TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 295.329 | Formula: C14H14FNO3S
H donors: 1 H acceptors: 3 LogP: 1.91 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)S(=O)(=O)C1=C(O)CC(CC1=N2)(C)C
InChi: 1S/C14H14FNO3S/c1-14(2)6-10-13(11(17)7-14)20(18,19)12-5-8(15)3-4-9(12)16-10/h3-5,17H,6-7H2,1-2H3
InChiKey: YLNPBVASXNVOGN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	cysteine proteinase falcipain 2a	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	vivapain-3	cysteine proteinase falcipain 2a	484 aa	497 aa	45.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0068	0.0182	0.0574
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0233	0.0228
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0067	0.0177	0.9517
Brugia malayi	Muscleblind-like protein	0.017	0.0591	0.0573
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0044	0.0085	0.0067
Loa Loa (eye worm)	fibroinase	0.0027	0.0018	0.0014
Brugia malayi	p70 ribosomal S6 kinase beta	0.013	0.043	0.0412
Entamoeba histolytica	protein kinase, putative	0.013	0.043	0.124
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0018	0.0058
Echinococcus multilocularis	snurportin 1	0.0351	0.1311	0.4143
Brugia malayi	Bromodomain containing protein	0.0086	0.0252	0.0234
Brugia malayi	Importin beta-1 subunit	0.0033	0.0042	0.0024
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0068	0.0183	0.0577
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0089	0.0264	0.0834
Echinococcus granulosus	serine/threonine protein kinase	0.0069	0.0185	0.0583
Echinococcus multilocularis	serine threonine protein kinase	0.0068	0.0182	0.0574
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0044	0.0085	0.008
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0264	0.0834
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0068	0.0182	0.0574
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0198	0.0699	1
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0018	0.0058
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0132	0.0438	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0069	0.0185	1
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0085	0.0269
Trichomonas vaginalis	serine/threonine-protein kinase, putative	0.0051	0.0113	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0182	0.0177
Echinococcus multilocularis	protein kinase c epsilon type	0.0075	0.0211	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0042	0.0037
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0039	0.0068	0.0214
Treponema pallidum	hypothetical protein	0.0032	0.0039	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0018	0.0003
Echinococcus multilocularis	nervana 2	0.0062	0.0159	0.0503
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0182	0.0163
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0075	0.0211	0.0207
Brugia malayi	Bromodomain containing protein	0.0044	0.0085	0.0067
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0018	0.0067
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0013	0.0043
Echinococcus granulosus	protein kinase c iota type	0.0075	0.0211	0.0668
Onchocerca volvulus		0.006	0.0151	0.042
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0042	0.0564
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0042	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0105	0.01
Echinococcus multilocularis	muscleblind protein 1	0.017	0.0591	0.1866
Toxoplasma gondii	AGC kinase	0.0044	0.0085	0.1619
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.0211	0.0668
Onchocerca volvulus		0.007	0.0189	0.0541
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0089	0.0264	0.5965
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Echinococcus granulosus	NDR protein kinase	0.0068	0.0182	0.0574
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0044	0.0085	0.4048
Echinococcus multilocularis	expressed conserved protein	0.0089	0.0264	0.0834
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0072	0.0198	0.018
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0068	0.0183	0.0577
Echinococcus granulosus	rho-associated protein kinase 1	0.0816	0.3166	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0182	0.0574
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0042	0.0133
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Loa Loa (eye worm)	hypothetical protein	0.006	0.0151	0.0146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.0211	0.0668
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus granulosus	cGMP dependent protein kinase	0.0089	0.0264	0.0834
Echinococcus granulosus	Glutaredoxin protein 5	0.0062	0.0159	0.0503
Onchocerca volvulus		0.0812	0.3148	0.9945
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Plasmodium falciparum	importin beta, putative	0.0033	0.0042	0.0965
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0062	0.0159	0.0503
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0351	0.1311	0.1307
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0182	0.0574
Schistosoma mansoni	hypothetical protein	0.0024	0.0005	0.0015
Loa Loa (eye worm)	cysteine protease	0.0027	0.0018	0.0014
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0089	0.0264	0.0834
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0042	0.0133
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0093	0.0228
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Echinococcus granulosus	snurportin 1	0.0351	0.1311	0.4143
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0039	0.0068	0.0214
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0074	0.0235
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0085	0.0269
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0068	0.0182	0.0574
Trichomonas vaginalis	aldehyde oxidase, putative	0.0198	0.0699	1
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0131	0.0433	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0089	0.0264	0.0834
Brugia malayi	Hr1 repeat family protein	0.0068	0.0182	0.0163
Schistosoma mansoni	atypical protein kinase C	0.0075	0.0211	0.0668
Onchocerca volvulus		0.0068	0.0181	0.0515
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0114	0.0366	0.0362
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Leishmania major	cysteine peptidase A (CPA)	0.0027	0.0018	0.0166
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0064	0.0168	0.0163
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0067	0.0177	0.5229
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0085	0.0269
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0018	0.0058
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Echinococcus multilocularis	protein kinase c iota type	0.0075	0.0211	0.0668
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0018	0.0017
Schistosoma mansoni	importin beta-1	0.0033	0.0042	0.0133
Schistosoma mansoni	bromodomain containing protein	0.0072	0.0199	0.0628
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0068	0.0182	0.0574
Brugia malayi	PHD-finger family protein	0.0028	0.0024	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0086	0.0081
Echinococcus granulosus	serine threonine protein kinase nrc	0.0067	0.0177	0.0558
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0018	0.0067
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0182	0.0574
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0072	0.0198	0.0193
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.0182	0.0574
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0018	0.0058
Schistosoma mansoni	serine/threonine protein kinase	0.0075	0.0211	0.0668
Brugia malayi	RNA, U transporter 1	0.0094	0.0284	0.0266
Brugia malayi	protein kinase C II.	0.0075	0.0211	0.0193
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0068	0.0182	0.0574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0114	0.0366	0.5118
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0096	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0089	0.0264	0.0834
Brugia malayi	Protein kinase domain containing protein	0.0114	0.0366	0.0349
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0044	0.0085	0.1587
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0182	0.2409
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0067	0.0177	0.0558
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0044	0.0085	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0053	0.0121	0.1521
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0059	0.0145	0.2678
Loa Loa (eye worm)	hypothetical protein	0.017	0.0591	0.0586
Brugia malayi	Egg laying defective protein 4	0.0089	0.0264	0.0246
Loa Loa (eye worm)	hypothetical protein	0.007	0.0189	0.0184
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0074	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0132	0.0438	0.042
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0044	0.0085	0.4048
Treponema pallidum	quinoline 2-oxidoreductase	0.0031	0.0036	0.8682
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0069	0.0185	0.0503
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.253	1	1
Schistosoma mansoni	protein kinase C mu	0.0072	0.0198	0.0625
Trichomonas vaginalis	AGC family protein kinase	0.0044	0.0085	0.0993
Entamoeba histolytica	hypothetical protein	0.0861	0.3346	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0018	0.0067
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Echinococcus granulosus	nervana 2	0.0062	0.0159	0.0503
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0018	0.0014
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0067	0.0177	0.0558
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus granulosus	cathepsin l1	0.0027	0.0018	0.0058
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0018	0.0067
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0018	0.0058
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0067	0.0177	1
Schistosoma mansoni	hypothetical protein	0.0351	0.1311	0.4143
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0069	0.0185	0.0503
Plasmodium falciparum	cGMP-dependent protein kinase	0.0089	0.0264	1
Echinococcus granulosus	protein kinase C gamma type	0.0068	0.0182	0.0574
Trichomonas vaginalis	AGC family protein kinase	0.0114	0.0366	0.5118
Loa Loa (eye worm)	ctsf protein	0.0027	0.0018	0.0014
Entamoeba histolytica	protein kinase, putative	0.0132	0.0438	0.1264
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0044	0.0085	0.4048
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0062	0.0159	0.0503
Schistosoma mansoni	serine/threonine-protein kinase	0.0069	0.0185	0.0583
Echinococcus granulosus	Protein kinase C brain isozyme	0.0075	0.0211	0.0668
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0044	0.0085	0.4048
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0018	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0053	0.0121	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0181	0.0176
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0044	0.0085	0.1619
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0046	0.0093	0.0228
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0198	0.0699	1
Echinococcus multilocularis	Glutaredoxin protein 5	0.0062	0.0159	0.0503
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0038	0.0061	0.0568
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0067	0.0177	0.3502
Brugia malayi	C1-like domain containing protein	0.0072	0.0198	0.018
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0068	0.0182	0.0574
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0013	0.0043
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0068	0.0182	0.0574
Echinococcus granulosus	protein kinase c epsilon type	0.0075	0.0211	0.0668
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0068	0.0182	0.0177
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0044	0.0085	0.1587
Echinococcus granulosus	nervana 2	0.0062	0.0159	0.0503
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.011	0.0349	0.4865
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0093	0.0283	0.618
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0013	0.0043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0044	0.0085	0.2714
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0018	0.0014
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0044	0.0085	0.1587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0018	0.0058
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0018	0.0067
Toxoplasma gondii	AGC kinase	0.013	0.043	1
Leishmania major	cathepsin L-like protease	0.0027	0.0018	0.0166
Echinococcus multilocularis	rho associated protein kinase	0.0816	0.3166	1
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Schistosoma mansoni	serine/threonine kinase	0.0068	0.0182	0.0574
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Loa Loa (eye worm)	hypothetical protein	0.017	0.0591	0.0586
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0089	0.0264	0.0259
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0044	0.0085	0.008
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0068	0.0182	0.0177
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus multilocularis	cysteine protease	0.0027	0.0018	0.0058
Toxoplasma gondii	AGC kinase	0.0044	0.0085	0.1619
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0044	0.0085	1
Trypanosoma cruzi	Protein kinase B	0.0069	0.0185	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0018	0.0058
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0075	0.0211	0.0668
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0089	0.0264	0.0834
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0042	0.1498
Leishmania major	protein kinase A catalytic subunit	0.0044	0.0085	1
Entamoeba histolytica	protein kinase, putative	0.0132	0.0438	0.1264
Giardia lamblia	Kinase, AGC PKA	0.0067	0.0177	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0042	0.0564
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0018	0.0058
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0067	0.0177	0.3502
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0085	0.008
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0068	0.0182	0.0177
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0093	0.0283	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Echinococcus granulosus	serine:threonine protein kinase N2	0.0068	0.0182	0.0574
Trichomonas vaginalis	cAMP-dependent protein kinase catalytic subunit, putative	0.0051	0.0113	0.1403
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Mycobacterium ulcerans	hypothetical protein	0.0084	0.0247	0.5267
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Schistosoma mansoni	serine/threonine-protein kinase	0.0069	0.0185	0.0583
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0067	0.0177	0.6442
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0068	0.0182	0.0177
Echinococcus multilocularis	rac serine:threonine kinase	0.0069	0.0185	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Trichomonas vaginalis	serine/threonine-protein kinase ypk, putative	0.0051	0.0113	0.1403
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0121	0.1521
Echinococcus multilocularis	cysteine protease	0.0027	0.0018	0.0058
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.013	0.043	0.0425
Echinococcus granulosus	muscleblind protein	0.017	0.0591	0.1866
Entamoeba histolytica	protein kinase 2, putative	0.0067	0.0177	0.0478
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0018	0.0014
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0044	0.0085	0.0269
Loa Loa (eye worm)	hypothetical protein	0.006	0.0151	0.0146
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0038	0.0061	0.0568
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0044	0.0085	0.4212
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0132	0.0438	0.0433
Echinococcus multilocularis	nervana 2	0.0062	0.0159	0.0503
Schistosoma mansoni	serine/threonine protein kinase	0.0816	0.3166	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0018	0.0017
Onchocerca volvulus		0.0816	0.3166	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0018	0.0003
Trichomonas vaginalis	AGC family protein kinase	0.0051	0.0113	0.1403
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0068	0.0182	0.0574
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.0374	0.5237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0018	0.0017
Entamoeba histolytica	protein kinase, putative	0.0068	0.0182	0.0494
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0093	0.0283	0.618
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.0438	0.6169
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0068	0.0182	0.0574
Echinococcus multilocularis	muscleblind protein	0.017	0.0591	0.1866

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	> 90 %	Percentage of organisms containing dark, swollen food vacuoles indicative of a block in hemoglobin degradation.	ChEMBL.	9276017
Cytoplasmic vacuolization (functional)	NT 0	Parasite cytoplasmic morphology was compared to that of controls and scored normal (-).	ChEMBL.	9276017
IC50 (functional)	= 5 uM	Inhibition of falcipain activity	ChEMBL.	9276017
IC50 (functional)	= 5 uM	Inhibition of falcipain activity	ChEMBL.	9276017
IC50 (functional)	= 30 uM	Tested for inhibition of parasite development (Ring-form parasitaemia).	ChEMBL.	9276017
IC50 (functional)	= 30 uM	Tested for inhibition of parasite development (Ring-form parasitaemia).	ChEMBL.	9276017
IC50 (functional)	= 100 uM	Tested for inhibition of parasite metabolism by measuring uptake of [3H]-hypoxanthine by cultured parasites.	ChEMBL.	9276017
IC50 (functional)	> 100 uM	Compound was tested for inhibition of MDCK cell metabolism using MTT assay method.	ChEMBL.	9276017
IC50 (functional)	= 100 uM	Tested for inhibition of parasite metabolism by measuring uptake of [3H]-hypoxanthine by cultured parasites.	ChEMBL.	9276017

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL91049

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 151237