Detailed information for compound 151341

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.828 | Formula: C18H14ClNOS
  • H donors: 1 H acceptors: 1 LogP: 4.27 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)SC1=C(O)CC(CC1=N2)c1ccccc1
  • InChi: 1S/C18H14ClNOS/c19-13-6-7-14-17(10-13)22-18-15(20-14)8-12(9-16(18)21)11-4-2-1-3-5-11/h1-7,10,12,21H,8-9H2
  • InChiKey: KMLXQGGKAVIFQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum cysteine proteinase falcipain 2a Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax vivapain-3 cysteine proteinase falcipain 2a 484 aa 497 aa 45.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.004 0.008 0.0251
Plasmodium falciparum cGMP-dependent protein kinase 0.009 0.0243 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0614 0.197 0.6178
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.01 0.0315
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0044 0.0093 0.0093
Brugia malayi Protein-tyrosine phosphatase 1 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.01 0.0315
Brugia malayi Protein-tyrosine phosphatase 0.004 0.008 0.008
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.008 0.0251
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0614 0.197 0.6178
Loa Loa (eye worm) hypothetical protein 0.006 0.0146 0.0146
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0036 0.0092
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0069 0.0174 0.0174
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Echinococcus granulosus protein tyrosine phosphatase n9 0.004 0.008 0.0251
Brugia malayi Egg laying defective protein 4 0.009 0.0243 0.0243
Onchocerca volvulus 0.006 0.0146 0.0436
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Loa Loa (eye worm) protein tyrosine phosphatase 0.004 0.008 0.008
Entamoeba histolytica hypothetical protein 0.0868 0.2807 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus serine threonine protein kinase nrc 0.0067 0.017 0.0533
Onchocerca volvulus 0.004 0.008 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus protein kinase c epsilon type 0.0076 0.0199 0.0623
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0043 0.2103
Brugia malayi Protein kinase domain containing protein 0.0134 0.0387 0.0387
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.008 0.0251
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0243 0.076
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Onchocerca volvulus 0.0979 0.3174 0.9951
Leishmania major tyrosine specific protein phosphatase, putative 0.004 0.008 0.7733
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.007 0.0177 0.0177
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0069 0.0174 0.0546
Echinococcus multilocularis inositol monophosphatase 1 0.0029 0.0043 0.0134
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Echinococcus multilocularis cysteine protease 0.0027 0.0036 0.0114
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.008 0.0251
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0053 0.0124 0.3064
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Onchocerca volvulus 0.0027 0.0036 0.0092
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Entamoeba histolytica protein kinase, putative 0.0069 0.0174 0.0596
Brugia malayi hypothetical protein 0.004 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0069 0.0174 0.0546
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0072 0.0186 0.0186
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0043 0.2103
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0036 0.0114
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.009 0.0243 0.5985
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.008 0.0251
Brugia malayi protein kinase C II. 0.0076 0.0199 0.0199
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0229 0.0701 0.2199
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0044 0.0093 0.1602
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.01 0.0315
Loa Loa (eye worm) AGC/NDR protein kinase 0.0069 0.0174 0.0174
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0036 0.0114
Onchocerca volvulus 0.0027 0.0036 0.0092
Loa Loa (eye worm) hypothetical protein 0.006 0.0146 0.0146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Brugia malayi C1-like domain containing protein 0.0072 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0036 0.0772
Giardia lamblia Kinase, AGC PKA 0.0044 0.0093 0.1418
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus protein kinase c iota type 0.0076 0.0199 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0093 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.008 0.0251
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0077 0.0242
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0069 0.0174 0.0546
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0614 0.197 0.197
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0174 0.0546
Loa Loa (eye worm) hypothetical protein 0.0137 0.04 0.04
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0177 0.0553
Toxoplasma gondii AGC kinase 0.0044 0.0093 0.1633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Onchocerca volvulus 0.004 0.008 0.0229
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Echinococcus granulosus cGMP dependent protein kinase 0.009 0.0243 0.076
Schistosoma mansoni serine/threonine kinase 0.0069 0.0174 0.0546
Echinococcus granulosus serine:threonine protein kinase N2 0.0069 0.0174 0.0546
Mycobacterium ulcerans hypothetical protein 0.0085 0.0227 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Onchocerca volvulus 0.004 0.008 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Echinococcus multilocularis cGMP dependent protein kinase 1 0.009 0.0243 0.076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0044 0.0093 0.5052
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0069 0.0174 0.0174
Toxoplasma gondii AGC kinase 0.0131 0.0381 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Brugia malayi p70 ribosomal S6 kinase beta 0.0131 0.0381 0.0381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0614 0.197 0.197
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0036 0.1733
Onchocerca volvulus 0.004 0.008 0.0229
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0229 0.0701 0.2199
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0043 0.1116
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0063 0.0154 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0199 0.0623
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0093 0.0291
Onchocerca volvulus 0.0068 0.017 0.0513
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.008 0.0251
Echinococcus multilocularis Glutaredoxin protein 5 0.0063 0.0154 0.0484
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Onchocerca volvulus 0.004 0.008 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Schistosoma mansoni inositol monophosphatase 0.0029 0.0043 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Onchocerca volvulus 0.004 0.008 0.0229
Toxoplasma gondii AGC kinase 0.0044 0.0093 0.1633
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.3051 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0069 0.0174 0.0546
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0072 0.0186 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0984 0.3189 1
Schistosoma mansoni inositol monophosphatase 0.0029 0.0043 0.0134
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Onchocerca volvulus 0.004 0.008 0.0229
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.004 0.008 0.0251
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0051 0.0117 0.2888
Brugia malayi cathepsin L-like precursor 0.0018 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0046 0.01 0.0315
Schistosoma mansoni rgs-gaip interacting protein gipc 0.004 0.008 0.0251
Loa Loa (eye worm) AGC/AKT protein kinase 0.0134 0.0387 0.0387
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0044 0.0093 0.5052
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0174 0.0546
Echinococcus multilocularis expressed conserved protein 0.009 0.0243 0.076
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0036 0.0036
Echinococcus granulosus inositol monophosphatase 1 0.0029 0.0043 0.0134
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0053 0.0124 0.3064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0046 0.01 0.0315
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0229 0.0701 0.2199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Echinococcus granulosus nervana 2 0.0063 0.0154 0.0484
Echinococcus granulosus cathepsin l1 0.0018 0.0007 0.0022
Brugia malayi Protein kinase domain containing protein 0.0115 0.0328 0.0328
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0328 0.8433
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0046 0.01 0.0315
Onchocerca volvulus 0.004 0.008 0.0229
Echinococcus multilocularis cGMP dependent protein kinase 1 0.009 0.0243 0.076
Leishmania major protein kinase A catalytic subunit 0.0044 0.0093 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0069 0.0177 1
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0093 0.2251
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0199 0.0623
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Schistosoma mansoni protein kinase C mu 0.0072 0.0186 0.0583
Echinococcus multilocularis rac serine:threonine kinase 0.0069 0.0177 0.0553
Echinococcus multilocularis protein kinase c epsilon type 0.0076 0.0199 0.0623
Onchocerca volvulus 0.0103 0.0288 0.0884
Echinococcus granulosus NDR protein kinase 0.0069 0.0174 0.0546
Brugia malayi Hr1 repeat family protein 0.0069 0.0174 0.0174
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Onchocerca volvulus 4.1 G protein, putative homolog 0.004 0.008 0.0229
Onchocerca volvulus 0.007 0.0177 0.0534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0067 0.017 0.0533
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.0036 0.1733
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0067 0.017 0.9606
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.008 0.43
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0026 0.0033 0.5
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.008 0.43
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0093 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0046 0.01 0.0315
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Onchocerca volvulus 0.004 0.008 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0076 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Leishmania major protein kinase A catalytic subunit isoform 1 0.0044 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Onchocerca volvulus 0.0027 0.0036 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0115 0.0328 0.8433
Brugia malayi Protein kinase domain containing protein 0.0069 0.0174 0.0174
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Schistosoma mansoni protein tyrosine phosphatase 0.0046 0.01 0.0315
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0044 0.0093 0.4216
Echinococcus multilocularis nervana 2 0.0063 0.0154 0.0484
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0063 0.0154 0.0484
Echinococcus multilocularis 0.004 0.008 0.0251
Echinococcus granulosus cGMP dependent protein kinase 1 0.009 0.0243 0.076
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0229 0.0701 0.0701
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0036 0.0105
Echinococcus multilocularis serine:threonine protein kinase 38 0.0069 0.0174 0.0546
Schistosoma mansoni atypical protein kinase C 0.0076 0.0199 0.0623
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0007
Brugia malayi hypothetical protein 0.004 0.008 0.008
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.004 0.008 0.008
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0069 0.0174 0.0546
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Loa Loa (eye worm) AGC/PKA protein kinase 0.0044 0.0093 0.0093
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0026 0.0033 0.5
Onchocerca volvulus 0.004 0.008 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0069 0.0174 0.0546
Echinococcus multilocularis rho associated protein kinase 0.0984 0.3189 1
Trichomonas vaginalis pten, drome, putative 0.004 0.008 0.1915
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.008 0.0251
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.0036 0.0036
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0029 0.0043 0.0179
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Onchocerca volvulus 0.004 0.008 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0131 0.0381 0.0381
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0036 0.1733
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0044 0.0093 0.2729
Onchocerca volvulus 0.004 0.008 0.0229
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.004 0.008 0.008
Loa Loa (eye worm) fibroinase 0.0027 0.0036 0.0036
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0046 0.01 0.0315
Onchocerca volvulus 0.004 0.008 0.0229
Onchocerca volvulus 0.004 0.008 0.0229
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.008 0.0251
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0097 0.0268 0.0268
Onchocerca volvulus 0.004 0.008 0.0229
Onchocerca volvulus Cathepsin L homolog 0.0027 0.0036 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0069 0.0174 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0199 0.0623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Loa Loa (eye worm) cysteine protease 0.0027 0.0036 0.0036
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0044 0.0093 0.1602
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0029 0.0043 0.5
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0177 0.0605
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0111 0.0312 0.8027
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.008 0.0251
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0229 0.0701 0.2199
Loa Loa (eye worm) hypothetical protein 0.0068 0.017 0.017
Schistosoma mansoni serine/threonine-protein kinase 0.0069 0.0177 0.0553
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Echinococcus multilocularis nervana 2 0.0063 0.0154 0.0484
Loa Loa (eye worm) ctsf protein 0.0027 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0029 0.0043 0.0127
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.0036 0.0114
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0046 0.01 0.01
Brugia malayi hypothetical protein 0.004 0.008 0.008
Schistosoma mansoni vav2 0.0018 0.0007 0.0021
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0077 0.0242
Onchocerca volvulus 0.0027 0.0036 0.0092
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.01 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Loa Loa (eye worm) AGC/PKA protein kinase 0.0044 0.0093 0.0093
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0099 0.033
Onchocerca volvulus 0.004 0.008 0.0229
Onchocerca volvulus 0.004 0.008 0.0229
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0067 0.017 0.0533
Echinococcus multilocularis serine threonine protein kinase 0.0069 0.0174 0.0546
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.004 0.008 0.43
Schistosoma mansoni protein-tyrosine phosphatase n9 0.004 0.008 0.0251
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0036 0.1733
Leishmania major protein kinase A catalytic subunit isoform 2 0.0044 0.0093 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0076 0.0199 0.0623
Trichomonas vaginalis inositol monophosphatase, putative 0.0029 0.0043 0.0937
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0043 0.0937
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0029 0.0043 0.0182
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Schistosoma mansoni pcd6 interacting protein-related 0.004 0.008 0.0251
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Onchocerca volvulus 0.0027 0.0036 0.0092
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Leishmania major protein-tyrosine phosphatase 1-like protein 0.004 0.008 0.7733
Onchocerca volvulus 0.004 0.008 0.0229
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0044 0.0093 0.1633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Onchocerca volvulus Cathepsin F homolog 0.0027 0.0036 0.0092
Entamoeba histolytica cysteine protease, putative 0.0027 0.0036 0.0105
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0614 0.197 0.6178
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.004 0.008 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0174 0.0546
Entamoeba histolytica protein kinase, putative 0.0134 0.0387 0.1359
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus nervana 2 0.0063 0.0154 0.0484
Onchocerca volvulus 0.004 0.008 0.0229
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0115 0.0328 0.0328
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0243 0.076
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0069 0.0174 0.0546
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0335 0.8609
Loa Loa (eye worm) hypothetical protein 0.0097 0.0268 0.0268
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0177 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.004 0.008 0.0251
Giardia lamblia Kinase, AGC PKA 0.0067 0.017 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.01 0.0315
Echinococcus granulosus protein kinase C gamma type 0.0069 0.0174 0.0546
Brugia malayi Inositol-1 0.0029 0.0043 0.0043
Brugia malayi Protein-tyrosine phosphatase 0.0144 0.0421 0.0421
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.008 0.0251
Brugia malayi Cathepsin L-like precursor 0.0027 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Onchocerca volvulus 0.0984 0.3189 1
Echinococcus multilocularis hypothetical protein 0.004 0.008 0.0251
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0036
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Echinococcus granulosus rho-associated protein kinase 1 0.0984 0.3189 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0046 0.01 0.0315
Entamoeba histolytica protein kinase, putative 0.0134 0.0387 0.1359
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0044 0.0093 0.5052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.0036 0.0114
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0229 0.0701 0.0701
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0067 0.017 0.6473
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0036 0.0114
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Entamoeba histolytica protein kinase, putative 0.0131 0.0381 0.1335
Trypanosoma brucei protein tyrosine phosphatase 1 0.004 0.008 0.1239
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.004 0.008 0.0251
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0051 0.0117 0.2888
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.0022
Loa Loa (eye worm) AGC/PKN protein kinase 0.0069 0.0174 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Onchocerca volvulus 0.004 0.008 0.0229
Echinococcus multilocularis cysteine protease 0.0027 0.0036 0.0114
Trypanosoma cruzi Protein kinase B 0.0069 0.0177 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0174 0.4389
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0124 0.3064
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0067 0.017 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Brugia malayi hypothetical protein 0.004 0.008 0.008
Echinococcus multilocularis serine:threonine protein kinase N2 0.0069 0.0174 0.0546
Onchocerca volvulus 0.004 0.008 0.0229
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0097 0.0268 0.0268
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0046 0.01 0.0315
Echinococcus multilocularis protein kinase c iota type 0.0076 0.0199 0.0623
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0099 0.033
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.0036 0.0114
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.0036 0.0772
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0036 0.0114
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.004 0.008 0.0251
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.0036 0.0114
Brugia malayi hypothetical protein 0.004 0.008 0.008
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0044 0.0093 0.1602
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0036 0.0105
Echinococcus granulosus Glutaredoxin protein 5 0.0063 0.0154 0.0484
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) hypothetical protein 0.004 0.008 0.008
Echinococcus granulosus serine/threonine protein kinase 0.0069 0.0177 0.0553
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.008 0.0251
Loa Loa (eye worm) inositol-1 0.0029 0.0043 0.0043
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.008 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0036 0.1733
Onchocerca volvulus 0.004 0.008 0.0229
Onchocerca volvulus 0.0027 0.0036 0.0092
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.008 0.0251
Brugia malayi Cathepsin L-like cysteine proteinase 0.0018 0.0007 0.0007
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.008 0.026
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0044 0.0093 0.5052
Brugia malayi Dual specificity protein phosphatase CDC14B 0.004 0.008 0.008
Trichomonas vaginalis AGC family protein kinase 0.0134 0.0387 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0065 0.0161 0.0161
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0051 0.0117 0.2888
Echinococcus multilocularis protein tyrosine phosphatase n9 0.004 0.008 0.0251
Echinococcus granulosus cGMP dependent protein kinase 1 0.009 0.0243 0.076
Echinococcus granulosus cathepsin l1 0.0027 0.0036 0.0114
Onchocerca volvulus 0.0027 0.0036 0.0092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.008 0.008
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.004 0.008 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0036 0.0772
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0174 0.0546
Onchocerca volvulus 0.004 0.008 0.0229
Trypanosoma brucei rac serine-threonine kinase, putative 0.0134 0.0387 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0076 0.0199 0.0623
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.004 0.008 0.008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0029 0.0043 0.0937
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.008 0.0251
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0117 0.2888
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.008 0.008
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0046 0.01 0.0315
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.01 0.0315
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.008 0.0251
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0044 0.0093 0.0291
Entamoeba histolytica protein kinase 2, putative 0.0067 0.017 0.0581
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0229 0.0701 0.2199
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0046 0.01 0.0315
Loa Loa (eye worm) AGC/PKG protein kinase 0.009 0.0243 0.0243

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM Inhibition of falcipain activity ChEMBL. 9276017
IC50 (functional) = 10 uM Inhibition of falcipain activity ChEMBL. 9276017

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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