Detailed information for compound 1536623

Basic information

Technical information
  • TDR Targets ID: 1536623
  • Name: [2-[2-[[2-(2,4-difluorobenzoyl)oxyacetyl]amin o]ethylamino]-2-oxoethyl] 2,4-difluorobenzoat e
  • MW: 456.344 | Formula: C20H16F4N2O6
  • H donors: 2 H acceptors: 4 LogP: 2.42 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)c1ccc(cc1F)F)NCCNC(=O)COC(=O)c1ccc(cc1F)F
  • InChi: 1S/C20H16F4N2O6/c21-11-1-3-13(15(23)7-11)19(29)31-9-17(27)25-5-6-26-18(28)10-32-20(30)14-4-2-12(22)8-16(14)24/h1-4,7-8H,5-6,9-10H2,(H,25,27)(H,26,28)
  • InChiKey: JDKZCIGIGNJEGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[2-[[2-(2,4-difluorobenzoyl)oxyacetyl]amino]ethylamino]-2-oxo-ethyl] 2,4-difluorobenzoate
  • 2,4-difluorobenzoic acid [2-[2-[[2-[(2,4-difluorophenyl)-oxomethoxy]-1-oxoethyl]amino]ethylamino]-2-oxoethyl] ester
  • 2,4-difluorobenzoic acid [2-[2-[[2-(2,4-difluorobenzoyl)oxyacetyl]amino]ethylamino]-2-keto-ethyl] ester
  • [2-[2-[2-(2,4-difluorophenyl)carbonyloxyethanoylamino]ethylamino]-2-oxo-ethyl] 2,4-difluorobenzoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0119 0.0086
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0119 0.017
Loa Loa (eye worm) DOMON domain-containing protein 0.0075 0.0585 0.1204
Echinococcus granulosus snurportin 1 0.0372 0.4297 0.9446
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0119 0.017
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0082 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus multilocularis nAChR subunit 0.0038 0.0119 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0119 0.0077
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Brugia malayi Cation transporter family protein 0.0038 0.0119 0.017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0119 0.0086
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0119 0.0077
Brugia malayi DOMON domain containing protein 0.0075 0.0585 0.1204
Onchocerca volvulus 0.0075 0.0585 1
Brugia malayi Cation transporter family protein 0.0038 0.0119 0.017
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0392 0.4546 1
Echinococcus granulosus nAChR subunit 0.0038 0.0119 0.017
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0119 0.017
Loa Loa (eye worm) DOMON domain-containing protein 0.0075 0.0585 0.1204
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0082 0.5
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0119 0.0077
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4297 0.9446
Brugia malayi DOMON domain containing protein 0.0075 0.0585 0.1204
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0392 0.4546 0.5071
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0119 0.017
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0119 0.017
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0192 0.2049 1
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0119 0.017
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0119 0.017
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0193 0.206 0.448
Schistosoma mansoni importin beta-1 0.0035 0.0082 0.0045
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0119 0.017
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0106 0.0064
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0119 0.017
Entamoeba histolytica hypothetical protein 0.0037 0.0106 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0038 0.0119 0.0086
Brugia malayi Cation transporter family protein 0.0038 0.0119 0.017
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0119 0.0077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0119 0.0077
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0119 0.0077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0119 0.017
Onchocerca volvulus 0.0075 0.0585 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0119 0.017
Echinococcus multilocularis snurportin 1 0.0372 0.4297 0.4272
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0392 0.4546 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0119 0.017
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0897 0.1898
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Schistosoma mansoni hypothetical protein 0.0068 0.0502 0.0517
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0119 0.017
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0119 0.017
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0119 0.017
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0392 0.4546 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0119 0.017
Leishmania major importin beta-1 subunit, putative 0.0028 0 0.5
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0199 0.2133 0.4642
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0119 0.017
Brugia malayi Importin beta-1 subunit 0.0035 0.0082 0.0089
Brugia malayi DOMON domain containing protein 0.0075 0.0585 0.1204
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0392 0.4546 1
Trichomonas vaginalis DNA-3-methyladenine glycosylase, putative 0.0192 0.2049 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0119 0.017
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0119 0.017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0119 0.017
Echinococcus granulosus importin subunit beta 1 0.0035 0.0082 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.145 0.3126
Schistosoma mansoni nAChR subunit 0.0038 0.0119 0.0086
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0502 0.1019
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0106 0.0072
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0119 0.0086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0119 0.017
Mycobacterium ulcerans DNA-3-methyladenine glycosylase I TagA 0.0192 0.2049 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0119 0.0077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Plasmodium falciparum importin beta, putative 0.0035 0.0082 0.5
Mycobacterium tuberculosis Probable DNA-3-methyladenine glycosylase I TagA (tag I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0095 0.0838 0.5
Brugia malayi RNA, U transporter 1 0.0099 0.0885 0.1872
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0119 0.0077
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0119 0.017
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0119 0.0077
Brugia malayi MH2 domain containing protein 0.0144 0.145 0.3126
Plasmodium vivax importin-beta 2, putative 0.0035 0.0082 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0119 0.0077
Entamoeba histolytica hypothetical protein 0.0037 0.0106 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.145 0.3126
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0119 0.0077
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0038 0.0119 0.0086
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.01 0.0897 0.1898
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0897 0.1898
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0119 0.017
Schistosoma mansoni peptidylglycine monooxygenase 0.0392 0.4546 0.5071
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0119 0.017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0106 0.0141
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0502 0.1019
Mycobacterium leprae PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE I TAGA (TAG I) (3-methyladenine-DNA glycosylase I, constitutive) (DNA-3-methyladenine g 0.0095 0.0838 0.5
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0119 0.017
Schistosoma mansoni dopamine-beta-monooxygenase 0.0742 0.8923 1
Entamoeba histolytica hypothetical protein 0.0037 0.0106 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0119 0.0077
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0119 0.0086
Schistosoma mansoni hypothetical protein 0.0372 0.4297 0.479
Entamoeba histolytica hypothetical protein 0.0037 0.0106 1
Schistosoma mansoni hypothetical protein 0.0037 0.0106 0.0072
Loa Loa (eye worm) hypothetical protein 0.0038 0.0119 0.017
Loa Loa (eye worm) hypothetical protein 0.0392 0.4546 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0392 0.4546 0.4523
Loa Loa (eye worm) DOMON domain-containing protein 0.0075 0.0585 0.1204
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0119 0.017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0119 0.017
Brugia malayi hypothetical protein 0.0037 0.0106 0.0141
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0897 0.1898
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0089
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0119 0.017
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0119 0.017
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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