TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 215.274 | Formula: C11H9N3S
H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1scc(n1)c1ccc2c(c1)cn[nH]2
InChi: 1S/C11H9N3S/c1-7-13-11(6-15-7)8-2-3-10-9(4-8)5-12-14-10/h2-6H,1H3,(H,12,14)
InChiKey: LYYSRRLDPCPRDC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rho-associated, coiled-coil containing protein kinase 2	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	p21 protein (Cdc42/Rac)-activated kinase 4	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	rho-associated protein kinase 1	Get druggable targets OG5_131020	All targets in OG5_131020
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase PAK 7	Get druggable targets OG5_131977	All targets in OG5_131977
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131020	All targets in OG5_131020
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing	Get druggable targets OG5_131020	All targets in OG5_131020
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	rho associated protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	Rho-associated protein kinase 1, putative	Get druggable targets OG5_131020	All targets in OG5_131020
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	PAK box P21 Rho binding	0.0019	0.0209	0.0394
Entamoeba histolytica	protein kinase, putative	0.0021	0.0253	0.0472
Echinococcus granulosus	neuroglian	0.0014	0.0121	0.0149
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0253	0.0472
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.007	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0189	0.0164
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0968	0.0945
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0183	0.3237	0.3191
Entamoeba histolytica	protein kinase, putative	0.007	0.1155	1
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0209	0.0142
Brugia malayi	Protein kinase domain	0.0021	0.0253	0.0186
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.007	0.1155	1
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0019	0.0209	0.0394
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0968	0.8026
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0021	0.0253	0.052
Echinococcus granulosus	twitchin	0.0017	0.0166	0.0274
Schistosoma mansoni	protein kinase	0.0019	0.0209	0.0604
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0253	0.052
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0253	0.052
Onchocerca volvulus		0.0167	0.2943	0.7943
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1155	0.1132
Schistosoma mansoni	hypothetical protein	0.0019	0.0209	0.0604
Schistosoma mansoni	protein kinase	0.0021	0.0253	0.0733
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0019	0.0209	0.0394
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.3454	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0068	0.0197
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0253	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Entamoeba histolytica	protein kinase , putative	0.007	0.1155	1
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.007	0.1155	0.3049
Leishmania major	protein kinase, putative	0.007	0.1155	1
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0968	0.8026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0209	0.0183
Entamoeba histolytica	protein kinase, putative	0.0021	0.0253	0.0472
Entamoeba histolytica	p21-activated kinase	0.0021	0.0253	0.0472
Trypanosoma cruzi	aurora B kinase, putative	0.007	0.1155	1
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.006	0.0968	0.2802
Brugia malayi	intracellular kinase	0.006	0.0968	0.0906
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0019	0.0209	0.0394
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.007	0.1155	1
Schistosoma mansoni	nephrin	0.0014	0.0121	0.0351
Toxoplasma gondii	aurora kinase	0.007	0.1155	1
Entamoeba histolytica	protein kinase, putative	0.0021	0.0253	0.0472
Echinococcus multilocularis	roundabout 2	0.0018	0.0189	0.0339
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.3454	0.9504
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0253	0.0472
Entamoeba histolytica	protein kinase, putative	0.006	0.0968	0.8026
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1155	1
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1155	1
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1155	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0183	0.3237	0.322
Schistosoma mansoni	tyrosine kinase	0.002	0.0228	0.0659
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0019	0.0209	0.0604
Entamoeba histolytica	protein kinase, putative	0.007	0.1155	1
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.315	0.9118
Echinococcus granulosus	protein kinase shaggy	0.006	0.0968	0.2525
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Echinococcus granulosus	aurora kinase A	0.007	0.1155	0.3049
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0968	0.0945
Echinococcus multilocularis	rho associated protein kinase	0.0178	0.315	0.8649
Brugia malayi	serine/threonine kinase 12	0.007	0.1155	0.1094
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0136	0.0393
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0228	0.0659
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3454	0.3438
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.1155	1
Echinococcus multilocularis	neuroglian	0.0014	0.0121	0.0149
Onchocerca volvulus	Tyrosine kinase homolog	0.0171	0.3015	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0189	0.0164
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.3454	0.9504
Schistosoma mansoni	hypothetical protein	0.0019	0.0209	0.0604
Brugia malayi	serine/threonine-protein kinase 6	0.007	0.1155	0.1094
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0209	0.0142
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.007	0.1155	1
Giardia lamblia	Aurora kinase	0.007	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0968	0.8026
Brugia malayi	Protein kinase domain containing protein	0.0194	0.3454	0.341
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0204	0.3631	1
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0204	0.3631	1
Echinococcus granulosus	PAK box P21 Rho binding	0.0019	0.0209	0.0394
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.3454	1
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1155	0.1132
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3454	0.3438
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0223	0.398	0.3964
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0968	0.8026
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0253	0.0472
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0253	0.0472
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0223	0.398	0.3938
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.006	0.0968	0.2525
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0068	0.0197
Loa Loa (eye worm)	AUR protein kinase	0.007	0.1155	0.1132
Trichomonas vaginalis	AGC family protein kinase	0.007	0.1155	1
Echinococcus granulosus	rho-associated protein kinase 1	0.0178	0.315	0.8649
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0068	0.0197
Plasmodium falciparum	serine/threonine protein kinase, putative	0.007	0.1155	1
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.3454	0.341
Schistosoma mansoni	hypothetical protein	0.0019	0.0209	0.0604
Schistosoma mansoni	protein kinase	0.0021	0.0253	0.0733
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0968	0.7928
Echinococcus multilocularis	aurora kinase A	0.007	0.1155	0.3049
Brugia malayi	WH1 domain containing protein	0.0019	0.0209	0.0142
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0021	0.0253	0.052
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.007	0.1155	0.3049
Schistosoma mansoni	protein kinase	0.0021	0.0253	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0136	0.011
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0968	0.7928
Onchocerca volvulus		0.0175	0.3105	0.8595
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0068	0.0042
Trypanosoma brucei	aurora B kinase	0.007	0.1155	1
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0253	0.052
Entamoeba histolytica	protein kinase, putative	0.0021	0.0253	0.0472
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0253	0.052
Brugia malayi	serine/threonine protein kinase 6	0.007	0.1155	0.1094
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.006	0.0968	0.2525
Onchocerca volvulus		0.0178	0.315	0.8775
Schistosoma mansoni	protein kinase	0.007	0.1155	0.3342
Echinococcus multilocularis	PAK box P21 Rho binding	0.0021	0.0253	0.052
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0136	0.019
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0019	0.0209	0.0183
Echinococcus granulosus	roundabout 2	0.0018	0.0189	0.0339
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.1155	0.3342
Echinococcus multilocularis	protein kinase shaggy	0.006	0.0968	0.2525

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)		Inhibition of JAK2	ChEMBL.	21288717
Ki (binding)	= 0.513 uM	Inhibition of Rock2	ChEMBL.	21288717
Ki (binding)	= 2.861 uM	Inhibition of GSK3-beta	ChEMBL.	21288717
Ki (binding)	> 3.75 uM	Inhibition of Pak4	ChEMBL.	21288717
Ki (binding)	= 4.156 uM	Inhibition of Pim1	ChEMBL.	21288717
Ki (binding)	= 4.45 uM	Inhibition of aurora 2	ChEMBL.	21288717
Ki (binding)	> 8.88 uM	Inhibition of KDR	ChEMBL.	21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1682542

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1506176