Detailed information for compound 1542327

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.374 | Formula: C19H21NO4
  • H donors: 1 H acceptors: 2 LogP: 2.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)OC1C=CC2[C@@]34C1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
  • InChi: 1S/C19H21NO4/c1-10(21)23-15-6-4-12-13-9-11-3-5-14(22)17-16(11)19(12,18(15)24-17)7-8-20(13)2/h3-6,12-13,15,18,22H,7-9H2,1-2H3/t12?,13-,15?,18?,19+/m1/s1
  • InChiKey: JJGYGPZNTOPXGV-XKYWSZKRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0102
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0334 0.0349
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.0708 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0106 0.0708 0.0739
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0033 0.0034
Plasmodium vivax ABC transporter G family member 2, putative 0.0012 0.0003 0.0011
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0289 0.0302
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0012 0.0007 0.0008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0658 0.4843 0.8159
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Brugia malayi EGF-like domain containing protein 0.002 0.0066 0.0069
Giardia lamblia Neurogenic locus Notch protein precursor 0.002 0.0066 0.0224
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Brugia malayi hypothetical protein 0.0095 0.0623 0.0651
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0061 0.011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.0228
Brugia malayi EGF-like domain containing protein 0.002 0.0066 0.0069
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.0334 0.0558
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0106 0.0708 0.1345
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0033 0.005
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0033 0.0103
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0114
Plasmodium falciparum plasmepsin IV 0.0048 0.0273 0.0949
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0106 0.0708 0.0739
Brugia malayi Integrin alpha cytoplasmic region family protein 0.023 0.1636 0.1708
Echinococcus granulosus integrin alpha 3 0.0233 0.1659 0.3149
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.0268
Onchocerca volvulus 0.005 0.0289 0.0289
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0033 0.0034
Loa Loa (eye worm) TK/EGFR protein kinase 0.0149 0.1031 0.1076
Plasmodium falciparum heat shock protein 90 0.0199 0.1404 0.4882
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0158 0.1101 0.3821
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0041 0.0219 0.073
Brugia malayi EGF-like domain containing protein 0.002 0.0066 0.0069
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.0708 0.0739
Echinococcus multilocularis geminin 0.0205 0.1447 0.2434
Schistosoma mansoni cpg binding protein 0.0028 0.0129 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Schistosoma mansoni endoplasmin 0.0199 0.1404 0.2668
Loa Loa (eye worm) TOPoisomerase family member 0.0041 0.0219 0.0228
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0069
Trypanosoma brucei developmentally regulated phosphoprotein 0.0041 0.0219 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0398
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.031
Echinococcus multilocularis dna polymerase eta 0.0019 0.0061 0.0098
Toxoplasma gondii aspartyl protease ASP1 0.0048 0.0273 0.0949
Echinococcus multilocularis FTZ F1 alpha 0.0106 0.0708 0.1188
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.0228
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0033 0.005
Echinococcus multilocularis heat shock protein 90 0.0199 0.1404 0.2361
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0733
Schistosoma mansoni glutaminase 0.033 0.2386 0.4535
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0733
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0395 0.2875 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0698 0.0728
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0733
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0033 0.0062
Plasmodium falciparum eukaryotic initiation factor 4A 0.0395 0.2875 1
Loa Loa (eye worm) hypothetical protein 0.1242 0.9208 0.961
Onchocerca volvulus Bile acid receptor homolog 0.0106 0.0708 0.0708
Echinococcus granulosus geminin 0.0205 0.1447 0.2745
Brugia malayi CXXC zinc finger family protein 0.0028 0.0129 0.0134
Plasmodium falciparum endoplasmin, putative 0.0122 0.0828 0.2881
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0044 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0398
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Echinococcus multilocularis integrin beta 2 0.0461 0.3367 0.567
Brugia malayi nuclear receptor NHR-67 0.005 0.0289 0.0302
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0041 0.0219 0.0904
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0219 0.076
Echinococcus multilocularis 0.0046 0.0261 0.0434
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0106 0.0708 0.1188
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0041 0.0219 0.0219
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0289 0.0302
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0041 0.0219 0.0363
Schistosoma mansoni DNA topoisomerase II 0.0041 0.0219 0.0415
Leishmania major hypothetical protein, conserved 0.0041 0.0219 0.075
Echinococcus multilocularis thyroid hormone receptor alpha 0.0106 0.0708 0.1188
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0158 0.1101 0.3808
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0041 0.0219 0.073
Giardia lamblia Tenascin precursor 0.002 0.0066 0.0224
Echinococcus multilocularis endoplasmin 0.0158 0.1101 0.185
Loa Loa (eye worm) glutaminase 0.033 0.2386 0.249
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0106 0.0708 0.0739
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0061 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0106 0.0708 0.0739
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0052 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0202
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0033 0.0103
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0041 0.0219 0.076
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.033
Trypanosoma cruzi heat shock protein 90, putative 0.0158 0.1101 0.3821
Loa Loa (eye worm) hypothetical protein 0.0071 0.045 0.047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.0708 0.1188
Plasmodium falciparum heat shock protein 90, putative 0.0081 0.0525 0.1827
Echinococcus multilocularis cpg binding protein 0.003 0.0141 0.0232
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.015 0.1037 0.1083
Echinococcus multilocularis epidermal growth factor receptor 0.008 0.0515 0.0862
Schistosoma mansoni nuclear hormone receptor 0.005 0.0289 0.055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0163 0.0269
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0052 0.0204
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0098 0.033
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0349
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Schistosoma mansoni multidrug resistance protein 0.0013 0.0009 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0106 0.0708 0.0739
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0009 0.0012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0289 0.0482
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0041 0.0219 0.041
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0009 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0386 0.0645
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0395 0.2875 1
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0289 0.0302
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0009 0.001
Giardia lamblia Tenascin-like 0.002 0.0066 0.0224
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Onchocerca volvulus 0.0024 0.0098 0.0098
Onchocerca volvulus 0.015 0.1037 0.1037
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Echinococcus granulosus fibrillin 2 0.002 0.0066 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.0106 0.0708 0.1345
Echinococcus multilocularis fibrillin 1 0.002 0.0066 0.0105
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0041 0.0219 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0163 0.017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0163 0.0304
Toxoplasma gondii heat shock protein 75, putative 0.0081 0.0525 0.1827
Giardia lamblia Pms1-like protein 0.0041 0.0219 0.0756
Plasmodium vivax heat shock protein, putative 0.0081 0.0525 0.1827
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0041 0.0219 0.0219
Trypanosoma brucei Heat shock protein 83, putative 0.0199 0.1404 0.4876
Schistosoma mansoni tyrosine kinase 0.0149 0.1031 0.1959
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0395 0.2875 0.4841
Plasmodium falciparum plasmepsin VI 0.0048 0.0273 0.0949
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0106 0.0708 0.1345
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.031
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0041 0.0219 0.073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.0708 0.0739
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0103
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0012 0.0003 0.0006
Brugia malayi Nuclear hormone receptor E75 0.005 0.0289 0.0302
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Plasmodium vivax heat shock protein 90, putative 0.0081 0.0525 0.1827
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0081 0.0525 0.0993
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Leishmania major p-glycoprotein 0.0013 0.0009 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0102
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0041 0.0219 0.073
Echinococcus multilocularis ecdysone induced protein 78C 0.0106 0.0708 0.1188
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0106 0.0708 0.1345
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Echinococcus granulosus adam 0.002 0.0066 0.0119
Leishmania major mitochondrial DNA topoisomerase II 0.0041 0.0219 0.075
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0013 0.0009 0.0033
Chlamydia trachomatis DNA gyrase subunit B 0.0041 0.0219 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Entamoeba histolytica P-glycoprotein-5 0.0013 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Schistosoma mansoni nuclear hormone receptor 0.0106 0.0708 0.1345
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0106 0.0708 0.0739
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0041 0.0219 0.075
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0098 0.0398
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0395 0.2875 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0041 0.0219 0.073
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0272 0.0511
Plasmodium falciparum plasmepsin I 0.0048 0.0273 0.0949
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0013 0.0009 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0163 0.017
Loa Loa (eye worm) RNA binding protein 0.0063 0.0386 0.0403
Loa Loa (eye worm) hypothetical protein 0.0239 0.1701 0.1776
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0395 0.2875 1
Leishmania major DNA topoisomerase ii 0.0041 0.0219 0.075
Giardia lamblia Grp94/Hsp90 0.0158 0.1101 0.3825
Entamoeba histolytica P-glyco protein 6, putative 0.0013 0.0009 0.0021
Entamoeba histolytica heat shock protein 90, putative 0.0199 0.1404 0.4876
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0395 0.2875 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0061 0.0209
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Trichomonas vaginalis heat shock protein, putative 0.0158 0.1101 0.3808
Loa Loa (eye worm) hypothetical protein 0.0105 0.0698 0.0728
Trypanosoma cruzi heat shock protein 85, putative 0.0158 0.1101 0.3821
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Plasmodium vivax endoplasmin, putative 0.0199 0.1404 0.4882
Echinococcus multilocularis GPCR, family 2 0.0033 0.0163 0.0269
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0349
Leishmania major heat shock protein, putative 0.0081 0.0525 0.1818
Brugia malayi hypothetical protein 0.0056 0.0334 0.0349
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0041 0.0219 0.073
Toxoplasma gondii DNA topoisomerase 2, putative 0.0041 0.0219 0.076
Plasmodium vivax DNA gyrase subunit B, putative 0.0041 0.0219 0.076
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0289 0.0544
Schistosoma mansoni integrin alpha 0.0304 0.219 0.4162
Brugia malayi Hsp90 protein 0.0081 0.0525 0.0548
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0202
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0319 0.1111
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0048 0.0273 0.0949
Leishmania major DNA polymerase eta, putative 0.0019 0.0061 0.0202
Schistosoma mansoni hypothetical protein 0.0071 0.045 0.0856
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0041 0.0219 0.0904
Plasmodium falciparum DNA gyrase subunit B 0.0041 0.0219 0.076
Brugia malayi tailless protein 0.005 0.0289 0.0302
Trypanosoma brucei heat shock protein 84, putative 0.0081 0.0525 0.1818
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0041 0.0219 0.0904
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0061 0.0244
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0041 0.0219 0.0363
Echinococcus granulosus GPCR family 2 0.0033 0.0163 0.0304
Brugia malayi nuclear hormone receptor 0.0106 0.0708 0.0739
Plasmodium falciparum heat shock protein 90, putative 0.0081 0.0525 0.1827
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Mycobacterium ulcerans putative regultory protein 0.0041 0.0219 0.0904
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0106 0.0708 0.1188
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0041 0.0219 0.073
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0041 0.0219 0.0363
Echinococcus granulosus FTZ F1 alpha 0.0106 0.0708 0.134
Echinococcus granulosus ecdysone induced protein 78C 0.0106 0.0708 0.134
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0395 0.2875 0.5465
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0041 0.0219 0.0904
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0061 0.0064
Brugia malayi conserved hypotetical protein 0.005 0.0289 0.0302
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) hypothetical protein 0.0065 0.0404 0.0422
Leishmania major developmentally regulated phosphoprotein-like protein 0.0041 0.0219 0.075
Giardia lamblia Heat shock protein HSP 90-alpha 0.0158 0.1101 0.3825
Schistosoma mansoni nuclear receptor 0.005 0.0289 0.055
Schistosoma mansoni thyroid hormone receptor 0.0106 0.0708 0.1345
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0061 0.0181
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Trichomonas vaginalis heat shock protein, putative 0.0081 0.0525 0.18
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0289 0.0544
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0041 0.0219 0.1203
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0106 0.0708 0.0739
Brugia malayi ABC transporter family protein 0.0013 0.0009 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0061 0.0064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0289 0.0289
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0041 0.0219 0.073
Mycobacterium ulcerans DNA gyrase subunit B 0.0041 0.0219 0.0904
Loa Loa (eye worm) DR-78 0.005 0.0289 0.0302
Plasmodium vivax plasmepsin IV, putative 0.0048 0.0273 0.0949
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0009 0.0012
Trypanosoma brucei unspecified product 0.0013 0.0016 0.0045
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0041 0.0219 0.0904
Echinococcus multilocularis multidrug resistance protein 1 0.0013 0.0009 0.001
Echinococcus granulosus heat shock protein 90 0.0199 0.1404 0.2663
Mycobacterium leprae Probable two component sensor kinase MprB 0.0041 0.0219 0.1203
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0009 0.0012
Treponema pallidum heat shock protein 90 0.0158 0.1101 0.332
Plasmodium vivax multidrug resistance protein 1, putative 0.0013 0.0009 0.0033
Trypanosoma cruzi DNA topoisomerase II, putative 0.0041 0.0219 0.075
Schistosoma mansoni nuclear hormone receptor 0.005 0.0289 0.055
Mycobacterium ulcerans two component regulator - sensor kinase 0.0041 0.0219 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.0708 0.0739
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Echinococcus granulosus eukaryotic initiation factor 4A 0.0395 0.2875 0.5462
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0103
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0041 0.0219 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Brugia malayi MH2 domain containing protein 0.0118 0.0802 0.0837
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0349
Schistosoma mansoni steroid hormone receptor ad4bp 0.0106 0.0708 0.1345
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0052 0.2029
Mycobacterium tuberculosis Probable two component sensor kinase 0.0041 0.0219 0.073
Loa Loa (eye worm) integrin alpha pat-2 0.0469 0.3422 0.3572
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0054
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0289 0.055
Echinococcus granulosus endoplasmin 0.0158 0.1101 0.2087
Brugia malayi hypothetical protein 0.005 0.0289 0.0302
Giardia lamblia High cysteine protein 0.002 0.0066 0.0224
Brugia malayi Probable DNA topoisomerase II 0.0041 0.0219 0.0228
Trypanosoma cruzi DNA topoisomerase II, putative 0.0041 0.0219 0.075
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0098 0.0309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0289 0.0544
Brugia malayi hypothetical protein 0.005 0.0289 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0106 0.0708 0.0739
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0267 0.0501
Schistosoma mansoni DNA polymerase eta 0.0019 0.0061 0.0117
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0802 0.0837
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0386 0.0403
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0009 0.0012
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0041 0.0219 0.073
Echinococcus granulosus dnaJ subfamily B 0.0406 0.2952 0.5608
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0061 0.0202
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0081 0.0525 0.088
Entamoeba histolytica P-glycoprotein-2 0.0013 0.0009 0.0021
Trichomonas vaginalis receptor histidine kinase, putative 0.0041 0.0219 0.073
Loa Loa (eye worm) steroid hormone receptor 0.0106 0.0708 0.0739
Brugia malayi Furin-like cysteine rich region family protein 0.0149 0.1031 0.1076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0044 0.0122
Echinococcus multilocularis adam 0.002 0.0066 0.0105
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) endoplasmin 0.0199 0.1404 0.1465
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.0708 0.1188
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0033 0.0081
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0009 0.0012
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0289 0.0302
Chlamydia trachomatis DNA gyrase subunit B 0.0041 0.0219 1
Trypanosoma cruzi heat shock protein 90, putative 0.0117 0.0794 0.2753
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0106 0.0708 0.1345
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0966
Brugia malayi Nuclear hormone receptor E75 0.005 0.0289 0.0302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0044 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0289 0.0302
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0395 0.2875 1
Entamoeba histolytica heat shock protein 90, putative 0.0199 0.1404 0.4876
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0098 0.033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0106 0.0708 0.134
Schistosoma mansoni tyrosine kinase 0.008 0.0515 0.0978
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0395 0.2875 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0733
Schistosoma mansoni heat shock protein 0.0081 0.0525 0.0998
Echinococcus granulosus epidermal growth factor receptor 0.0149 0.1031 0.1954
Mycobacterium tuberculosis Conserved protein 0.0041 0.0219 0.073
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0061 0.0202
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0041 0.0219 0.073
Trichomonas vaginalis heat shock protein, putative 0.0199 0.1404 0.4865
Trichomonas vaginalis endoplasmin, putative 0.0122 0.0828 0.2858
Echinococcus granulosus integrin alpha ps 0.0065 0.0404 0.0763
Echinococcus multilocularis integrin alpha 3 0.0233 0.1659 0.2791
Trypanosoma brucei DNA topoisomerase ii 0.0041 0.0219 0.075
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0289 0.0482
Trichomonas vaginalis glutaminase, putative 0.033 0.2386 0.8293
Schistosoma mansoni cathepsin D (A01 family) 0.0141 0.0969 0.1842
Giardia lamblia Tenascin-X 0.002 0.0066 0.0224
Trichomonas vaginalis sensor histidine kinase, putative 0.0041 0.0219 0.073
Trypanosoma brucei unspecified product 0.0013 0.0016 0.0045
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0041 0.0219 0.0904
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.045 0.047
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Plasmodium vivax aspartyl proteinase, putative 0.0048 0.0273 0.0949
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0013 0.0009 0.0033
Trypanosoma cruzi heat shock protein 85, putative 0.0199 0.1404 0.4876
Plasmodium falciparum multidrug resistance protein 1 0.0013 0.0009 0.0033
Echinococcus granulosus tar DNA binding protein 0.0063 0.0386 0.0727
Plasmodium falciparum DNA topoisomerase 2 0.0041 0.0219 0.076
Schistosoma mansoni integrin alpha-ps 0.0136 0.0935 0.1777
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0052 0.018
Echinococcus granulosus epidermal growth factor receptor 0.008 0.0515 0.0972
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0386 0.0403
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.005
Echinococcus multilocularis heat shock protein 0.0199 0.1404 0.2361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0163 0.0269
Mycobacterium leprae Probable two-component sensor kinase 0.0041 0.0219 0.1203
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0048 0.0273 0.0513
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0009 0.001
Loa Loa (eye worm) glutaminase 2 0.033 0.2386 0.249
Brugia malayi nuclear hormone receptor 0.1292 0.9581 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0041 0.0219 0.075
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0013 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.001
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0041 0.0219 0.076
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0349
Giardia lamblia Neurogenic locus notch-like protein 0.002 0.0066 0.0224
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0012 0.0003 0.0011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0048 0.0273 0.0519
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0106 0.0708 0.134
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0106 0.0708 0.0739
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.3349 0.5639
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0095 0.0623 0.0651
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.2952 0.4971
Schistosoma mansoni hypothetical protein 0.0065 0.0404 0.0768
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0163 0.0304
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0098 0.0398
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.3349 0.5639
Schistosoma mansoni pyruvate dehydrogenase 0.0041 0.0219 0.0415
Brugia malayi glutaminase DH11.1 0.033 0.2386 0.249
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0966
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0158 0.1101 0.2087
Echinococcus granulosus dna polymerase eta 0.0019 0.0061 0.011
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Onchocerca volvulus 0.005 0.0289 0.0289
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.0056
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.0334 0.0349
Brugia malayi ecdysone receptor 0.005 0.0289 0.0302
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0048 0.0273 0.0919
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0098 0.0398
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0061 0.0098
Giardia lamblia hypothetical protein 0.002 0.0066 0.0224
Entamoeba histolytica P-glycoprotein 5, putative 0.0013 0.0009 0.0021
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0061 0.0098
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0061 0.0181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0106 0.0708 0.1188
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0106 0.0708 0.1188
Echinococcus multilocularis fibrillin 2 0.002 0.0066 0.0105
Brugia malayi hypothetical protein 0.0056 0.0334 0.0349
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0267 0.0506
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Trichomonas vaginalis DNA topoisomerase II, putative 0.0041 0.0219 0.073
Echinococcus multilocularis insulin receptor 0.0048 0.0272 0.0453
Entamoeba histolytica P-glycoprotein-2, putative 0.0013 0.0009 0.0021
Brugia malayi nuclear receptor NHR-88 0.005 0.0289 0.0302
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0386 0.0403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0368 0.0699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0267 0.0506
Toxoplasma gondii heat shock protein 90, putative 0.0199 0.1404 0.4882
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0158 0.1101 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0033 0.0103
Onchocerca volvulus 0.0106 0.0708 0.0708
Schistosoma mansoni cpg binding protein 0.003 0.0141 0.0268
Echinococcus granulosus cpg binding protein 0.003 0.0141 0.0262
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0395 0.2875 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0041 0.0219 0.1203
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Schistosoma mansoni integrin beta subunit 0.0367 0.2659 0.5054
Echinococcus granulosus dna polymerase kappa 0.0019 0.0061 0.011
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0041 0.0219 0.076
Echinococcus granulosus multidrug resistance protein 1 0.0013 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0273 0.0285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0054
Echinococcus multilocularis protein jagged 2 0.002 0.0066 0.0105
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0041 0.0219 0.0904
Schistosoma mansoni heat shock protein 0.0199 0.1404 0.2668
Loa Loa (eye worm) hypothetical protein 0.0033 0.0163 0.017
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Loa Loa (eye worm) hypothetical protein 0.0041 0.0219 0.0228
Schistosoma mansoni smdr2 0.0013 0.0009 0.0018
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0041 0.0219 0.075
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Loa Loa (eye worm) nuclear receptor nhr-7B 0.1292 0.9581 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0061 0.0117
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.005
Mycobacterium ulcerans glutaminase 0.033 0.2386 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0048 0.0273 0.0285
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0061 0.0064
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.031
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0395 0.2875 0.5462
Brugia malayi TAR-binding protein 0.0063 0.0386 0.0403
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Schistosoma mansoni tyrosine kinase 0.008 0.0515 0.0978
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0267 0.0278
Echinococcus multilocularis integrin alpha ps 0.0136 0.0935 0.1571
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0267 0.0278
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0698 0.0728
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0061 0.0117
Brugia malayi steroid hormone receptor 0.0106 0.0708 0.0739
Trichomonas vaginalis receptor histidine kinase, putative 0.0041 0.0219 0.073
Plasmodium falciparum ABC transporter G family member 2 0.0012 0.0003 0.0011
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0158 0.1101 1
Onchocerca volvulus 0.0028 0.0129 0.0129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0106 0.0708 0.0739
Brugia malayi RNA binding protein 0.0063 0.0386 0.0403
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0081 0.0525 0.0525
Echinococcus multilocularis integrin alpha ps 0.0065 0.0404 0.0676
Brugia malayi EGF-like domain containing protein 0.002 0.0066 0.0069
Loa Loa (eye worm) integrin beta-2 0.0623 0.4575 0.4775
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.0708 0.134
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.033
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0009 0.001
Onchocerca volvulus 0.0013 0.0009 0.0009
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0395 0.2875 1
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0289 0.0482
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0272 0.0453
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0041 0.0219 0.041
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Trypanosoma cruzi heat shock protein, putative 0.0081 0.0525 0.1818
Toxoplasma gondii heat shock protein HSP90 0.0199 0.1404 0.4882
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.002 0.0066 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0106 0.0708 0.134
Schistosoma mansoni heat shock protein 0.0199 0.1404 0.2668
Brugia malayi eukaryotic initiation factor 4A 0.0395 0.2875 0.3001
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Loa Loa (eye worm) heat shock protein 75 0.0081 0.0525 0.0548
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0106 0.0708 0.0739
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0802 0.0837
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0009 0.001
Brugia malayi Integrin beta pat-3 precursor 0.0623 0.4575 0.4775
Schistosoma mansoni hypothetical protein 0.0406 0.2952 0.561
Brugia malayi Endoplasmin precursor 0.0199 0.1404 0.1465
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0041 0.0219 0.075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0106 0.0708 0.1345
Echinococcus granulosus heat shock protein 0.0199 0.1404 0.2663
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0061 0.0181
Toxoplasma gondii Hsp90 domain-containing protein 0.0081 0.0525 0.1827
Brugia malayi nuclear receptor RXR 0.0056 0.0334 0.0349
Onchocerca volvulus Protein ultraspiracle homolog 0.0106 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0395 0.2875 0.3001
Brugia malayi photoreceptor-specific nuclear receptor 0.0106 0.0708 0.0739
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0129 0.0134
Loa Loa (eye worm) hypothetical protein 0.0056 0.0334 0.0349
Trichomonas vaginalis heat shock protein, putative 0.0158 0.1101 0.3808
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Brugia malayi nuclear receptor RXR 0.005 0.0289 0.0302
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Plasmodium vivax RNA helicase-1, putative 0.0395 0.2875 1
Brugia malayi hypothetical protein 0.015 0.1037 0.1083
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0267 0.0506
Schistosoma mansoni nuclear receptor 0.005 0.0289 0.055
Echinococcus granulosus integrin beta 2 0.0461 0.3367 0.6397
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0386 0.0733
Schistosoma mansoni zinc finger protein 0.005 0.0289 0.055
Trypanosoma brucei heat shock protein 90, putative 0.0199 0.1404 0.4876
Trypanosoma cruzi Heat shock protein 83, putative 0.0199 0.1404 0.4876
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0395 0.2875 0.4841
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0395 0.2875 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0199 0.1404 0.488
Trichomonas vaginalis heat shock protein, putative 0.0158 0.1101 0.3808
Echinococcus granulosus insulin receptor 0.0048 0.0272 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0106 0.0708 0.0739
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0289 0.0482
Echinococcus granulosus heat shock protein 90 0.0158 0.1101 0.2087
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.008 0.0515 0.0972
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0289 0.0289
Echinococcus multilocularis ATP binding cassette sub family B 0.0012 0.0007 0.0007
Brugia malayi heat shock protein 90 0.0199 0.1404 0.1465
Echinococcus multilocularis integrin alpha ps 0.0136 0.0935 0.1571
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0106 0.0708 0.1345
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0041 0.0219 0.073
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0061 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0106 0.0708 0.0739
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.0708 0.134
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0289 0.0544
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0106 0.0708 0.0739
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0081 0.0525 0.1818
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0651
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0013 0.0009 0.001
Trichomonas vaginalis hypothetical protein 0.002 0.0066 0.0196
Trypanosoma cruzi heat shock protein 90, putative 0.0199 0.1404 0.4876
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0289 0.0544
Mycobacterium ulcerans heat shock protein 90 0.0158 0.1101 0.4606
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0289 0.0544
Schistosoma mansoni multidrug resistance protein 0.0013 0.0009 0.0018
Plasmodium vivax heat shock protein 86, putative 0.0199 0.1404 0.4882
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0106 0.0708 0.134
Trypanosoma brucei unspecified product 0.0019 0.0061 0.0202
Leishmania major heat shock protein 83-1 0.0199 0.1404 0.4876
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0033 0.0114
Loa Loa (eye worm) hypothetical protein 0.0071 0.0446 0.0466
Brugia malayi Kelch motif family protein 0.0095 0.0623 0.0651
Mycobacterium ulcerans two component sensor kinase MprB 0.0041 0.0219 0.0904
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0016 0.0045
Plasmodium falciparum plasmepsin II 0.0048 0.0273 0.0949
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0041 0.0219 0.075
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0041 0.0219 0.073
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0714 0.5262 1
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0966
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0041 0.0219 0.076
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0098 0.0398
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0069
Echinococcus granulosus fibrillin 1 0.002 0.0066 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0102
Loa Loa (eye worm) multidrug resistance protein 3 0.0013 0.0009 0.001
Echinococcus multilocularis epidermal growth factor receptor 0.0149 0.1031 0.1732
Echinococcus granulosus neuropeptide s receptor 0.0459 0.3349 0.6362
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0041 0.0219 0.073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0106 0.0708 0.0739
Loa Loa (eye worm) hypothetical protein 0.002 0.0066 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Trypanosoma brucei heat shock protein 90, putative 0.0199 0.1404 0.4876
Schistosoma mansoni cathepsin D (A01 family) 0.0141 0.0969 0.1842
Loa Loa (eye worm) hypothetical protein 0.023 0.1636 0.1708
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0106 0.0708 0.0739
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0289 0.0302
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0102
Schistosoma mansoni tyrosine kinase 0.0048 0.0272 0.0517
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0041 0.0219 0.0228
Entamoeba histolytica P-glycoprotein-1 0.0013 0.0009 0.0021
Giardia lamblia High cysteine protein 0.002 0.0066 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0267 0.0501
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0102
Schistosoma mansoni coup transcription factor 0.0106 0.0708 0.1345
Echinococcus multilocularis heat shock protein 90 0.0158 0.1101 0.185
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.5936 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0106 0.0708 0.0739
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0041 0.0219 0.073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0163 0.017
Schistosoma mansoni retinoic acid receptor RXR 0.0714 0.5262 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0016 0.0045
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0041 0.0219 0.0904
Brugia malayi multidrug resistance protein 3 0.0013 0.0009 0.001
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0041 0.0219 0.073
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0395 0.2875 0.2875
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0398
Brugia malayi kinase, mitochondrial precursor 0.0041 0.0219 0.0228
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0052 0.0148
Brugia malayi isocitrate dehydrogenase 0.0016 0.0033 0.0034
Schistosoma mansoni hypothetical protein 0.0205 0.1447 0.275
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0289 0.0482
Loa Loa (eye worm) hypothetical protein 0.0168 0.117 0.1222
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0048 0.0273 0.0455
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.0334 0.0635
Loa Loa (eye worm) heat shock protein 90 0.0199 0.1404 0.1465
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0267 0.0444
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0272 0.0284
Schistosoma mansoni hypothetical protein 0.0205 0.1447 0.275
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0098 0.033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0106 0.0708 0.1345
Leishmania major eukaryotic initiation factor 4a, putative 0.0395 0.2875 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0041 0.0219 0.073
Trypanosoma brucei heat shock protein, putative 0.0199 0.1404 0.4876
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0334 0.0635
Schistosoma mansoni endoplasmin 0.0199 0.1404 0.2668
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0395 0.2875 0.5465
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0289 0.055
Schistosoma mansoni tyrosine kinase 0.0048 0.0272 0.0517
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0033 0.005
Leishmania major DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Onchocerca volvulus 0.002 0.0066 0.0066
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0041 0.0219 0.073
Loa Loa (eye worm) hypothetical protein 0.005 0.0289 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0016 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.3349 0.6362
Mycobacterium ulcerans hypothetical protein 0.0024 0.0098 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0098 0.0309
Brugia malayi ecdysteroid receptor 0.0106 0.0708 0.0739
Toxoplasma gondii hypothetical protein 0.002 0.0066 0.0228
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0033 0.0114
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.0334 0.0629
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0334 0.0349
Trypanosoma cruzi heat shock protein 85, putative 0.0199 0.1404 0.4876
Leishmania major eukaryotic initiation factor 4a, putative 0.0395 0.2875 1
Trichomonas vaginalis heat shock protein, putative 0.0122 0.0828 0.2858
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0033 0.0114
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0013 0.0009 0.0012
Giardia lamblia Tenascin-37 0.002 0.0066 0.0224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0102
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0041 0.0219 1
Brugia malayi Integrin alpha pat-2 precursor 0.0304 0.219 0.2286
Brugia malayi Protein kinase domain containing protein 0.0048 0.0272 0.0284
Schistosoma mansoni integrin alpha-ps 0.0071 0.0446 0.0848
Treponema pallidum ATP-dependent RNA helicase 0.0395 0.2875 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0041 0.0219 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0061 0.0202
Entamoeba histolytica DNA topoisomerase II, putative 0.0041 0.0219 0.075
Schistosoma mansoni multidrug resistance protein 0.0013 0.0009 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0044 0.0122
Echinococcus granulosus integrin alpha ps 0.0136 0.0935 0.1772
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0698 0.0728
Brugia malayi nuclear receptor NHR-88 0.0106 0.0708 0.0739
Schistosoma mansoni hypothetical protein 0.0033 0.0163 0.031
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0289 0.055
Brugia malayi Nuclear hormone receptor-like 1 0.0106 0.0708 0.0739
Loa Loa (eye worm) hypothetical protein 0.0106 0.0708 0.0739
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0267 0.0444
Plasmodium vivax DNA topoisomerase II, putative 0.0041 0.0219 0.076
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0041 0.0219 0.075
Trypanosoma cruzi heat shock protein 85, putative 0.0199 0.1404 0.4876

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1458 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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