TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.362 | Formula: C18H18N4
H donors: 1 H acceptors: 3 LogP: 3.34 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1C)CNc1nccc(n1)c1ccncc1
InChi: 1S/C18H18N4/c1-13-3-4-15(11-14(13)2)12-21-18-20-10-7-17(22-18)16-5-8-19-9-6-16/h3-11H,12H2,1-2H3,(H,20,21,22)
InChiKey: OLLPGHZLMCFDEB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0329	0.9178	1
Trypanosoma brucei	beta tubulin	0.0028	0.0463	0.0826
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Echinococcus granulosus	tubulin alpha 1C chain	0.0042	0.0853	0.0853
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0042	0.0853	0.1523
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0055	0.1241	0.1353
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0019	0.0181	0.0198
Trypanosoma cruzi	epsilon tubulin, putative	0.0028	0.0463	0.0826
Echinococcus granulosus	tubulin alpha 3 chain	0.0042	0.0853	0.0853
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0123	0.3208	0.3495
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.1099	0.3079
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0853	0.093
Echinococcus multilocularis	tubulin beta 1 chain	0.0048	0.1033	0.1033
Loa Loa (eye worm)	BEN-1 protein	0.0048	0.1033	0.1125
Leishmania major	gamma-tubulin	0.0028	0.0463	0.0826
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1142	0.1142
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Trichomonas vaginalis	tubulin, putative	0.0016	0.0108	0.0192
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0181	0.052
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0125	0.3258	1
Onchocerca volvulus	Putative GMP reductase	0.0055	0.1241	0.125
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Brugia malayi	GMP reductase	0.0055	0.1241	0.1353
Loa Loa (eye worm)	tubulin alpha 2	0.0029	0.0498	0.0543
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0133	0.3487	0.3487
Echinococcus granulosus	peroxisome assembly protein 26	0.0042	0.0853	0.0853
Plasmodium vivax	glutathione reductase, putative	0.0053	0.1193	0.3661
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.1193	0.1193
Toxoplasma gondii	beta-1 tubulin, putative	0.0048	0.1033	0.2962
Echinococcus multilocularis	hypothetical protein	0.0042	0.0853	0.0853
Trypanosoma brucei	epsilon tubulin	0.0028	0.0463	0.0826
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	0.5345
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.1193	0.13
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1864	0.5345
Leishmania major	epsilon tubulin, putative	0.0028	0.0463	0.0826
Echinococcus granulosus	tubulin epsilon chain	0.0028	0.0463	0.0463
Brugia malayi	Thioredoxin reductase	0.0053	0.1193	0.13
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0125	0.3258	1
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus granulosus	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0019	0.0181	0.0323
Giardia lamblia	Kinase, PLK	0.0206	0.5604	1
Echinococcus multilocularis	tubulin alpha chain	0.0042	0.0853	0.0853
Mycobacterium tuberculosis	Probable reductase	0.0122	0.3176	0.8896
Schistosoma mansoni	tubulin subunit gamma	0.0028	0.0463	0.0463
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0019	0.0181	0.052
Toxoplasma gondii	hypothetical protein	0.0026	0.0409	0.1174
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.0323
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0019	0.0181	0.052
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	1
Giardia lamblia	Alpha-tubulin	0.0042	0.0853	0.1523
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Brugia malayi	Tubulin gamma chain	0.0028	0.0463	0.0504
Echinococcus granulosus	tubulin alpha 3 chain	0.0042	0.0853	0.0853
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.2595	0.463
Loa Loa (eye worm)	tubulin alpha 2	0.0013	0.0035	0.0039
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0026	0.0391	0.0425
Plasmodium falciparum	alpha tubulin 2	0.0042	0.0853	0.2619
Brugia malayi	Tubulin beta-1 chain	0.0048	0.1033	0.1125
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0019	0.0181	0.0556
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0063	0.147	0.4116
Brugia malayi	glutathione reductase	0.0053	0.1193	0.13
Echinococcus multilocularis	tubulin alpha chain	0.0042	0.0853	0.0853
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0133	0.3487	0.3487
Loa Loa (eye worm)	tubulin gamma chain	0.0028	0.0463	0.0504
Entamoeba histolytica	tubulin alpha-1 chain	0.0042	0.0853	0.076
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0063	0.147	0.4215
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	0.5345
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.0181
Trichomonas vaginalis	tubulin alpha chain, putative	0.0048	0.1033	0.1843
Toxoplasma gondii	NADPH-glutathione reductase	0.0019	0.0181	0.052
Brugia malayi	alpha-tubulin	0.0042	0.0853	0.093
Onchocerca volvulus		0.0329	0.9178	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0048	0.1033	0.1125
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Echinococcus multilocularis	tubulin alpha chain	0.0042	0.0853	0.0853
Plasmodium falciparum	thioredoxin reductase	0.0053	0.1193	0.3661
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0042	0.0853	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0189	0.5124	0.5583
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.007	0.1662	0.4655
Echinococcus granulosus	tubulin alpha chain	0.0042	0.0853	0.0853
Giardia lamblia	Alpha-tubulin	0.0042	0.0853	0.1523
Echinococcus granulosus	tubulin beta 1 chain	0.0048	0.1033	0.1033
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.0323
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.1864	0.5345
Trypanosoma brucei	alpha tubulin	0.0042	0.0853	0.1523
Trypanosoma cruzi	trypanothione reductase, putative	0.0019	0.0181	0.0323
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus granulosus	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0133	0.3487	0.3799
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0122	0.3176	0.8896
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0026	0.0391	0.0697
Toxoplasma gondii	beta-tubulin, putative	0.0048	0.1033	0.2962
Schistosoma mansoni	alpha tubulin	0.0042	0.0853	0.0853
Brugia malayi	beta-tubulin, identical	0.0048	0.1033	0.1125
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0029	0.0498	0.0889
Trichomonas vaginalis	glutathione reductase, putative	0.0019	0.0181	0.0323
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0048	0.1033	0.1843
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.2595	0.463
Plasmodium falciparum	tubulin gamma chain	0.0028	0.0463	0.142
Trichomonas vaginalis	tubulin beta chain, putative	0.0016	0.0108	0.0192
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0133	0.3487	0.6221
Brugia malayi	tubulin alpha-2 chain	0.0042	0.0853	0.093
Trichomonas vaginalis	tubulin, putative	0.0048	0.1033	0.1843
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Trichomonas vaginalis	tubulin alpha chain, putative	0.0016	0.0108	0.0192
Trichomonas vaginalis	tubulin alpha chain, putative	0.0028	0.0463	0.0826
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0028	0.0463	0.1327
Giardia lamblia	Beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	peroxisome assembly protein 26	0.0042	0.0853	0.0853
Loa Loa (eye worm)	tubulin beta-2A chain	0.0048	0.1033	0.1125
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0133	0.3487	0.6221
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0122	0.3176	0.8896
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0133	0.3487	0.3799
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0042	0.0853	0.1523
Echinococcus granulosus	tubulin alpha chain	0.0042	0.0853	0.0853
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Schistosoma mansoni	peptidase Clp (S14 family)	0.0077	0.1864	0.1864
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.1142	0.1245
Brugia malayi	Tubulin alpha-2 chain	0.0042	0.0853	0.093
Loa Loa (eye worm)	tubulin alpha 2	0.0029	0.0498	0.0543
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0048	0.1033	0.1033
Toxoplasma gondii	alpha tubulin TUBA1	0.0042	0.0853	0.2447
Loa Loa (eye worm)	beta-tubulin	0.0048	0.1033	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0391	0.0425
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0019	0.0181	0.0323
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0133	0.3487	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Loa Loa (eye worm)	tubulin alpha chain	0.0042	0.0853	0.093
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0206	0.5604	0.5604
Echinococcus granulosus	tubulin beta 4A class IVa	0.0048	0.1033	0.1033
Brugia malayi	Tubulin alpha-2 chain	0.0042	0.0853	0.093
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Echinococcus multilocularis	tubulin alpha 1C chain	0.0042	0.0853	0.0853
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Echinococcus granulosus	alpha tubulin	0.0042	0.0853	0.0853
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0019	0.0181	0.052
Schistosoma mansoni	kinase	0.0105	0.2674	0.2674
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	0.5719
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1142	0.1142
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0042	0.0853	0.093
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0136	0.357	1
Echinococcus granulosus	tubulin alpha chain	0.0042	0.0853	0.0853
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Loa Loa (eye worm)	tubulin beta-4 chain	0.0048	0.1033	0.1125
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Trypanosoma brucei	polo-like protein kinase	0.0206	0.5604	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0136	0.357	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Plasmodium vivax	tubulin epsilon chain, putative	0.0028	0.0463	0.142
Echinococcus multilocularis	beta tubulin	0.0048	0.1033	0.1033
Trypanosoma brucei	GMP reductase	0.0133	0.3487	0.6221
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0042	0.0853	0.093
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0122	0.3176	0.8896
Trypanosoma brucei	alpha tubulin	0.0042	0.0853	0.1523
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.1864	0.522
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Echinococcus granulosus	tubulin alpha	0.0028	0.0463	0.0463
Treponema pallidum	NADH oxidase	0.0019	0.0181	0.0973
Loa Loa (eye worm)	tubulin beta chain	0.0048	0.1033	0.1125
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0122	0.3176	0.8896
Toxoplasma gondii	alpha-tubulin I, putative	0.0042	0.0853	0.2447
Schistosoma mansoni	alpha tubulin	0.0042	0.0853	0.0853
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0019	0.0181	0.0508
Giardia lamblia	Gamma tubulin	0.0028	0.0463	0.0826
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0181	0.0323
Giardia lamblia	Beta tubulin	0.0048	0.1033	0.1843
Plasmodium falciparum	tubulin beta chain	0.0048	0.1033	0.3169
Echinococcus granulosus	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Trypanosoma brucei	alpha tubulin	0.0042	0.0853	0.1523
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.1099	0.3079
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0189	0.5124	0.5531
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1864	0.203
Trypanosoma cruzi	alpha tubulin, putative	0.0042	0.0853	0.1523
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	tubulin alpha	0.0028	0.0463	0.0463
Brugia malayi	tubulin alpha chain - mouse	0.0042	0.0853	0.093
Plasmodium vivax	tubulin alpha chain, putative	0.0042	0.0853	0.2619
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.3268	0.3561
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.1864	0.1864
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Toxoplasma gondii	thioredoxin reductase	0.0053	0.1193	0.3421
Echinococcus granulosus	tubulin subunit beta	0.0048	0.1033	0.1033
Trypanosoma cruzi	GMP reductase	0.0133	0.3487	0.6221
Echinococcus granulosus	beta tubulin	0.0048	0.1033	0.1033
Echinococcus granulosus	tubulin gamma 1 chain	0.0028	0.0463	0.0463
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0014	0.0039	0.0042
Echinococcus granulosus	beta tubulin	0.0048	0.1033	0.1033
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0123	0.3208	0.3495
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Trichomonas vaginalis	tubulin beta chain, putative	0.0048	0.1033	0.1843
Loa Loa (eye worm)	alpha-tubulin	0.0042	0.0853	0.093
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Trypanosoma cruzi	beta tubulin, putative	0.0048	0.1033	0.1843
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.1099	0.1099
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0136	0.357	1
Schistosoma mansoni	tubulin subunit alpha	0.0042	0.0853	0.0853
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0048	0.1033	0.1843
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0029	0.0498	0.0543
Echinococcus multilocularis	geminin	0.0358	1	1
Echinococcus multilocularis	beta tubulin	0.0048	0.1033	0.1033
Brugia malayi	Tubulin alpha chain	0.0042	0.0853	0.093
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0206	0.5604	1
Schistosoma mansoni	serine/threonine protein kinase	0.0206	0.5604	0.5604
Schistosoma mansoni	alpha tubulin	0.0042	0.0853	0.0853
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Echinococcus multilocularis	tubulin alpha chain	0.0042	0.0853	0.0853
Trypanosoma cruzi	tubulin gamma chain	0.0028	0.0463	0.0826
Plasmodium falciparum	alpha tubulin 1	0.0042	0.0853	0.2619
Toxoplasma gondii	beta tubulin	0.0048	0.1033	0.2962
Toxoplasma gondii	IMP dehydrogenas	0.0133	0.3487	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.3268	0.3561
Brugia malayi	MH2 domain containing protein	0.0125	0.3268	0.3561
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Trypanosoma brucei	beta tubulin	0.0048	0.1033	0.1843
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1142	0.1142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1142	0.1142
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0133	0.3487	0.9766
Trypanosoma brucei	epsilon tubulin	0.0028	0.0463	0.0826
Leishmania major	guanosine monophosphate reductase	0.0133	0.3487	0.6221
Trypanosoma cruzi	polo-like protein kinase, putative	0.0206	0.5604	1
Leishmania major	trypanothione reductase	0.0053	0.1193	0.2129
Plasmodium falciparum	thioredoxin reductase	0.0019	0.0181	0.0556
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	tubulin gamma 1 chain	0.0028	0.0463	0.0463
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0206	0.5604	0.5604
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Echinococcus granulosus	tubulin subunit TubB	0.0042	0.0853	0.0853
Echinococcus granulosus	tubulin alpha chain	0.0042	0.0853	0.0853
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0019	0.0181	0.0323
Plasmodium vivax	tubulin beta chain, putative	0.0048	0.1033	0.3169
Trypanosoma brucei	beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Trichomonas vaginalis	tubulin beta chain, putative	0.0042	0.0853	0.1523
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0016	0.0108	0.0192
Loa Loa (eye worm)	tubulin alpha chain	0.0042	0.0853	0.093
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0123	0.3208	0.3208
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0019	0.0181	0.0323
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0123	0.3208	0.3208
Schistosoma mansoni	tubulin subunit epsilon	0.0028	0.0463	0.0463
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0133	0.3487	0.3487
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Brugia malayi	Tubulin beta chain	0.0016	0.0108	0.0117
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Echinococcus multilocularis	tubulin subunit TubB	0.0042	0.0853	0.0853
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1142	0.1142
Plasmodium falciparum	tubulin epsilon chain, putative	0.0028	0.0463	0.142
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0019	0.0181	0.0556
Echinococcus multilocularis	tubulin subunit beta	0.0048	0.1033	0.1033
Trypanosoma brucei	epsilon tubulin	0.0028	0.0463	0.0826
Echinococcus multilocularis	tubulin alpha 3 chain	0.0042	0.0853	0.0853
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Trichomonas vaginalis	tubulin, putative	0.0016	0.0108	0.0192
Trypanosoma cruzi	epsilon tubulin, putative	0.0028	0.0463	0.0826
Trichomonas vaginalis	CAMK family protein kinase	0.0206	0.5604	1
Trypanosoma brucei	tubulin gamma chain	0.0028	0.0463	0.0826
Trypanosoma cruzi	polo-like protein kinase, putative	0.0206	0.5604	1
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0409	0.1146
Plasmodium falciparum	glutathione reductase	0.0019	0.0181	0.0556
Loa Loa (eye worm)	glutathione reductase	0.0053	0.1193	0.13
Echinococcus multilocularis	tubulin alpha chain	0.0042	0.0853	0.0853
Trichomonas vaginalis	tubulin gamma chain, putative	0.0028	0.0463	0.0826
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0019	0.0181	0.0556
Brugia malayi	N-terminal motif family protein	0.0189	0.5124	0.5583
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.1864	0.1864
Trichomonas vaginalis	mercuric reductase, putative	0.0019	0.0181	0.0323
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0019	0.0181	0.0323
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0019	0.0181	0.0556
Echinococcus multilocularis	tubulin alpha 1C chain	0.0042	0.0853	0.0853
Echinococcus granulosus	tubulin alpha 1C chain	0.0042	0.0853	0.0853
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.0181
Trichomonas vaginalis	tubulin gamma chain, putative	0.0028	0.0463	0.0826
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0409	0.1256
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.1142	0.1245
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0133	0.3487	0.6221
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0133	0.3487	0.6221
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1142	0.1142
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.007	0.1662	0.4655
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Echinococcus multilocularis	tubulin epsilon chain	0.0028	0.0463	0.0463
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0019	0.0181	0.0323
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1142	0.1142
Giardia lamblia	Beta tubulin	0.0048	0.1033	0.1843
Schistosoma mansoni	tubulin subunit alpha	0.0042	0.0853	0.0853
Trichomonas vaginalis	tubulin alpha chain, putative	0.0016	0.0108	0.0192
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0206	0.5604	1
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Plasmodium vivax	tubulin gamma chain, putative	0.0028	0.0463	0.142
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.1193	0.3341
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0498	0.0543
Brugia malayi	Probable ClpP-like protease	0.0077	0.1864	0.203
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0042	0.0853	0.0853
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0125	0.3258	0.9346
Echinococcus granulosus	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Trichomonas vaginalis	tubulin alpha chain, putative	0.0016	0.0108	0.0192
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0117	0.3046	0.3046
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0136	0.357	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0206	0.5604	0.6106
Trypanosoma brucei	beta tubulin	0.0048	0.1033	0.1843
Plasmodium falciparum	glutathione reductase	0.0053	0.1193	0.3661
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.052
Schistosoma mansoni	tubulin subunit beta	0.0048	0.1033	0.1033
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0206	0.5604	0.606
Entamoeba histolytica	tubulin family protein	0.0048	0.1033	0.1108
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0019	0.0181	0.052
Brugia malayi	serine/threonine-protein kinase plk-2	0.0206	0.5604	0.6106
Plasmodium vivax	tubulin alpha chain, putative	0.0042	0.0853	0.2619
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0014	0.0039	0.0042
Mycobacterium tuberculosis	Probable dehydrogenase	0.0122	0.3176	0.8896
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.1193	0.2129
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0133	0.3487	0.6221
Schistosoma mansoni	hypothetical protein	0.0358	1	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0409	0.2196
Loa Loa (eye worm)	BEN-1 protein	0.0048	0.1033	0.1125
Trypanosoma brucei	alpha tubulin, putative	0.0016	0.0108	0.0192
Entamoeba histolytica	tubulin alpha chain, putative	0.0042	0.0853	0.076
Trypanosoma brucei	alpha tubulin	0.0042	0.0853	0.1523
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.1099	0.3079
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.1864	0.5345
Echinococcus granulosus	tubulin alpha chain	0.0042	0.0853	0.0853
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0133	0.3487	0.9766
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Schistosoma mansoni	tubulin subunit alpha	0.0042	0.0853	0.0853
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0055	0.1241	0.1353
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.1099	0.1099
Trypanosoma brucei	trypanothione reductase	0.0053	0.1193	0.2129
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0409	0.1256
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.1193	0.1193
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.1864	0.5719
Loa Loa (eye worm)	GMP reductase	0.0055	0.1241	0.1353
Brugia malayi	hypothetical protein	0.0329	0.9178	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0048	0.1033	0.1843
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0133	0.3487	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0122	0.3176	0.8896
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0019	0.0181	0.0323
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Trypanosoma cruzi	GMP reductase	0.0133	0.3487	0.6221
Leishmania major	alpha tubulin	0.0042	0.0853	0.1523
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0019	0.0181	0.0181
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.1193	0.3661
Echinococcus multilocularis	Tubulin beta 2C chain	0.0048	0.1033	0.1033
Trypanosoma brucei	beta tubulin	0.0048	0.1033	0.1843
Echinococcus multilocularis	tubulin alpha 3 chain	0.0042	0.0853	0.0853
Leishmania major	beta tubulin	0.0048	0.1033	0.1843
Entamoeba histolytica	tubulin family protein	0.0048	0.1033	0.1108

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	ND 0 uM	In vitro inhibition of histamine release from human basophils.	ChEMBL.	8410986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 150885