Detailed information for compound 1528581

Basic information

Technical information
  • TDR Targets ID: 1528581
  • Name: [1,3]thiazolo[3,2-a]benzimidazole
  • MW: 174.222 | Formula: C9H6N2S
  • H donors: 0 H acceptors: 1 LogP: 2.47 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)n1ccsc1n2
  • InChi: 1S/C9H6N2S/c1-2-4-8-7(3-1)10-9-11(8)5-6-12-9/h1-6H
  • InChiKey: IHCQWURUZRYCIU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • thiazolo[3,2-a]benzimidazole
  • STOCK1S-57872
  • SMR000039495
  • MLS000078903

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0165 0.2933
Echinococcus multilocularis cysteine protease 0.0019 0.0009 0.0046
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.016 0.0426 0.088
Mycobacterium tuberculosis Conserved protein 0.0201 0.0546 0.054
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.1636 0.4776 0.4772
Toxoplasma gondii ABC1 family protein 0.0201 0.0546 1
Trichomonas vaginalis D-aminoacylase, putative 0.0201 0.0546 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Leishmania major cathepsin L-like protease 0.0072 0.0165 0.2933
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Trypanosoma brucei beta lactamase 0.1636 0.4776 1
Leishmania major hypothetical protein, conserved 0.0201 0.0546 1
Echinococcus granulosus lamin 0.0029 0.004 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0009 0.0046
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.016 0.0426 0.042
Onchocerca volvulus 0.0019 0.0009 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0119
Trichomonas vaginalis penicillin-binding protein, putative 0.0201 0.0546 1
Echinococcus granulosus lamin dm0 0.0029 0.004 0.0626
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0021 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0021 0.026
Mycobacterium leprae Probable lipase LipE 0.0201 0.0546 0.1131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Mycobacterium ulcerans lipoprotein LpqF 0.1636 0.4776 0.4772
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.016 0.0426 0.042
Leishmania major cathepsin L-like protease 0.0019 0.0009 0.0046
Plasmodium vivax vivapain-2 0.0019 0.0009 0.0046
Mycobacterium ulcerans lipase LipD 0.0201 0.0546 0.054
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.1636 0.4776 1
Brugia malayi hypothetical protein 0.0021 0.0017 0.031
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0021 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Onchocerca volvulus 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0009 0.1786
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0009 0.1786
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0021 0.026
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0009 0.0046
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0021 0.026
Trichomonas vaginalis D-aminoacylase, putative 0.0201 0.0546 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0009 0.1786
Mycobacterium tuberculosis Probable lipase LipD 0.0201 0.0546 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0009 0.1786
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0009 0.0046
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0009 0.0046
Leishmania major cathepsin L-like protease 0.0019 0.0009 0.0046
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0018 0.0006 0.0119
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0201 0.0546 1
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0017 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0018 0.0006 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0546 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0017 0.0194
Brugia malayi beta-lactamase family protein 0.0201 0.0546 1
Onchocerca volvulus 0.0201 0.0546 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0021 0.0376
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0017 0.0194
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.3408 1 1
Treponema pallidum penicillin-binding protein (pbp-2) 0.016 0.0426 1
Schistosoma mansoni hypothetical protein 0.0021 0.0017 0.0194
Mycobacterium leprae conserved hypothetical protein 0.0201 0.0546 0.1131
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0201 0.0546 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Echinococcus granulosus beta LACTamase domain containing family member 0.0201 0.0546 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0201 0.0546 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.016 0.0426 0.042
Treponema pallidum penicillin-binding protein (pbp-3) 0.016 0.0426 1
Loa Loa (eye worm) ctsf protein 0.0019 0.0009 0.0165
Mycobacterium tuberculosis Probable lipase LipE 0.0201 0.0546 0.054
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0009 0.0046
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0201 0.0546 1
Brugia malayi hypothetical protein 0.0021 0.0017 0.031
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.016 0.0426 1
Mycobacterium tuberculosis Probable esterase LipL 0.0201 0.0546 0.054
Trichomonas vaginalis D-aminoacylase, putative 0.0201 0.0546 1
Trichomonas vaginalis conserved hypothetical protein 0.016 0.0426 0.7779
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0021 0.0334
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.016 0.0426 0.042
Treponema pallidum penicillin-binding protein (pbp-1) 0.016 0.0426 1
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.016 0.0426 0.088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Brugia malayi metallo-beta-lactamase superfamily protein 0.0018 0.0006 0.0119
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1284 0.3738 0.3734
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0021 0.0334
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0021 0.026
Schistosoma mansoni polycystin 1-related 0.0021 0.0017 0.0194
Leishmania major cathepsin L-like protease 0.0019 0.0009 0.0046
Onchocerca volvulus 0.0021 0.0017 0.0194
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0018 0.0006 0.0119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0021 0.026
Echinococcus granulosus intermediate filament protein 0.0029 0.004 0.0626
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Schistosoma mansoni ap endonuclease 0.0023 0.0021 0.026
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0017 0.0194
Schistosoma mansoni lipoxygenase 0.009 0.0219 0.3931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Brugia malayi hypothetical protein 0.0018 0.0006 0.0119
Mycobacterium ulcerans penicillin-binding lipoprotein 0.016 0.0426 0.042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0119
Onchocerca volvulus 0.0019 0.0009 0.0046
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0009 0.0165
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0021 0.0029
Onchocerca volvulus 0.0201 0.0546 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0129 0.0333 0.6046
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0009 0.1786
Leishmania major cathepsin L-like protease 0.0019 0.0009 0.0046
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.012 0.2095
Toxoplasma gondii cathepsin CPL 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0021 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0201 0.0546 1
Echinococcus granulosus cathepsin l1 0.0019 0.0009 0.0046
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0021 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0017 0.0194
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0021 0.026
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.016 0.0426 0.088
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0129 0.0333 0.6046
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0009 0.0046
Schistosoma mansoni loxhd1 0.0021 0.0017 0.0194
Schistosoma mansoni intermediate filament proteins 0.0029 0.004 0.0626
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0009 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0009 0.0046
Echinococcus multilocularis cysteine protease 0.0019 0.0009 0.0046
Echinococcus multilocularis lamin 0.0029 0.004 0.0626
Trypanosoma brucei hypothetical protein, conserved 0.0201 0.0546 0.1131
Mycobacterium ulcerans hypothetical protein 0.0201 0.0546 0.054
Toxoplasma gondii exonuclease III APE 0.0023 0.0021 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0201 0.0546 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0009 0.0046
Schistosoma mansoni lamin 0.0029 0.004 0.0626
Onchocerca volvulus 0.0021 0.0017 0.0194
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.016 0.0426 0.042
Chlamydia trachomatis transglycolase/transpeptidase 0.016 0.0426 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0009 0.0046
Schistosoma mansoni rab6-interacting 0.0021 0.0017 0.0194
Schistosoma mansoni lamin 0.0029 0.004 0.0626
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0018 0.0006 0.0119
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0017 0.0194
Plasmodium vivax hypothetical protein, conserved 0.0201 0.0546 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Plasmodium vivax vivapain-2 0.0019 0.0009 0.0046
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0018 0.0006 0.0119
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.016 0.0426 0.042
Mycobacterium tuberculosis Conserved protein 0.0201 0.0546 0.054
Onchocerca volvulus 0.0201 0.0546 1
Onchocerca volvulus 0.0019 0.0009 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0029 0.004 0.0737
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0009 0.0165
Mycobacterium ulcerans esterase/lipase LipP 0.0201 0.0546 0.054
Trypanosoma cruzi hypothetical protein, conserved 0.0201 0.0546 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.004 0.0737
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0009 0.0046
Leishmania major cathepsin L-like protease 0.0019 0.0009 0.0046
Mycobacterium tuberculosis Conserved protein 0.0201 0.0546 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0017 0.7451
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0165 0.2933
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0017 0.0194
Echinococcus multilocularis musashi 0.0029 0.004 0.0626
Leishmania major cathepsin L-like protease 0.0072 0.0165 0.2933
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0201 0.0546 0.054
Chlamydia trachomatis transglycolase/transpeptidase 0.016 0.0426 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0009 0.0046
Schistosoma mansoni rab6-interacting 0.0021 0.0017 0.0194
Schistosoma mansoni ap endonuclease 0.0023 0.0021 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.031
Brugia malayi intermediate filament protein 0.0029 0.004 0.0737
Trichomonas vaginalis penicillin-binding protein, putative 0.0201 0.0546 1
Brugia malayi Doublecortin family protein 0.0021 0.0017 0.031
Loa Loa (eye worm) beta-lactamase 0.0201 0.0546 1
Echinococcus multilocularis RUN 0.0021 0.0017 0.0194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0009 0.0046
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0201 0.0546 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0165 0.2933
Onchocerca volvulus 0.0019 0.0009 0.0046
Onchocerca volvulus 0.0019 0.0009 0.0046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.004 0.0737
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0119
Echinococcus granulosus RUN 0.0021 0.0017 0.0194
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0021 0.0376
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0021 0.0014
Brugia malayi beta-lactamase family protein 0.0201 0.0546 1
Onchocerca volvulus 0.0029 0.004 0.0626
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0021 0.026
Brugia malayi beta-lactamase 0.0201 0.0546 1
Loa Loa (eye worm) fibroinase 0.0019 0.0009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0165
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0009 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Mycobacterium tuberculosis Probable hydrolase 0.0201 0.0546 0.054
Brugia malayi Cathepsin L-like precursor 0.0019 0.0009 0.0165
Leishmania major cathepsin L-like protease 0.0072 0.0165 0.2933
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0708
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0165 0.2933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0201 0.0546 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0165 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.016 0.0426 0.088
Loa Loa (eye worm) cysteine protease 0.0019 0.0009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0201 0.0546 1
Echinococcus multilocularis lamin dm0 0.0029 0.004 0.0626
Onchocerca volvulus 0.0029 0.004 0.0626
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0021 0.026
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0146 0.2594
Mycobacterium ulcerans beta-lactamase 0.0201 0.0546 0.054
Trichomonas vaginalis esterase, putative 0.0201 0.0546 1
Schistosoma mansoni lipoxygenase 0.0129 0.0333 0.6046
Mycobacterium ulcerans penicillin-binding protein PbpA 0.016 0.0426 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0009 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0009 0.0046
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0009 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0017 0.0194
Onchocerca volvulus 0.0019 0.0009 0.0046
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0009 0.0165
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0737
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.031
Brugia malayi ethe1-prov protein 0.0018 0.0006 0.0119
Entamoeba histolytica cysteine protease, putative 0.0019 0.0009 0.1786

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3981 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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