Detailed information for compound 1567654

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.471 | Formula: C16H27N3S
  • H donors: 1 H acceptors: 0 LogP: 4.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=c1[nH]nc(n1C1CCCCC1)CCC1CCCCC1
  • InChi: 1S/C16H27N3S/c20-16-18-17-15(12-11-13-7-3-1-4-8-13)19(16)14-9-5-2-6-10-14/h13-14H,1-12H2,(H,18,20)
  • InChiKey: SCNNLYSQYBOFMI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Onchocerca volvulus 0.0271 0.7742 1
Trypanosoma brucei unspecified product 0.0039 0.0824 0.2322
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0644 0.0644
Entamoeba histolytica hypothetical protein 0.0026 0.0433 0.1315
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.2443 0.2443
Brugia malayi Smad1 0.0017 0.0161 0.0208
Echinococcus multilocularis dna polymerase eta 0.0111 0.2965 0.2965
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Schistosoma mansoni hypothetical protein 0.0033 0.0644 0.0644
Schistosoma mansoni blooms syndrome DNA helicase 0.0059 0.1412 0.1412
Echinococcus granulosus dna polymerase kappa 0.0087 0.2248 0.2248
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.1354 0.1354
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.057 0.1734
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0365
Brugia malayi MH2 domain containing protein 0.0017 0.0161 0.0208
Schistosoma mansoni tsg101-related 0.0123 0.3308 0.3308
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0178 0.0178
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0161 0.0161
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0177 0.0356
Brugia malayi hypothetical protein 0.0147 0.4044 0.5224
Brugia malayi Ets-domain containing protein 0.0082 0.2082 0.269
Echinococcus multilocularis smad 0.0017 0.0161 0.0161
Schistosoma mansoni hypothetical protein 0.0347 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.2026 0.6635
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.2082 0.2082
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0117 0.0071
Schistosoma mansoni DNA helicase recq1 0.0031 0.057 0.057
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.7196 0.7196
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.2248 0.743
Brugia malayi hypothetical protein 0.0034 0.0676 0.0873
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.2248 0.7484
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.1787 0.5866
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1031 0.3148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0857 0.0857
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0382 0.0931
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.1354 0.8412
Schistosoma mansoni tsg101-related 0.0123 0.3308 0.3308
Leishmania major hypothetical protein, conserved 0.0047 0.1053 0.3143
Leishmania major importin beta-1 subunit, putative 0.0026 0.0433 0.092
Trypanosoma brucei unspecified product 0.008 0.2026 0.6635
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.2248 1
Schistosoma mansoni importin beta-1 0.0032 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0072 0.1802 0.1802
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Echinococcus multilocularis GPCR, family 2 0.0033 0.0644 0.0644
Brugia malayi STAT protein, DNA binding domain containing protein 0.013 0.354 0.4572
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Brugia malayi RNA, U transporter 1 0.0092 0.2405 0.3106
Schistosoma mansoni Smad4 0.0017 0.0161 0.0161
Schistosoma mansoni DNA polymerase eta 0.0111 0.2965 0.2965
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.1241 0.3816
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0147 0.4044 0.4044
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1802 0.2327
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Schistosoma mansoni ets-related 0.0248 0.7041 0.7041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.2248 0.7484
Loa Loa (eye worm) fli-1 protein 0.0248 0.7041 0.7041
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Plasmodium vivax importin-beta 2, putative 0.0032 0.0617 0.4533
Brugia malayi ImpB/MucB/SamB family protein 0.0111 0.2965 0.3829
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0857 0.0857
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.2248 0.7484
Loa Loa (eye worm) hypothetical protein 0.007 0.1729 0.1729
Schistosoma mansoni hypothetical protein 0.0024 0.0362 0.0362
Loa Loa (eye worm) RecQ helicase 0.0075 0.1882 0.1882
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2383
Plasmodium falciparum importin beta, putative 0.0032 0.0617 0.3068
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Schistosoma mansoni hypothetical protein 0.0033 0.0644 0.0644
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0178 0.023
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.057 0.057
Brugia malayi Fli-1 protein 0.0248 0.7041 0.9096
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2542
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.1354 0.1354
Leishmania major DNA polymerase kappa, putative 0.0065 0.1576 0.5018
Schistosoma mansoni DNA helicase recq5 0.0031 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0275 0.786 0.786
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.1354 0.4942
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0178 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0177 0.0209
Loa Loa (eye worm) hypothetical protein 0.0111 0.2965 0.2965
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0644 0.0644
Schistosoma mansoni hypothetical protein 0.0033 0.0644 0.0644
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0644 0.0644
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2799 0.2799
Echinococcus granulosus smad 0.0017 0.0161 0.0161
Brugia malayi Ets-domain containing protein 0.0082 0.2082 0.269
Trichomonas vaginalis DNA helicase recq, putative 0.0075 0.1882 0.7281
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0161 0.0161
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0178 0.0011
Loa Loa (eye worm) hypothetical protein 0.0033 0.0644 0.0644
Echinococcus multilocularis Smad4 0.0017 0.0161 0.0161
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0177 0.0209
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1241 0.3945
Schistosoma mansoni hypothetical protein 0.0033 0.0644 0.0644
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0433 0.111
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0398 0.1684
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2799 0.3615
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.2248 0.743
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.2248 0.9056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.2248 0.7484
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0617 0.0617
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0177 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1071 0.3208
Entamoeba histolytica hypothetical protein 0.0041 0.0857 0.2984
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0617 0.299
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.7196 0.7196
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1241 0.7418
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.0736
Trypanosoma brucei DNA polymerase eta, putative 0.0111 0.2965 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0161 0.0161
Giardia lamblia DINP protein human, muc B family 0.0065 0.1576 0.6175
Brugia malayi isocitrate dehydrogenase 0.0018 0.0178 0.023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0433 0.0247
Echinococcus granulosus dna polymerase eta 0.0111 0.2965 0.2965
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.1241 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0047 0.1053 0.3143
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Entamoeba histolytica recQ family helicase, putative 0.004 0.0841 0.2922
Trypanosoma brucei unspecified product 0.0039 0.0824 0.2322
Brugia malayi Bloom's syndrome protein homolog 0.0075 0.1882 0.2431
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.2443 0.2443
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0178 0.0178
Treponema pallidum ATP-dependent DNA helicase 0.0016 0.0117 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0841 0.2383
Loa Loa (eye worm) hypothetical protein 0.0053 0.1241 0.1241
Loa Loa (eye worm) Smad1 0.0017 0.0161 0.0161
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1354 0.1749
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0161 0.0161
Loa Loa (eye worm) STAT protein 0.013 0.354 0.354
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Loa Loa (eye worm) hypothetical protein 0.0031 0.057 0.057
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0051 0.1158 0.928
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.057 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1241 0.7418
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1031 0.3148
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.057 0.274
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0177 0.0209
Schistosoma mansoni gabp alpha 0.0082 0.2082 0.2082
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.2248 0.9056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Schistosoma mansoni hypothetical protein 0.0041 0.0857 0.0857
Loa Loa (eye worm) pax transcription factor protein 2 0.0271 0.7742 0.7742
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0362 0.0362
Brugia malayi MH2 domain containing protein 0.0253 0.7196 0.9295
Brugia malayi MH1 domain containing protein 0.0017 0.0161 0.0208
Trypanosoma cruzi DNA polymerase eta, putative 0.0111 0.2965 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0117 0.0117
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0362 0.0362
Echinococcus granulosus GPCR family 2 0.0033 0.0644 0.0644
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.2443 0.2443
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0161 0.0161
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0047 0.1053 0.3287
Echinococcus granulosus Smad4 0.0017 0.0161 0.0161
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.2709
Echinococcus multilocularis bloom syndrome protein 0.0075 0.1882 0.1882
Brugia malayi hypothetical protein 0.0041 0.0857 0.1107
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0214
Schistosoma mansoni hypothetical protein 0.0072 0.1802 0.1802
Leishmania major hypothetical protein, conserved 0.0053 0.1241 0.3816
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.2082 0.2082
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.01 0.2638 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.2082 0.2082
Echinococcus granulosus importin subunit beta 1 0.0032 0.0617 0.0617
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0178 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2443 0.8167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0617 0.0617
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.2248 1
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0841 0.2227
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.1354 0.1354
Schistosoma mansoni smad1 5 8 and 0.0017 0.0161 0.0161
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.1576 0.5018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.0736
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.1576 1
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0147 0.4044 0.4044
Schistosoma mansoni tsg101-related 0.01 0.2638 0.2638
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.1576 0.5018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0644 0.0832
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.114 0.6127
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0738
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.2443 0.8128
Leishmania major DNA polymerase eta, putative 0.0072 0.1787 0.5777
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0433 0.0247
Schistosoma mansoni kinase 0.0048 0.1068 0.1068
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0178 0.0365
Trichomonas vaginalis hypothetical protein 0.0072 0.1788 0.6825
Entamoeba histolytica hypothetical protein 0.0025 0.0382 0.1115
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2799 0.3615
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.057 0.2709
Leishmania major DNA polymerase eta, putative 0.0111 0.2965 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0177 0.0209
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0644 0.0644
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.057 0.057
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.1354 0.1354
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0161 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1046 0.3118
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0644 0.0832
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.2443 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0072 0.1787 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0857 0.0857
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.2443 0.9231
Brugia malayi polk-prov protein 0.0048 0.1071 0.1383
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.2443 0.2443
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.1354 0.1354
Trypanosoma brucei polo-like protein kinase 0.0094 0.2443 0.8128
Brugia malayi MH2 domain containing protein 0.0017 0.0161 0.0208
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0617 0.1578
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0178 0.0178
Echinococcus multilocularis dna polymerase kappa 0.0087 0.2248 0.2248
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0178 0.0214
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0161 0.0161
Echinococcus granulosus bloom syndrome protein 0.0075 0.1882 0.1882
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0178 0.0006
Trichomonas vaginalis DNA helicase recq1, putative 0.0075 0.1882 0.7281
Loa Loa (eye worm) hypothetical protein 0.0048 0.1071 0.1071
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.1071 0.3208
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.2443 0.3155
Brugia malayi Pax transcription factor protein 2 0.0271 0.7742 1
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0177 0.0678
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.057 0.057
Brugia malayi MH1 domain containing protein 0.0017 0.0161 0.0208
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0382 0.0931
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0644 0.0644
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.2248 0.743
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.2443 0.8167
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.1241 0.6727
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0433 0.0247
Loa Loa (eye worm) hypothetical protein 0.0147 0.4044 0.4044
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0025 0.0382 0.0931
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0066 0.1611 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.057 0.057
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0617 0.1578
Echinococcus multilocularis snurportin 1 0.0347 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1241 0.3945
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0106 0.2799 0.2799
Schistosoma mansoni smad 0.0017 0.0161 0.0161
Giardia lamblia Kinase, PLK 0.0094 0.2443 1
Brugia malayi hypothetical protein 0.0053 0.1241 0.1602
Brugia malayi Importin beta-1 subunit 0.0032 0.0617 0.0796
Loa Loa (eye worm) hypothetical protein 0.0016 0.0117 0.0117
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0178 0.0691

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 50 ug ml-1 Antituberculosis activity against drug-sensitive Mycobacterium tuberculosis isolate Spec. 210 by twofold serial dilution method ChEMBL. 22153872
MIC (functional) = 100 ug ml-1 Antituberculosis activity against multidrug-resistant Mycobacterium tuberculosis isolate Spec. 192 by twofold serial dilution method ChEMBL. 22153872

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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