Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0418 | 0.0405 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1468 | 0.2331 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.0193 | 0.011 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.4091 | 0.9875 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0129 | 0.0316 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0129 | 0.0188 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2095 | 0.5122 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.002 | 0.0047 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2095 | 0.3546 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.0193 | 0.011 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1468 | 0.2475 |
Echinococcus granulosus | ubiquitin | 0.0011 | 0.0222 | 0.0161 |
Entamoeba histolytica | recQ family DNA helicase | 0.0005 | 0.002 | 0.0074 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0695 | 0.1698 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0193 | 0.0465 |
Plasmodium vivax | small ubiquitin-related modifier, putative | 0.003 | 0.0932 | 0.092 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.0193 | 0.0296 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1468 | 0.2331 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0129 | 0.0188 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0129 | 0.0316 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0695 | 0.1677 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0222 | 0.0543 |
Toxoplasma gondii | small ubiquitin family modifier, putative | 0.003 | 0.0932 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2095 | 0.5058 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1468 | 0.359 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2095 | 0.3546 |
Leishmania major | small ubiquitin protein, putative | 0.003 | 0.0932 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0193 | 0.1896 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0515 | 0.0846 |
Echinococcus granulosus | Small ubiquitin modifier 2 | 0.003 | 0.0932 | 0.1397 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0281 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.4091 | 0.9875 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2095 | 0.3423 |
Entamoeba histolytica | hypothetical protein | 0.0011 | 0.0222 | 0.2275 |
Schistosoma mansoni | ubiquitin-like protein sumo/smt3-related | 0.003 | 0.0932 | 0.1559 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2095 | 0.5058 |
Echinococcus multilocularis | Small ubiquitin modifier 2 | 0.003 | 0.0932 | 0.1397 |
Echinococcus multilocularis | ubiquitin | 0.0011 | 0.0222 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0222 | 0.0536 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0296 | 0.1049 |
Schistosoma mansoni | smad | 0.0008 | 0.0129 | 0.0188 |
Loa Loa (eye worm) | SMO-1 protein | 0.003 | 0.0932 | 0.225 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0591 | 0.0406 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.4091 | 1 |
Onchocerca volvulus | 0.0011 | 0.0222 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5873 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0129 | 0.0188 |
Plasmodium falciparum | small ubiquitin-related modifier | 0.003 | 0.0932 | 0.0754 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0193 | 0.0471 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0695 | 0.6655 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0129 | 0.0316 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1468 | 0.2331 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0129 | 0.0313 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0695 | 0.0984 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2095 | 0.3546 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0695 | 0.6655 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5873 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2095 | 0.5122 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2095 | 0.5058 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0193 | 0.1896 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0129 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4142 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1468 | 0.2475 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.0193 | 0.011 |
Trichomonas vaginalis | conserved hypothetical protein | 0.003 | 0.0932 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2095 | 0.3546 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.0193 | 0.0296 |
Brugia malayi | Smad1 | 0.0008 | 0.0129 | 0.0316 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.003 | 0.0932 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0129 | 0.0313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1468 | 0.2331 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2095 | 0.5122 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0281 | 1 | 1 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0193 | 0.0471 |
Trypanosoma brucei | small ubiquitin-related modifier | 0.003 | 0.0932 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0411 | 0.4288 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.0193 | 0.0465 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0129 | 0.0188 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1468 | 0.3545 |
Entamoeba histolytica | ubiquitin like protein | 0.003 | 0.0932 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0296 | 0.3033 |
Giardia lamblia | Sentrin | 0.003 | 0.0932 | 1 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0281 | 1 | 0.5 |
Brugia malayi | Ubiquitin-like protein SMT3 | 0.003 | 0.0932 | 0.2279 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0129 | 0.0313 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0129 | 0.0188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2095 | 0.3546 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1468 | 0.2475 |
Echinococcus multilocularis | geminin | 0.0167 | 0.5873 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2095 | 0.3423 |
Trypanosoma cruzi | small ubiquitin protein, putative | 0.003 | 0.0932 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.0193 | 0.011 |
Treponema pallidum | hypothetical protein | 0.0281 | 1 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0695 | 0.0984 |
Echinococcus granulosus | geminin | 0.0167 | 0.5873 | 1 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0281 | 1 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0296 | 0.3085 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 12 mm | Antibacterial activity against Escherichia coli at 100 ug/ml after 24 hrs by disc diffusion method | ChEMBL. | 21920741 |
IZ (functional) | = 14 mm | Antibacterial activity against Escherichia coli at 200 ug/ml after 24 hrs by disc diffusion method | ChEMBL. | 21920741 |
IZ (functional) | = 17 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hrs by disc diffusion method | ChEMBL. | 21920741 |
IZ (functional) | = 21 mm | Antifungal activity against Candida albicans at 200 ug/ml after 48 hrs by disc diffusion method | ChEMBL. | 21920741 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.