Detailed information for compound 1567230

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.386 | Formula: C20H18FN5O4
  • H donors: 2 H acceptors: 4 LogP: 2.62 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@@H]1COc2n(C1)cc(n2)[N+](=O)[O-])NCc1ccc(cc1)c1ccc(cc1)F
  • InChi: 1S/C20H18FN5O4/c21-16-7-5-15(6-8-16)14-3-1-13(2-4-14)9-22-19(27)23-17-10-25-11-18(26(28)29)24-20(25)30-12-17/h1-8,11,17H,9-10,12H2,(H2,22,23,27)/t17-/m0/s1
  • InChiKey: IORKEBUTVQHWHU-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0042 0.0037
Schistosoma mansoni nuclear receptor 0.001 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0182 0.019
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0354 0.1234
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0026 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0182 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Echinococcus multilocularis Smad4 0.0009 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0182 0.0174
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0057 0.0099
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0182 0.019
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.013 0.0331
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0042 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0258 0.3149 0.3432
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0182 0.0499
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0133
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0026 0.002
Onchocerca volvulus 0.0029 0.0282 0.1092
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0735 0.0794
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0099
Schistosoma mansoni hypothetical protein 0.0071 0.081 0.0877
Brugia malayi CXXC zinc finger family protein 0.0029 0.0282 0.0821
Echinococcus multilocularis Ankyrin 0.0185 0.2243 0.2236
Echinococcus granulosus microtubule associated protein 2 0.0737 0.9158 1
Loa Loa (eye worm) RNA binding protein 0.0258 0.3149 1
Schistosoma mansoni hypothetical protein 0.0185 0.2243 0.2442
Schistosoma mansoni ankyrin 23/unc44 0.0185 0.2243 0.2442
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0026 0.0018
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0185 0.2243 0.7098
Brugia malayi Uncoordinated protein 44 0.0185 0.2243 0.7098
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.5118 0.5114
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0735 0.0728
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.0122
Echinococcus granulosus expressed protein 0.0008 0.0023 0.0016
Brugia malayi conserved hypotetical protein 0.001 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0354 0.1049
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0499 0.0536
Brugia malayi hypothetical protein 0.0011 0.0057 0.0099
Echinococcus multilocularis geminin 0.0353 0.4341 0.4336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0182 0.0499
Echinococcus granulosus tar DNA binding protein 0.0258 0.3149 0.3432
Schistosoma mansoni hypothetical protein 0.0353 0.4341 0.4735
Brugia malayi hypothetical protein 0.0011 0.0057 0.0099
Schistosoma mansoni microtubule-associated protein tau 0.0737 0.9158 1
Brugia malayi ecdysone receptor 0.001 0.0042 0.0051
Brugia malayi Protein kinase domain containing protein 0.009 0.1052 0.3285
Echinococcus granulosus dnaJ subfamily B 0.0415 0.5118 0.5585
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0182 0.0635
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0042 0.0034
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0499 0.0536
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0037
Brugia malayi Death domain containing protein 0.0185 0.2243 0.7098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0057 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0182 0.0499
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0057 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0499 0.0536
Schistosoma mansoni ferritin light chain 0.0008 0.0023 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0182 0.0499
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0182 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0182 0.0499
Brugia malayi Protein kinase domain containing protein 0.0186 0.2248 0.7117
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.003 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1516 0.4771
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0042 0.0037
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0185 0.2243 0.2442
Loa Loa (eye worm) hypothetical protein 0.009 0.1046 0.3267
Loa Loa (eye worm) DR-78 0.001 0.0042 0.0051
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0354 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.2243 0.7098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0182 0.019
Schistosoma mansoni tar DNA-binding protein 0.0258 0.3149 0.3432
Entamoeba histolytica protein kinase, putative 0.009 0.1052 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0185 0.2243 0.7098
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0182 0.019
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0042 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0182 0.0499
Schistosoma mansoni tar DNA-binding protein 0.0258 0.3149 0.3432
Echinococcus multilocularis cpg binding protein 0.0031 0.0303 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0354 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1052 1
Schistosoma mansoni serine/threonine protein kinase 0.009 0.1052 0.1141
Brugia malayi Muscleblind-like protein 0.0151 0.1817 0.5734
Echinococcus multilocularis smad 0.0009 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0331
Schistosoma mansoni hypothetical protein 0.0415 0.5118 0.5585
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.0133
Mycobacterium tuberculosis Conserved protein 0.0035 0.0354 0.1234
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0185 0.2243 0.2442
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0133
Schistosoma mansoni nuclear receptor 0.001 0.0042 0.0037
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0354 0.1234
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0376 0.1121
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1817 0.181
Entamoeba histolytica protein kinase, putative 0.009 0.1052 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0026 0.002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.0133
Brugia malayi RNA recognition motif domain containing protein 0.0258 0.3149 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0182 0.019
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0182 0.019
Schistosoma mansoni hypothetical protein 0.0353 0.4341 0.4735
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0182 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0182 0.0499
Loa Loa (eye worm) hypothetical protein 0.0151 0.1817 0.5734
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0182 0.019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.081 0.0877
Schistosoma mansoni zinc finger protein 0.001 0.0042 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0499 0.1514
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0609 0.6699
Echinococcus granulosus ferritin 0.0008 0.0023 0.0016
Brugia malayi beta-lactamase 0.0035 0.0354 0.1049
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0042 0.0037
Echinococcus multilocularis netrin receptor unc 5 0.0185 0.2243 0.2236
Schistosoma mansoni apoferritin-2 0.0008 0.0023 0.0016
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0042 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.009 0.1052 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0057 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0354 0.0378
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0692 0.0747
Schistosoma mansoni ferritin 0.0008 0.0023 0.0016
Onchocerca volvulus Netrin receptor homolog 0.0185 0.2243 1
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0042 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0283 0.3466 0.3779
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0182 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0354 0.1049
Schistosoma mansoni Smad4 0.0009 0.0026 0.002
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0042 0.0051
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0735 0.546
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0057 0.0099
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0735 0.0794
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0589 0.1801
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.003 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0182 0.019
Treponema pallidum bacterioferrin (TpF1) 0.0008 0.0023 0.5
Loa Loa (eye worm) beta-lactamase 0.0035 0.0354 0.1049
Entamoeba histolytica hypothetical protein 0.009 0.1052 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0354 0.1234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0354 0.1234
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0182 0.0635
Echinococcus granulosus GPCR family 2 0.0017 0.013 0.0133
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0042 0.0037
Brugia malayi steroid hormone receptor 0.0021 0.0182 0.0499
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0354 0.0378
Mycobacterium leprae Probable lipase LipE 0.0035 0.0354 1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0735 0.0794
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0182 0.019
Echinococcus granulosus muscleblind protein 0.0151 0.1817 0.1977
Brugia malayi TAR-binding protein 0.0258 0.3149 1
Brugia malayi hypothetical protein 0.0071 0.081 0.2512
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0182 0.019
Brugia malayi nuclear receptor RXR 0.001 0.0042 0.0051
Echinococcus multilocularis expressed protein 0.0008 0.0023 0.0015
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0499 0.1514
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0354 0.0378
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.0122
Loa Loa (eye worm) hypothetical protein 0.0054 0.0589 0.1801
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0735 1
Schistosoma mansoni coup transcription factor 0.0021 0.0182 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0182 0.019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0182 0.0174
Onchocerca volvulus 0.0162 0.1952 0.868
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Loa Loa (eye worm) histone methyltransferase 0.0009 0.003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Echinococcus multilocularis tar DNA binding protein 0.0258 0.3149 0.3143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0589 0.1801
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0042 0.0051
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0023 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0354 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0182 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0017 0.013 0.0331
Echinococcus granulosus geminin 0.0353 0.4341 0.4735
Brugia malayi RNA binding protein 0.0258 0.3149 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0037
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0258 0.3149 1
Schistosoma mansoni ferritin 0.0008 0.0023 0.0016
Brugia malayi hypothetical protein 0.0162 0.1952 0.6168
Onchocerca volvulus 0.0035 0.0354 0.1416
Echinococcus granulosus smad 0.0009 0.0026 0.002
Brugia malayi MH2 domain containing protein 0.0127 0.1516 0.4771
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0182 0.0499
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0735 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0735 0.2655
Echinococcus multilocularis ferritin 0.0008 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0099
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0499 0.0536
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.1052 1
Onchocerca volvulus 0.0035 0.0354 0.1416
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0042 0.0037
Brugia malayi nuclear hormone receptor 0.0021 0.0182 0.0499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0034
Schistosoma mansoni ferritin 0.0008 0.0023 0.0016
Brugia malayi hypothetical protein 0.001 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0042 0.0051
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0182 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0182 0.0499
Echinococcus granulosus cpg binding protein 0.0031 0.0303 0.0323
Mycobacterium tuberculosis Conserved protein 0.0035 0.0354 0.1234
Brugia malayi Nuclear hormone receptor E75 0.001 0.0042 0.0051
Mycobacterium ulcerans lipase LipD 0.0035 0.0354 0.4646
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.081 0.0877
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.013 0.0331
Echinococcus multilocularis dual specificity 0.009 0.1052 0.1045
Echinococcus multilocularis GPCR, family 2 0.0017 0.013 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0354 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0282 0.0821
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0182 0.019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0182 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0185 0.2243 0.2236
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.1052 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0042 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0182 0.019
Trichomonas vaginalis esterase, putative 0.0035 0.0354 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0182 0.0174
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0354 0.1234
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0735 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0057 0.0054
Schistosoma mansoni cpg binding protein 0.0029 0.0282 0.03
Echinococcus multilocularis microtubule associated protein 2 0.0737 0.9158 0.9158
Brugia malayi nuclear receptor NHR-88 0.0021 0.0182 0.0499
Brugia malayi nuclear receptor NHR-67 0.001 0.0042 0.0051
Loa Loa (eye worm) TAR-binding protein 0.0258 0.3149 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0182 0.0499
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0042 0.0034
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.1052 0.3285
Schistosoma mansoni netrin receptor unc5 0.0185 0.2243 0.2442
Schistosoma mansoni tar DNA-binding protein 0.0258 0.3149 0.3432
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.1052 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Onchocerca volvulus 0.0021 0.0182 0.0635
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0354 0.4646
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Schistosoma mansoni cpg binding protein 0.0031 0.0303 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0042 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0182 0.0499
Brugia malayi beta-lactamase family protein 0.0035 0.0354 0.1049
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0182 0.0499
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0735 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0182 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0182 0.0499
Echinococcus granulosus netrin receptor unc 5 0.0185 0.2243 0.2442
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0182 0.019
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0182 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0499 0.0491
Schistosoma mansoni ferritin 0.0008 0.0023 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0499 0.0491
Brugia malayi nuclear receptor NHR-88 0.001 0.0042 0.0051
Schistosoma mansoni apoferritin-2 0.0008 0.0023 0.0016
Mycobacterium tuberculosis Conserved protein 0.0035 0.0354 0.1234
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0182 0.019
Loa Loa (eye worm) hypothetical protein 0.009 0.1046 0.3267
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0182 0.019
Brugia malayi beta-lactamase family protein 0.0035 0.0354 0.1049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0354 0.1234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0182 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.081 0.0803
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0376 0.1121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0182 0.0499
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0042 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0029 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0182 0.0499
Echinococcus granulosus Smad4 0.0009 0.0026 0.002
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0354 0.1234
Loa Loa (eye worm) hypothetical protein 0.0162 0.1952 0.6168
Schistosoma mansoni hypothetical protein 0.0037 0.0376 0.0402
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0182 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2705 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0182 0.0499
Brugia malayi tailless protein 0.001 0.0042 0.0051
Echinococcus multilocularis muscleblind protein 0.0151 0.1817 0.181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0182 0.0499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0057 0.0054
Echinococcus granulosus dual specificity 0.009 0.1052 0.1141
Schistosoma mansoni ferritin light chain 0.0008 0.0023 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0182 0.0499
Brugia malayi ecdysteroid receptor 0.0021 0.0182 0.0499
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0283 0.3466 0.3461
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1516 0.4771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0099
Schistosoma mansoni smad 0.0009 0.0026 0.002
Schistosoma mansoni smad1 5 8 and 0.0009 0.0026 0.002
Loa Loa (eye worm) hypothetical protein 0.0185 0.2243 0.7098
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0354 0.4646
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0589 0.1801
Schistosoma mansoni tumor necrosis factor receptor related 0.0283 0.3466 0.3779
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0042 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0258 0.3149 0.3432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0499 0.0536
Brugia malayi nuclear hormone receptor 0.001 0.0042 0.0051
Brugia malayi nuclear receptor RXR 0.0011 0.0057 0.0099
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0182 0.0499
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0182 0.019
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0182 0.0499
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0042 0.0051
Loa Loa (eye worm) hypothetical protein 0.0151 0.1817 0.5734
Brugia malayi Nuclear hormone receptor E75 0.001 0.0042 0.0051
Mycobacterium ulcerans hypothetical protein 0.0035 0.0354 0.4646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0182 0.0499
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0354 1
Echinococcus granulosus Ankyrin 0.0185 0.2243 0.2442
Mycobacterium ulcerans beta-lactamase 0.0035 0.0354 0.4646
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0354 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Brugia malayi hypothetical protein 0.001 0.0042 0.0051
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0354 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0182 0.0499
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0283 0.3466 0.3461
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0051
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0133
Schistosoma mansoni cpg binding protein 0.0031 0.0303 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0182 0.0499
Loa Loa (eye worm) hypothetical protein 0.0035 0.0354 0.1049
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0283 0.3466 0.3779
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0182 0.0499
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0182 0.0499
Echinococcus granulosus death domain containing protein 0.0185 0.2243 0.2442
Onchocerca volvulus 0.0035 0.0354 0.1416
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0042 0.0037
Trichomonas vaginalis ferritin, putative 0.0008 0.0023 0.0641

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.11 uM Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring pFCA-lux AB gene measured under aerobic condition after 8 days by luminescence analysis ChEMBL. 22148391
MIC (functional) = 26 uM Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 harboring pFCA-lux AB gene measured under anaerobic condition after 11 days by luminescence analysis ChEMBL. 22148391

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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