Detailed information for compound 1503220

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 229.238 | Formula: C11H11N5O
  • H donors: 1 H acceptors: 3 LogP: 0.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1nnn(c1)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C11H11N5O/c1-17-7-9-6-16(15-13-9)10-2-3-11-8(4-10)5-12-14-11/h2-6H,7H2,1H3,(H,12,14)
  • InChiKey: LFEYLOGKMJBODS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0123 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0014 0.0038
Echinococcus granulosus orexin receptor type 2 0.0013 0.0014 0.0038
Schistosoma mansoni protein kinase 0.0021 0.0168 0.0458
Trichomonas vaginalis AGC family protein kinase 0.007 0.1078 1
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.3005 0.884
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.1078 0.3014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0104 0.009
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.0014 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0014 0.0038
Echinococcus multilocularis epidermal growth factor receptor 0.0183 0.3183 0.8897
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0168 0.0435
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.005 0.014
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.3927 0.3919
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.3576 1
Echinococcus multilocularis neuroglian 0.0014 0.0035 0.0061
Schistosoma mansoni tyrosine kinase 0.006 0.0897 0.2609
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0014 0.0038
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0889 0.8026
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0548 1 1
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.3927 0.3919
Echinococcus multilocularis rho associated protein kinase 0.0178 0.309 0.8637
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0185 0.3229 0.322
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0014 0.0038
Echinococcus granulosus g protein coupled receptor 0.0013 0.0014 0.0038
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0123 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0014 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0099 0.1628 0.4553
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.1078 0.2987
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.1078 1
Trichomonas vaginalis STE family protein kinase 0.0021 0.0168 0.0472
Brugia malayi Protein kinase domain containing protein 0.006 0.0897 0.0884
Echinococcus granulosus insulin growth factor 1 receptor beta 0.006 0.0897 0.2507
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0014 0.0038
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0889 0.2487
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0014 0.0038
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0014 0.0038
Loa Loa (eye worm) TK/EGFR protein kinase 0.0183 0.3183 0.3174
Schistosoma mansoni protein kinase 0.0019 0.0123 0.0325
Trichomonas vaginalis AGC family protein kinase 0.007 0.1078 1
Schistosoma mansoni tyrosine kinase 0.0023 0.0193 0.0531
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0123 0.0345
Brugia malayi serine/threonine protein kinase 6 0.007 0.1078 0.1066
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0014 0.0038
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.1078 1
Entamoeba histolytica protein kinase domain containing protein 0.007 0.1078 1
Echinococcus granulosus aurora kinase A 0.007 0.1078 0.3014
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0193 0.0531
Loa Loa (eye worm) hypothetical protein 0.0018 0.0104 0.009
Trichomonas vaginalis STE family protein kinase 0.0021 0.0168 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0889 0.8026
Trypanosoma cruzi aurora B kinase, putative 0.007 0.1078 1
Loa Loa (eye worm) AUR protein kinase 0.007 0.1078 0.1066
Entamoeba histolytica p21-activated kinase 0.0021 0.0168 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0889 0.8026
Entamoeba histolytica protein kinase, putative 0.0021 0.0168 0.0472
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0014 0.0038
Echinococcus multilocularis insulin receptor 0.006 0.0897 0.2479
Schistosoma mansoni tyrosine kinase 0.0099 0.1628 0.4771
Schistosoma mansoni protein kinase 0.0021 0.0168 0.0458
Loa Loa (eye worm) hypothetical protein 0.0019 0.0123 0.011
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0325
Echinococcus granulosus neuropeptide receptor 0.0013 0.0014 0.0038
Echinococcus multilocularis epidermal growth factor receptor 0.0099 0.1628 0.4533
Echinococcus granulosus insulin receptor 0.006 0.0897 0.2507
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0123 0.0309
Onchocerca volvulus 0.0167 0.2882 0.8475
Toxoplasma gondii aurora kinase 0.007 0.1078 1
Echinococcus multilocularis aurora kinase A 0.007 0.1078 0.2987
Trichomonas vaginalis STE family protein kinase 0.0021 0.0168 0.0472
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0014 0.0038
Echinococcus multilocularis roundabout 2 0.0018 0.0104 0.0253
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0123 0.0345
Echinococcus granulosus sex peptide receptor 0.0013 0.0014 0.0038
Schistosoma mansoni tyrosine kinase 0.0096 0.1558 0.4565
Brugia malayi intracellular kinase 0.006 0.0889 0.0877
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.3229 0.322
Loa Loa (eye worm) AUR protein kinase 0.007 0.1078 0.1066
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0889 0.0877
Echinococcus granulosus epidermal growth factor receptor 0.0099 0.1628 0.4553
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0889 0.8026
Brugia malayi Protein kinase domain 0.0021 0.0168 0.0155
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0014 0.0038
Echinococcus granulosus hypothetical protein 0.0013 0.0014 0.0038
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0014 0.0038
Trichomonas vaginalis STE family protein kinase 0.0021 0.0168 0.0472
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.1078 1
Brugia malayi Furin-like cysteine rich region family protein 0.0183 0.3183 0.3174
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0123 0.011
Trichomonas vaginalis AGC family protein kinase 0.007 0.1078 1
Echinococcus granulosus neuropeptide receptor 0.0013 0.0014 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Trichomonas vaginalis STE family protein kinase 0.0021 0.0168 0.0472
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.3398 0.3389
Echinococcus granulosus somatostatin receptor 0.0013 0.0014 0.0038
Entamoeba histolytica protein kinase, putative 0.0021 0.0168 0.0472
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0037
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.3398 0.3389
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.3576 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0014 0.0038
Echinococcus granulosus g protein coupled receptor 0.0013 0.0014 0.0038
Echinococcus granulosus twitchin 0.0017 0.008 0.0224
Schistosoma mansoni protein kinase 0.007 0.1078 0.3145
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0014 0.0038
Brugia malayi Protein kinase domain containing protein 0.0194 0.3398 0.3389
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0325
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.309 0.8642
Schistosoma mansoni tyrosine kinase 0.0096 0.1558 0.4565
Brugia malayi serine/threonine kinase 12 0.007 0.1078 0.1066
Echinococcus granulosus g protein coupled receptor 0.0013 0.0014 0.0038
Trypanosoma brucei aurora B kinase 0.007 0.1078 1
Giardia lamblia Kinase, CMGC GSK 0.006 0.0889 0.7928
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0168 0.0435
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.3398 0.9501
Schistosoma mansoni tyrosine kinase 0.0099 0.1628 0.4771
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Entamoeba histolytica protein kinase, putative 0.0021 0.0168 0.0472
Loa Loa (eye worm) TK/INSR protein kinase 0.006 0.0897 0.0884
Trichomonas vaginalis AGC family protein kinase 0.007 0.1078 1
Echinococcus multilocularis protein kinase shaggy 0.006 0.0889 0.2458
Giardia lamblia Aurora kinase 0.007 0.1078 1
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0014 0.0038
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0168 0.0435
Leishmania major protein kinase, putative 0.007 0.1078 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0014 0.0038
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.0168 0.0435
Schistosoma mansoni tyrosine kinase 0.006 0.0897 0.2609
Entamoeba histolytica protein kinase, putative 0.007 0.1078 1
Schistosoma mansoni nephrin 0.0014 0.0035 0.0064
Echinococcus granulosus epidermal growth factor receptor 0.0183 0.3183 0.8901
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.3398 0.95
Schistosoma mansoni cell adhesion molecule 0.0015 0.005 0.0108
Echinococcus granulosus neuroglian 0.0014 0.0035 0.0099
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.0168 0.0471
Echinococcus granulosus roundabout 2 0.0018 0.0104 0.029
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0889 0.2588
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0889 0.2458
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0123 0.0309
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0168 0.0471
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0014 0.0038
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0889 0.0877
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0014 0.0038
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.3398 1
Echinococcus multilocularis 0.0056 0.0812 0.2242
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0014 0.0038
Entamoeba histolytica protein kinase, putative 0.006 0.0889 0.8026
Onchocerca volvulus 0.0178 0.309 0.9092
Loa Loa (eye worm) AUR protein kinase 0.007 0.1078 0.1066
Echinococcus granulosus allatostatin A receptor 0.0013 0.0014 0.0038
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0014 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Brugia malayi WH1 domain containing protein 0.0019 0.0123 0.011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0014 0.0038
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.1078 1
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0014 0.0038
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0168 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.007 0.1078 0.3145
Onchocerca volvulus 0.006 0.0889 0.2588
Giardia lamblia Kinase, CMGC GSK 0.006 0.0889 0.7928
Echinococcus granulosus protein kinase shaggy 0.006 0.0889 0.2487
Entamoeba histolytica protein kinase, putative 0.0021 0.0168 0.0472
Entamoeba histolytica protein kinase , putative 0.007 0.1078 1
Schistosoma mansoni tyrosine kinase 0.0096 0.1558 0.4565
Echinococcus granulosus fmrfamide receptor 0.0013 0.0014 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0013 0.0014 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.3398 1
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0123 0.0325
Brugia malayi serine/threonine-protein kinase 6 0.007 0.1078 0.1066
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.309 0.9092
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0014 0.0038
Schistosoma mansoni tyrosine kinase 0.0183 0.3183 0.9366
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0014 0.0038
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0123 0.0345
Schistosoma mansoni hypothetical protein 0.0019 0.0123 0.0325
Onchocerca volvulus 0.0175 0.3045 0.8959
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.3398 0.3389
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.006 0.0897 0.2479
Echinococcus granulosus serotonin receptor 0.0013 0.0014 0.0038
Entamoeba histolytica protein kinase, putative 0.007 0.1078 1
Schistosoma mansoni protein kinase 0.0021 0.0168 0.0458
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.1078 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.635 uM Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate ChEMBL. 21282054
Ki (binding) > 1.45 uM Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate ChEMBL. 21282054
Ki (binding) > 1.8 uM Inhibition of EGFR after 1 hr ChEMBL. 21282054
Ki (binding) > 3.75 uM Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrate ChEMBL. 21282054
Ki (binding) > 4.9 uM Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrate ChEMBL. 21282054
Ki (binding) > 5.45 uM Inhibition of GSK3-beta after 1 hr ChEMBL. 21282054
Ki (binding) > 8.57 uM Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate ChEMBL. 21282054
Ki (binding) > 8.88 uM Inhibition of KDR after 1 hr ChEMBL. 21282054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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