Detailed information for compound 157147

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 627.45 | Formula: C20H30N5O16P--
  • H donors: 9 H acceptors: 12 LogP: -9.37 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCC(=O)NC1C(O)CC(OC1[C@H](C(CO)O)O)(OP(=O)(OCC1OC(C(C1O)O)n1ccc(nc1=O)N)[O-])C(=O)[O-]
  • InChi: 1S/C20H32N5O16P/c21-4-11(29)24-12-7(27)3-20(18(33)34,40-16(12)13(30)8(28)5-26)41-42(36,37)38-6-9-14(31)15(32)17(39-9)25-2-1-10(22)23-19(25)35/h1-2,7-9,12-17,26-28,30-32H,3-6,21H2,(H,24,29)(H,33,34)(H,36,37)(H2,22,23,35)/p-2/t7?,8?,9?,12?,13-,14?,15?,16?,17?,20?/m1/s1
  • InChiKey: ADBBPRGEOJTHFJ-DNCBCXAZSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii microneme protein MIC4 0.0038 0.0077 0.02
Brugia malayi larval opioid receptor 0.0424 0.228 0.6345
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.014 0.0155
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.0616
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0039 0.0084 0.0086
Echinococcus granulosus peptide allatostatin:somatostatin 0.0424 0.228 0.2775
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Giardia lamblia High cysteine membrane protein Group 2 0.016 0.0777 0.3357
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Brugia malayi map kinase activated protein kinase protein 2 0.019 0.0948 0.2638
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0052 0.0047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0156 0.0174
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0074 0.0287 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0046 0.0129
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0038 0.0077 0.02
Schistosoma mansoni hypothetical protein 0.0032 0.0046 0.0032
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Echinococcus granulosus serotonin receptor 0.0424 0.228 0.2775
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0424 0.228 0.2775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.014 0.0301
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0424 0.228 0.227
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0398
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Echinococcus granulosus beta tubulin 0.0313 0.1645 0.1997
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0032 0.0046 0.0039
Brugia malayi ORL1-like opioid receptor 0.0424 0.228 0.6345
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Loa Loa (eye worm) BEN-1 protein 0.0313 0.1645 0.3533
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0823 0.455 0.5554
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Schistosoma mansoni hypothetical protein 0.0038 0.0077 0.0063
Brugia malayi G-protein coupled receptor 0.0424 0.228 0.6345
Schistosoma mansoni replication factor A 1 rfa1 0.0034 0.0057 0.0043
Echinococcus multilocularis GPCR, family 2 0.008 0.032 0.0376
Echinococcus multilocularis neuropeptide s receptor 0.0424 0.228 0.2775
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0424 0.228 0.227
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.0859
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.1962 1
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Schistosoma mansoni myosin xvIII 0.0424 0.228 0.227
Schistosoma mansoni neuropeptide f receptor 76f 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis nmda type glutamate receptor 0.0114 0.0515 0.0614
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0099 0.0426 0.0915
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Echinococcus granulosus furin 0.0432 0.2324 0.2828
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni hypothetical protein 0.0084 0.0339 0.0326
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0325 0.0381
Schistosoma mansoni biogenic amine (5HT) receptor 0.0424 0.228 0.227
Echinococcus granulosus somatostatin receptor 0.0424 0.228 0.2775
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.1119 0.3114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0424 0.228 0.6345
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus granulosus glutamate receptor subunit protein glur 0.0032 0.0046 0.0039
Schistosoma mansoni tgf-beta family 0.0032 0.0046 0.0033
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus Neuropeptide F receptor homolog 0.0424 0.228 0.4883
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0091 0.0398
Brugia malayi Melatonin receptor type 1A 0.0424 0.228 0.6345
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.032 0.0688
Echinococcus granulosus geminin 0.019 0.0948 0.1144
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0052 0.0047
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0028 0.002 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0054 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.0718 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) G-protein coupled receptor 0.0424 0.228 0.4898
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0084 0.0339 0.0991
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Echinococcus multilocularis beta tubulin 0.0313 0.1645 0.1997
Brugia malayi putative neuropeptide receptor 0.0424 0.228 0.6345
Schistosoma mansoni biogenic amine (5HT) receptor 0.0424 0.228 0.227
Echinococcus multilocularis serotonin receptor 0.0424 0.228 0.2775
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Echinococcus multilocularis Furin 1 0.0102 0.0444 0.0527
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) hypothetical protein 0.0188 0.0936 0.201
Echinococcus multilocularis serotonin receptor 0.0424 0.228 0.2775
Echinococcus multilocularis dro:myosuppressin receptor 0.0424 0.228 0.2775
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0126 0.0582 0.0695
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0424 0.228 0.6345
Echinococcus multilocularis NMDA receptor 0.0032 0.0046 0.0039
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0034 0.0057 0.0053
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0039 0.0084 0.0086
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Echinococcus multilocularis neuropeptides capa receptor 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide Y receptor 0.0424 0.228 0.2775
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Schistosoma mansoni tyrosine kinase 0.0081 0.0325 0.0312
Brugia malayi Serotonin receptor 0.0424 0.228 0.6345
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0046 0.0032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Toxoplasma gondii hypothetical protein 0.0038 0.0077 0.02
Loa Loa (eye worm) endoprotease bli-4 0.0432 0.2324 0.4991
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.014 0.0154
Leishmania major chitinase 0.008 0.0318 0.1564
Echinococcus multilocularis G-protein coupled receptor, putative 0.0424 0.228 0.2775
Echinococcus granulosus tyrosine kinase 0.0035 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi follicle stimulating hormone receptor 0.0424 0.228 0.6345
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Loa Loa (eye worm) microfilarial chitinase 0.0068 0.0251 0.0539
Echinococcus multilocularis fmrfamide receptor 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide receptor 0.0424 0.228 0.2775
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Toxoplasma gondii beta tubulin 0.0313 0.1645 0.5125
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0549 0.2989 0.6422
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Onchocerca volvulus 0.0038 0.0077 0.0137
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0156 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.2025 0.6721
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Onchocerca volvulus 0.0038 0.0077 0.0137
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Schistosoma mansoni hypothetical protein 0.0399 0.2136 0.2125
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0424 0.228 0.2775
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0424 0.228 0.6345
Schistosoma mansoni growth hormone secretagogue receptor 0.0424 0.228 0.227
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0424 0.228 0.2775
Echinococcus granulosus biogenic amine 5HT receptor 0.0424 0.228 0.2775
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Toxoplasma gondii subtilisin SUB12 0.0056 0.0182 0.053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0424 0.228 0.2775
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.2136 0.2598
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0424 0.228 0.2775
Onchocerca volvulus 0.0424 0.228 0.4883
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Loa Loa (eye worm) hypothetical protein 0.014 0.0661 0.1421
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0262 0.1358 0.1646
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0032 0.0046 0.0039
Echinococcus granulosus tm gpcr rhodopsin 0.146 0.8183 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0036 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis insulin receptor 0.0049 0.014 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Toxoplasma gondii PAN/Apple domain-containing protein 0.0038 0.0077 0.02
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0026 0.0013 0.0027
Brugia malayi neuropeptide F receptor 0.0424 0.228 0.6345
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.146 0.8183 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.1962 0.546
Brugia malayi RE15519p 0.0424 0.228 0.6345
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0039 0.0084 0.0086
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0948 0.0936
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) chitinase I 0.008 0.0318 0.0684
Brugia malayi Serotonin receptor 0.0424 0.228 0.6345
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi sulfakinin receptor protein 0.0424 0.228 0.6345
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis beta tubulin 0.0313 0.1645 0.1997
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0099 0.0426 0.0505
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus multilocularis somatostatin receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) apoptosis regulator protein 0.0143 0.0679 0.1458
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0034 0.0057 0.0122
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Onchocerca volvulus 0.0074 0.0287 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Loa Loa (eye worm) hypothetical protein 0.0368 0.1962 0.4215
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0099 0.0426 0.1296
Echinococcus granulosus tyrosine protein kinase Blk 0.0035 0.0063 0.0061
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0099 0.0426 0.0413
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.019 0.0948 0.0936
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0076
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.1962 1
Echinococcus granulosus dro:myosuppressin receptor 0.0424 0.228 0.2775
Echinococcus granulosus tyrosine protein kinase HCK 0.0031 0.0041 0.0034
Echinococcus multilocularis glutamate receptor 2 0.0049 0.014 0.0154
Loa Loa (eye worm) G-protein coupled receptor 0.0424 0.228 0.4898
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0046 0.0032
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Echinococcus multilocularis 0.0046 0.0125 0.0137
Brugia malayi putative neuropeptide receptor NPR1 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus nmda type glutamate receptor 0.0114 0.0515 0.0614
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis neuropeptide Y receptor 0.0424 0.228 0.2775
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Onchocerca volvulus 0.0032 0.0046 0.0071
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0046 0.0127
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0823 0.455 0.5554
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0039 0.0084 0.0086
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2715
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.014 0.0154
Loa Loa (eye worm) bone morphogenic protein 6 0.0126 0.0582 0.1249
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0549 0.2989 0.8318
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0077 0.0063
Toxoplasma gondii beta-1 tubulin, putative 0.0313 0.1645 0.5125
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.0169 0.0828 0.1778
Loa Loa (eye worm) tubulin beta-4 chain 0.0313 0.1645 0.3533
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.032 0.0376
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis neuropeptide FF receptor 2 0.0655 0.3594 0.4383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Brugia malayi Transforming growth factor beta like domain containing protein 0.0032 0.0046 0.0129
Loa Loa (eye worm) tubulin beta chain 0.0313 0.1645 0.3533
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi polk-prov protein 0.003 0.0036 0.0099
Schistosoma mansoni tyrosine kinase 0.0081 0.0325 0.0312
Brugia malayi proprotein convertase 2 0.0271 0.1409 0.3921
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0156 0.0174
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Brugia malayi G-protein coupled receptor 0.0424 0.228 0.6345
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0084 0.0339 0.0991
Echinococcus granulosus tubulin beta 4A class IVa 0.0313 0.1645 0.1997
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0424 0.228 0.227
Brugia malayi neuropeptide F receptor 0.0424 0.228 0.6345
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Loa Loa (eye worm) LjBmp2/4b 0.0032 0.0046 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0036 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0156 0.0174
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.014 0.0154
Echinococcus granulosus tm gpcr rhodopsin 0.0424 0.228 0.2775
Toxoplasma gondii microneme protein MIC17C 0.0038 0.0077 0.02
Toxoplasma gondii microneme protein MIC17B 0.0038 0.0077 0.02
Schistosoma mansoni hypothetical protein 0.019 0.0948 0.0936
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0287 0.0815
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Onchocerca volvulus 0.0424 0.228 0.4883
Toxoplasma gondii hypothetical protein 0.0038 0.0077 0.02
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0325 0.0381
Schistosoma mansoni tyrosine kinase 0.0049 0.014 0.0127
Onchocerca volvulus 0.0032 0.0046 0.0071
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Onchocerca volvulus 0.0038 0.0077 0.0137
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0432 0.2324 0.2313
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0032 0.0046 0.0039
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Echinococcus granulosus neuropeptide s receptor 0.0424 0.228 0.2775
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0424 0.228 0.4898
Brugia malayi G protein-coupled receptor F59B2.13 0.0424 0.228 0.6345
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0083 0.0338 0.5
Loa Loa (eye worm) beta-tubulin 0.0313 0.1645 0.3533
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0026 0.0013 0.0027
Schistosoma mansoni histamine h1 receptor 0.0424 0.228 0.227
Echinococcus multilocularis geminin 0.019 0.0948 0.1144
Echinococcus granulosus tgf beta family 0.0032 0.0046 0.004
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus neuropeptide receptor A26 0.0424 0.228 0.2775
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.032 0.0376
Brugia malayi replication factor A 73 kDa subunit 0.0034 0.0057 0.0158
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0026 0.0092
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0661 0.184
Loa Loa (eye worm) hypothetical protein 0.0068 0.0251 0.0539
Schistosoma mansoni apoptosis regulator bax 0.0143 0.0679 0.0666
Toxoplasma gondii microneme protein MIC17A 0.0038 0.0077 0.02
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0077 0.0077
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0424 0.228 0.4883
Echinococcus granulosus bone morphogenetic protein 2 0.0032 0.0046 0.004
Echinococcus granulosus allatostatin A receptor 0.0841 0.4655 0.5682
Onchocerca volvulus 0.0038 0.0077 0.0137
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0424 0.228 0.227
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Onchocerca volvulus 0.0038 0.0077 0.0137
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0057 0.0033
Echinococcus multilocularis SWI:SNF matrix associated 0.0074 0.0287 0.0335
Onchocerca volvulus 0.0038 0.0077 0.0137
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0084 0.0086
Echinococcus granulosus epidermal growth factor receptor 0.015 0.0718 0.0862
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0046 0.0098
Loa Loa (eye worm) tubulin beta-1 chain 0.0313 0.1645 0.3533
Onchocerca volvulus Glucosylceramidase homolog 0.036 0.1914 0.4095
Loa Loa (eye worm) TYRA-2 protein 0.0424 0.228 0.4898
Loa Loa (eye worm) SRC-1 0.0039 0.0084 0.0181
Echinococcus multilocularis G protein coupled receptor 139 0.0424 0.228 0.2775
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0074 0.0287 0.0335
Brugia malayi celfurPC protein 0.0348 0.1848 0.5141
Echinococcus granulosus neuroendocrine convertase 2 0.0271 0.1409 0.1708
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0143 0.0679 0.0666
Brugia malayi Protein kinase domain containing protein 0.0049 0.014 0.0389
Echinococcus multilocularis neuropeptides capa receptor 0.0424 0.228 0.2775
Echinococcus granulosus MAP kinase activated protein kinase 2 0.019 0.0948 0.1144
Brugia malayi Tubulin beta-1 chain 0.0313 0.1645 0.4577
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0032 0.0046 0.0039
Echinococcus granulosus tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0119 0.0539 0.2715
Echinococcus granulosus Furin 1 0.0102 0.0444 0.0527
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0325 0.0381
Brugia malayi Transforming growth factor beta like domain containing protein 0.0126 0.0582 0.1618
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.014 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.01
Trypanosoma cruzi WLM domain containing protein, putative 0.0026 0.0013 0.0027
Echinococcus multilocularis fmrfamide receptor 0.0424 0.228 0.2775
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0046 0.0032
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0084 0.0339 0.0991
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0039 0.0084 0.0086
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Toxoplasma gondii microneme protein, putative 0.0038 0.0077 0.02
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0424 0.228 0.6345
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0071
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0099 0.0426 0.2117
Trichomonas vaginalis glucosylceramidase, putative 0.0379 0.2025 0.6721
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0091 0.015
Brugia malayi Dopamine receptor protein 2 0.0424 0.228 0.6345
Echinococcus multilocularis dna polymerase kappa 0.004 0.0091 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Echinococcus granulosus tm gpcr rhodopsin 0.0424 0.228 0.2775
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0029 0.0026 0.0092
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0424 0.228 0.2775
Loa Loa (eye worm) TK protein kinase 0.0031 0.0041 0.0089
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.1119 0.3114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2695
Loa Loa (eye worm) BEN-1 protein 0.0313 0.1645 0.3533
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus neuropeptides capa receptor 0.0424 0.228 0.2775
Echinococcus multilocularis tgf beta family 0.0032 0.0046 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.0424 0.228 0.4898
Echinococcus granulosus neuropeptide Y receptor 0.0424 0.228 0.2775
Echinococcus multilocularis sex peptide receptor 0.0424 0.228 0.2775
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Trichomonas vaginalis tubulin gamma chain, putative 0.0313 0.1645 0.543
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.014 0.0154
Plasmodium vivax tubulin beta chain, putative 0.0313 0.1645 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus SWI:SNF matrix associated 0.0074 0.0287 0.0335
Loa Loa (eye worm) neuropeptide F receptor 0.0424 0.228 0.4898
Echinococcus granulosus tubulin subunit beta 0.0313 0.1645 0.1997
Echinococcus multilocularis bone morphogenetic protein 2 0.0032 0.0046 0.004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0036 0.0023
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Onchocerca volvulus 0.0038 0.0077 0.0137
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.1185
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0424 0.228 0.4898
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Trypanosoma cruzi beta tubulin, putative 0.0313 0.1645 0.8375
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0084 0.0086
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0424 0.228 0.2775
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.019 0.0948 0.1144
Loa Loa (eye worm) proprotein convertase 2 0.0102 0.0444 0.0953
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0082 0.0332 0.9814
Echinococcus granulosus GPCR family 2 0.008 0.032 0.0376
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0262 0.1358 0.1646
Brugia malayi brahma associated protein 60 kDa 0.0074 0.0287 0.0798
Mycobacterium tuberculosis Possible chitinase 0.0068 0.0251 0.7157
Brugia malayi Latrophilin receptor protein 2 0.008 0.032 0.0892
Trichomonas vaginalis tubulin beta chain, putative 0.0313 0.1645 0.543
Onchocerca volvulus 0.0424 0.228 0.4883
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0083 0.0338 0.5
Brugia malayi Endochitinase 0.008 0.0318 0.0885
Echinococcus granulosus hypothetical protein 0.0424 0.228 0.2775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Brugia malayi neuroendocrine convertase 1 precursor 0.0271 0.1409 0.3921
Loa Loa (eye worm) hypothetical protein 0.0655 0.3594 0.772
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0046 0.0098
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0046 0.0039
Onchocerca volvulus 0.0038 0.0077 0.0137
Echinococcus granulosus g protein coupled receptor 0.0424 0.228 0.2775
Brugia malayi GnHR receptor homolog 0.0424 0.228 0.6345
Echinococcus granulosus 7TM GPCR rhodopsin 0.0424 0.228 0.2775
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0114 0.0515 0.0614
Chlamydia trachomatis glutamine binding protein 0.0082 0.0332 0.3241
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0091 0.0424
Schistosoma mansoni brg-1 associated factor 0.0074 0.0287 0.0274
Toxoplasma gondii PAN domain-containing protein 0.0585 0.3197 1
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0119 0.0539 0.2695
Brugia malayi beta-tubulin, identical 0.0313 0.1645 0.4577
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Schistosoma mansoni alpha-1 adrenergic receptor 0.0424 0.228 0.227
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Schistosoma mansoni serine-type protease inhibitor 0.1779 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni tyrosine kinase 0.0079 0.0314 0.0301
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Echinococcus multilocularis neuropeptide receptor A26 0.0424 0.228 0.2775
Echinococcus granulosus tachykinin peptides receptor 99D 0.0424 0.228 0.2775
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Echinococcus multilocularis tubulin subunit beta 0.0313 0.1645 0.1997
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.003 0.0036 0.0023
Echinococcus granulosus glutamate NMDA receptor subunit 0.0271 0.1407 0.1706
Loa Loa (eye worm) hypothetical protein 0.0143 0.0679 0.1458
Echinococcus granulosus dnaJ subfamily B 0.0399 0.2136 0.2598
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.1676
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Brugia malayi Dopamine receptor protein 1 0.0424 0.228 0.6345
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0026 0.0013 0.0038
Brugia malayi hypothetical protein 0.0038 0.0077 0.0213
Onchocerca volvulus 0.0424 0.228 0.4883
Mycobacterium ulcerans chitinase/cellulase 0.0068 0.0251 0.6491
Echinococcus granulosus 7tm_1 domain containing protein 0.0424 0.228 0.2775
Echinococcus granulosus insulin receptor 0.0049 0.014 0.0155
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.014 0.0126
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Onchocerca volvulus 0.0424 0.228 0.4883
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Brugia malayi G protein-coupled receptor 0.0424 0.228 0.6345
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0119 0.0539 0.2715
Brugia malayi endochitinase 0.008 0.0318 0.0885
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus g-protein coupled receptor 0.0424 0.228 0.2775
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Schistosoma mansoni adenoreceptor 0.0424 0.228 0.227
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0143 0.0679 0.0815
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Schistosoma mansoni tyrosine kinase 0.0039 0.0084 0.0071
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0083 0.0338 1
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Toxoplasma gondii beta-tubulin, putative 0.0313 0.1645 0.5125
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.2138
Trypanosoma cruzi WLM domain containing protein, putative 0.0026 0.0013 0.0027
Schistosoma mansoni biogenic amine receptor 0.0424 0.228 0.227
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0119 0.0539 0.2695
Onchocerca volvulus 0.0841 0.4655 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0074 0.0287 0.1676
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus multilocularis tyrosine protein kinase HCK 0.0031 0.0041 0.0034
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Loa Loa (eye worm) tubulin beta-2A chain 0.0313 0.1645 0.3533
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0074 0.0287 0.0859
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0424 0.228 0.2775
Echinococcus granulosus neuropeptide receptor 0.0424 0.228 0.2775
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0039 0.0084 0.0086
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0102 0.0444 0.0431
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.019 0.0948 0.2036
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0084 0.0086
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0143 0.0679 0.1889
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0841 0.4655 0.4648
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0034 0.0057 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0026 0.0013 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Brugia malayi hypothetical protein 0.0032 0.0046 0.0129
Trypanosoma brucei hypothetical protein 0.0119 0.0539 0.2695
Loa Loa (eye worm) melatonin receptor type 1A 0.0424 0.228 0.4898
Schistosoma mansoni neuropeptide F-like receptor 0.0424 0.228 0.227
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0091 0.0398
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0035 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.014 0.0661 0.0649
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0083 0.0338 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1358 0.4456
Trypanosoma brucei beta tubulin 0.0313 0.1645 0.8371
Brugia malayi Tachykinin-like peptides receptor 99D 0.0655 0.3594 1
Echinococcus granulosus dna polymerase kappa 0.004 0.0091 0.0095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0424 0.228 0.227
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0424 0.228 0.2775
Schistosoma mansoni amine GPCR 0.0424 0.228 0.227
Schistosoma mansoni tgf-beta family 0.0032 0.0046 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0156 0.0142
Trypanosoma brucei calpain-like protein, putative 0.0119 0.0539 0.2695
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0424 0.228 0.2775
Trichomonas vaginalis tubulin, putative 0.0313 0.1645 0.543
Echinococcus granulosus tyrosine protein kinase Src64B 0.0039 0.0084 0.0086
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0083 0.0338 0.0988
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0039 0.0084 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0013 0.0027
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0087 0.009
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni furin-1 (S08 family) 0.0188 0.0933 0.0921
Echinococcus multilocularis 0.0348 0.1848 0.2245
Loa Loa (eye worm) brahma associated protein 0.0074 0.0287 0.0616
Schistosoma mansoni tyrosine kinase 0.015 0.0718 0.0705
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis allatostatin A receptor 0.0841 0.4655 0.5682
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0099 0.0426 0.2529
Onchocerca volvulus 0.0424 0.228 0.4883
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Brugia malayi PAN domain containing protein 0.0038 0.0077 0.0215
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.0718 0.0862
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.032 0.0376
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0032 0.0046 0.0039
Trichomonas vaginalis tubulin epsilon chain, putative 0.0313 0.1645 0.543
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0029 0.0026 0.0065
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0099 0.0426 0.0505
Echinococcus granulosus neuropeptide FF receptor 2 0.0655 0.3594 0.4383
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0099 0.0426 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Giardia lamblia Beta tubulin 0.0313 0.1645 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.1119 0.2404
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.032 0.0376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0102 0.0444 0.1348
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Echinococcus granulosus beta tubulin 0.0313 0.1645 0.1997
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0029
Brugia malayi hypothetical protein 0.0032 0.0046 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0156 0.0433
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Brugia malayi protein-tyrosine kinase 0.0035 0.0063 0.0175
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Onchocerca volvulus 0.0038 0.0077 0.0137
Brugia malayi endoprotease bli-4 precursor 0.0432 0.2324 0.6466
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0126 0.0582 0.0695
Schistosoma mansoni hypothetical protein 0.008 0.032 0.0307
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.1024
Echinococcus multilocularis tyrosine protein kinase Srms 0.0035 0.0063 0.0061
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0424 0.228 0.227
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Trypanosoma brucei unspecified product 0.0034 0.0054 0.021
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0156 0.0174
Echinococcus granulosus G protein coupled receptor 139 0.0424 0.228 0.2775
Brugia malayi brahma associated protein 60 kDa 0.0074 0.0287 0.0798
Entamoeba histolytica hypothetical protein 0.0038 0.0077 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0424 0.228 0.2775
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.0718 0.1542
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0082 0.0332 0.3241
Echinococcus multilocularis neuropeptide Y receptor 0.0424 0.228 0.2775
Echinococcus granulosus tubulin beta 1 chain 0.0313 0.1645 0.1997
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0026 0.0013 0.0027
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0424 0.228 0.227
Toxoplasma gondii PAN domain-containing protein 0.0038 0.0077 0.02
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus granulosus biogenic amine 5HT receptor 0.0424 0.228 0.2775
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Schistosoma mansoni hypothetical protein 0.0143 0.0679 0.0666
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0424 0.228 0.4898
Echinococcus multilocularis orexin receptor type 2 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0074 0.0287 0.0274
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0026 0.0013 0.0027
Trichomonas vaginalis tubulin alpha chain, putative 0.0313 0.1645 0.543
Trypanosoma brucei RNA helicase, putative 0.0201 0.1009 0.511
Onchocerca volvulus Putative endochitinase 0.008 0.0318 0.0657
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0082 0.0332 0.977
Echinococcus multilocularis g-protein coupled receptor 0.0424 0.228 0.2775
Onchocerca volvulus 0.0038 0.0077 0.0137
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi Dopamine receptor 0.0424 0.228 0.6345
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0339 0.0991
Echinococcus multilocularis tyrosine protein kinase Blk 0.0035 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) TK protein kinase 0.0035 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.1119 0.2404
Echinococcus multilocularis tubulin beta 1 chain 0.0313 0.1645 0.1997
Onchocerca volvulus 0.0424 0.228 0.4883
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Echinococcus multilocularis neuropeptide receptor 0.0424 0.228 0.2775
Schistosoma mansoni neuropeptide F-like receptor 0.0424 0.228 0.227
Schistosoma mansoni glutamate receptor NMDA 0.0271 0.1407 0.1395
Echinococcus granulosus glutamate receptor 2 0.0049 0.014 0.0154
Loa Loa (eye worm) hypothetical protein 0.0841 0.4655 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0424 0.228 0.227
Schistosoma mansoni tyrosine kinase 0.0049 0.014 0.0127
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Toxoplasma gondii PAN domain-containing protein 0.0585 0.3197 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0424 0.228 0.4898
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0424 0.228 0.4898
Trichomonas vaginalis tubulin epsilon chain, putative 0.0313 0.1645 0.543
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.0063 0.0061
Brugia malayi AKH receptor 0.0424 0.228 0.6345
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0424 0.228 0.2775
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0057 0.0033
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0424 0.228 0.6345
Trypanosoma brucei calpain, putative 0.0119 0.0539 0.2695
Onchocerca volvulus 0.0424 0.228 0.4883
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0099 0.0426 0.2117
Leishmania major beta tubulin 0.0313 0.1645 0.8371
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0271 0.1407 0.1706
Echinococcus granulosus alpha 1A adrenergic receptor 0.0424 0.228 0.2775
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0262 0.1358 0.4456
Brugia malayi YY1-associated factor 2 0.0026 0.0013 0.0038
Echinococcus granulosus orexin receptor type 2 0.0424 0.228 0.2775
Echinococcus multilocularis neuropeptide receptor 0.0424 0.228 0.2775
Echinococcus granulosus sex peptide receptor 0.0424 0.228 0.2775
Brugia malayi endochitinase 0.008 0.0318 0.0885
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0032 0.0046 0.0039
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Onchocerca volvulus 0.0424 0.228 0.4883
Onchocerca volvulus 0.0424 0.228 0.4883
Brugia malayi SWIB/MDM2 domain containing protein 0.0074 0.0287 0.0798
Mycobacterium ulcerans chitinase/cellulase 0.0068 0.0251 0.6491
Echinococcus granulosus fmrfamide receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) growth/differentiation factor 10 0.0032 0.0046 0.01
Entamoeba histolytica tubulin family protein 0.0313 0.1645 1
Onchocerca volvulus 0.0424 0.228 0.4883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.008 0.032 0.0688
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.003 0.0036 0.0049
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Loa Loa (eye worm) cuticular endochitinase 0.008 0.0318 0.0684
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Brugia malayi SRC-1 0.0039 0.0084 0.0234
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0424 0.228 0.227
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0046 0.0127
Plasmodium falciparum tubulin beta chain 0.0313 0.1645 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0143 0.0679 0.0815
Echinococcus granulosus neuropeptides capa receptor 0.0424 0.228 0.2775
Trichomonas vaginalis hypothetical protein 0.0084 0.0339 0.0991
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.032 0.0892
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Echinococcus multilocularis neuroendocrine convertase 2 0.0271 0.1409 0.1708
Schistosoma mansoni neuropeptide receptor 0.0424 0.228 0.227
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.2989 1
Loa Loa (eye worm) hypothetical protein 0.0432 0.2324 0.4991
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0424 0.228 0.227
Schistosoma mansoni opsin-like receptor 0.0424 0.228 0.227
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0046 0.0032
Echinococcus multilocularis g protein coupled receptor 0.0424 0.228 0.2775
Loa Loa (eye worm) PAN domain-containing protein 0.0038 0.0077 0.0166
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0424 0.228 0.2775
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0424 0.228 0.2775
Schistosoma mansoni hypothetical protein 0.0424 0.228 0.227
Entamoeba histolytica chitinase, putative 0.008 0.0318 0.1727
Brugia malayi hypothetical protein 0.0424 0.228 0.6345
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0091 0.015
Loa Loa (eye worm) hypothetical protein 0.0424 0.228 0.4898
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0099 0.0426 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.1962 1
Schistosoma mansoni tubulin subunit beta 0.0313 0.1645 0.1633
Entamoeba histolytica tubulin family protein 0.0313 0.1645 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.01
Echinococcus granulosus rhodopsin orphan GPCR 0.0424 0.228 0.2775
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.1914 0.6346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0077 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.0313 0.1645 0.1997
Schistosoma mansoni hypothetical protein 0.0201 0.1009 0.0997

Activities

Activity type Activity value Assay description Source Reference
Km (binding) = 45 uM Evaluation of michaelis Menton constant of rat liver GaI-beta-1,4GIcNAc alpha2,6-sialyltransferase in presence of compound ChEMBL. No reference
Ratio (binding) = 22.2 Evaluation of ratio of michaelis Menton constant to that of kinetic constant against 2,6-sialyltransferase in presence of compound ChEMBL. No reference
Relative Vmax (binding) = 1 Evaluation of kinetic constant for rat liver GaI-beta-1,4GIcNAc alpha2,6-sialyltransferase in presence of compound ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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