TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 501.409 | Formula: C26H29BrO5
H donors: 1 H acceptors: 2 LogP: 6.85 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1C(C(=C)C)C)C(=O)/C=C/c1cc(Br)c(cc1O)OC1CCCCO1
InChi: 1S/C26H29BrO5/c1-16(2)17(3)20-13-18(9-11-24(20)30-4)22(28)10-8-19-14-21(27)25(15-23(19)29)32-26-7-5-6-12-31-26/h8-11,13-15,17,26,29H,1,5-7,12H2,2-4H3/b10-8+
InChiKey: LYOJJHXOAUWTNC-CSKARUKUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0051	0.0259
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Onchocerca volvulus		0.0087	0.0334	0.5325
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.0002	0.0008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0134	0.1243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0147	0.0625	0.3177
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0002	0.0008
Onchocerca volvulus		0.0087	0.0334	0.5325
Loa Loa (eye worm)	beta-lactamase	0.0147	0.0625	0.3183
Loa Loa (eye worm)	cysteine protease	0.0087	0.0334	0.1699
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0197	0.2377
Chlamydia trachomatis	transglycolase/transpeptidase	0.0098	0.0389	0.5
Mycobacterium tuberculosis	Probable lipase LipE	0.0147	0.0625	0.0246
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0045	0.0134	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0197	0.1005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Mycobacterium leprae	conserved hypothetical protein	0.0147	0.0625	0.0541
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Onchocerca volvulus		0.0147	0.0625	1
Echinococcus granulosus	cathepsin b	0.0062	0.0213	0.1075
Mycobacterium tuberculosis	Conserved protein	0.0147	0.0625	0.0246
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0147	0.0625	0.3177
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.0334	1
Schistosoma mansoni	cathepsin s	0.0028	0.0051	0.0251
Mycobacterium tuberculosis	Probable esterase LipL	0.0147	0.0625	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.2082	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0028	0.0051	0.0259
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0147	0.0625	0.3183
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Giardia lamblia	Cathepsin B precursor	0.0031	0.0064	0.5
Plasmodium vivax	vivapain-2	0.0087	0.0334	0.4923
Trypanosoma cruzi	hypothetical protein, conserved	0.0147	0.0625	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0147	0.0625	0.0246
Brugia malayi	beta-lactamase family protein	0.0147	0.0625	0.3177
Leishmania major	cathepsin L-like protease	0.0087	0.0334	0.4806
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0937	0.4456	0.4232
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Onchocerca volvulus		0.0058	0.0197	0.3139
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0087	0.0334	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Leishmania major	cathepsin L-like protease	0.0119	0.049	0.759
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Loa Loa (eye worm)	cathepsin B	0.0031	0.0064	0.0325
Brugia malayi	beta-lactamase family protein	0.0147	0.0625	0.3177
Onchocerca volvulus		0.0147	0.0625	1
Giardia lamblia	Cathepsin B precursor	0.0031	0.0064	0.5
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0079	0.0295	0.1495
Schistosoma mansoni	lipoxygenase	0.0079	0.0295	0.1495
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0134	0.0673
Trichomonas vaginalis	D-aminoacylase, putative	0.0147	0.0625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Echinococcus multilocularis	cathepsin L	0.0045	0.0134	0.0673
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0134	0.1243
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0031	0.0064	0.0318
Echinococcus granulosus	cysteine protease	0.0045	0.0134	0.0673
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0062	0.0213	0.2815
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0087	0.0334	0.1699
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0197	0.0997
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0028	0.0051	0.0251
Echinococcus multilocularis	cysteine protease	0.0087	0.0334	0.1692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.0389	0.5789
Mycobacterium tuberculosis	Conserved protein	0.0147	0.0625	0.0246
Leishmania major	cathepsin L-like protease	0.0087	0.0334	0.4806
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Plasmodium vivax	vivapain-3	0.0045	0.0134	0.1441
Echinococcus granulosus	beta LACTamase domain containing family member	0.0147	0.0625	0.3177
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0423	0.1965	1
Brugia malayi	beta-lactamase	0.0147	0.0625	0.3177
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0213	0.1075
Trypanosoma brucei	beta lactamase	0.0999	0.4756	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0147	0.0625	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Onchocerca volvulus		0.0087	0.0334	0.5325
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0197	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Mycobacterium tuberculosis	Probable hydrolase	0.0147	0.0625	0.0246
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0213	0.1075
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0999	0.4756	0.4543
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0087	0.0334	0.1692
Mycobacterium leprae	Probable lipase LipE	0.0147	0.0625	0.0541
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0147	0.0625	0.3177
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0147	0.0625	0.0246
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0423	0.1965	1
Mycobacterium ulcerans	lipoprotein LpqF	0.0999	0.4756	0.4543
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Echinococcus multilocularis	cathepsin b	0.0062	0.0213	0.1075
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0999	0.4756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0134	0.0149
Plasmodium vivax	unspecified product	0.0045	0.0134	0.1441
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0087	0.0334	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Leishmania major	cathepsin L-like protease	0.0087	0.0334	0.4806
Onchocerca volvulus	Cathepsin F homolog	0.0087	0.0334	0.5325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0423	0.1965	1
Echinococcus multilocularis	cathepsin b	0.0062	0.0213	0.1075
Mycobacterium ulcerans	hypothetical protein	0.0147	0.0625	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0051	0.0259
Loa Loa (eye worm)	fibroinase	0.0087	0.0334	0.1699
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0134	0.0673
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0087	0.0334	0.4806
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0147	0.0625	0.3177
Trichomonas vaginalis	penicillin-binding protein, putative	0.0147	0.0625	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0197	0.2377
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0098	0.0389	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0134	0.1441
Onchocerca volvulus		0.0087	0.0334	0.5325
Mycobacterium ulcerans	esterase/lipase LipP	0.0147	0.0625	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0087	0.0334	0.4806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0119	0.049	0.0908
Loa Loa (eye worm)	ctsf protein	0.0087	0.0334	0.1699
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0154	0.1789
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0134	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0197	0.1005
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.049	0.7645
Echinococcus granulosus	cathepsin l1	0.0058	0.0197	0.0997
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0197	0.0997
Echinococcus granulosus	cathepsin L	0.0045	0.0134	0.0673
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0087	0.0334	0.1692
Trypanosoma cruzi	hypothetical protein, conserved	0.0147	0.0625	1
Onchocerca volvulus		0.0087	0.0334	0.5325
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.0197	0.0997
Trypanosoma cruzi	cysteine peptidase, putative	0.0045	0.0134	0.1441
Schistosoma mansoni	cathepsin F (C01 family)	0.0087	0.0334	0.1692
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0423	0.1965	1
Echinococcus multilocularis	cysteine protease	0.0087	0.0334	0.1692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0087	0.0334	1
Leishmania major	cathepsin L-like protease	0.0087	0.0334	0.4806
Echinococcus multilocularis	cathepsin L cysteine protease	0.0087	0.0334	0.1692
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Onchocerca volvulus	Cathepsin L homolog	0.0087	0.0334	0.5325
Trypanosoma brucei	hypothetical protein, conserved	0.0147	0.0625	0.1197
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0031	0.0064	0.0226
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0091	0.0354	0.527
Treponema pallidum	penicillin-binding protein (pbp-3)	0.0098	0.0389	0.5
Entamoeba histolytica	cysteine protease, putative	0.0087	0.0334	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0147	0.0625	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0213	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0334	0.1699
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0098	0.0389	0.5
Schistosoma mansoni	lipoxygenase	0.0055	0.0181	0.0912
Trypanosoma cruzi	cysteine peptidase, putative	0.0087	0.0334	0.4923
Mycobacterium ulcerans	lipase LipD	0.0147	0.0625	0.0246
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0058	0.0197	0.0997
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0062	0.0213	0.1075
Onchocerca volvulus		0.0087	0.0334	0.5325
Trichomonas vaginalis	D-aminoacylase, putative	0.0147	0.0625	1
Mycobacterium ulcerans	beta-lactamase	0.0147	0.0625	0.0246
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0134	0.0673
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0134	0.0673
Echinococcus multilocularis	cathepsin L cysteine protease	0.0087	0.0334	0.1692
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0423	0.1965	1
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.0002	0.0008
Brugia malayi	cathepsin L-like precursor	0.0058	0.0197	0.0997
Leishmania major	hypothetical protein, conserved	0.0147	0.0625	1
Plasmodium vivax	vivapain-2	0.0087	0.0334	0.4923
Brugia malayi	Cathepsin L-like precursor	0.0028	0.0051	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0625	0.3183
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0087	0.0334	0.1692
Chlamydia trachomatis	transglycolase/transpeptidase	0.0098	0.0389	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0051	0.0259
Giardia lamblia	Cathepsin B precursor	0.0031	0.0064	0.5
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Onchocerca volvulus	Cathepsin L homolog	0.0087	0.0334	0.5325
Trypanosoma cruzi	cruzipain precursor, putative	0.0119	0.049	0.7645
Trichomonas vaginalis	penicillin-binding protein, putative	0.0147	0.0625	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0147	0.0625	0.0246
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0134	0.0149
Echinococcus granulosus	cathepsin L cysteine protease	0.0045	0.0134	0.0673
Leishmania major	cathepsin L-like protease	0.0119	0.049	0.759
Trypanosoma cruzi	cysteine protease, putative	0.0045	0.0134	0.1441
Toxoplasma gondii	ABC1 family protein	0.0147	0.0625	1
Toxoplasma gondii	cathepsin CPL	0.0087	0.0334	0.4806
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0098	0.0389	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.0334	0.4806
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0079	0.0295	0.1495
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.0334	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0087	0.0334	0.4806
Brugia malayi	cathepsin B-like cysteine proteinase	0.0062	0.0213	0.1075
Leishmania major	cathepsin L-like protease	0.0087	0.0334	0.4806
Plasmodium vivax	hypothetical protein, conserved	0.0147	0.0625	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.049	0.7645
Brugia malayi	Cathepsin L-like precursor	0.0087	0.0334	0.1692
Schistosoma mansoni	cathepsin F (C01 family)	0.0087	0.0334	0.1692
Brugia malayi	cathepsin F-like cysteine proteinase	0.0028	0.0051	0.0251
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.049	0.7645
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0087	0.0334	0.1692
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0197	0.1005
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.0334	0.1692
Echinococcus granulosus	cathepsin l1	0.0087	0.0334	0.1692
Mycobacterium tuberculosis	Conserved protein	0.0147	0.0625	0.0246
Echinococcus granulosus	cathepsin b	0.0062	0.0213	0.1075
Leishmania major	cathepsin L-like protease	0.0119	0.049	0.759
Onchocerca volvulus		0.0147	0.0625	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0087	0.0334	0.1699
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0147	0.0625	0.0246
Leishmania major	cysteine peptidase A (CPA)	0.0087	0.0334	0.4806
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0134	0.1441
Onchocerca volvulus		0.0087	0.0334	0.5325
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.0213	0.1075
Trichomonas vaginalis	esterase, putative	0.0147	0.0625	1
Plasmodium vivax	vivapain-1	0.0045	0.0134	0.1441

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.9 uM	Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 mins	ChEMBL.	21555221

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1779056

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1524519