Detailed information for compound 1503221

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.356 | Formula: C16H19N5
  • H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCC(CC1)Cc1nnn(c1)c1ccc2c(c1)cn[nH]2
  • InChi: 1S/C16H19N5/c1-2-4-12(5-3-1)8-14-11-21(20-18-14)15-6-7-16-13(9-15)10-17-19-16/h6-7,9-12H,1-5,8H2,(H,17,19)
  • InChiKey: LBNUFTOENPMFSK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens Janus kinase 2 Starlite/ChEMBL References
Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 4 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) STE/STE20/PAKB protein kinase Get druggable targets OG5_131977 All targets in OG5_131977
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase PAK 7 Get druggable targets OG5_131977 All targets in OG5_131977
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase PAK 4 Get druggable targets OG5_131977 All targets in OG5_131977
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Aurora kinase 0.007 0.1094 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0906 0.8026
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Echinococcus multilocularis insulin receptor 0.006 0.0913 0.2545
Echinococcus multilocularis neuroglian 0.0014 0.0053 0.0149
Entamoeba histolytica protein kinase domain containing protein 0.007 0.1094 1
Schistosoma mansoni tyrosine kinase 0.0183 0.3195 0.9372
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.007 0.1094 1
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0906 0.0906
Brugia malayi intracellular kinase 0.006 0.0906 0.0906
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0194 0.341 0.9504
Trypanosoma cruzi aurora B kinase, putative 0.007 0.1094 1
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0021 0.0186 0.052
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0099 0.1643 0.4581
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0194 0.341 0.9504
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0068
Brugia malayi serine/threonine-protein kinase 6 0.007 0.1094 0.1094
Onchocerca volvulus 0.0178 0.3103 0.8775
Schistosoma mansoni tyrosine kinase 0.0096 0.1574 0.4616
Leishmania major protein kinase, putative 0.007 0.1094 1
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0019 0.0142 0.0394
Entamoeba histolytica p21-activated kinase 0.0021 0.0186 0.0472
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.341 0.341
Schistosoma mansoni protein kinase 0.007 0.1094 0.3208
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0021 0.0186 0.052
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.341 1
Schistosoma mansoni cell adhesion molecule 0.0015 0.0068 0.02
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0204 0.3588 1
Echinococcus multilocularis roundabout 2 0.0018 0.0122 0.0339
Schistosoma mansoni serine/threonine protein kinase 0.007 0.1094 0.3208
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.3103 0.8649
Echinococcus granulosus epidermal growth factor receptor 0.0183 0.3195 0.8907
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Entamoeba histolytica protein kinase, putative 0.007 0.1094 1
Echinococcus multilocularis aurora kinase A 0.007 0.1094 0.3049
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0142 0.0394
Onchocerca volvulus 0.0175 0.3058 0.8595
Echinococcus granulosus PAK box P21 Rho binding 0.0019 0.0142 0.0394
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0906 0.2525
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0194 0.341 0.341
Giardia lamblia Kinase, CMGC GSK 0.006 0.0906 0.7928
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Brugia malayi serine/threonine protein kinase 6 0.007 0.1094 0.1094
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0906 0.8026
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0906 0.8026
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0194 0.341 0.341
Toxoplasma gondii aurora kinase 0.007 0.1094 1
Schistosoma mansoni tyrosine kinase 0.0096 0.1574 0.4616
Echinococcus multilocularis protein kinase shaggy 0.006 0.0906 0.2525
Echinococcus multilocularis rho associated protein kinase 0.0178 0.3103 0.8649
Brugia malayi Protein kinase domain containing protein 0.0194 0.341 0.341
Schistosoma mansoni tyrosine kinase 0.0023 0.0211 0.0619
Brugia malayi WH1 domain containing protein 0.0019 0.0142 0.0142
Plasmodium falciparum serine/threonine protein kinase, putative 0.007 0.1094 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0122
Schistosoma mansoni tyrosine kinase 0.006 0.0913 0.2678
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0142 0.0142
Brugia malayi Protein kinase domain containing protein 0.006 0.0913 0.0913
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0068 0.019
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0194 0.341 1
Schistosoma mansoni nephrin 0.0014 0.0053 0.0157
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Giardia lamblia Kinase, CMGC GSK 0.006 0.0906 0.7928
Echinococcus multilocularis epidermal growth factor receptor 0.0183 0.3195 0.8907
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.006 0.0913 0.2545
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0019 0.0142 0.0394
Echinococcus granulosus aurora kinase A 0.007 0.1094 0.3049
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Echinococcus granulosus epidermal growth factor receptor 0.0099 0.1643 0.4581
Echinococcus granulosus insulin growth factor 1 receptor beta 0.006 0.0913 0.2545
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Brugia malayi serine/threonine kinase 12 0.007 0.1094 0.1094
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0906 0.2525
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0223 0.3938 0.3938
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.3103 0.91
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0906 0.2657
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0548 1 1
Echinococcus granulosus insulin receptor 0.006 0.0913 0.2545
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.3242 0.3242
Brugia malayi Furin-like cysteine rich region family protein 0.0183 0.3195 0.3195
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0019 0.0142 0.0394
Echinococcus multilocularis PAK box P21 Rho binding 0.0021 0.0186 0.052
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.007 0.1094 1
Onchocerca volvulus Tyrosine kinase homolog 0.0173 0.3018 0.8435
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0018 0.0122 0.0122
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0204 0.3588 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0012 0.0018 0.0051
Brugia malayi serine/threonine-protein kinase PAK 7 0.0223 0.3938 0.3938
Echinococcus granulosus neuroglian 0.0014 0.0053 0.0149
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0021 0.0186 0.052
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.007 0.1094 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0183 0.3195 0.3195
Brugia malayi P21-Rho-binding domain containing protein 0.0019 0.0142 0.0142
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0019 0.0142 0.0415
Echinococcus granulosus twitchin 0.0017 0.0098 0.0274
Plasmodium vivax serine/threonine protein kinase 6, putative 0.007 0.1094 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.007 0.1094 0.3049
Loa Loa (eye worm) hypothetical protein 0.0019 0.0142 0.0142
Schistosoma mansoni tyrosine kinase 0.006 0.0913 0.2678
Schistosoma mansoni tyrosine kinase 0.0099 0.1643 0.482
Entamoeba histolytica protein kinase, putative 0.006 0.0906 0.8026
Schistosoma mansoni protein kinase 0.0021 0.0186 0.0547
Schistosoma mansoni tyrosine kinase 0.0096 0.1574 0.4616
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0185 0.3242 0.3242
Echinococcus multilocularis 0.0056 0.0829 0.231
Entamoeba histolytica protein kinase , putative 0.007 0.1094 1
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0019 0.0142 0.0142
Schistosoma mansoni protein kinase 0.0019 0.0142 0.0415
Echinococcus granulosus protein kinase shaggy 0.006 0.0906 0.2525
Echinococcus multilocularis epidermal growth factor receptor 0.0099 0.1643 0.4581
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0906 0.8026
Schistosoma mansoni hypothetical protein 0.0019 0.0142 0.0415
Onchocerca volvulus 0.0167 0.2895 0.7943
Schistosoma mansoni tyrosine kinase 0.0099 0.1643 0.482
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0211 0.0619
Loa Loa (eye worm) AUR protein kinase 0.007 0.1094 0.1094
Echinococcus granulosus serine:threonine protein kinase 12 B 0.007 0.1094 0.3049
Trichomonas vaginalis AGC family protein kinase 0.007 0.1094 1
Trichomonas vaginalis STE family protein kinase 0.0021 0.0186 0.0472
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0906 0.0906
Entamoeba histolytica protein kinase, putative 0.007 0.1094 1
Brugia malayi Protein kinase domain 0.0021 0.0186 0.0186
Echinococcus granulosus roundabout 2 0.0018 0.0122 0.0339
Entamoeba histolytica protein kinase, putative 0.0021 0.0186 0.0472
Loa Loa (eye worm) TK/INSR protein kinase 0.006 0.0913 0.0913
Trypanosoma brucei aurora B kinase 0.007 0.1094 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.1 uM Inhibition of Rock2 after 1 hr using biotinylated longS peptide as substrate ChEMBL. 21282054
Ki (binding) = 0.281 uM Inhibition of JAK2 after 1 hr using biotinylated PDKtide as substrate ChEMBL. 21282054
Ki (binding) = 0.891 uM Inhibition of GSK3-beta after 1 hr ChEMBL. 21282054
Ki (binding) > 1.8 uM Inhibition of EGFR after 1 hr ChEMBL. 21282054
Ki (binding) > 3.75 uM Inhibition of Pak4 after 1 hr using biotinylated L15 peptide as substrate ChEMBL. 21282054
Ki (binding) > 4.9 uM Inhibition of Aurora kinase 2 after 1 hr using biotinylated kemptide as substrate ChEMBL. 21282054
Ki (binding) > 8.57 uM Inhibition of Pim1 after 1 hr using biotinylated AL1peptide as substrate ChEMBL. 21282054
Ki (binding) > 8.88 uM Inhibition of KDR after 1 hr ChEMBL. 21282054

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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