Detailed information for compound 150698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.529 | Formula: C30H23FN4
  • H donors: 2 H acceptors: 0 LogP: 6.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1C1=N[C@H](Cc2c[nH]c3c2cccc3)C(=Nc2c1cccc2)Nc1ccccc1
  • InChi: 1S/C30H23FN4/c31-25-15-7-4-13-23(25)29-24-14-6-9-17-27(24)35-30(33-21-10-2-1-3-11-21)28(34-29)18-20-19-32-26-16-8-5-12-22(20)26/h1-17,19,28,32H,18H2,(H,33,35)/t28-/m1/s1
  • InChiKey: OFANVAYBWIKXQI-MUUNZHRXSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor F59B2.13 0.0048 0.0386 0.0386
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.2924 0.3565
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0386 0.0386
Schistosoma mansoni survival motor neuron protein 0.0057 0.0741 0.0903
Brugia malayi Dopamine receptor 0.0048 0.0386 0.0386
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni amine GPCR 0.0048 0.0386 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis sex peptide receptor 0.0048 0.0386 0.0386
Entamoeba histolytica protein kinase 2, putative 0.0042 0.0122 0.0639
Echinococcus granulosus orexin receptor type 2 0.0048 0.0386 0.0386
Echinococcus multilocularis dro:myosuppressin receptor 0.0048 0.0386 0.0386
Giardia lamblia Kinase, CMGC GSK 0.0084 0.1902 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0084 0.1902 0.1902
Brugia malayi Tachykinin-like peptides receptor 99D 0.0048 0.0386 0.0386
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi neuropeptide F receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0386 0.0386
Onchocerca volvulus 0.0084 0.1902 0.194
Echinococcus granulosus allatostatin A receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0048 0.0386 0.047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0386 0.047
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0048 0.0386 0.047
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0234 0.8202 0.8202
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Echinococcus granulosus hypothetical protein 0.0048 0.0386 0.0386
Trypanosoma brucei endonuclease G, putative 0.0065 0.1105 0.5809
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0289 0.1517
Brugia malayi G-protein coupled receptor 0.0048 0.0386 0.0386
Schistosoma mansoni amine GPCR 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Onchocerca volvulus 0.0109 0.2924 0.3247
Echinococcus granulosus Endonuclease G 0.0065 0.1105 0.1105
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0048 0.0386 0.047
Echinococcus granulosus survival motor neuron protein 1 0.0277 1 1
Brugia malayi GnHR receptor homolog 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis allatostatin A receptor 0.0048 0.0386 0.0386
Schistosoma mansoni neuropeptide receptor 0.0048 0.0386 0.047
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0289 0.1517
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0386 0.0386
Toxoplasma gondii AGC kinase 0.0062 0.0972 0.14
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0289 0.0289
Echinococcus multilocularis nervana 2 0.004 0.0036 0.0036
Echinococcus multilocularis nervana 2 0.004 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi follicle stimulating hormone receptor 0.0048 0.0386 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Entamoeba histolytica protein kinase, putative 0.0084 0.1902 1
Mycobacterium ulcerans chorismate synthase 0.0204 0.6944 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0048 0.0386 0.047
Echinococcus granulosus neuropeptides capa receptor 0.0048 0.0386 0.0386
Schistosoma mansoni growth hormone secretagogue receptor 0.0048 0.0386 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis ectonucleotide 0.0091 0.2207 0.2207
Brugia malayi Melatonin receptor type 1A 0.0048 0.0386 0.0386
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0048 0.0386 0.047
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus neuropeptide s receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine receptor 0.0048 0.0386 0.047
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus protein kinase shaggy 0.0084 0.1902 0.1902
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0048 0.0386 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni endonuclease related 0.0065 0.1105 0.1347
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0048 0.0386 0.0386
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0048 0.0386 0.0386
Echinococcus granulosus 7tm_1 domain containing protein 0.0048 0.0386 0.0386
Entamoeba histolytica protein kinase, putative 0.0066 0.1139 0.599
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0386 0.0386
Trypanosoma cruzi endonuclease G, putative 0.0065 0.1105 0.5809
Brugia malayi G protein-coupled receptor 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine receptor 0.0048 0.0386 0.047
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0289 0.0352
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0386 0.0386
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0048 0.0386 0.047
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0048 0.0386 0.0386
Schistosoma mansoni alpha-1 adrenergic receptor 0.0048 0.0386 0.047
Plasmodium falciparum chorismate synthase 0.0204 0.6944 1
Brugia malayi G-protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis Endonuclease G 0.0065 0.1105 0.1105
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Loa Loa (eye worm) hypothetical protein 0.0109 0.2924 0.2924
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0065 0.1105 0.5809
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.004 0.0036 0.0036
Echinococcus granulosus alpha 1A adrenergic receptor 0.0048 0.0386 0.0386
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.1902 1
Trichomonas vaginalis CMGC family protein kinase 0.0084 0.1902 1
Schistosoma mansoni hypothetical protein 0.0057 0.0741 0.0903
Giardia lamblia Kinase, CMGC GSK 0.0084 0.1902 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0048 0.0386 0.0386
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0084 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi Dopamine receptor protein 2 0.0048 0.0386 0.0386
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0048 0.0386 0.0386
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0741 0.0741
Brugia malayi sulfakinin receptor protein 0.0048 0.0386 0.0386
Brugia malayi Protein kinase domain containing protein 0.0066 0.1139 0.1139
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0386 0.0386
Schistosoma mansoni amine GPCR 0.0048 0.0386 0.047
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0042 0.0122 0.0175
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0048 0.0386 0.0386
Brugia malayi ORL1-like opioid receptor 0.0048 0.0386 0.0386
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.1139 0.599
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0386 0.0386
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus Glutaredoxin protein 5 0.004 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0277 1 1
Onchocerca volvulus 0.0057 0.0741 0.0454
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni neuropeptide f receptor 76f 0.0048 0.0386 0.047
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0048 0.0386 0.0386
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.1902 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0289 0.1517
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0386 0.0386
Entamoeba histolytica protein kinase, putative 0.0062 0.0972 0.5113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0048 0.0386 0.0386
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0084 0.1902 0.2319
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0109 0.2924 0.2924
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0289 0.0289
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Onchocerca volvulus 0.0234 0.8202 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0386 0.047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0386 0.047
Echinococcus multilocularis neuropeptide receptor 0.0048 0.0386 0.0386
Echinococcus granulosus neuropeptide receptor 0.0048 0.0386 0.0386
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0122 0.0122
Echinococcus granulosus neuropeptide Y receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0084 0.1902 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Brugia malayi neuropeptide F receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0972 0.0972
Echinococcus granulosus sex peptide receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Echinococcus multilocularis protein kinase shaggy 0.0084 0.1902 0.1902
Entamoeba histolytica protein kinase, putative 0.0066 0.1139 0.599
Onchocerca volvulus 0.0109 0.2924 0.3247
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0048 0.0386 0.0386
Brugia malayi putative neuropeptide receptor 0.0048 0.0386 0.0386
Leishmania major endonuclease G, putative 0.0065 0.1105 0.5809
Giardia lamblia Kinase, AGC PKA 0.0042 0.0122 0.0639
Schistosoma mansoni amine GPCR 0.0048 0.0386 0.047
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.004 0.0036 0.0036
Trypanosoma brucei protein kinase, putative 0.0084 0.1902 1
Schistosoma mansoni biogenic amine receptor 0.0048 0.0386 0.047
Trypanosoma cruzi Protein kinase B 0.0046 0.0289 0.1517
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus nervana 2 0.004 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Trypanosoma brucei endonuclease G, putative 0.0065 0.1105 0.5809
Mycobacterium leprae Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). 0.0101 0.2597 0.5
Echinococcus granulosus g protein coupled receptor 0.0048 0.0386 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Echinococcus multilocularis somatostatin receptor 0.0048 0.0386 0.0386
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Loa Loa (eye worm) G-protein coupled receptor 0.0048 0.0386 0.0386
Brugia malayi intracellular kinase 0.0084 0.1902 0.1902
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0048 0.0386 0.0386
Schistosoma mansoni opsin-like receptor 0.0048 0.0386 0.047
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Schistosoma mansoni hypothetical protein 0.0234 0.8202 1
Mycobacterium tuberculosis Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) 0.0101 0.2597 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Brugia malayi Serotonin receptor 0.0048 0.0386 0.0386
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0386 0.047
Echinococcus multilocularis neuropeptides capa receptor 0.0048 0.0386 0.0386
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0065 0.1105 0.5809
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Schistosoma mansoni neuropeptide receptor 0.0048 0.0386 0.047
Echinococcus granulosus g protein coupled receptor 0.0048 0.0386 0.0386
Plasmodium vivax chorismate synthase 0.0204 0.6944 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0048 0.0386 0.0386
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0084 0.1902 0.1902
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni myosin xvIII 0.0048 0.0386 0.047
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0048 0.0386 0.0386
Echinococcus granulosus tm gpcr rhodopsin 0.0048 0.0386 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0109 0.2924 0.2924
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni opsin-like receptor 0.0048 0.0386 0.047
Echinococcus granulosus somatostatin receptor 0.0048 0.0386 0.0386
Brugia malayi Serotonin receptor 0.0048 0.0386 0.0386
Schistosoma mansoni histamine h1 receptor 0.0048 0.0386 0.047
Schistosoma mansoni opsin-like receptor 0.0048 0.0386 0.047
Echinococcus multilocularis serotonin receptor 0.0048 0.0386 0.0386
Toxoplasma gondii chorismate synthase, putative 0.0204 0.6944 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0042 0.0122 0.0175
Echinococcus granulosus ectonucleotide 0.0091 0.2207 0.2207
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Schistosoma mansoni adenoreceptor 0.0048 0.0386 0.047
Echinococcus granulosus neuropeptide receptor 0.0048 0.0386 0.0386
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.2924 0.3565
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0289 0.0352
Trypanosoma cruzi endonuclease G, putative 0.0065 0.1105 0.5809
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus peptide allatostatin:somatostatin 0.0048 0.0386 0.0386
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0084 0.1902 1
Echinococcus multilocularis orexin receptor type 2 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0048 0.0386 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus G protein coupled receptor 139 0.0048 0.0386 0.0386
Echinococcus multilocularis neuropeptide receptor A26 0.0048 0.0386 0.0386
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.1139 0.1139
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0091 0.2207 0.2207
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0065 0.1105 0.5809
Echinococcus granulosus nervana 2 0.004 0.0036 0.0036
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0109 0.2924 0.2924
Echinococcus granulosus g protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus granulosus g-protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis neuropeptide Y receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis survival motor neuron protein 1 0.0277 1 1
Chlamydia trachomatis chorismate synthase 0.0204 0.6944 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0084 0.1902 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0048 0.0386 0.0386
Echinococcus granulosus serotonin receptor 0.0048 0.0386 0.0386
Brugia malayi AKH receptor 0.0048 0.0386 0.0386
Schistosoma mansoni hypothetical protein 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0091 0.2207 0.2207
Brugia malayi RE15519p 0.0048 0.0386 0.0386
Echinococcus multilocularis g-protein coupled receptor 0.0048 0.0386 0.0386
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0048 0.0386 0.0386
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0048 0.0386 0.047
Echinococcus granulosus tachykinin peptides receptor 99D 0.0048 0.0386 0.0386
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0042 0.0122 0.0639
Echinococcus multilocularis rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0048 0.0386 0.0386
Echinococcus multilocularis g protein coupled receptor 0.0048 0.0386 0.0386
Brugia malayi putative neuropeptide receptor NPR1 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0048 0.0386 0.0386
Schistosoma mansoni neuropeptide F-like receptor 0.0048 0.0386 0.047
Echinococcus multilocularis G protein coupled receptor 139 0.0048 0.0386 0.0386
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0386 0.0386
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0122 0.0122
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0386 0.0386
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0091 0.2207 0.2207
Echinococcus granulosus dro:myosuppressin receptor 0.0048 0.0386 0.0386
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Echinococcus granulosus fmrfamide receptor 0.0048 0.0386 0.0386
Echinococcus granulosus biogenic amine 5HT receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0048 0.0386 0.0386
Trypanosoma brucei endonuclease G, putative 0.0065 0.1105 0.5809
Schistosoma mansoni neuropeptide receptor 0.0048 0.0386 0.047
Brugia malayi hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis Glutaredoxin protein 5 0.004 0.0036 0.0036
Echinococcus granulosus 7TM GPCR rhodopsin 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0972 0.0972
Plasmodium vivax glycogen synthase kinase 3, putative 0.0084 0.1902 0.2739
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0109 0.2924 0.2924
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Brugia malayi Dopamine receptor protein 1 0.0048 0.0386 0.0386
Echinococcus multilocularis serotonin receptor 0.0048 0.0386 0.0386
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0122 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0048 0.0386 0.0386
Schistosoma mansoni neuropeptide receptor 0.0048 0.0386 0.047
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0048 0.0386 0.0386
Echinococcus multilocularis fmrfamide receptor 0.0048 0.0386 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0066 0.1139 0.599
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni amine GPCR 0.0048 0.0386 0.047
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0065 0.1105 0.1591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0048 0.0386 0.047
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0084 0.1902 0.2739
Schistosoma mansoni biogenic amine (5HT) receptor 0.0048 0.0386 0.047
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Echinococcus multilocularis neuropeptide s receptor 0.0048 0.0386 0.0386
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.2924 0.3565
Echinococcus multilocularis G-protein coupled receptor, putative 0.0048 0.0386 0.0386
Plasmodium falciparum glycogen synthase kinase 3 0.0084 0.1902 0.2739
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0048 0.0386 0.0386
Brugia malayi larval opioid receptor 0.0048 0.0386 0.0386
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0084 0.1902 0.1902
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0048 0.0386 0.0386
Brugia malayi endonuclease G, mitochondrial precursor 0.0065 0.1105 0.1105
Loa Loa (eye worm) TYRA-2 protein 0.0048 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0048 0.0386 0.0386
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0048 0.0386 0.047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0048 0.0386 0.047
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0109 0.2924 0.3565
Brugia malayi Thrombospondin type 1 domain containing protein 0.0234 0.8202 0.8202
Loa Loa (eye worm) neuropeptide F receptor 0.0048 0.0386 0.0386

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 34 uM Binding affinity of the compound towards cholecystokinin receptor by the displacement of [125I]-CCK-33 in rat pancreatic tissue ChEMBL. 3336026
IC50 (binding) = 34 uM Binding affinity of the compound towards cholecystokinin receptor by the displacement of [125I]-CCK-33 in rat pancreatic tissue ChEMBL. 3336026
IC50 (binding) = 100 uM Binding affinity towards cholecystokinin receptor by displacement of [125I]-CCK-33 from guinea pig brain tissue ChEMBL. 3336026
IC50 (functional) = 100 uM Inhibition of binding of [125I]-gastrin to guinea pig gastric glands ChEMBL. 3336026
IC50 (binding) = 100 uM Binding affinity towards cholecystokinin receptor by displacement of [125I]-CCK-33 from guinea pig brain tissue ChEMBL. 3336026

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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