Detailed information for compound 1567653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 148.185 | Formula: C8H10N3+
  • H donors: 2 H acceptors: 0 LogP: -0.16 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CC[n+]1ccc(c(c1)N)N
  • InChi: 1S/C8H9N3/c1-2-4-11-5-3-7(9)8(10)6-11/h1,3,5-6,9H,4,10H2/p+1
  • InChiKey: PGFZQLNFAHQPBF-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0644 0.0832
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0178 0.0178
Brugia malayi Fli-1 protein 0.0249 0.7041 0.9096
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0088 0.2248 0.9055
Giardia lamblia Kinase, PLK 0.0094 0.2443 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2443 0.8168
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0117 0.0071
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.7742 0.7742
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0433 0.0247
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0362 0.0362
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.7196 0.7196
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0161 0.0161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2799 0.2799
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0178 0.0691
Leishmania major DNA polymerase eta, putative 0.0112 0.2965 1
Brugia malayi hypothetical protein 0.0041 0.0857 0.1107
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2248 0.7484
Echinococcus granulosus dna polymerase eta 0.0112 0.2965 0.2965
Brugia malayi Pax transcription factor protein 2 0.0272 0.7742 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0059 0.1412 0.1412
Leishmania major DNA polymerase kappa, putative 0.0065 0.1576 0.5018
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Schistosoma mansoni tsg101-related 0.0123 0.3309 0.3309
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0161 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0177 0.0209
Trichomonas vaginalis hypothetical protein 0.0072 0.1789 0.6825
Loa Loa (eye worm) hypothetical protein 0.0148 0.4044 0.4044
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1241 0.3946
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Trypanosoma brucei unspecified product 0.004 0.0824 0.2322
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0617 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.2082 0.2082
Schistosoma mansoni DNA helicase recq1 0.0031 0.057 0.057
Brugia malayi MH2 domain containing protein 0.0017 0.0161 0.0208
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.0736
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0382 0.0931
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0382 0.0931
Brugia malayi isocitrate dehydrogenase 0.0018 0.0178 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2799 0.3616
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0398 0.1684
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.057 0.057
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0161 0.0161
Schistosoma mansoni kinase 0.0048 0.1068 0.1068
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0365
Brugia malayi Importin beta-1 subunit 0.0033 0.0617 0.0796
Brugia malayi Ets-domain containing protein 0.0082 0.2082 0.269
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0348 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.1241 0.3946
Echinococcus granulosus Smad4 0.0017 0.0161 0.0161
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0617 0.299
Trichomonas vaginalis DNA helicase recq, putative 0.0075 0.1882 0.728
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0161 0.0161
Schistosoma mansoni smad 0.0017 0.0161 0.0161
Schistosoma mansoni tsg101-related 0.0101 0.2638 0.2638
Entamoeba histolytica recQ family helicase, putative 0.004 0.0841 0.2922
Brugia malayi Bloom's syndrome protein homolog 0.0075 0.1882 0.2432
Plasmodium falciparum importin beta, putative 0.0033 0.0617 0.3067
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2248 0.7484
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Brugia malayi MH2 domain containing protein 0.0017 0.0161 0.0208
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2542
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Brugia malayi RNA, U transporter 1 0.0093 0.2405 0.3106
Echinococcus multilocularis dna polymerase eta 0.0112 0.2965 0.2965
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0644 0.0644
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Brugia malayi hypothetical protein 0.0054 0.1241 0.1603
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.7196 0.7196
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.057 0.274
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0177 0.0678
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.1354 0.1354
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0617 0.1578
Schistosoma mansoni hypothetical protein 0.0041 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.007 0.1729 0.1729
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.1241 0.6727
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0177 0.0209
Echinococcus granulosus GPCR family 2 0.0034 0.0644 0.0644
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.1354 0.1354
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Schistosoma mansoni hypothetical protein 0.0073 0.1802 0.1802
Loa Loa (eye worm) hypothetical protein 0.0048 0.1071 0.1071
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1241 0.7419
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0117 0.0117
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0177 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0101 0.2638 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0088 0.2248 0.9055
Echinococcus multilocularis GPCR, family 2 0.0034 0.0644 0.0644
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1031 0.3148
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.2248 0.743
Schistosoma mansoni hypothetical protein 0.0034 0.0644 0.0644
Schistosoma mansoni hypothetical protein 0.0024 0.0362 0.0362
Echinococcus multilocularis snurportin 1 0.0348 1 1
Echinococcus granulosus bloom syndrome protein 0.0075 0.1882 0.1882
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.1354 0.1354
Echinococcus granulosus smad 0.0017 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Loa Loa (eye worm) fli-1 protein 0.0249 0.7041 0.7041
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.1141 0.6127
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.2709
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0433 0.0247
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.1576 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0005
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0841 0.2227
Brugia malayi MH1 domain containing protein 0.0017 0.0161 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Trypanosoma brucei unspecified product 0.004 0.0824 0.2322
Brugia malayi MH2 domain containing protein 0.0254 0.7196 0.9296
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Brugia malayi hypothetical protein 0.0148 0.4044 0.5224
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.1241 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0178 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2799 0.3616
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.1354 0.1354
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0161 0.0161
Brugia malayi MH1 domain containing protein 0.0017 0.0161 0.0208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0644 0.0644
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.2082 0.2082
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0066 0.1611 1
Schistosoma mansoni tsg101-related 0.0123 0.3309 0.3309
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.0736
Schistosoma mansoni hypothetical protein 0.0034 0.0644 0.0644
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2248 0.7484
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1071 0.3208
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0433 0.111
Schistosoma mansoni hypothetical protein 0.0034 0.0644 0.0644
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.2443 0.8129
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1071 0.3208
Trichomonas vaginalis DNA helicase recq1, putative 0.0075 0.1882 0.728
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.2443 0.3156
Loa Loa (eye worm) Smad1 0.0017 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.1576 0.5018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0644 0.0832
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.2082 0.2082
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0433 0.0247
Loa Loa (eye worm) hypothetical protein 0.0073 0.1802 0.1802
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.2709
Leishmania major hypothetical protein, conserved 0.0047 0.1053 0.3144
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0148 0.4044 0.4044
Loa Loa (eye worm) STAT protein 0.0131 0.354 0.354
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0178 0.023
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0857 0.0857
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.057 0.057
Schistosoma mansoni Smad4 0.0017 0.0161 0.0161
Echinococcus granulosus dna polymerase kappa 0.0088 0.2248 0.2248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0857 0.0857
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.2443 0.2443
Plasmodium vivax importin-beta 2, putative 0.0033 0.0617 0.4532
Brugia malayi polk-prov protein 0.0048 0.1071 0.1383
Schistosoma mansoni ets-related 0.0249 0.7041 0.7041
Giardia lamblia DINP protein human, muc B family 0.0065 0.1576 0.6174
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.2443 0.2443
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0644 0.0644
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Brugia malayi ImpB/MucB/SamB family protein 0.0112 0.2965 0.383
Echinococcus multilocularis bloom syndrome protein 0.0075 0.1882 0.1882
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0617 0.1578
Entamoeba histolytica hypothetical protein 0.0026 0.0433 0.1315
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0148 0.4044 0.4044
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0047 0.1053 0.3144
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Loa Loa (eye worm) hypothetical protein 0.0031 0.057 0.057
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.2248 0.743
Brugia malayi hypothetical protein 0.0035 0.0676 0.0873
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.1241 0.7419
Loa Loa (eye worm) RecQ helicase 0.0075 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.0106 0.2799 0.2799
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.2443 0.2443
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0005
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.057 0.057
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0034 0.0644 0.0644
Schistosoma mansoni DNA polymerase eta 0.0112 0.2965 0.2965
Onchocerca volvulus 0.0272 0.7742 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0161 0.0161
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0857 0.0857
Leishmania major hypothetical protein, conserved 0.0054 0.1241 0.3816
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.2443 0.9232
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.1787 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.1576 0.5018
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Schistosoma mansoni importin beta-1 0.0033 0.0617 0.0617
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.2026 0.6634
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.1354 0.8412
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0644 0.0644
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1354 0.1749
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2383
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1787 0.5866
Trypanosoma brucei DNA polymerase eta, putative 0.0112 0.2965 1
Trypanosoma brucei polo-like protein kinase 0.0094 0.2443 0.8129
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1802 0.2327
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.057 0.057
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.1241 0.3816
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0088 0.2248 0.7484
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0177 0.0209
Echinococcus multilocularis Smad4 0.0017 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0054 0.1241 0.1241
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0177 0.0356
Schistosoma mansoni gabp alpha 0.0082 0.2082 0.2082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0644 0.0644
Trypanosoma brucei DNA polymerase kappa, putative 0.0088 0.2248 0.743
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.1354 0.1354
Leishmania major importin beta-1 subunit, putative 0.0026 0.0433 0.092
Echinococcus granulosus importin subunit beta 1 0.0033 0.0617 0.0617
Echinococcus multilocularis dna polymerase kappa 0.0088 0.2248 0.2248
Brugia malayi STAT protein, DNA binding domain containing protein 0.0131 0.354 0.4573
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0047 0.1053 0.3287
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0738
Trypanosoma cruzi DNA polymerase eta, putative 0.0112 0.2965 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2443 0.8168
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.1354 0.4942
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.057 0.1734
Loa Loa (eye worm) hypothetical protein 0.0112 0.2965 0.2965
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0365
Schistosoma mansoni DNA helicase recq5 0.0031 0.057 0.057
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0362 0.0362
Brugia malayi Smad1 0.0017 0.0161 0.0208
Treponema pallidum ATP-dependent DNA helicase 0.0016 0.0117 0.5
Schistosoma mansoni hypothetical protein 0.0348 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0088 0.2248 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.2443 0.2443
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0178 0.0178
Schistosoma mansoni hypothetical protein 0.0034 0.0644 0.0644
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0033 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0276 0.786 0.786
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0214
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0177 0.0209
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0178 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.1031 0.3148
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0178 0.0178
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0051 0.1158 0.9279
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma brucei unspecified product 0.008 0.2026 0.6634
Mycobacterium ulcerans DNA polymerase IV 0.0088 0.2248 1
Leishmania major DNA polymerase eta, putative 0.0072 0.1787 0.5777
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0178 0.0011
Echinococcus multilocularis smad 0.0017 0.0161 0.0161
Brugia malayi Ets-domain containing protein 0.0082 0.2082 0.269
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2383

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 1.2 hr Half life in iv dosed mouse ChEMBL. 21975066

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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