TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.529 | Formula: C30H23FN4
H donors: 2 H acceptors: 0 LogP: 6.27 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccccc1C1=N[C@H](Cc2c[nH]c3c2cccc3)C(=Nc2c1cccc2)Nc1ccccc1
InChi: 1S/C30H23FN4/c31-25-15-7-4-13-23(25)29-24-14-6-9-17-27(24)35-30(33-21-10-2-1-3-11-21)28(34-29)18-20-19-32-26-16-8-5-12-22(20)26/h1-17,19,28,32H,18H2,(H,33,35)/t28-/m1/s1
InChiKey: OFANVAYBWIKXQI-MUUNZHRXSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Kinase, CMGC GSK	0.0084	0.1902	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0046	0.0289	0.1517
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0084	0.1902	0.1902
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0042	0.0122	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus granulosus	Endonuclease G	0.0065	0.1105	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0386	0.047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Onchocerca volvulus		0.0109	0.2924	0.3247
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0109	0.2924	0.3565
Chlamydia trachomatis	chorismate synthase	0.0204	0.6944	0.5
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0386	0.047
Echinococcus granulosus	7tm_1 domain containing protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	amine GPCR	0.0048	0.0386	0.047
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0048	0.0386	0.0386
Giardia lamblia	Kinase, CMGC GSK	0.0084	0.1902	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0048	0.0386	0.047
Echinococcus multilocularis	sex peptide receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0084	0.1902	0.1902
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.1902	1
Onchocerca volvulus		0.0234	0.8202	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptide s receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	neuropeptide f receptor 76f	0.0048	0.0386	0.047
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0386	0.047
Brugia malayi	Dopamine receptor protein 1	0.0048	0.0386	0.0386
Echinococcus granulosus	neuropeptide FF receptor 2	0.0048	0.0386	0.0386
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0084	0.1902	0.2319
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0048	0.0386	0.0386
Echinococcus multilocularis	Endonuclease G	0.0065	0.1105	0.1105
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2924	0.2924
Brugia malayi	putative neuropeptide receptor NPR1	0.0048	0.0386	0.0386
Brugia malayi	neuropeptide F receptor	0.0048	0.0386	0.0386
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0289	0.1517
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	serine/threonine protein kinase	0.0046	0.0289	0.0289
Entamoeba histolytica	protein kinase 2, putative	0.0042	0.0122	0.0639
Brugia malayi	p70 ribosomal S6 kinase beta	0.0062	0.0972	0.0972
Brugia malayi	endonuclease G, mitochondrial precursor	0.0065	0.1105	0.1105
Echinococcus multilocularis	nervana 2	0.004	0.0036	0.0036
Echinococcus multilocularis	survival motor neuron protein 1	0.0277	1	1
Trypanosoma brucei	endonuclease G, putative	0.0065	0.1105	0.5809
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0066	0.1139	0.599
Brugia malayi	Dopamine receptor protein 2	0.0048	0.0386	0.0386
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	serotonin receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0048	0.0386	0.0386
Echinococcus multilocularis	allatostatin A receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	opsin-like receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Entamoeba histolytica	protein kinase, putative	0.0062	0.0972	0.5113
Brugia malayi	G-protein coupled receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Entamoeba histolytica	protein kinase, putative	0.0066	0.1139	0.599
Brugia malayi	sulfakinin receptor protein	0.0048	0.0386	0.0386
Plasmodium vivax	chorismate synthase	0.0204	0.6944	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0386	0.047
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0048	0.0386	0.0386
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	hypothetical protein	0.0048	0.0386	0.047
Brugia malayi	RE15519p	0.0048	0.0386	0.0386
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0042	0.0122	0.0175
Giardia lamblia	Kinase, AGC PKA	0.0042	0.0122	0.0639
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0386	0.047
Echinococcus granulosus	neuropeptide receptor A26	0.0048	0.0386	0.0386
Echinococcus multilocularis	rac serine:threonine kinase	0.0046	0.0289	0.0289
Echinococcus multilocularis	ectonucleotide	0.0091	0.2207	0.2207
Brugia malayi	ORL1-like opioid receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	myosin xvIII	0.0048	0.0386	0.047
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptide receptor A26	0.0048	0.0386	0.0386
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0048	0.0386	0.047
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0289	0.1517
Schistosoma mansoni	hypothetical protein	0.0234	0.8202	1
Trypanosoma cruzi	endonuclease G, putative	0.0065	0.1105	0.5809
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Schistosoma mansoni	amine GPCR	0.0048	0.0386	0.047
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0109	0.2924	0.3565
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0109	0.2924	0.3565
Trypanosoma cruzi	endonuclease G, putative	0.0065	0.1105	0.5809
Schistosoma mansoni	adenoreceptor	0.0048	0.0386	0.047
Trypanosoma brucei	protein kinase, putative	0.0084	0.1902	1
Mycobacterium ulcerans	chorismate synthase	0.0204	0.6944	0.5
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0048	0.0386	0.047
Schistosoma mansoni	neuropeptide F-like receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0386	0.0386
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	survival motor neuron protein	0.0057	0.0741	0.0903
Loa Loa (eye worm)	G-protein coupled receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0048	0.0386	0.047
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.004	0.0036	0.0036
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0048	0.0386	0.047
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0386	0.0386
Schistosoma mansoni	hypothetical protein	0.0057	0.0741	0.0903
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0386	0.0386
Echinococcus granulosus	G protein coupled receptor 139	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Schistosoma mansoni	growth hormone secretagogue receptor	0.0048	0.0386	0.047
Echinococcus granulosus	7TM GPCR rhodopsin	0.0048	0.0386	0.0386
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0386	0.0386
Brugia malayi	follicle stimulating hormone receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0109	0.2924	0.2924
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0386	0.047
Trypanosoma cruzi	Protein kinase B	0.0046	0.0289	0.1517
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0066	0.1139	0.1139
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0048	0.0386	0.047
Echinococcus granulosus	g-protein coupled receptor	0.0048	0.0386	0.0386
Brugia malayi	larval opioid receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Echinococcus granulosus	neuropeptide receptor	0.0048	0.0386	0.0386
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0057	0.0741	0.0741
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0109	0.2924	0.3565
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	nervana 2	0.004	0.0036	0.0036
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0386	0.047
Schistosoma mansoni	histamine h1 receptor	0.0048	0.0386	0.047
Echinococcus granulosus	nervana 2	0.004	0.0036	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0048	0.0386	0.0386
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0084	0.1902	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0048	0.0386	0.0386
Schistosoma mansoni	hypothetical protein	0.0048	0.0386	0.047
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0091	0.2207	0.2207
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0386	0.047
Schistosoma mansoni	biogenic amine receptor	0.0048	0.0386	0.047
Echinococcus granulosus	Glutaredoxin protein 5	0.004	0.0036	0.0036
Brugia malayi	Serotonin receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0386	0.047
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.004	0.0036	0.0036
Schistosoma mansoni	hypothetical protein	0.0048	0.0386	0.047
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0386	0.0386
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0065	0.1105	0.1591
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2924	0.2924
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0091	0.2207	0.2207
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	serine/threonine-protein kinase	0.0046	0.0289	0.0352
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0234	0.8202	0.8202
Plasmodium falciparum	glycogen synthase kinase 3	0.0084	0.1902	0.2739
Onchocerca volvulus		0.0109	0.2924	0.3247
Echinococcus multilocularis	G protein coupled receptor 139	0.0048	0.0386	0.0386
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0065	0.1105	0.5809
Echinococcus granulosus	orexin receptor type 2	0.0048	0.0386	0.0386
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Toxoplasma gondii	chorismate synthase, putative	0.0204	0.6944	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0048	0.0386	0.0386
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	biogenic amine 5HT receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	allatostatin A receptor	0.0048	0.0386	0.0386
Plasmodium falciparum	chorismate synthase	0.0204	0.6944	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0042	0.0122	0.0122
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus granulosus	sex peptide receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	amine GPCR	0.0048	0.0386	0.047
Echinococcus multilocularis	neuropeptides capa receptor	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0386	0.0386
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Schistosoma mansoni	amine GPCR	0.0048	0.0386	0.047
Loa Loa (eye worm)	hypothetical protein	0.0277	1	1
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0065	0.1105	0.5809
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Mycobacterium leprae	Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase).	0.0101	0.2597	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Brugia malayi	intracellular kinase	0.0084	0.1902	0.1902
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0048	0.0386	0.0386
Echinococcus granulosus	neuropeptide s receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Brugia malayi	neuropeptide F receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	endonuclease related	0.0065	0.1105	0.1347
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0386	0.0386
Brugia malayi	Dopamine receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0048	0.0386	0.047
Brugia malayi	Protein kinase domain containing protein	0.0066	0.1139	0.1139
Echinococcus granulosus	ectonucleotide	0.0091	0.2207	0.2207
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0084	0.1902	0.2739
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0048	0.0386	0.0386
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	dro:myosuppressin receptor	0.0048	0.0386	0.0386
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.1139	0.599
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0048	0.0386	0.0386
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0048	0.0386	0.047
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0234	0.8202	0.8202
Brugia malayi	AKH receptor	0.0048	0.0386	0.0386
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0042	0.0122	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0048	0.0386	0.047
Onchocerca volvulus		0.0084	0.1902	0.194
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	survival motor neuron protein 1	0.0277	1	1
Echinococcus multilocularis	somatostatin receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	serine/threonine-protein kinase	0.0046	0.0289	0.0352
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0048	0.0386	0.0386
Brugia malayi	Melatonin receptor type 1A	0.0048	0.0386	0.0386
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0084	0.1902	0.1902
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0091	0.2207	0.2207
Brugia malayi	G protein-coupled receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	fmrfamide receptor	0.0048	0.0386	0.0386
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Schistosoma mansoni	opsin-like receptor	0.0048	0.0386	0.047
Loa Loa (eye worm)	TYRA-2 protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	nervana 2	0.004	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Onchocerca volvulus		0.0057	0.0741	0.0454
Brugia malayi	putative neuropeptide receptor	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0048	0.0386	0.0386
Echinococcus multilocularis	g protein coupled receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0048	0.0386	0.0386
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0048	0.0386	0.0386
Echinococcus multilocularis	protein kinase shaggy	0.0084	0.1902	0.1902
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Trypanosoma brucei	endonuclease G, putative	0.0065	0.1105	0.5809
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0048	0.0386	0.0386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Echinococcus granulosus	neuropeptide Y receptor	0.0048	0.0386	0.0386
Entamoeba histolytica	protein kinase domain containing protein	0.0084	0.1902	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0048	0.0386	0.047
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	dro:myosuppressin receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	neuropeptide F receptor	0.0048	0.0386	0.0386
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0084	0.1902	1
Trichomonas vaginalis	CMGC family protein kinase	0.0084	0.1902	1
Echinococcus granulosus	g protein coupled receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	opsin-like receptor	0.0048	0.0386	0.047
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0042	0.0122	0.0122
Trypanosoma brucei	endonuclease G, putative	0.0065	0.1105	0.5809
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0084	0.1902	0.1902
Brugia malayi	Serotonin receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0048	0.0386	0.0386
Brugia malayi	GnHR receptor homolog	0.0048	0.0386	0.0386
Mycobacterium tuberculosis	Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase)	0.0101	0.2597	0.5
Brugia malayi	G-protein coupled receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0048	0.0386	0.047
Leishmania major	endonuclease G, putative	0.0065	0.1105	0.5809
Echinococcus granulosus	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	melatonin receptor type 1A	0.0048	0.0386	0.0386
Toxoplasma gondii	AGC kinase	0.0062	0.0972	0.14
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0062	0.0972	0.0972
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Trichomonas vaginalis	CMGC family protein kinase	0.0084	0.1902	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Entamoeba histolytica	protein kinase, putative	0.0084	0.1902	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0048	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0109	0.2924	0.2924
Echinococcus granulosus	serotonin receptor	0.0048	0.0386	0.0386
Entamoeba histolytica	protein kinase, putative	0.0066	0.1139	0.599
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0109	0.2924	0.2924
Echinococcus multilocularis	Glutaredoxin protein 5	0.004	0.0036	0.0036
Echinococcus multilocularis	fmrfamide receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	g-protein coupled receptor	0.0048	0.0386	0.0386
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0084	0.1902	0.2739
Echinococcus granulosus	neuropeptides capa receptor	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	serine threonine protein kinase nrc	0.0042	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus granulosus	rhodopsin orphan GPCR	0.0048	0.0386	0.0386
Schistosoma mansoni	neuropeptide receptor	0.0048	0.0386	0.047
Echinococcus multilocularis	serotonin receptor	0.0048	0.0386	0.0386
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0048	0.0386	0.0386
Brugia malayi	G protein-coupled receptor F59B2.13	0.0048	0.0386	0.0386
Echinococcus granulosus	protein kinase shaggy	0.0084	0.1902	0.1902
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0065	0.1105	0.5809
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386
Echinococcus multilocularis	orexin receptor type 2	0.0048	0.0386	0.0386
Echinococcus granulosus	somatostatin receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	amine GPCR	0.0048	0.0386	0.047
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0048	0.0386	0.0386
Echinococcus granulosus	tm gpcr rhodopsin	0.0048	0.0386	0.0386
Echinococcus multilocularis	neuropeptide receptor	0.0048	0.0386	0.0386
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0048	0.0386	0.0386
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0048	0.0386	0.047
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0048	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0386	0.0386

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 34 uM	Binding affinity of the compound towards cholecystokinin receptor by the displacement of [125I]-CCK-33 in rat pancreatic tissue	ChEMBL.	3336026
IC50 (binding)	= 34 uM	Binding affinity of the compound towards cholecystokinin receptor by the displacement of [125I]-CCK-33 in rat pancreatic tissue	ChEMBL.	3336026
IC50 (binding)	= 100 uM	Binding affinity towards cholecystokinin receptor by displacement of [125I]-CCK-33 from guinea pig brain tissue	ChEMBL.	3336026
IC50 (functional)	= 100 uM	Inhibition of binding of [125I]-gastrin to guinea pig gastric glands	ChEMBL.	3336026
IC50 (binding)	= 100 uM	Binding affinity towards cholecystokinin receptor by displacement of [125I]-CCK-33 from guinea pig brain tissue	ChEMBL.	3336026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL314081

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 150698