Detailed information for compound 1580679

Basic information

Technical information
  • TDR Targets ID: 1580679
  • Name: 2-amino-5-[[5-(3-chlorophenyl)furan-2-yl]meth ylidene]-1,3-thiazol-4-one
  • MW: 304.751 | Formula: C14H9ClN2O2S
  • H donors: 1 H acceptors: 1 LogP: 3.68 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N=C1NC(=O)/C(=C/c2ccc(o2)c2cccc(c2)Cl)/S1
  • InChi: 1S/C14H9ClN2O2S/c15-9-3-1-2-8(6-9)11-5-4-10(19-11)7-12-13(18)17-14(16)20-12/h1-7H,(H2,16,17,18)/b12-7-
  • InChiKey: JUDQUEPWMOKMGQ-GHXNOFRVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-2-amino-5-[[5-(3-chlorophenyl)furan-2-yl]methylidene]-1,3-thiazol-4-one
  • 2-amino-5-[[5-(3-chlorophenyl)-2-furyl]methylene]thiazol-4-one
  • (5Z)-2-amino-5-[[5-(3-chlorophenyl)-2-furyl]methylene]thiazol-4-one
  • 2-amino-5-[[5-(3-chlorophenyl)-2-furyl]methylene]-4-thiazolone
  • (5Z)-2-amino-5-[[5-(3-chlorophenyl)-2-furyl]methylene]-4-thiazolone
  • AG-690/40144799
  • ZINC00975870
  • CBMicro_025191
  • 5-[5-(3-Chloro-phenyl)-furan-2-ylmethylene]-2-imino-thiazolidin-4-one
  • BAS 03301965

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0125 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.8273 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.0521 0.0911
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0122 0.0122
Echinococcus granulosus lamin 0.0026 0.0008 0.0014
Echinococcus granulosus choline O acetyltransferase 0.1076 0.128 0.2238
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0265 0.0463
Onchocerca volvulus 0.1076 0.128 1
Brugia malayi MH2 domain containing protein 0.012 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0148 0.0155 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.1076 0.128 0.5615
Loa Loa (eye worm) glutamate receptor 0.012 0.0122 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.018 0.5
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.1076 0.128 0.128
Schistosoma mansoni hypothetical protein 0.0031 0.0014 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0122 0.0122
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.0128 0.0128
Brugia malayi Metabotropic glutamate receptor precursor. 0.012 0.0122 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0128 0.1003
Echinococcus granulosus lamin dm0 0.0026 0.0008 0.0014
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0031 0.0014 0.0014
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.4742 0.5722 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0008 0.0008
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.002 0.0159
Brugia malayi Receptor family ligand binding region containing protein 0.0031 0.0014 0.0014
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.0789 0.6163
Onchocerca volvulus 0.0081 0.0074 0.0581
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0109 0.0108 0.0108
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0014 0.0014
Onchocerca volvulus 0.0026 0.0008 0.0064
Loa Loa (eye worm) hypothetical protein 0.0238 0.0265 0.0265
Schistosoma mansoni metabotropic glutamate receptor 0.0058 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.0099 0.0096 0.0096
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0014 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0014 0.0025
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.1076 0.128 0.5615
Loa Loa (eye worm) hypothetical protein 0.0067 0.0058 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0128 0.1003
Onchocerca volvulus 0.1076 0.128 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0048 1
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.4742 0.5722 1
Echinococcus granulosus microtubule associated protein 2 0.0671 0.0789 0.1379
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1076 0.128 0.5615
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0048 1
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.0185 0.0185
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.0521 0.0911
Loa Loa (eye worm) hypothetical protein 0.0172 0.0185 0.0185
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.4742 0.5722 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0048 0.0084
Schistosoma mansoni survival motor neuron protein 0.0049 0.0035 0.0276
Echinococcus multilocularis tar DNA binding protein 0.0125 0.0128 0.0224
Onchocerca volvulus 0.0026 0.0008 0.0064
Echinococcus granulosus GPCR family 2 0.0031 0.0014 0.0025
Loa Loa (eye worm) glutamate receptor 0.0047 0.0034 0.0034
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1899 0.2277 0.2277
Echinococcus multilocularis choline O acetyltransferase 0.1076 0.128 0.2238
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.1899 0.2277 0.2244
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.4742 0.5722 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0128 0.1003
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.4742 0.5722 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0014 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0031 0.0014 0.0111
Loa Loa (eye worm) TAR-binding protein 0.0125 0.0128 0.0128
Leishmania major carnitine/choline acetyltransferase, putative 0.1076 0.128 0.2232
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0048 0.0374
Echinococcus multilocularis lamin 0.0026 0.0008 0.0014
Leishmania major carnitine palmitoyltransferase-like protein 0.1899 0.2277 0.3976
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.1076 0.128 0.5615
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.1076 0.128 0.128
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0048 1
Schistosoma mansoni choline o-acyltransferase 0.1076 0.128 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0074 0.0074
Echinococcus granulosus metabotropic glutamate receptor 5 0.0148 0.0155 0.0271
Echinococcus granulosus intermediate filament protein 0.0026 0.0008 0.0014
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0004 0.5
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0031 0.0014 0.0014
Entamoeba histolytica hypothetical protein 0.0036 0.002 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.0521 0.0911
Schistosoma mansoni hypothetical protein 0.0067 0.0058 0.0454
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.0128 0.0128
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0074 0.013
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1076 0.128 0.128
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0004 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0014 0.0025
Schistosoma mansoni lamin 0.0026 0.0008 0.0064
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.1899 0.2277 0.398
Entamoeba histolytica hypothetical protein 0.0036 0.002 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0014 0.0025
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.1899 0.2277 0.2277
Loa Loa (eye worm) hypothetical protein 0.0031 0.0014 0.0014
Brugia malayi hypothetical protein 0.0238 0.0265 0.0265
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0048 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0014 0.0111
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0058 0.0058
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0074 0.013
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0048 1
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1899 0.2277 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0048 0.0077
Brugia malayi TAR-binding protein 0.0125 0.0128 0.0128
Brugia malayi Choline O-acetyltransferase 0.1076 0.128 0.128
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.002 0.0036
Loa Loa (eye worm) choline O-acetyltransferase 0.1076 0.128 0.128
Brugia malayi metabotropic glutamate receptor type 2 0.0058 0.0047 0.0047
Onchocerca volvulus 0.1076 0.128 1
Schistosoma mansoni hypothetical protein 0.0031 0.0014 0.0111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0035 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0096 0.0096
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0004 0.5
Loa Loa (eye worm) RNA binding protein 0.0125 0.0128 0.0128
Entamoeba histolytica hypothetical protein 0.0036 0.002 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0008 0.0008
Schistosoma mansoni metabotropic glutamate receptor 0.01 0.0098 0.0766
Brugia malayi intermediate filament protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0014 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0096 0.0096
Schistosoma mansoni intermediate filament proteins 0.0026 0.0008 0.0064
Brugia malayi hypothetical protein 0.0036 0.002 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0048 0.0374
Echinococcus granulosus neuropeptide s receptor 0.0449 0.0521 0.0911
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0014 0.0025
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0136 0.0142 0.1105
Echinococcus multilocularis musashi 0.0026 0.0008 0.0014
Schistosoma mansoni choline o-acyltransferase 0.1076 0.128 1
Entamoeba histolytica hypothetical protein 0.0036 0.002 1
Onchocerca volvulus 0.1076 0.128 1
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0128 0.1003
Echinococcus multilocularis lamin dm0 0.0026 0.0008 0.0014
Echinococcus granulosus metabotropic glutamate receptor 2 0.01 0.0098 0.0171
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0004 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.0789 0.1379
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0074 0.0581
Schistosoma mansoni lamin 0.0026 0.0008 0.0064
Schistosoma mansoni hypothetical protein 0.0036 0.002 0.0159
Echinococcus multilocularis metabotropic glutamate receptor 2 0.01 0.0098 0.0171
Echinococcus granulosus tar DNA binding protein 0.0125 0.0128 0.0224
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0148 0.0155 0.0271
Brugia malayi Choline O-acetyltransferase 0.1076 0.128 0.128
Schistosoma mansoni hypothetical protein 0.0049 0.0035 0.0276
Onchocerca volvulus 0.0049 0.0035 0.0276
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.1899 0.2277 0.398
Schistosoma mansoni tar DNA-binding protein 0.0125 0.0128 0.1003
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0008 0.0008
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0074 0.0074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.002 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0048 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0004 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0096 0.0096
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0265 0.0463
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0008

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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