Detailed information for compound 1537944

Basic information

Technical information
  • TDR Targets ID: 1537944
  • Name: N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4 -(methylsulfonyl-(phenylmethyl)amino)benzamid e
  • MW: 490.574 | Formula: C26H26N4O4S
  • H donors: 1 H acceptors: 4 LogP: 3.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)N(S(=O)(=O)C)Cc1ccccc1)Nc1c(=O)n(n(c1C)C)c1ccccc1
  • InChi: 1S/C26H26N4O4S/c1-19-24(26(32)30(28(19)2)23-12-8-5-9-13-23)27-25(31)21-14-16-22(17-15-21)29(35(3,33)34)18-20-10-6-4-7-11-20/h4-17H,18H2,1-3H3,(H,27,31)
  • InChiKey: KJBMIVOLDBZOKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-4-(methylsulfonyl-(phenylmethyl)amino)benzamide
  • N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-4-(methylsulfonyl-(phenylmethyl)amino)benzamide
  • 4-(benzyl-mesyl-amino)-N-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)benzamide
  • ZINC00839854
  • MLS000714632
  • SMR000274611
  • Oprea1_096914
  • BAS 00845382
  • Oprea1_175217

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi chromobox protein homolog 3 0.0043 0.0343 0.1229
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0229 0.0459
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0108 0.0216
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0575 0.1151
Echinococcus granulosus solute carrier family 22 0.003 0.0194 0.0389
Echinococcus granulosus solute carrier family 22 0.003 0.0194 0.0389
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0724 0.2584
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0112 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0392 0.0392
Echinococcus multilocularis General substrate transporter 0.0181 0.1912 0.3826
Plasmodium vivax importin-beta 2, putative 0.003 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0065 0.059 0.1697
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0638 0.2281
Trichomonas vaginalis set domain proteins, putative 0.026 0.28 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0473 0.136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0219 0.0438
Leishmania major hypothetical protein, conserved 0.0026 0.0155 0.0799
Brugia malayi Sugar transporter family protein 0.003 0.0194 0.0695
Echinococcus multilocularis solute carrier family 22 0.003 0.0194 0.0389
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0311 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0575 0.2054
Loa Loa (eye worm) hypothetical protein 0.0063 0.0575 0.1655
Plasmodium vivax hypothetical protein, conserved 0.0032 0.022 0.022
Trichomonas vaginalis chromobox protein, putative 0.0046 0.038 0.1358
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0386
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0133 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.059 0.2107
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0392 0.0784
Schistosoma mansoni importin beta-1 0.003 0.0197 0.0567
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Onchocerca volvulus 0.003 0.0194 0.0694
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.059 0.0893
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Schistosoma mansoni ran 0.0022 0.0108 0.031
Brugia malayi Sugar transporter family protein 0.003 0.0194 0.0695
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.059 0.0893
Trypanosoma cruzi glucose transporter, putative 0.003 0.0194 0.1477
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.022 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0599 0.2141
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.022 0.0441
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Loa Loa (eye worm) hypothetical protein 0.0026 0.0155 0.0445
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.059 0.059
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0599 0.8386
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0392 0.1127
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0194 0.2954
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.059 0.059
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0194 0.2954
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.1044 0.209
Mycobacterium ulcerans sugar transporter 0.003 0.0194 0.2954
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0998 0.3571
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0392 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0219 0.0438
Onchocerca volvulus 0.003 0.0194 0.0694
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0229 0.0459
Brugia malayi hypothetical protein 0.003 0.0194 0.0695
Trichomonas vaginalis ran, putative 0.0022 0.0108 0.0385
Plasmodium falciparum importin beta, putative 0.003 0.0197 0.0197
Brugia malayi Pre-SET motif family protein 0.0228 0.2443 0.874
Plasmodium vivax sugar transporter, putative 0.003 0.0194 0.0194
Echinococcus granulosus General substrate transporter 0.0181 0.1912 0.3826
Brugia malayi jmjC domain containing protein 0.0105 0.1044 0.3736
Brugia malayi major facilitator superfamily protein 0.003 0.0194 0.0695
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0599 0.2141
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.1044 0.209
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0392 0.1127
Onchocerca volvulus 0.0034 0.0239 0.0852
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0606 0.1743
Brugia malayi PHD-finger family protein 0.0032 0.022 0.0789
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0575 1
Loa Loa (eye worm) sugar transporter 0.003 0.0194 0.0559
Schistosoma mansoni hypothetical protein 0.0053 0.0457 0.1316
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0694
Onchocerca volvulus 0.0053 0.0457 0.1633
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0599 0.8386
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0326 0.1164
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0694 1
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0724 0.2584
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0311 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0371 0.1067
Plasmodium vivax hexose transporter 0.0211 0.2248 0.2248
Leishmania major glucose transporter, lmgt3 0.0065 0.0599 0.8386
Echinococcus granulosus GPCR family 2 0.0032 0.0219 0.0438
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0194 0.0389
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0155 0.0155
Onchocerca volvulus 0.003 0.0194 0.0694
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0219 0.063
Schistosoma mansoni hypothetical protein 0.0032 0.0219 0.063
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Loa Loa (eye worm) hypothetical protein 0.003 0.0197 0.0567
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0599 0.8386
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0194 0.0559
Echinococcus multilocularis solute carrier family 22 0.003 0.0194 0.0389
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Onchocerca volvulus 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.2248 0.4499
Brugia malayi Heterochromatin protein 1 0.0076 0.0724 0.2589
Schistosoma mansoni protein kinase 0.0065 0.059 0.1697
Loa Loa (eye worm) hypothetical protein 0.0069 0.0638 0.1834
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.059 0.059
Trypanosoma cruzi hexose transporter, putative 0.003 0.0194 0.1477
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0599 0.8386
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Trypanosoma brucei glucose transporter 1E 0.0065 0.0599 0.8386
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0155 0.0234
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2443 0.7028
Echinococcus granulosus chromobox protein 1 0.0076 0.0724 0.1448
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0202 0.0721
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0108
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.059 0.1697
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.059 0.1697
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0229 0.0659
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Onchocerca volvulus 0.003 0.0194 0.0694
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0392 0.1401
Echinococcus multilocularis peregrin 0.0032 0.022 0.0441
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.059 0.059
Leishmania major glucose transporter, lmgt2 0.0065 0.0599 0.8386
Schistosoma mansoni protein kinase 0.0065 0.059 0.1697
Brugia malayi SET domain containing protein 0.0014 0.0014 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0219 0.0438
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0392 0.0593
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0197 0.1526
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0194 0.0695
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Onchocerca volvulus 0.003 0.0194 0.0694
Brugia malayi hypothetical protein 0.0259 0.2795 1
Leishmania major hypothetical protein, conserved 0.003 0.0194 0.1477
Echinococcus multilocularis solute carrier family 22 0.003 0.0194 0.0389
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.2795 0.5594
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Loa Loa (eye worm) hypothetical protein 0.0055 0.0479 0.1378
Brugia malayi MH2 domain containing protein 0.0131 0.1341 0.4798
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0194 0.0389
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Schistosoma mansoni hypothetical protein 0.0176 0.185 0.5322
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.4997 1
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0194 0.2954
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0392 1
Onchocerca volvulus Alhambra homolog 0.0032 0.022 0.0787
Entamoeba histolytica Ran family GTPase 0.0022 0.0108 0.1827
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0194 0.1477
Entamoeba histolytica hypothetical protein 0.0024 0.0133 0.2257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0229 0.0659
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0575 0.1655
Onchocerca volvulus 0.003 0.0194 0.0694
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0694 1
Leishmania major glucose transporter, lmgt1 0.0065 0.0599 0.8386
Giardia lamblia PHD finger protein 15 0.0032 0.022 0.241
Loa Loa (eye worm) hypothetical protein 0.0032 0.0219 0.063
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0575 0.2058
Schistosoma mansoni hypothetical protein 0.0319 0.3476 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0694 1
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0724 0.2082
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0108 0.0216
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0599 0.2141
Schistosoma mansoni chromobox protein 0.0076 0.0724 0.2082
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0194 0.0694
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0545 0.109
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0155 0.0799
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Brugia malayi hypothetical protein 0.003 0.0194 0.0695
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0599 0.8386
Echinococcus granulosus Chromobox protein 3 0.0013 0.000000015529 0.000000031079
Echinococcus multilocularis snurportin 1 0.0319 0.3476 0.6957
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0219 0.0784
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0362 0.0725
Echinococcus multilocularis chromobox protein 1 0.0076 0.0724 0.1448
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.059 0.0893
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0155 0.0155
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0392 0.4843
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Toxoplasma gondii sugar transporter ST1 0.003 0.0194 0.0294
Onchocerca volvulus 0.003 0.0194 0.0694
Schistosoma mansoni hypothetical protein 0.0032 0.0219 0.063
Brugia malayi Sugar transporter family protein 0.0211 0.2248 0.8042
Schistosoma mansoni sugar transporter 0.003 0.0194 0.0559
Trypanosoma cruzi hexose transporter 0.0065 0.0599 0.8386
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.022 0.0334
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0155 0.0799
Trypanosoma brucei glucose transporter 2A 0.0065 0.0599 0.8386
Echinococcus granulosus snurportin 1 0.0319 0.3476 0.6957
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0694
Schistosoma mansoni chromobox protein 0.0076 0.0724 0.2082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0297 0.0853
Schistosoma mansoni sugar transporter 0.003 0.0194 0.0559
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0297 0.0594
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0194 0.0694
Echinococcus multilocularis geminin 0.0176 0.185 0.3702
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0998 0.3571
Echinococcus granulosus geminin 0.0176 0.185 0.3702
Plasmodium falciparum protein kinase 7 0.0596 0.661 0.661
Echinococcus multilocularis tumor protein p63 0.0371 0.4055 0.8115
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus granulosus solute carrier family 22 0.003 0.0194 0.0389
Toxoplasma gondii sugar transporter ST2 0.003 0.0194 0.0294
Plasmodium falciparum hexose transporter 0.0211 0.2248 0.2248
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0362 0.0725
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Trypanosoma cruzi sugar transporter, putative 0.003 0.0194 0.1477
Loa Loa (eye worm) hypothetical protein 0.0259 0.2795 0.8041
Echinococcus granulosus tumor protein p63 0.0371 0.4055 0.8115
Schistosoma mansoni glucose transport protein 0.0211 0.2248 0.6467
Echinococcus granulosus chromobox protein 1 0.0076 0.0724 0.1448
Brugia malayi Importin beta-1 subunit 0.003 0.0197 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0343 0.1226
Onchocerca volvulus 0.003 0.0194 0.0694
Brugia malayi RNA, U transporter 1 0.0085 0.0822 0.2941
Trichomonas vaginalis chromobox protein, putative 0.0046 0.038 0.1358
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0575 0.1655
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.1341 0.3858
Onchocerca volvulus 0.003 0.0194 0.0694
Schistosoma mansoni hypothetical protein 0.0176 0.185 0.5322
Entamoeba histolytica hypothetical protein 0.0047 0.0392 0.6639
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.059 0.059
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0155 0.0799
Echinococcus granulosus importin subunit beta 1 0.003 0.0197 0.0395
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.022 0.0441
Schistosoma mansoni protein kinase 0.0065 0.059 0.1697
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0343 0.1226
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0599 0.2141
Entamoeba histolytica protein kinase, putative 0.0065 0.059 1
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0194 0.1477
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0155 0.0155
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0392 0.4843
Loa Loa (eye worm) hypothetical protein 0.0043 0.0343 0.0988
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0215 0.0431
Schistosoma mansoni ran 0.0022 0.0108 0.031
Echinococcus multilocularis chromobox protein 1 0.0076 0.0724 0.1448
Onchocerca volvulus 0.0013 0.000000015529 0.000000055456
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.059 0.2111
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0599 0.2141
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0229 0.0347
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0133 0.0476
Onchocerca volvulus 0.003 0.0194 0.0694
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0392 0.1399
Entamoeba histolytica protein kinase, putative 0.0065 0.059 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.059 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0599 0.2141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0343 0.1226
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0194 0.0194
Brugia malayi Pre-SET motif family protein 0.0033 0.0229 0.082
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Echinococcus granulosus peregrin 0.0032 0.022 0.0441
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0392 0.0392
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0392 0.0784
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.2248 0.8027
Echinococcus multilocularis Chromobox protein 3 0.0013 0.000000015529 0.000000031079
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0108 0.0163
Brugia malayi jmjC domain containing protein 0.0039 0.0297 0.1061
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0545 0.109
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0473 0.136
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Plasmodium vivax SET domain protein, putative 0.0033 0.0229 0.0229
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0133 0.0476
Echinococcus multilocularis GPCR, family 2 0.0032 0.0219 0.0438
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.059 0.059
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.4997 1
Schistosoma mansoni hypothetical protein 0.0032 0.0219 0.063
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0694
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.022 0.0634
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Leishmania major importin beta-1 subunit, putative 0.0024 0.0133 0.0433
Loa Loa (eye worm) hypothetical protein 0.0101 0.0998 0.2872
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0694
Schistosoma mansoni hypothetical protein 0.0069 0.0638 0.1834
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.059 0.1181
Onchocerca volvulus 0.003 0.0194 0.0694
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0694 0.105
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0194 0.0695
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0194 0.0389
Schistosoma mansoni survival motor neuron protein 0.0053 0.0457 0.1316
Schistosoma mansoni hypothetical protein 0.0032 0.0219 0.063
Brugia malayi hypothetical protein 0.003 0.0194 0.0695
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.3476 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0194 0.0559
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0392 0.3046
Plasmodium vivax CDK-related protein kinase 6, putative 0.0896 1 1
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0392 0.6074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0229 0.0659
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0263 0.2655
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Brugia malayi hypothetical protein 0.0026 0.0155 0.0553
Plasmodium falciparum phd finger protein, putative 0.0032 0.022 0.022
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0341 0.372 0.372
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0032 0.022 0.0634
Onchocerca volvulus 0.003 0.0194 0.0694
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0998 0.2872
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0194 0.0559
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0297 0.0853
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0197 0.0298
Loa Loa (eye worm) hypothetical protein 0.0034 0.0239 0.0686
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0219 0.0438
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0194 0.0294
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.022 0.0634
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0202 0.0721
Plasmodium falciparum mitogen-activated protein kinase 2 0.0341 0.372 0.372
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Giardia lamblia Sugar-proton symporter 0.003 0.0194 0.1852
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0599 0.8386
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0599 0.8386
Brugia malayi Cam kinase protein 1 0.0065 0.059 0.2111
Brugia malayi hypothetical protein 0.0017 0.005 0.0178
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0801 0.2303
Loa Loa (eye worm) sugar transporter 0.0211 0.2248 0.6467
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.059 0.8226
Onchocerca volvulus 0.003 0.0194 0.0694
Loa Loa (eye worm) hypothetical protein 0.0033 0.0229 0.0659
Trypanosoma brucei sugar transporter, putative 0.003 0.0194 0.1477
Loa Loa (eye worm) hypothetical protein 0.0051 0.0441 0.1268
Onchocerca volvulus 0.0054 0.0473 0.1688
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.059 0.059
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Onchocerca volvulus 0.003 0.0194 0.0694
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2248 0.4499
Toxoplasma gondii sugar transporter ST3 0.003 0.0194 0.0294
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.059 0.1181
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0392 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0694 1
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.4997 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0229 0.0459
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.1341 0.3858
Schistosoma mansoni glucose transport protein 0.0211 0.2248 0.6467
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.059 0.059
Onchocerca volvulus 0.026 0.28 1
Onchocerca volvulus Putative transporter 0.003 0.0194 0.0694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0575 0.1151
Giardia lamblia Hexose transporter 0.003 0.0194 0.1852
Schistosoma mansoni sugar transporter 0.003 0.0194 0.0559
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0197 0.1526
Onchocerca volvulus 0.003 0.0194 0.0694
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0694 0.0694
Brugia malayi Bromodomain containing protein 0.0032 0.022 0.0789
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.2248 0.3401
Onchocerca volvulus 0.0045 0.0371 0.1324
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0575 0.2058
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.0634
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.059 0.1697
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0194 0.0389
Toxoplasma gondii protein kinase, putative 0.0596 0.661 1
Brugia malayi major facilitator superfamily protein 0.003 0.0194 0.0695
Echinococcus granulosus solute carrier family 22 0.003 0.0194 0.0389
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0194 0.0695
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0392 0.4843
Schistosoma mansoni glucose transporter 0.003 0.0194 0.0559
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0694 1
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0575 1
Leishmania major protein kinase, putative 0.0065 0.059 0.8226
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.031
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0153 0.0439
Trypanosoma brucei glucose transporter, putative 0.0065 0.0599 0.8386
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0297 0.0853
Echinococcus multilocularis solute carrier family 22 0.003 0.0194 0.0389
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0297 0.0594
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.2795 0.5594
Trichomonas vaginalis sugar transporter, putative 0.003 0.0194 0.0694
Loa Loa (eye worm) hypothetical protein 0.0063 0.0575 0.1655
Schistosoma mansoni sugar transporter 0.003 0.0194 0.0559
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0133 0.0433
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0219 0.0784
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0599 0.2141
Echinococcus multilocularis importin subunit beta 1 0.003 0.0197 0.0395
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0694 0.0694
Schistosoma mansoni hypothetical protein 0.0211 0.2248 0.6467
Echinococcus granulosus neuropeptide s receptor 0.0454 0.4997 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.038 0.1358
Loa Loa (eye worm) hypothetical protein 0.003 0.0194 0.0559
Schistosoma mansoni glucose transport protein 0.0211 0.2248 0.6467
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0575 0.9749
Trichomonas vaginalis glucose transporter, putative 0.003 0.0194 0.0694
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0457 0.1636
Loa Loa (eye worm) hypothetical protein 0.0047 0.0392 0.1127
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0341 0.372 0.5628

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.