosus carbonic anhydrase 0.0468 0.5367 0.5355
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.2169 0.2148
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0116 0.0089
Trypanosoma cruzi aurora B kinase, putative 0.007 0.0714 0.0126
Brugia malayi serine/threonine kinase 12 0.007 0.0714 0.0689
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.2169 1
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.1977 0.1955
Toxoplasma gondii aurora kinase 0.007 0.0714 0.0248
Schistosoma mansoni protein kinase 0.0021 0.0144 0.0117
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0116 0.0116
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.0144 0.0117
Brugia malayi Protein kinase domain containing protein 0.0548 0.6311 0.6301
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0116 0.0089
Echinococcus multilocularis aurora kinase A 0.007 0.0714 0.0689
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0144 0.0117
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0089
Loa Loa (eye worm) AUR protein kinase 0.007 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.2032 0.2032
Trichomonas vaginalis STE family protein kinase 0.0021 0.0144 0.0472
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0596 0.0596
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0548 0.6311 0.6311
Trypanosoma brucei aurora B kinase 0.007 0.0714 0.0126
Loa Loa (eye worm) hypothetical protein 0.0468 0.5367 0.5367
Echinococcus multilocularis carbonic anhydrase 0.0468 0.5367 0.5355
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.2502 0.2502
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0863 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0103 0.0103
Echinococcus multilocularis neuroglian 0.0014 0.006 0.0034
Leishmania major protein kinase, putative 0.007 0.0714 0.0126
Trichomonas vaginalis AGC family protein kinase 0.007 0.0714 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.2032 0.2011
Echinococcus granulosus protein kinase shaggy 0.006 0.0596 0.0571
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.0714 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.0714 1
Entamoeba histolytica protein kinase, putative 0.0021 0.0144 0.0472
Leishmania major carbonic anhydrase-like protein 0.0863 1 1
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0596 0.8026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0116
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.5367 0.5355
Trichomonas vaginalis STE family protein kinase 0.0021 0.0144 0.0472
Brugia malayi Protein kinase domain containing protein 0.0194 0.2169 0.2148
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0144 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1977 0.1955
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Echinococcus granulosus carbonic anhydrase 0.0468 0.5367 0.5355
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.5367 0.5355
Trichomonas vaginalis AGC family protein kinase 0.007 0.0714 1
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0089
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of JAK2 ChEMBL. 21288717
Ki (binding) = 0.888 uM Inhibition of Rock2 ChEMBL. 21288717
Ki (binding) = 1.952 uM Inhibition of Pim1 ChEMBL. 21288717
Ki (binding) = 3.406 uM Inhibition of aurora 2 ChEMBL. 21288717
Ki (binding) > 3.75 uM Inhibition of Pak4 ChEMBL. 21288717
Ki (binding) = 3.925 uM Inhibition of GSK3-beta ChEMBL. 21288717
Ki (binding) > 8.88 uM Inhibition of KDR ChEMBL. 21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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