TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.424 | Formula: C21H23N3O5
H donors: 1 H acceptors: 3 LogP: 2.62 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(C(=O)Cn1c(=O)oc2c1cccc2)CC(=O)Nc1ccccc1OC
InChi: 1S/C21H23N3O5/c1-3-12-23(13-19(25)22-15-8-4-6-10-17(15)28-2)20(26)14-24-16-9-5-7-11-18(16)29-21(24)27/h4-11H,3,12-14H2,1-2H3,(H,22,25)
InChiKey: IAMSZXKNMJFUFJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.2941	0.2772
Trichomonas vaginalis	tubulin, putative	0.0146	1	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0026	0.0462	0.0067
Trypanosoma brucei	beta tubulin	0.0146	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.2941	0.2941
Plasmodium falciparum	tubulin gamma chain	0.0057	0.2941	0.2648
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Trichomonas vaginalis	tubulin, putative	0.0025	0.0398	0.0169
Trichomonas vaginalis	tubulin gamma chain, putative	0.0025	0.0398	0.0169
Leishmania major	beta tubulin	0.0146	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0146	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0146	1	1
Loa Loa (eye worm)	FAD binding domain-containing protein	0.0026	0.0462	0.0067
Giardia lamblia	Gamma tubulin	0.0057	0.2941	0.2772
Giardia lamblia	Beta tubulin	0.0146	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0057	0.2941	0.2772
Trichomonas vaginalis	sulfite reductase, putative	0.0026	0.0462	0.0235
Trypanosoma brucei	beta tubulin	0.0057	0.2941	0.2648
Onchocerca volvulus		0.0032	0.099	0.5
Echinococcus granulosus	tubulin alpha chain	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0025	0.0398	0.0169
Trypanosoma cruzi	epsilon tubulin, putative	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0025	0.0398	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0146	1	1
Brugia malayi	Tubulin gamma chain	0.0057	0.2941	0.2941
Trichomonas vaginalis	tubulin gamma chain, putative	0.0146	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.0032	0.099	0.0774
Trypanosoma brucei	beta tubulin	0.0146	1	1
Echinococcus multilocularis	tubulin alpha	0.0057	0.2941	0.2648
Trypanosoma brucei	beta tubulin	0.0146	1	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0025	0.0398	0.0169
Leishmania major	beta tubulin	0.0146	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0146	1	1
Brugia malayi	hypothetical protein	0.003	0.0853	0.0853
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.0026	0.0462	0.0067
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0032	0.099	0.0616
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.2941	0.2941
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Brugia malayi	Cell division protein ftsZ	0.0025	0.0398	0.0398
Echinococcus multilocularis	beta tubulin	0.0146	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.2941	0.2772
Trichomonas vaginalis	tubulin, putative	0.0032	0.099	0.0774
Leishmania major	beta tubulin	0.0146	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.2941	0.2648
Brugia malayi	Tubulin alpha chain	0.0025	0.0398	0.0398
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0146	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0853	0.0474
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.0026	0.0462	0.0067
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.2941	0.2648
Trypanosoma cruzi	epsilon tubulin, putative	0.0057	0.2941	0.2648
Echinococcus granulosus	tubulin beta 1 chain	0.0146	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0032	0.099	0.0774
Loa Loa (eye worm)	BEN-1 protein	0.0146	1	1
Echinococcus granulosus	tubulin epsilon chain	0.0057	0.2941	0.2648
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0026	0.0462	0.0067
Trypanosoma brucei	alpha tubulin, putative	0.0032	0.099	0.0616
Trichomonas vaginalis	tubulin, putative	0.0032	0.099	0.0774
Schistosoma mansoni	alpha tubulin	0.0057	0.2941	0.2648
Loa Loa (eye worm)	tubulin beta chain	0.0146	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0057	0.2941	0.2648
Plasmodium falciparum	alpha tubulin 2	0.0057	0.2941	0.2648
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.2941	0.2648
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0057	0.2941	0.2648
Echinococcus granulosus	alpha tubulin	0.0057	0.2941	0.2648
Echinococcus multilocularis	Tubulin beta 2C chain	0.0146	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.2941	0.2648
Trypanosoma brucei	epsilon tubulin	0.0057	0.2941	0.2648
Trypanosoma brucei	NADPH-cytochrome p450 reductase, putative	0.0026	0.0462	0.0067
Echinococcus granulosus	tubulin alpha chain	0.0057	0.2941	0.2648
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.0026	0.0462	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0057	0.2941	0.2648
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Leishmania major	beta tubulin	0.0146	1	1
Trypanosoma brucei	alpha tubulin	0.0057	0.2941	0.2648
Toxoplasma gondii	alpha tubulin TUBA1	0.0057	0.2941	0.2648
Treponema pallidum	cell division protein FtsZ	0.0025	0.0398	0.5
Leishmania major	beta tubulin	0.0146	1	1
Giardia lamblia	Epsilon tubulin	0.0025	0.0398	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0462	0.0067
Toxoplasma gondii	alpha-tubulin I, putative	0.0057	0.2941	0.2648
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.2941	0.2648
Trypanosoma cruzi	tubulin gamma chain	0.0057	0.2941	0.2648
Plasmodium falciparum	nitric oxide synthase, putative	0.0026	0.0462	0.0067
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.0026	0.0462	0.0235
Loa Loa (eye worm)	beta-tubulin	0.0146	1	1
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Giardia lamblia	Beta tubulin	0.0146	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0146	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0146	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0146	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Brugia malayi	tubulin alpha-2 chain	0.0057	0.2941	0.2941
Leishmania major	zeta tubulin, putative	0.0025	0.0398	0.0169
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Loa Loa (eye worm)	tubulin beta-2A chain	0.0146	1	1
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Giardia lamblia	Alpha-tubulin	0.0057	0.2941	0.2772
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0025	0.0398	0.0169
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.2941	0.2648
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0853	0.0474
Loa Loa (eye worm)	tubulin gamma chain	0.0057	0.2941	0.2648
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0853	0.0474
Leishmania major	beta tubulin	0.0146	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.2941	0.2648
Trypanosoma brucei	beta tubulin	0.0146	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0025	0.0398	0.5
Echinococcus granulosus	tubulin alpha chain	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0146	1	1
Brugia malayi	Tubulin alpha chain	0.0057	0.2941	0.2941
Leishmania major	gamma-tubulin	0.0057	0.2941	0.2772
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Toxoplasma gondii	beta tubulin	0.0146	1	1
Giardia lamblia	Beta tubulin	0.0146	1	1
Leishmania major	hypothetical protein, conserved	0.003	0.0853	0.0634
Brugia malayi	beta-tubulin, identical	0.0146	1	1
Brugia malayi	FAD binding domain containing protein	0.0026	0.0462	0.0462
Schistosoma mansoni	cytochrome P450 reductase	0.0026	0.0462	0.0067
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.2941	0.2648
Loa Loa (eye worm)	BEN-1 protein	0.0146	1	1
Brugia malayi	tubulin alpha chain - mouse	0.0057	0.2941	0.2941
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0032	0.099	0.0774
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.2941	0.2772
Trypanosoma brucei	alpha tubulin	0.0057	0.2941	0.2648
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.0026	0.0462	0.0067
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Plasmodium vivax	delta tubulin, putative	0.0025	0.0398	0.0169
Leishmania major	beta tubulin	0.0146	1	1
Leishmania major	delta tubulin, putative	0.0025	0.0398	0.0169
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Schistosoma mansoni	tubulin subunit gamma	0.0057	0.2941	0.2648
Toxoplasma gondii	beta-tubulin, putative	0.0146	1	1
Trypanosoma brucei	alpha tubulin	0.0057	0.2941	0.2648
Trypanosoma brucei	tubulin gamma chain	0.0057	0.2941	0.2648
Echinococcus granulosus	tubulin subunit beta	0.0146	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0057	0.2941	0.2648
Echinococcus granulosus	beta tubulin	0.0146	1	1
Echinococcus multilocularis	hypothetical protein	0.0057	0.2941	0.2648
Plasmodium falciparum	tubulin epsilon chain, putative	0.0057	0.2941	0.2648
Trypanosoma brucei	alpha tubulin	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.0146	1	1
Trypanosoma brucei	epsilon tubulin	0.0057	0.2941	0.2648
Trypanosoma cruzi	beta tubulin, putative	0.0146	1	1
Leishmania major	beta tubulin	0.0146	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0057	0.2941	0.2772
Trypanosoma cruzi	alpha tubulin, putative	0.0057	0.2941	0.2648
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.099	0.0774
Leishmania major	epsilon tubulin, putative	0.0057	0.2941	0.2772
Loa Loa (eye worm)	tubulin alpha 2	0.0032	0.099	0.0616
Leishmania major	beta tubulin	0.0146	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin subunit beta	0.0146	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0853	0.0634
Entamoeba histolytica	tubulin family protein	0.0146	1	1
Schistosoma mansoni	alpha tubulin	0.0057	0.2941	0.2648
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Trypanosoma brucei	epsilon tubulin	0.0057	0.2941	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.2941	0.2648
Trypanosoma cruzi	p450 reductase, putative	0.0026	0.0462	0.0067
Echinococcus granulosus	tubulin alpha chain	0.0057	0.2941	0.2648
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.0026	0.0462	0.0067
Giardia lamblia	Delta tubulin	0.0025	0.0398	0.0169
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0398	0.0169
Echinococcus multilocularis	tubulin epsilon chain	0.0057	0.2941	0.2648
Echinococcus granulosus	beta tubulin	0.0146	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Leishmania major	p450 reductase, putative	0.0026	0.0462	0.0235
Brugia malayi	Tubulin beta chain	0.0025	0.0398	0.0398
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0025	0.0398	0.5
Trichomonas vaginalis	tubulin gamma chain, putative	0.0057	0.2941	0.2772
Leishmania major	beta tubulin	0.0146	1	1
Trypanosoma brucei	NADPH--cytochrome P450 reductase, putative	0.0026	0.0462	0.0067
Echinococcus granulosus	Tubulin beta 2C chain	0.0146	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.2941	0.2772
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0853	0.0474
Loa Loa (eye worm)	hypothetical protein	0.003	0.0853	0.0474
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.2941	0.2648
Echinococcus granulosus	Tubulin beta 2C chain	0.0146	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0032	0.099	0.0616
Entamoeba histolytica	tubulin family protein	0.0146	1	1
Leishmania major	beta tubulin	0.0146	1	1
Plasmodium falciparum	alpha tubulin 1	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Echinococcus multilocularis	tubulin beta 1 chain	0.0146	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0057	0.2941	0.2772
Schistosoma mansoni	tubulin subunit beta	0.0146	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0853	0.0474
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0853	0.0474
Leishmania major	beta tubulin	0.0146	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0057	0.2941	0.2648
Echinococcus granulosus	tubulin alpha chain	0.0057	0.2941	0.2648
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Echinococcus granulosus	tubulin alpha	0.0057	0.2941	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0032	0.099	0.0616
Schistosoma mansoni	tubulin subunit epsilon	0.0057	0.2941	0.2648
Echinococcus granulosus	tubulin subunit TubB	0.0057	0.2941	0.2648
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.099	0.0774
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0398	0.0169
Schistosoma mansoni	alpha tubulin	0.0057	0.2941	0.2648
Mycobacterium ulcerans	formate dehydrogenase H FdhF	0.0026	0.0462	1
Giardia lamblia	Alpha-tubulin	0.0057	0.2941	0.2772
Loa Loa (eye worm)	tubulin beta-4 chain	0.0146	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.099	0.0774
Echinococcus multilocularis	Tubulin beta 2C chain	0.0146	1	1
Brugia malayi	flavodoxin family protein	0.0026	0.0462	0.0462
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.0026	0.0462	0.0235
Plasmodium vivax	tubulin epsilon chain, putative	0.0057	0.2941	0.2772
Trypanosoma brucei	NADPH-dependent diflavin oxidoreductase 1	0.0026	0.0462	0.0067
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.2941	0.2772
Brugia malayi	alpha-tubulin	0.0057	0.2941	0.2941
Leishmania major	alpha tubulin	0.0057	0.2941	0.2772
Brugia malayi	Tubulin beta chain	0.0032	0.099	0.099
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.0026	0.0462	0.0067
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.2941	0.2772
Plasmodium vivax	tubulin beta chain, putative	0.0146	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0146	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0057	0.2941	0.2648
Plasmodium falciparum	tubulin beta chain	0.0146	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0146	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0146	1	1
Echinococcus multilocularis	beta tubulin	0.0146	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.2941	0.2648
Leishmania major	beta tubulin	0.0146	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0146	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7079 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1866287

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1569461