Detailed information for compound 1549504

Basic information

Technical information
  • TDR Targets ID: 1549504
  • Name: N-(cyclohexylcarbamoyl)-2-[5-(3,4-dimethoxyph enyl)tetrazol-2-yl]acetamide
  • MW: 388.421 | Formula: C18H24N6O4
  • H donors: 2 H acceptors: 5 LogP: 3.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)c1nnn(n1)CC(=O)NC(=O)NC1CCCCC1
  • InChi: 1S/C18H24N6O4/c1-27-14-9-8-12(10-15(14)28-2)17-21-23-24(22-17)11-16(25)20-18(26)19-13-6-4-3-5-7-13/h8-10,13H,3-7,11H2,1-2H3,(H2,19,20,25,26)
  • InChiKey: HINLDENCNMOQRP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(cyclohexylamino)-oxomethyl]-2-[5-(3,4-dimethoxyphenyl)-2-tetrazolyl]acetamide
  • N-(cyclohexylcarbamoyl)-2-[5-(3,4-dimethoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamide
  • ZINC08394977
  • T5562669

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.001 0.0005
Brugia malayi jmjC domain containing protein 0.0066 0.0205 0.1134
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0168 0.7078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Echinococcus granulosus macrophage expressed protein 0.2005 0.7254 0.7254
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0128 0.1132
Trypanosoma brucei unspecified product 0.0038 0.0102 0.437
Plasmodium falciparum perforin-like protein 2 0.0222 0.0771 0.4226
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0005 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0123
Brugia malayi jmjC domain containing protein 0.0064 0.0199 0.1098
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.012 0.5067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0023 0.0022
Brugia malayi MH2 domain containing protein 0.013 0.0439 0.2426
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0227 0.1253
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0168 0.7078
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Loa Loa (eye worm) glutaminase 0.0299 0.1051 0.5803
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0022 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0005 0.0005
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0169 0.0168
Schistosoma mansoni chromobox protein 0.0012 0.001 0.0005
Entamoeba histolytica hypothetical protein 0.0038 0.0104 0.4314
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0064 0.0199 0.0198
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0104 0.052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0087 0.0477
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Schistosoma mansoni glutaminase 0.0299 0.1051 0.1046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0029
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0027 0.0022
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0168 0.7078
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0024 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0168 0.0167
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0089 0.0487
Echinococcus multilocularis chromobox protein 1 0.0076 0.0242 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0027
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0112 0.4367
Onchocerca volvulus Deterin homolog 0.0059 0.018 0.0968
Onchocerca volvulus 0.0033 0.0087 0.0451
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0027 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0128 0.0175
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0017 0.0012
Echinococcus multilocularis geminin 0.0185 0.0638 0.0638
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0112 0.0112
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0227 1
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0128 0.5548
Echinococcus granulosus Polycystic kidney disease protein 0.0508 0.181 0.181
Onchocerca volvulus 0.0012 0.001 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0128 0.1132
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Echinococcus granulosus dna polymerase eta 0.0016 0.0023 0.0022
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0276 0.0271
Schistosoma mansoni lipoxygenase 0.1847 0.6678 0.6677
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0208 0.1028
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0276 0.1745
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0072 0.0343
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0206 0.0206
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0168 0.151
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0168 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0027
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0112 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Schistosoma mansoni cpg binding protein 0.0031 0.0079 0.0074
Schistosoma mansoni chromobox protein 0.0076 0.0242 0.0237
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0029
Echinococcus granulosus microtubule associated protein 2 0.0754 0.2706 0.2705
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0128 0.516
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0169 0.7868
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0027 0.0022
Brugia malayi Heterochromatin protein 1 0.0076 0.0242 0.1336
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0112 0.0976
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0005 0.0029
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0168 0.7313
Echinococcus granulosus tumor protein p63 0.0369 0.1307 0.1307
Schistosoma mansoni hypothetical protein 0.0059 0.018 0.0175
Schistosoma mansoni hypothetical protein 0.0447 0.159 0.1585
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Toxoplasma gondii hypothetical protein 0.0029 0.0072 0.0826
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0029
Schistosoma mansoni loxhd1 0.0508 0.181 0.1806
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0112 0.5324
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0027 0.0022
Brugia malayi Inositol-1 0.004 0.0112 0.0618
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.001 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0112 0.0112
Brugia malayi beta-NAC-like protein 0.0038 0.0104 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0075 0.062
Brugia malayi nuclear receptor NHR-88 0.0011 0.0005 0.0029
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0023 0.0022
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0049 0.128
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0089 0.3766
Schistosoma mansoni hypothetical protein 0.0185 0.0638 0.0633
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0069 0.2866
Loa Loa (eye worm) hypothetical protein 0.0043 0.012 0.0662
Echinococcus multilocularis transcription factor btf3 0.0038 0.0104 0.0104
Echinococcus multilocularis Polycystic kidney disease protein 0.0508 0.181 0.181
Echinococcus multilocularis dna polymerase eta 0.0016 0.0023 0.0022
Echinococcus granulosus flap endonuclease 1 0.0028 0.0069 0.0068
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.2761 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0112 0.4367
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.001 0.0058
Echinococcus granulosus lipoxygenase domain containing protein 0.0508 0.181 0.181
Brugia malayi Phospholipase A2 family protein 0.0165 0.0565 0.3123
Echinococcus granulosus transcription factor btf3 0.0038 0.0104 0.0104
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0112 0.4358
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0017 0.0091
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0059 0.018 0.0175
Brugia malayi Valyl-tRNA synthetase 0.0012 0.001 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0027 0.0027
Brugia malayi Probable ClpP-like protease 0.0085 0.0276 0.1523
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0227 0.1256
Echinococcus granulosus RUN 0.0508 0.181 0.181
Echinococcus multilocularis inhibitor of apoptosis protein 0.0059 0.018 0.018
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0104 0.0572
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0205 0.1131
Brugia malayi hypothetical protein 0.0508 0.181 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0096 0.3976
Echinococcus multilocularis Chromobox protein 3 0.0012 0.001 0.001
Plasmodium vivax perforin-like protein 5 0.0222 0.0771 0.4226
Loa Loa (eye worm) hypothetical protein 0.0475 0.1691 0.9338
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Trypanosoma brucei protein kinase, putative 0.0056 0.0168 0.7313
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0049 0.1979
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Loa Loa (eye worm) hypothetical protein 0.0085 0.0276 0.1521
Schistosoma mansoni transcription factor btf3 0.0038 0.0104 0.0099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0276 0.1745
Schistosoma mansoni cpg binding protein 0.0033 0.0086 0.008
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0112 0.4684
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0031 0.1177
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0205 0.02
Brugia malayi CXXC zinc finger family protein 0.0031 0.0079 0.0438
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0168 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0112 0.0619
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0027 0.0239
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0023 0.0017
Schistosoma mansoni polycystin 1-related 0.0508 0.181 0.1806
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0168 0.0167
Plasmodium vivax multidomain scavenger receptor, putative 0.0508 0.181 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0206 0.8973
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0112 0.0111
Echinococcus multilocularis chromobox protein 1 0.0076 0.0242 0.0241
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0993
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0117 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0178 0.0979
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0227 1
Echinococcus granulosus cpg binding protein 0.0033 0.0086 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0005 0.0029
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0208 0.0203
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0112 0.0975
Schistosoma mansoni rab6-interacting 0.0508 0.181 0.1806
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0132 0.1169
Onchocerca volvulus 0.0054 0.0162 0.0866
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.012 0.1056
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0169 0.4744
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0027 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0102 0.437
Echinococcus multilocularis lipoxygenase domain containing protein 0.0508 0.181 0.181
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0023 0.0017
Brugia malayi Doublecortin family protein 0.0508 0.181 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0005 0.0027
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0027 0.0094
Echinococcus multilocularis lysine specific demethylase 5A 0.0064 0.0199 0.0198
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0069 0.2244
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.012 0.061
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0112 0.4818
Chlamydia trachomatis hypothetical protein 0.0222 0.0771 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0005 0.0027
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0276 0.1474
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0104 0.4314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0128 0.516
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0276 0.1474
Schistosoma mansoni hypothetical protein 0.0185 0.0638 0.0633
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0005 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.001 0.0005
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0012 0.001 0.0005
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.0541 0.054
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0168 0.151
Echinococcus granulosus chromobox protein 2 0.0012 0.001 0.001
Schistosoma mansoni inositol monophosphatase 0.004 0.0112 0.0107
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0059 0.018 0.0995
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0027 0.0027
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0134 0.1644
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0152
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0069 0.0559
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0993
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0049 0.1411
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0031 0.1177
Onchocerca volvulus 0.0031 0.0079 0.0409
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0205 0.02
Echinococcus granulosus lipoxygenase domain containing protein 0.0508 0.181 0.181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0208 0.1028
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0064 0.0199 0.0198
Schistosoma mansoni hypothetical protein 0.0508 0.181 0.1806
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0195 0.2443
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0208 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0024 0.0133
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0017 0.0017
Brugia malayi ecdysteroid receptor 0.0011 0.0005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0165 0.0565 0.3121
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0005 0.0029
Onchocerca volvulus 0.0012 0.001 0.0029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0033 0.0086 0.008
Echinococcus multilocularis lipoxygenase domain containing protein 0.0508 0.181 0.181
Brugia malayi hypothetical protein 0.0012 0.001 0.0058
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0168 0.7078
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0168 0.0167
Brugia malayi SET domain containing protein 0.0013 0.0013 0.0071
Brugia malayi nuclear hormone receptor 0.0011 0.0005 0.0029
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0069 0.0068
Loa Loa (eye worm) glutaminase 2 0.0299 0.1051 0.5803
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.0541 0.0536
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0208 0.1151
Plasmodium vivax perforin-like protein 3 0.0222 0.0771 0.4226
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0242 0.2224
Echinococcus granulosus Chromobox protein 3 0.0012 0.001 0.001
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0208 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0168 0.2078
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0005 0.0029
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0169 0.7868
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0027 0.0239
Plasmodium vivax perforin-like protein 1 0.0222 0.0771 0.4226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0005 0.0029
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.001 0.001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0276 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0027 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0206 0.1006
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0112 0.4811
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0149
Echinococcus granulosus phd:f box containing protein 0.0017 0.0027 0.0027
Leishmania major basic transcription factor 3a, putative 0.0038 0.0104 0.3976
Brugia malayi polk-prov protein 0.0034 0.0089 0.0489
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0128 0.0175
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0227 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0227 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0036 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0168 0.151
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0069 0.1663
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0112 0.0976
Schistosoma mansoni chromobox protein 0.0076 0.0242 0.0237
Echinococcus multilocularis cpg binding protein 0.0033 0.0086 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0005 0.0027
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0112 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0005 0.0029
Schistosoma mansoni lipoxygenase 0.2761 1 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0027 0.0235
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.001 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0154 0.0525 0.0524
Plasmodium vivax perforin-like protein 4 0.0222 0.0771 0.4226
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0276 0.0275
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0013 0.0008
Schistosoma mansoni inositol monophosphatase 0.004 0.0112 0.0107
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0168 0.7078
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0027 0.0027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0029
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0276 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0112 0.0107
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0027 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0439 0.2424
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Plasmodium falciparum perforin-like protein 1 0.0222 0.0771 0.4226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0207 0.0202
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0112 0.4675
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0242 0.2224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0276 0.3498
Plasmodium falciparum flap endonuclease 1 0.0028 0.0069 0.0323
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0112 0.1347
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0005 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0227 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0112 0.4358
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0034 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.012 0.1056
Plasmodium falciparum perforin-like protein 3 0.0222 0.0771 0.4226
Plasmodium vivax perforin-like protein 2 0.0222 0.0771 0.4226
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0128 0.516
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0169 0.0168
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0206 0.0201
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0072 0.0343
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0089 0.3766
Echinococcus multilocularis RUN 0.0508 0.181 0.181
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0096 0.1194
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0059 0.018 0.018
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0439 0.2424
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0023 0.0125
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0134 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0168 0.151
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0005 0.0005
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0017 0.0017
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0208 0.0208
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0112 0.0107
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0205 0.0205
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0034 0.0034
Loa Loa (eye worm) acetyltransferase 0.0158 0.0541 0.2985
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0168 0.0167
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0206 0.0201
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0023 0.0125
Schistosoma mansoni inhibitor of apoptosis protein 0.0059 0.018 0.0175
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0227 0.0227
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0134 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0104 0.0899
Echinococcus granulosus chromobox protein 1 0.0076 0.0242 0.0241
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0112 0.0112
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.001 0.0058
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.001 0.0016
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0027 0.0027
Echinococcus granulosus chromobox protein 1 0.0076 0.0242 0.0241
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0059 0.018 0.018
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0075 0.062
Brugia malayi Flap endonuclease-1 0.0028 0.0069 0.0379
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0208 0.9072
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0027 0.1018
Echinococcus granulosus geminin 0.0185 0.0638 0.0638
Echinococcus multilocularis tumor protein p63 0.0369 0.1307 0.1307
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.012 0.6024
Schistosoma mansoni jumonji domain containing protein 0.0064 0.0199 0.0194
Loa Loa (eye worm) hypothetical protein 0.0508 0.181 1
Loa Loa (eye worm) doublecortin family protein 0.0508 0.181 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0206 0.1006
Echinococcus multilocularis Chromo domain 0.0012 0.001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0031 0.1177
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0054 0.0162 0.089
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0149
Onchocerca volvulus Phospholipase A2 homolog 0.0165 0.0565 0.3102
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0206 0.9891
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0112 0.0975
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0276 0.0275
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0222 0.0771 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0242 0.1334
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0168 0.0923
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0132 0.0702
Leishmania major hypothetical protein, conserved 0.0017 0.0027 0.0235
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0276 0.3498
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0027 0.0027
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0069 0.2244
Echinococcus multilocularis chromobox protein 2 0.0012 0.001 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0112 0.4358
Brugia malayi hypothetical protein 0.0508 0.181 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0079 0.0435
Brugia malayi MAP kinase sur-1 0.0056 0.0168 0.0925
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.012 0.0637
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0069 0.2681
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0134 0.0689
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0112 0.4367
Onchocerca volvulus 0.0508 0.181 1
Echinococcus granulosus dna polymerase kappa 0.0045 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0055
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.001 0.0016
Trichomonas vaginalis glutaminase, putative 0.0299 0.1051 1
Schistosoma mansoni DNA polymerase eta 0.0016 0.0023 0.0017
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0104 0.4459
Brugia malayi CHD4 protein 0.0014 0.0017 0.0094
Plasmodium falciparum LCCL domain-containing protein 0.0508 0.181 1
Onchocerca volvulus 0.0508 0.181 1
Brugia malayi Protein cec-1. 0.0012 0.001 0.0058
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0104 0.1244
Schistosoma mansoni hypothetical protein 0.2005 0.7254 0.7253
Loa Loa (eye worm) hypothetical protein 0.0508 0.181 1
Plasmodium vivax JmjC domain containing protein 0.0017 0.0027 0.0094
Echinococcus granulosus Chromo domain 0.0012 0.001 0.001
Schistosoma mansoni microtubule-associated protein tau 0.0754 0.2706 0.2702
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0276 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.0049 0.128
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0069 0.0376
Brugia malayi steroid hormone receptor 0.0011 0.0005 0.0029
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0206 0.1006
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0005 0.0005
Schistosoma mansoni flap endonuclease-1 0.0026 0.0059 0.0053
Brugia malayi glutaminase DH11.1 0.0299 0.1051 0.5804
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0134 0.1192
Schistosoma mansoni chromobox protein 0.0012 0.001 0.0005
Onchocerca volvulus 0.0013 0.0013 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0005 0.0029
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0104 0.0899
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0005 0.0029
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0152
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0112 0.0975
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0059 0.018 0.0995
Echinococcus multilocularis macrophage expressed protein 0.2005 0.7254 0.7254
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0112 0.0111
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0069 0.0779
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0023 0.0562
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0023 0.0802
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0036 0.0248
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0168 0.7078
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Echinococcus multilocularis microtubule associated protein 2 0.0754 0.2706 0.2705
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0104 0.3976
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0005 0.0029
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0227 0.0227
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0036 0.0248
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0132 0.1169
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0027
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0128 0.516
Echinococcus granulosus inhibitor of apoptosis protein 0.0059 0.018 0.018
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.159 0.1589
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0005 0.0029
Toxoplasma gondii perforin-like protein PLP1 0.0222 0.0771 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0005 0.0029
Onchocerca volvulus 0.0059 0.018 0.0968
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0162 0.0156
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0227 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0616
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0005 0.0005
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0027 0.0235
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0104 0.052
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.0541 0.2987
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0117 0.0116
Mycobacterium ulcerans glutaminase 0.0299 0.1051 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0023 0.0123
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0112 0.0976
Brugia malayi jmjC domain containing protein 0.0017 0.0027 0.0152
Brugia malayi chromobox protein homolog 3 0.0043 0.012 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0104 0.0899
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0104 0.3976
Plasmodium falciparum perforin-like protein 4 0.0222 0.0771 0.4226
Loa Loa (eye worm) inositol-1 0.004 0.0112 0.0615
Schistosoma mansoni rab6-interacting 0.0508 0.181 0.1806
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0005 0.0005
Plasmodium falciparum perforin-like protein 5 0.0222 0.0771 0.4226
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0128 0.5548
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0128 0.5548
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0134 0.1192
Loa Loa (eye worm) helicase 0.0012 0.001 0.0055
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0005 0.0005
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0069 0.0323
Echinococcus granulosus dnaJ subfamily B 0.0447 0.159 0.1589
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0206 0.2587
Onchocerca volvulus Phospholipase A2 homolog 0.0475 0.1691 0.9336
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0027 0.0027

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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