Detailed information for compound 1527066

Basic information

Technical information
  • TDR Targets ID: 1527066
  • Name: 2-(2-methoxyphenyl)-1H-pyrrole
  • MW: 173.211 | Formula: C11H11NO
  • H donors: 1 H acceptors: 0 LogP: 2.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1c1[nH]ccc1
  • InChi: 1S/C11H11NO/c1-13-11-7-3-2-5-9(11)10-6-4-8-12-10/h2-8,12H,1H3
  • InChiKey: UCSKMYPSQKBZGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0169 0.4355 0.4482
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0643 0.2439
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Schistosoma mansoni cpg binding protein 0.003 0.0585 0.0489
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0285 0.0199
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0071 0.168 0.7305
Mycobacterium tuberculosis Possible oxidoreductase 0.0071 0.168 0.352
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.3793 0.45
Leishmania major UDP-galactopyranose mutase 0.0071 0.168 0.1909
Loa Loa (eye worm) hypothetical protein 0.0348 0.9202 0.9201
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0541 0.0538
Brugia malayi MH2 domain containing protein 0.0124 0.3129 0.3129
Trypanosoma cruzi UDP-galactopyranose mutase 0.0071 0.168 0.1909
Schistosoma mansoni cpg binding protein 0.0029 0.0541 0.0442
Schistosoma mansoni hypothetical protein 0.0016 0.0207 0.0089
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.3789 1
Echinococcus granulosus heat shock protein 0.0032 0.0643 0.0669
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0348 0.9202 0.962
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.8005 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0207 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0285 0.0199
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0071 0.168 0.7305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Brugia malayi heat shock protein 90 0.0032 0.0643 0.0643
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1052 0.1052
Schistosoma mansoni heat shock protein 0.0032 0.0643 0.0551
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Plasmodium falciparum endoplasmin, putative 0.002 0.0303 0.0842
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0464 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Trypanosoma cruzi UDP-galactopyranose mutase 0.0071 0.168 0.1909
Onchocerca volvulus 0.004 0.0843 0.0729
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Echinococcus granulosus dna polymerase eta 0.0019 0.0285 0.0295
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0285 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0207 0.0207
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0285 0.0206
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0071 0.168 0.3659
Entamoeba histolytica hypothetical protein 0.0029 0.0561 0.0555
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1052 0.1097
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0843 0.0879
Plasmodium falciparum protoporphyrinogen oxidase 0.0071 0.168 0.7305
Loa Loa (eye worm) hypothetical protein 0.004 0.0843 0.0841
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0092 0.2255 0.4969
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0643 0.066
Onchocerca volvulus 0.0377 1 1
Loa Loa (eye worm) hypothetical protein 0.0361 0.9565 0.9565
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0123 0.0126
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0207 0.0213
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0643 0.2439
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans hypothetical protein 0.0092 0.2255 0.4969
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0843 0.0879
Echinococcus granulosus protein MICAL 3 0.0092 0.2255 0.2355
Loa Loa (eye worm) hypothetical protein 0.0029 0.0561 0.0558
Loa Loa (eye worm) hypothetical protein 0.0035 0.0723 0.072
Brugia malayi GH02984p 0.0361 0.9565 0.9565
Echinococcus granulosus high affinity choline transporter 1 0.0361 0.9565 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0207 0.0213
Echinococcus granulosus lysine specific histone demethylase 1A 0.0348 0.9202 0.962
Toxoplasma gondii SWIRM domain-containing protein 0.0029 0.0561 0.2053
Mycobacterium ulcerans hypothetical protein 0.0092 0.2255 0.4969
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.8005 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.3129 0.3127
Toxoplasma gondii hypothetical protein 0.0051 0.1136 0.4751
Trypanosoma brucei unspecified product 0.0019 0.0285 0.0199
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0643 0.066
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.3793 0.45
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.8279 1
Plasmodium falciparum heat shock protein 90 0.0032 0.0643 0.2439
Giardia lamblia hypothetical protein 0.0029 0.0561 0.0357
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0092 0.2255 0.5387
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0123 0.0126
Echinococcus multilocularis dna polymerase eta 0.0019 0.0285 0.0295
Brugia malayi amine oxidase, flavin-containing family protein 0.01 0.2479 0.2479
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0092 0.2255 0.2355
Echinococcus granulosus GPCR family 2 0.0016 0.0207 0.0213
Brugia malayi hypothetical protein 0.0071 0.168 0.168
Schistosoma mansoni hypothetical protein 0.0092 0.2255 0.2258
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Echinococcus granulosus dna polymerase kappa 0.0019 0.0285 0.0295
Mycobacterium tuberculosis Possible oxidoreductase 0.0092 0.2255 0.4969
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0464 0.045
Echinococcus multilocularis cpg binding protein 0.003 0.0585 0.0609
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.2255 0.4969
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Echinococcus granulosus heat shock protein 90 0.0032 0.0643 0.0669
Echinococcus granulosus cpg binding protein 0.003 0.0585 0.0609
Schistosoma mansoni sodium/solute symporter 0.004 0.0843 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Echinococcus multilocularis endoplasmin 0.0026 0.0464 0.0482
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0643 0.0638
Schistosoma mansoni high-affinity choline transporter 0.0361 0.9565 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0643 0.0638
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.3789 0.884
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0285 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0285 0.0285
Leishmania major hypothetical protein, conserved 0.0092 0.2255 0.2613
Trichomonas vaginalis endoplasmin, putative 0.002 0.0303 0.0228
Schistosoma mansoni endoplasmin 0.0032 0.0643 0.0551
Mycobacterium tuberculosis Possible oxidoreductase 0.0092 0.2255 0.4969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1052 0.1097
Echinococcus multilocularis geminin 0.0169 0.4355 0.4551
Loa Loa (eye worm) hypothetical protein 0.0052 0.1168 0.1165
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0643 0.0464
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0464 0.0432
Trypanosoma brucei Monooxygenase, putative 0.0092 0.2255 0.2614
Plasmodium falciparum FAD-dependent monooxygenase, putative 0.0092 0.2255 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0285 0.0199
Toxoplasma gondii FAD binding domain-containing protein 0.0092 0.2255 1
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0643 0.066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0285 0.0282
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0123 0.012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1052 0.1097
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0071 0.168 0.352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1168 0.1165
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.8279 1
Trypanosoma brucei kynurenine 3-monooxygenase, putative 0.0092 0.2255 0.2614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0207 0.0213
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1413 0.1366
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0029 0.0561 0.0583
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0464 0.0418
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.096 0.1026
Schistosoma mansoni hypothetical protein 0.0016 0.0207 0.0089
Echinococcus multilocularis heat shock protein 90 0.0032 0.0643 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0285 0.0295
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0282 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.8005 1
Trichomonas vaginalis heat shock protein, putative 0.002 0.0303 0.0228
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0643 0.0638
Schistosoma mansoni SWI/SNF complex-related 0.0029 0.0561 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0071 0.168 0.352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans oxidoreductase 0.0092 0.2255 0.4969
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0843 0.0879
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0843 0.3379
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.3793 0.45
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0643 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1052 0.0984
Plasmodium vivax hypothetical protein, conserved 0.0071 0.168 0.7305
Plasmodium vivax hypothetical protein, conserved 0.0071 0.168 0.7305
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.8279 1
Echinococcus granulosus geminin 0.0169 0.4355 0.4551
Schistosoma mansoni inositol transporter 0.004 0.0843 0.0763
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Plasmodium vivax hypothetical protein, conserved 0.0092 0.2255 1
Mycobacterium ulcerans hypothetical protein 0.0092 0.2255 0.4969
Loa Loa (eye worm) hypothetical protein 0.0348 0.9202 0.9201
Mycobacterium ulcerans oxidoreductase 0.0071 0.168 0.352
Echinococcus multilocularis heat shock protein 0.0032 0.0643 0.0669
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0643 0.0638
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0285 0.0282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0561 0.0555
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0843 0.0879
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0464 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1052 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0285 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.1222 0.1347
Schistosoma mansoni monoxygenase 0.0092 0.2255 0.2258
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0723 0.0723
Chlamydia trachomatis monooxygenase 0.0092 0.2255 1
Schistosoma mansoni hypothetical protein 0.0016 0.0207 0.0089
Schistosoma mansoni hypothetical protein 0.0016 0.0207 0.0089
Loa Loa (eye worm) endoplasmin 0.0032 0.0643 0.064
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.8005 1
Echinococcus multilocularis solute carrier family 5 0.004 0.0843 0.0879
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0092 0.2255 0.4969
Leishmania major DNA polymerase eta, putative 0.0019 0.0285 0.0199
Brugia malayi Endoplasmin precursor 0.0032 0.0643 0.0643
Schistosoma mansoni amine oxidase 0.0071 0.168 0.1649
Plasmodium vivax FAD-dependent monooxygenase, putative 0.0092 0.2255 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0843 0.0879
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0092 0.2255 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0071 0.168 0.7305
Brugia malayi SWIRM domain containing protein 0.0029 0.0561 0.0561
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0643 0.064
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0285 0.0206
Schistosoma mansoni amine oxidase 0.0071 0.168 0.1649
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0207 0.0213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0207 0.0204
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Loa Loa (eye worm) hypothetical protein 0.0071 0.168 0.1678
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0092 0.2255 0.2355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1168 0.1168
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0285 0.0295
Leishmania major hypothetical protein, conserved 0.0092 0.2255 0.2613
Schistosoma mansoni heat shock protein 0.0032 0.0643 0.0551
Echinococcus multilocularis protoporphyrinogen oxidase 0.0071 0.168 0.1754
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0464 0.045
Schistosoma mansoni hypothetical protein 0.0035 0.0723 0.0636
Brugia malayi Sodium:solute symporter family protein 0.004 0.0843 0.0843
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1168 0.1168
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Schistosoma mansoni inositol transporter 0.004 0.0843 0.0763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Echinococcus multilocularis high affinity choline transporter 1 0.0361 0.9565 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0285 0.0172
Entamoeba histolytica SWIRM domain protein 0.0029 0.0561 0.0555
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0643 0.0638
Brugia malayi Hsp90 protein 0.0013 0.0123 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0643 0.0638
Leishmania major DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.4249 1
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0843 0.0879
Toxoplasma gondii FAD binding domain-containing protein 0.0092 0.2255 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1052 0.1097
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0092 0.2255 0.4969
Echinococcus multilocularis heat shock protein 90 0.0026 0.0464 0.0482
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0348 0.9202 0.9615
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.3129 0.3127
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1052 0.1049
Mycobacterium ulcerans oxidoreductase 0.0092 0.2255 0.4969
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0207 0.0207
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans hypothetical protein 0.0165 0.4249 1
Schistosoma mansoni hypothetical protein 0.0169 0.4355 0.4482
Toxoplasma gondii histone lysine-specific demethylase 0.0071 0.168 0.7305
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0072 0.1728 0.7528
Mycobacterium ulcerans monoamine oxidase 0.0071 0.168 0.352
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0643 0.0638
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0071 0.168 0.352
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Echinococcus granulosus solute carrier family 5 0.004 0.0843 0.0879
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0071 0.168 0.7305
Echinococcus multilocularis protein MICAL 3 0.0092 0.2255 0.2355
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.096 0.1026
Trypanosoma cruzi Monooxygenase, putative 0.0092 0.2255 0.2613
Loa Loa (eye worm) hypothetical protein 0.0092 0.2255 0.2252
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0464 0.0432
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0643 0.0638
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.096 0.1026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.096 0.1026
Loa Loa (eye worm) hypothetical protein 0.0071 0.168 0.1678
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.3789 0.884
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.2255 0.2613
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0464 0.0418
Loa Loa (eye worm) hypothetical protein 0.0377 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0561 0.0555
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0285 0.0199
Leishmania major heat shock protein 83-1 0.0032 0.0643 0.0638
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0285 0.0295
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1052 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium tuberculosis Possible oxidoreductase 0.0092 0.2255 0.4969
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0843 0.0879
Schistosoma mansoni cpg binding protein 0.003 0.0585 0.0489
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans oxidoreductase GMC-type 0.0092 0.2255 0.4969
Schistosoma mansoni endoplasmin 0.0032 0.0643 0.0551
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0285 0.0199
Mycobacterium ulcerans dehydrogenase 0.0071 0.168 0.352
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0464 0.0418
Giardia lamblia Grp94/Hsp90 0.0026 0.0464 0.0231
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.8279 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.168 0.352
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0029 0.0561 0.0583
Entamoeba histolytica SWIRM domain protein 0.0029 0.0561 0.0555
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0541 0.0541
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1237 0.5225
Echinococcus granulosus lysine specific histone demethylase 1A 0.0071 0.168 0.1754
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.8005 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0285 0.0172
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0207 0.0213
Echinococcus granulosus heat shock protein 90 0.0026 0.0464 0.0482
Onchocerca volvulus 0.0029 0.0541 0.0423
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0643 0.2439
Plasmodium vivax endoplasmin, putative 0.0032 0.0643 0.2439
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0464 0.0231
Loa Loa (eye worm) hypothetical protein 0.01 0.2479 0.2477
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.2255 0.4969
Echinococcus multilocularis 0.0071 0.168 0.1754
Echinococcus granulosus endoplasmin 0.0026 0.0464 0.0482
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0071 0.168 0.1649

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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