TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 216.262 | Formula: C10H8N4S
H donors: 2 H acceptors: 2 LogP: 1.9 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Nc1scc(n1)c1ccc2c(c1)cn[nH]2
InChi: 1S/C10H8N4S/c11-10-13-9(5-15-10)6-1-2-8-7(3-6)4-12-14-8/h1-5H,(H2,11,13)(H,12,14)
InChiKey: IHKNEMYSHFRMOS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rho-associated, coiled-coil containing protein kinase 2	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	p21 protein (Cdc42/Rac)-activated kinase 4	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing	Get druggable targets OG5_131020	All targets in OG5_131020
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	rho associated protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Rho-associated protein kinase 1, putative	Get druggable targets OG5_131020	All targets in OG5_131020
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	rho-associated protein kinase 1	Get druggable targets OG5_131020	All targets in OG5_131020
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase PAK 7	Get druggable targets OG5_131977	All targets in OG5_131977
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131020	All targets in OG5_131020
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.011	0.019
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0938	0.2638
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Toxoplasma gondii	aurora kinase	0.007	0.1132	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	protein kinase	0.0021	0.0228	0.0547
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	serotonin receptor	0.006	0.0938	0.2507
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.0938	0.2638
Schistosoma mansoni	opsin-like receptor	0.006	0.0938	0.2638
Echinococcus granulosus	roundabout 2	0.0018	0.0164	0.0339
Brugia malayi	Dopamine receptor protein 2	0.006	0.0938	0.0899
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.0938	0.2507
Echinococcus multilocularis	serotonin receptor	0.006	0.0938	0.2507
Entamoeba histolytica	protein kinase, putative	0.0021	0.0228	0.0472
Brugia malayi	RE15519p	0.006	0.0938	0.0899
Leishmania major	protein kinase, putative	0.007	0.1132	1
Onchocerca volvulus		0.0178	0.3132	0.8778
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Echinococcus multilocularis	roundabout 2	0.0018	0.0164	0.0339
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0228	0.0472
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.006	0.0938	0.2507
Echinococcus granulosus	dro:myosuppressin receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0015	0.011	0.011
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Echinococcus granulosus	aurora kinase A	0.007	0.1132	0.3049
Schistosoma mansoni	hypothetical protein	0.0019	0.0183	0.0415
Brugia malayi	Dopamine receptor protein 1	0.006	0.0938	0.0899
Echinococcus multilocularis	neuropeptide receptor A26	0.006	0.0938	0.2507
Giardia lamblia	Aurora kinase	0.007	0.1132	1
Schistosoma mansoni	protein kinase	0.0021	0.0228	0.0547
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.006	0.0938	0.2638
Trypanosoma cruzi	aurora B kinase, putative	0.007	0.1132	1
Schistosoma mansoni	nephrin	0.0014	0.0096	0.0157
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	serotonin receptor	0.006	0.0938	0.2507
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0228	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	amine GPCR	0.006	0.0938	0.2638
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0938	0.2507
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0945	0.8026
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0228	0.0472
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.0938	0.2507
Entamoeba histolytica	p21-activated kinase	0.0021	0.0228	0.0472
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0945	0.7928
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	neuropeptide receptor	0.006	0.0938	0.2638
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Schistosoma mansoni	tyrosine kinase	0.002	0.0202	0.0471
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.006	0.0938	0.2507
Brugia malayi	serine/threonine kinase 12	0.007	0.1132	0.1094
Onchocerca volvulus		0.0175	0.3087	0.8599
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0938	0.2507
Entamoeba histolytica	protein kinase, putative	0.0021	0.0228	0.0472
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0938	0.2507
Entamoeba histolytica	protein kinase , putative	0.007	0.1132	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1132	1
Schistosoma mansoni	protein kinase	0.007	0.1132	0.3208
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0938	0.2507
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.006	0.0938	0.2638
Echinococcus granulosus	g protein coupled receptor	0.006	0.0938	0.2507
Schistosoma mansoni	protein kinase	0.0021	0.0228	0.0547
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0204	0.3615	1
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0223	0.3964	0.3964
Echinococcus granulosus	peptide allatostatin:somatostatin	0.006	0.0938	0.2507
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.006	0.0938	0.2507
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1132	0.1132
Schistosoma mansoni	neuropeptide receptor	0.006	0.0938	0.2638
Brugia malayi	G-protein coupled receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	biogenic amine 5HT receptor	0.006	0.0938	0.2507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Onchocerca volvulus		0.006	0.0945	0.0026
Echinococcus granulosus	neuroglian	0.0014	0.0096	0.0149
Brugia malayi	sulfakinin receptor protein	0.006	0.0938	0.0899
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.322	0.322
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	neuropeptide receptor	0.006	0.0938	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Echinococcus granulosus	neuropeptide receptor A26	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	tachykinin peptides receptor 99D	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.006	0.0938	0.0899
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1132	1
Entamoeba histolytica	protein kinase, putative	0.0021	0.0228	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0164	0.0164
Echinococcus granulosus	7tm_1 domain containing protein	0.006	0.0938	0.2507
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.007	0.1132	0.3049
Entamoeba histolytica	protein kinase, putative	0.007	0.1132	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.3438	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Echinococcus granulosus	g protein coupled receptor	0.006	0.0938	0.2507
Trypanosoma brucei	aurora B kinase	0.007	0.1132	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.006	0.0938	0.0899
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0945	0.8026
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.006	0.0938	0.2507
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.006	0.0938	0.0899
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.0938	0.2507
Echinococcus granulosus	twitchin	0.0017	0.014	0.0274
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3438	0.3438
Schistosoma mansoni	neuropeptide f receptor 76f	0.006	0.0938	0.2638
Entamoeba histolytica	protein kinase, putative	0.0021	0.0228	0.0472
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.0938	0.2507
Schistosoma mansoni	hypothetical protein	0.006	0.0938	0.2638
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	neuropeptide receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.006	0.0938	0.0938
Echinococcus granulosus	hypothetical protein	0.006	0.0938	0.2507
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0021	0.0228	0.052
Brugia malayi	neuropeptide F receptor	0.006	0.0938	0.0899
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.006	0.0938	0.2638
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0228	0.052
Echinococcus granulosus	tm gpcr rhodopsin	0.006	0.0938	0.2507
Schistosoma mansoni	neuropeptide receptor	0.006	0.0938	0.2638
Echinococcus granulosus	somatostatin receptor	0.006	0.0938	0.2507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	hypothetical protein	0.006	0.0938	0.2638
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0938	0.2638
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.1132	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.006	0.0938	0.2507
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0228	0.0472
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.1132	0.3208
Echinococcus multilocularis	dro:myosuppressin receptor	0.006	0.0938	0.2507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Echinococcus multilocularis	G protein coupled receptor 139	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	G-protein coupled receptor, putative	0.006	0.0938	0.2507
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.006	0.0938	0.2507
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0019	0.0183	0.0394
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.006	0.0938	0.0938
Schistosoma mansoni	hypothetical protein	0.0019	0.0183	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0164	0.0164
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0183	0.0142
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0204	0.3615	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Brugia malayi	larval opioid receptor	0.006	0.0938	0.0899
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1132	1
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0228	0.0472
Brugia malayi	follicle stimulating hormone receptor	0.006	0.0938	0.0899
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.006	0.0938	0.2638
Echinococcus granulosus	neuropeptide s receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	neuropeptide FF receptor 2	0.006	0.0938	0.2507
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.006	0.0945	0.2525
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	amine GPCR	0.006	0.0938	0.2638
Echinococcus multilocularis	aurora kinase A	0.007	0.1132	0.3049
Echinococcus multilocularis	g protein coupled receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	serine/threonine-protein kinase 6	0.007	0.1132	0.1094
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.322	0.3191
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	WH1 domain containing protein	0.0019	0.0183	0.0142
Echinococcus multilocularis	fmrfamide receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	fmrfamide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Echinococcus granulosus	orexin receptor type 2	0.006	0.0938	0.2507
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Brugia malayi	neuropeptide F receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	melatonin receptor type 1A	0.006	0.0938	0.0938
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Brugia malayi	serine/threonine protein kinase 6	0.007	0.1132	0.1094
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.007	0.1132	0.3049
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1132	0.1132
Echinococcus granulosus	neuropeptide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	hypothetical protein	0.006	0.0938	0.2638
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.0938	0.0938
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0945	0.7928
Echinococcus multilocularis	neuropeptide receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	adenoreceptor	0.006	0.0938	0.2638
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.006	0.0938	0.0938
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	cell adhesion molecule	0.0015	0.011	0.02
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	neuroglian	0.0014	0.0096	0.0149
Brugia malayi	G protein-coupled receptor F59B2.13	0.006	0.0938	0.0899
Echinococcus granulosus	neuropeptide receptor	0.006	0.0938	0.2507
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0228	0.052
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.0938	0.2507
Schistosoma mansoni	amine GPCR	0.006	0.0938	0.2638
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.007	0.1132	1
Schistosoma mansoni	biogenic amine receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0019	0.0183	0.0394
Plasmodium falciparum	serine/threonine protein kinase, putative	0.007	0.1132	1
Brugia malayi	Protein kinase domain	0.0021	0.0228	0.0186
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	rho-associated protein kinase 1	0.0178	0.3132	0.8649
Echinococcus multilocularis	sex peptide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	biogenic amine receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	neuropeptide Y receptor	0.006	0.0938	0.2507
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Brugia malayi	Dopamine receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0945	0.0945
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.006	0.0938	0.2507
Echinococcus granulosus	protein kinase shaggy	0.006	0.0945	0.2525
Echinococcus multilocularis	somatostatin receptor	0.006	0.0938	0.2507
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	hypothetical protein	0.0019	0.0183	0.0415
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.006	0.0938	0.2638
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0223	0.3964	0.3938
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0019	0.0183	0.0394
Brugia malayi	putative neuropeptide receptor	0.006	0.0938	0.0899
Entamoeba histolytica	protein kinase, putative	0.006	0.0945	0.8026
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0548	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	hypothetical protein	0.006	0.0938	0.2638
Brugia malayi	AKH receptor	0.006	0.0938	0.0899
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.006	0.0938	0.2638
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	alpha 1A adrenergic receptor	0.006	0.0938	0.2507
Entamoeba histolytica	protein kinase, putative	0.007	0.1132	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	Serotonin receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	PAK box P21 Rho binding	0.0019	0.0183	0.0394
Echinococcus granulosus	fmrfamide receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	Protein kinase domain containing protein	0.0194	0.3438	0.341
Echinococcus granulosus	g protein coupled receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1132	0.1132
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.007	0.1132	1
Echinococcus granulosus	neuropeptides capa receptor	0.006	0.0938	0.2507
Schistosoma mansoni	biogenic amine receptor	0.006	0.0938	0.2638
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0945	0.0945
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.3132	0.91
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.0938	0.0938
Echinococcus multilocularis	orexin receptor type 2	0.006	0.0938	0.2507
Schistosoma mansoni	histamine h1 receptor	0.006	0.0938	0.2638
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Schistosoma mansoni	neuropeptide F-like receptor	0.006	0.0938	0.2638
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0945	0.8026
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.006	0.0938	0.2507
Echinococcus multilocularis	protein kinase shaggy	0.006	0.0945	0.2525
Echinococcus granulosus	allatostatin A receptor	0.006	0.0938	0.2507
Echinococcus granulosus	g-protein coupled receptor	0.006	0.0938	0.2507
Brugia malayi	Melatonin receptor type 1A	0.006	0.0938	0.0899
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.006	0.0938	0.0899
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0228	0.0472
Echinococcus multilocularis	neuropeptide s receptor	0.006	0.0938	0.2507
Schistosoma mansoni	myosin xvIII	0.006	0.0938	0.2638
Echinococcus granulosus	G protein coupled receptor 139	0.006	0.0938	0.2507
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.006	0.0938	0.2638
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.2997	0.8237
Echinococcus granulosus	7TM GPCR rhodopsin	0.006	0.0938	0.2507
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.3438	1
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.006	0.0945	0.2657
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.007	0.1132	1
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.006	0.0945	0.2525
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0042	0.0042
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3438	0.3438
Schistosoma mansoni	biogenic amine (5HT) receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0021	0.0228	0.052
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0938	0.2507
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0945	0.8026
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0228	0.052
Schistosoma mansoni	amine GPCR	0.006	0.0938	0.2638
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0019	0.0183	0.0183
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0202	0.0471
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.006	0.0938	0.0938
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1132	1
Loa Loa (eye worm)	TYRA-2 protein	0.006	0.0938	0.0938
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.007	0.1132	1
Echinococcus multilocularis	allatostatin A receptor	0.006	0.0938	0.2507
Echinococcus granulosus	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	GnHR receptor homolog	0.006	0.0938	0.0899
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.006	0.0938	0.2638
Echinococcus multilocularis	rho associated protein kinase	0.0178	0.3132	0.8649
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.006	0.0938	0.2638
Brugia malayi	ORL1-like opioid receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	G-protein coupled receptor	0.006	0.0938	0.0938
Brugia malayi	Serotonin receptor	0.006	0.0938	0.0899
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Schistosoma mansoni	amine GPCR	0.006	0.0938	0.2638
Brugia malayi	hypothetical protein	0.006	0.0938	0.0899
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.3438	0.341
Schistosoma mansoni	alpha-1 adrenergic receptor	0.006	0.0938	0.2638
Brugia malayi	G protein-coupled receptor	0.006	0.0938	0.0899
Loa Loa (eye worm)	neuropeptide F receptor	0.006	0.0938	0.0938
Schistosoma mansoni	growth hormone secretagogue receptor	0.006	0.0938	0.2638
Schistosoma mansoni	protein kinase	0.0019	0.0183	0.0415
Echinococcus granulosus	PAK box P21 Rho binding	0.0019	0.0183	0.0394
Brugia malayi	putative neuropeptide receptor NPR1	0.006	0.0938	0.0899
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.006	0.0938	0.2507
Echinococcus granulosus	neuropeptide Y receptor	0.006	0.0938	0.2507
Echinococcus granulosus	sex peptide receptor	0.006	0.0938	0.2507
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0019	0.0183	0.0415
Echinococcus multilocularis	PAK box P21 Rho binding	0.0021	0.0228	0.052
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Echinococcus multilocularis	g-protein coupled receptor	0.006	0.0938	0.2507
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.3438	0.9504
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.006	0.0938	0.0899
Schistosoma mansoni	opsin-like receptor	0.006	0.0938	0.2638
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.3438	0.9504
Echinococcus multilocularis	rhodopsin orphan GPCR	0.006	0.0938	0.2507
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.006	0.0938	0.0938
Loa Loa (eye worm)	hypothetical protein	0.006	0.0938	0.0938
Brugia malayi	intracellular kinase	0.006	0.0945	0.0906
Onchocerca volvulus		0.0167	0.2925	0.7948
Brugia malayi	G-protein coupled receptor	0.006	0.0938	0.0899
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0183	0.0142
Echinococcus multilocularis	neuropeptides capa receptor	0.006	0.0938	0.2507
Schistosoma mansoni	opsin-like receptor	0.006	0.0938	0.2638

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)		Inhibition of JAK2	ChEMBL.	21288717
Ki (binding)		Inhibition of EGFR	ChEMBL.	21288717
Ki (binding)	= 0.909 uM	Inhibition of Rock2	ChEMBL.	21288717
Ki (binding)	= 2.125 uM	Inhibition of aurora 2	ChEMBL.	21288717
Ki (binding)	= 2.899 uM	Inhibition of Pim1	ChEMBL.	21288717
Ki (binding)	> 3.75 uM	Inhibition of Pak4	ChEMBL.	21288717
Ki (binding)	= 4.472 uM	Inhibition of GSK3-beta	ChEMBL.	21288717
Ki (binding)	> 8.88 uM	Inhibition of KDR	ChEMBL.	21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1682543

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1503263