TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 397.451 | Formula: C19H19N5O3S
H donors: 3 H acceptors: 6 LogP: 2.47 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)NC(=O)C)CSc1nc(O)c2c(n1)nc(cc2C)C
InChi: 1S/C19H19N5O3S/c1-10-8-11(2)20-17-16(10)18(27)24-19(23-17)28-9-15(26)22-14-6-4-13(5-7-14)21-12(3)25/h4-8H,9H2,1-3H3,(H,21,25)(H,22,26)(H,20,23,24,27)
InChiKey: VJMVKLNXWLDMIB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0117	0.0142
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0203	0.0171
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0053	0.0203	0.0248
Plasmodium falciparum	protein kinase 5	0.014	0.0636	0.6085
Brugia malayi	Cyclin C	0.0054	0.0204	0.0173
Brugia malayi	hypothetical protein	0.0031	0.0091	0.006
Echinococcus granulosus	cyclins	0.0223	0.1045	0.1276
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0024	0.0182
Schistosoma mansoni	Cyclin fold protein	0.0054	0.0204	0.025
Trypanosoma cruzi	hypothetical protein, conserved	0.0054	0.0204	0.1568
Schistosoma mansoni	g1/s-specific cyclin C	0.0054	0.0204	0.025
Echinococcus multilocularis	Immunoglobulin	0.0031	0.0091	0.0112
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0193	0.109
Echinococcus granulosus	Cyclin L1	0.0054	0.0204	0.025
Entamoeba histolytica	protein kinase, putative	0.0072	0.0294	0.2254
Giardia lamblia	Kinase, CMGC CDK	0.014	0.0636	0.4096
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Toxoplasma gondii	AGC kinase	0.0141	0.0639	0.8221
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0054	0.0204	0.025
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Schistosoma mansoni	cyclin G2	0.0054	0.0204	0.025
Loa Loa (eye worm)	hypothetical protein	0.006	0.0237	0.0205
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0017	0.0024	0.0305
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0054	0.0204	0.025
Echinococcus granulosus	protein kinase c epsilon type	0.0053	0.0203	0.0248
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Brugia malayi	hypothetical protein	0.0054	0.0204	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Schistosoma mansoni	cyclin B	0.0275	0.1304	0.1593
Schistosoma mansoni	atypical protein kinase C	0.0053	0.0203	0.0248
Schistosoma mansoni	protein kinase	0.0072	0.0294	0.0359
Echinococcus granulosus	serine/threonine protein kinase	0.0105	0.046	0.0562
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Trichomonas vaginalis	cyclin B, putative	0.0275	0.1304	0.8232
Echinococcus multilocularis	protein kinase c epsilon type	0.0053	0.0203	0.0248
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0053	0.0203	0.0171
Trichomonas vaginalis	cyclin A, putative	0.0275	0.1304	0.8232
Trichomonas vaginalis	cyclin B, putative	0.0275	0.1304	0.8232
Trypanosoma brucei	rac serine-threonine kinase, putative	0.015	0.0683	0.5235
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0032	0.0039
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0117	0.1499
Echinococcus granulosus	cyclins	0.0054	0.0204	0.025
Entamoeba histolytica	cyclin family protein	0.0223	0.1045	0.801
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.0636	0.3934
Trypanosoma brucei	cyclin 3	0.0054	0.0204	0.1568
Entamoeba histolytica	hypothetical protein	0.0096	0.0416	0.3188
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0031	0.0091	0.006
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0096	0.0416	0.3188
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.136	0.8591
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0035	0.0111	0.008
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0096	0.0416	0.0509
Echinococcus multilocularis	rac serine:threonine kinase	0.0105	0.046	0.0562
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0212	0.0259
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0074	0.0305	0.0274
Echinococcus granulosus	protein kinase c iota type	0.0053	0.0203	0.0248
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.1659	0.8188	0.8182
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.014	0.0636	0.4874
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0035	0.0111	0.008
Leishmania major	protein kinase, putative	0.0017	0.0024	0.0182
Trypanosoma brucei	cdc2-related kinase 1	0.014	0.0636	0.4874
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0223	0.1045	0.1016
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0053	0.0203	0.0171
Entamoeba histolytica	cell division protein kinase 2, putative	0.014	0.0636	0.4874
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Giardia lamblia	G2/mitotic-specific cyclin B	0.0275	0.1304	1
Entamoeba histolytica	protein kinase, putative	0.015	0.0683	0.5235
Echinococcus granulosus	protein kinase C gamma type	0.0053	0.0203	0.0248
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0172	0.1318
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0096	0.0416	0.3188
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Trypanosoma brucei	aurora B kinase	0.0072	0.0294	0.2254
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1193	0.1165
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0212	0.0259
Entamoeba histolytica	cell division protein kinase 2, putative	0.014	0.0636	0.4874
Entamoeba histolytica	protein kinase, putative	0.0141	0.0639	0.49
Echinococcus multilocularis	cyclin dependent kinase 1	0.014	0.0636	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1304	0.1276
Echinococcus granulosus	Glutaredoxin protein 5	0.0088	0.0374	0.0456
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0259
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0203	0.115
Brugia malayi	glutaminase DH11.1	0.033	0.1579	0.1552
Onchocerca volvulus	Cyclin L homolog	0.0054	0.0204	0.0707
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0275	0.1304	0.1276
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0072	0.0294	0.2254
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.0808	0.0987
Trichomonas vaginalis	cyclins, putative	0.0275	0.1304	0.8232
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0141	0.0639	0.0609
Onchocerca volvulus	Cyclin L homolog	0.0054	0.0204	0.0707
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.014	0.0636	0.0606
Trypanosoma cruzi	cdc2-related kinase 1	0.014	0.0636	0.4874
Schistosoma mansoni	nephrin	0.0031	0.0091	0.0112
Leishmania major	protein kinase, putative	0.0072	0.0294	0.2254
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0204	0.0173
Schistosoma mansoni	cell adhesion molecule	0.0031	0.0091	0.0112
Giardia lamblia	Cyclin fold protein 1, putative	0.0054	0.0204	0.0288
Echinococcus granulosus	nervana 2	0.0088	0.0374	0.0456
Entamoeba histolytica	hypothetical protein	0.0017	0.0024	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0193	0.0236
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0142	0.011
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0373	0.0342
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0054	0.0204	0.025
Echinococcus multilocularis	dnaJ subfamily C 6	0.0074	0.0305	0.0373
Loa Loa (eye worm)	cyclin domain-containing protein	0.0223	0.1045	0.1016
Echinococcus multilocularis	cyclin B3 1	0.0223	0.1045	0.1276
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0054	0.0204	0.263
Trypanosoma cruzi	NIMA-related kinase, putative	0.0017	0.0024	0.0182
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Brugia malayi	map kinase activated protein kinase protein 2	0.1659	0.8188	0.8182
Plasmodium falciparum	cyclin	0.0223	0.1045	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0204	0.0173
Echinococcus granulosus	cyclin b3	0.0223	0.1045	0.1276
Loa Loa (eye worm)	CYL-1 protein	0.0054	0.0204	0.0173
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Echinococcus multilocularis	Immunoglobulin	0.0031	0.0091	0.0112
Onchocerca volvulus		0.0054	0.0204	0.0707
Trichomonas vaginalis	cyclin B, putative	0.0223	0.1045	0.6564
Trypanosoma brucei	cyclin 9	0.0054	0.0204	0.1568
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0193	0.2485
Echinococcus granulosus	NDR protein kinase	0.0053	0.0203	0.0248
Giardia lamblia	Hypothetical protein	0.0054	0.0204	0.0288
Giardia lamblia	Hypothetical protein	0.0223	0.1045	0.7708
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0204	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0204	0.1162
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0017	0.0024	0.0182
Entamoeba histolytica	cyclin, domain containing protein	0.0054	0.0204	0.1568
Giardia lamblia	Kinase, AGC PKA	0.0096	0.0416	0.216
Echinococcus multilocularis	cyclin dependent kinase 1	0.014	0.0636	0.0776
Echinococcus granulosus	aurora kinase A	0.0072	0.0294	0.0359
Plasmodium vivax	SET domain protein, putative	0.0036	0.0117	0.1516
Trichomonas vaginalis	cyclins, putative	0.0275	0.1304	0.8232
Giardia lamblia	Hypothetical protein	0.0054	0.0204	0.0288
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0237	0.0205
Leishmania major	mitotic cyclin, putative	0.0054	0.0204	0.1568
Schistosoma mansoni	vesicular amine transporter	0.0031	0.0091	0.0112
Trichomonas vaginalis	cyclin B3, putative	0.0223	0.1045	0.6564
Echinococcus multilocularis	Glutaredoxin protein 5	0.0088	0.0374	0.0456
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Trypanosoma brucei	protein kinase, putative	0.0017	0.0024	0.0182
Brugia malayi	protein kinase C II.	0.0053	0.0203	0.0171
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0053	0.0203	0.0248
Leishmania major	protein kinase, putative	0.0017	0.0024	0.0182
Trypanosoma cruzi	mitotic cyclin, putative	0.0054	0.0204	0.1568
Trypanosoma brucei	cdc2-related kinase 3	0.014	0.0636	0.4874
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0096	0.0416	0.3987
Mycobacterium ulcerans	glutaminase	0.033	0.1579	0.5
Trypanosoma cruzi	cdc2-related kinase 3	0.014	0.0636	0.4874
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.1045	0.6564
Toxoplasma gondii	hypothetical protein	0.0169	0.0777	1
Toxoplasma gondii	hypothetical protein	0.0054	0.0204	0.263
Trypanosoma cruzi	mitotic cyclin, putative	0.0054	0.0204	0.1568
Entamoeba histolytica	protein kinase 2, putative	0.0096	0.0416	0.3193
Echinococcus multilocularis	cyclin B	0.0275	0.1304	0.1593
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0252	0.1193	0.1457
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0053	0.0203	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.0808	0.0987
Echinococcus multilocularis	cyclin G2	0.0054	0.0204	0.025
Echinococcus multilocularis	cyclin G2	0.0054	0.0204	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Echinococcus granulosus	neuroglian	0.0031	0.0091	0.0112
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0275	0.1304	0.1276
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0212	0.0259
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0294	0.1737
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0203	0.0171
Brugia malayi	serine/threonine-protein kinase 6	0.0072	0.0294	0.0263
Echinococcus granulosus	histone lysine methyltransferase setb	0.0036	0.0117	0.0142
Echinococcus granulosus	defective proboscis extension response	0.0031	0.0091	0.0112
Trichomonas vaginalis	cyclins, putative	0.0275	0.1304	0.8232
Entamoeba histolytica	protein kinase, putative	0.0017	0.0024	0.0182
Loa Loa (eye worm)	glutaminase 2	0.033	0.1579	0.1552
Trypanosoma cruzi	cyclin 9, putative	0.0054	0.0204	0.1568
Echinococcus granulosus	nervana 2	0.0088	0.0374	0.0456
Echinococcus multilocularis	cyclin A3 4	0.0054	0.0204	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.014	0.0636	0.0776
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0024	0.0182
Entamoeba histolytica	protein kinase, putative	0.0017	0.0024	0.0182
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.014	0.0636	0.4874
Echinococcus multilocularis	dual specificity	0.0096	0.0416	0.0508
Entamoeba histolytica	hypothetical protein	0.0054	0.0204	0.1568
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0193	0.2485
Entamoeba histolytica	protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.4082	0.4985
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0053	0.0203	0.0248
Trichomonas vaginalis	AGC family protein kinase	0.0062	0.0246	0.1431
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0053	0.0203	0.0171
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0054	0.0204	0.1957
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0054	0.0204	0.025
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0117	0.0085
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Echinococcus multilocularis	protein kinase c iota type	0.0053	0.0203	0.0248
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0053	0.0203	0.0248
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.4082	0.4985
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0416	0.0508
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Toxoplasma gondii	aurora kinase	0.0072	0.0294	0.3781
Entamoeba histolytica	cyclin, putative	0.0223	0.1045	0.801
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0294	0.1737
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0117	0.0142
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0223	0.1045	0.1276
Schistosoma mansoni	hypothetical protein	0.0054	0.0204	0.025
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0074	0.0305	0.1809
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0039
Echinococcus granulosus	cyclin	0.0054	0.0204	0.025
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0032	0.0039
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0054	0.0204	0.1568
Trypanosoma cruzi	aurora B kinase, putative	0.0072	0.0294	0.2254
Echinococcus granulosus	cyclin y	0.0054	0.0204	0.025
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.046	0.3528
Entamoeba histolytica	protein kinase, putative	0.0017	0.0024	0.0182
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0237	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0294	0.1737
Leishmania major	folate/biopterin transporter, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclin dependent kinase 5	0.014	0.0636	0.0776
Echinococcus multilocularis	serine threonine protein kinase	0.0053	0.0203	0.0248
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0072	0.0294	0.0359
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0045	0.016	0.0875
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0117	0.0142
Echinococcus granulosus	cyclin G2	0.0054	0.0204	0.025
Entamoeba histolytica	cyclin, domain containing protein	0.0054	0.0204	0.1568
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0031	0.0091	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0096	0.0416	0.6418
Trypanosoma brucei	mitotic cyclin	0.0054	0.0204	0.1568
Echinococcus granulosus	Protein kinase C brain isozyme	0.0053	0.0203	0.0248
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0054	0.0204	0.1957
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0054	0.0204	0.2953
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0024	0.0182
Brugia malayi	hypothetical protein	0.0054	0.0204	0.0173
Loa Loa (eye worm)	glutaminase	0.033	0.1579	0.1552
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0054	0.0204	0.263
Onchocerca volvulus	Protein CNPPD1 homolog	0.0054	0.0204	0.0707
Giardia lamblia	Cyclin A	0.0223	0.1045	0.7708
Echinococcus multilocularis	cyclin dependent kinase 5	0.014	0.0636	0.0776
Trichomonas vaginalis	AGC family protein kinase	0.015	0.0683	0.4237
Echinococcus multilocularis	neuroglian	0.0031	0.0091	0.0112
Echinococcus granulosus	cyclin k	0.0054	0.0204	0.025
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.1659	0.8188	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclin A3 4	0.0054	0.0204	0.025
Echinococcus multilocularis	cyclin y	0.0054	0.0204	0.025
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0105	0.046	0.3528
Trypanosoma cruzi	cdc2-related kinase 1	0.014	0.0636	0.4874
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0142	0.011
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0032	0.0039
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0105	0.046	0.3528
Echinococcus granulosus	cyclin B3 1	0.0223	0.1045	0.1276
Trichomonas vaginalis	cyclins, putative	0.0054	0.0204	0.1162
Entamoeba histolytica	protein kinase, putative	0.0096	0.0416	0.3188
Brugia malayi	Pre-SET motif family protein	0.0251	0.1187	0.1159
Leishmania major	serine/threonine-protein kinase a, putative	0.0017	0.0024	0.0182
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0031	0.0091	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0203	0.115
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0053	0.0203	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.1659	0.8188	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0117	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0204	0.1162
Echinococcus granulosus	roundabout 2	0.0031	0.0091	0.0112
Trichomonas vaginalis	cyclin A, putative	0.0054	0.0204	0.1162
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.4082	0.4985
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0017	0.0024	0.0182
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.014	0.0636	0.8176
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0039
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0204	0.0173
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclins	0.0223	0.1045	0.1276
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0054	0.0204	0.263
Trichomonas vaginalis	cyclins, putative	0.0054	0.0204	0.1162
Schistosoma mansoni	cyclin d	0.0054	0.0204	0.025
Trypanosoma brucei	mitotic cyclin 6	0.0275	0.1304	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0096	0.0416	0.0509
Entamoeba histolytica	cyclin C, putative	0.0054	0.0204	0.1568
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0096	0.0416	0.3188
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0072	0.0294	0.2254
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0017	0.0024	0.0182
Schistosoma mansoni	serine/threonine-protein kinase	0.0105	0.046	0.0562
Schistosoma mansoni	hypothetical protein	0.0041	0.0142	0.0173
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0017	0.0024	0.0182
Echinococcus multilocularis	aurora kinase A	0.0072	0.0294	0.0359
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0252	0.1193	0.1457
Brugia malayi	Protein kinase domain containing protein	0.014	0.0636	0.0606
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0204	0.1162
Trichomonas vaginalis	cyclin D, putative	0.0223	0.1045	0.6564
Brugia malayi	cyclin fold protein 1 variant b	0.0054	0.0204	0.0173
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0294	0.0359
Trichomonas vaginalis	cyclins, putative	0.0223	0.1045	0.6564
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0031	0.0091	0.0112
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0053	0.0203	0.0171
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.1659	0.8188	1
Brugia malayi	cell division control protein 2 homolog	0.014	0.0636	0.0606
Entamoeba histolytica	protein kinase domain containing protein	0.0096	0.0416	0.3188
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0538	0.0508
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0088	0.0374	0.0456
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0223	0.1045	0.1276
Entamoeba histolytica	protein kinase, putative	0.0096	0.0416	0.3188
Loa Loa (eye worm)	cyclin C	0.0054	0.0204	0.0173
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.0636	0.0776
Trichomonas vaginalis	cyclin B3, putative	0.0054	0.0204	0.1162
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.1187	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0538	0.0508
Echinococcus granulosus	Immunoglobulin	0.0031	0.0091	0.0112
Trichomonas vaginalis	cyclin B, putative	0.0275	0.1304	0.8232
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Trichomonas vaginalis	cyclin D, putative	0.0054	0.0204	0.1162
Entamoeba histolytica	protein kinase, putative	0.0053	0.0203	0.1554
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	serine:threonine protein kinase N2	0.0053	0.0203	0.0248
Leishmania major	mitotic cyclin, putative	0.0054	0.0204	0.1568
Echinococcus granulosus	cyclin B	0.0275	0.1304	0.1593
Trypanosoma cruzi	Protein kinase B	0.0105	0.046	0.3528
Trichomonas vaginalis	cyclin B3, putative	0.0054	0.0204	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Schistosoma mansoni	cyclin G	0.0054	0.0204	0.025
Trichomonas vaginalis	cyclin B, putative	0.0054	0.0204	0.1162
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0072	0.0294	0.0359
Brugia malayi	serine/threonine protein kinase 6	0.0072	0.0294	0.0263
Brugia malayi	hypothetical protein	0.0121	0.0538	0.0508
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0212	0.0181
Giardia lamblia	Kinase, CMGC CDK	0.014	0.0636	0.4096
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0204	0.0173
Giardia lamblia	Aurora kinase	0.0072	0.0294	0.1078
Loa Loa (eye worm)	acetyltransferase	0.0175	0.0808	0.0778
Echinococcus multilocularis	nervana 2	0.0088	0.0374	0.0456
Trichomonas vaginalis	cyclin B, putative	0.0275	0.1304	0.8232
Echinococcus granulosus	cyclins	0.0223	0.1045	0.1276
Echinococcus multilocularis	nervana 2	0.0088	0.0374	0.0456
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.011	0.0134
Trichomonas vaginalis	cyclin D, putative	0.0223	0.1045	0.6564
Echinococcus multilocularis	G1:S specific cyclin D1	0.0054	0.0204	0.025
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0204	0.0173
Echinococcus multilocularis	cyclin b3	0.0223	0.1045	0.1276
Plasmodium vivax	protein kinase Crk2	0.014	0.0636	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0105	0.046	0.0562
Echinococcus multilocularis	cyclin k	0.0054	0.0204	0.025
Echinococcus granulosus	cyclins	0.0223	0.1045	0.1276
Trypanosoma cruzi	cyclin, putative	0.0275	0.1304	1
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0096	0.0416	0.0385
Echinococcus multilocularis	cyclin dependent kinase	0.014	0.0636	0.0776
Trypanosoma cruzi	cdc2-related kinase 3	0.014	0.0636	0.4874
Onchocerca volvulus		0.0286	0.136	1
Brugia malayi	Fibronectin type III domain containing protein	0.0031	0.0091	0.006
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0017	0.0024	0.0182
Brugia malayi	Pre-SET motif family protein	0.0036	0.0117	0.0085
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0053	0.0203	0.0248
Entamoeba histolytica	protein kinase, putative	0.0072	0.0294	0.2254
Schistosoma mansoni	cyclin B3	0.0223	0.1045	0.1276
Brugia malayi	Hr1 repeat family protein	0.0053	0.0203	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1304	0.1276
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0031	0.0091	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0054	0.0204	0.025
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Loa Loa (eye worm)	AUR protein kinase	0.0072	0.0294	0.0263
Loa Loa (eye worm)	cyclin domain-containing protein	0.2023	1	1
Echinococcus multilocularis	cyclin y	0.0054	0.0204	0.025
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.014	0.0636	0.0606
Schistosoma mansoni	cyclin l	0.0054	0.0204	0.025
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Trichomonas vaginalis	glutaminase, putative	0.033	0.1579	1
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Echinococcus granulosus	twitchin	0.004	0.0134	0.0164
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0212	0.0181
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0036	0.0117	0.0142
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.0636	0.3934
Loa Loa (eye worm)	cyclin domain-containing protein	0.0054	0.0204	0.0173
Loa Loa (eye worm)	AUR protein kinase	0.0072	0.0294	0.0263
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0204	0.1162
Loa Loa (eye worm)	AUR protein kinase	0.0072	0.0294	0.0263
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclin dependent kinase 1	0.014	0.0636	0.0776
Plasmodium falciparum	cyclin 1	0.0054	0.0204	0.1957
Echinococcus multilocularis	cyclin	0.0054	0.0204	0.025
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0039
Entamoeba histolytica	hypothetical protein	0.0017	0.0024	0.0182
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0096	0.0416	0.3188
Trypanosoma cruzi	cyclin, putative	0.0275	0.1304	1
Brugia malayi	serine/threonine kinase 12	0.0072	0.0294	0.0263
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclin t1	0.0054	0.0204	0.025
Schistosoma mansoni	serine/threonine kinase	0.0053	0.0203	0.0248
Trichomonas vaginalis	cyclins, putative	0.0106	0.0464	0.283
Brugia malayi	Protein kinase domain containing protein	0.0096	0.0416	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0197	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0373	0.0342
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0275	0.1304	1
Leishmania major	cyclin	0.0275	0.1304	1
Echinococcus multilocularis	Cyclin L1	0.0054	0.0204	0.025
Entamoeba histolytica	protein kinase , putative	0.0072	0.0294	0.2254
Onchocerca volvulus		0.0275	0.1304	0.9551
Entamoeba histolytica	cyclin, putative	0.0275	0.1304	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0072	0.0294	0.2814
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0072	0.0294	0.2254
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0053	0.0203	0.0248
Entamoeba histolytica	protein kinase, putative	0.015	0.0683	0.5235
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0193	0.109
Entamoeba histolytica	protein kinase, putative	0.0017	0.0024	0.0182
Trichomonas vaginalis	AGC family protein kinase	0.0072	0.0294	0.1737
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0203	0.0171
Echinococcus granulosus	GPCR family 2	0.0019	0.0032	0.0039
Schistosoma mansoni	glutaminase	0.033	0.1579	0.1929
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0053	0.0203	0.0248
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0017	0.0024	0.0182
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0053	0.0203	0.0171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0259
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0053	0.0203	0.0248
Echinococcus granulosus	dnaJ subfamily C 6	0.0074	0.0305	0.0373
Echinococcus granulosus	cyclin dependent kinase	0.014	0.0636	0.0776
Echinococcus granulosus	dual specificity	0.0096	0.0416	0.0508
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Echinococcus granulosus	G1:S specific cyclin D1	0.0054	0.0204	0.025
Plasmodium vivax	cyclin 4, putative	0.0054	0.0204	0.2953
Echinococcus multilocularis	cyclins	0.0223	0.1045	0.1276
Brugia malayi	Protein kinase domain containing protein	0.015	0.0683	0.0653
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0072	0.0294	0.4416
Entamoeba histolytica	p21-activated kinase	0.0017	0.0024	0.0182
Brugia malayi	DnaJ domain containing protein	0.0074	0.0305	0.0274
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0275	0.1304	1
Trichomonas vaginalis	cyclins, putative	0.0275	0.1304	0.8232
Schistosoma mansoni	hypothetical protein	0.0074	0.0305	0.0373
Schistosoma mansoni	cyclin k	0.0054	0.0204	0.025
Entamoeba histolytica	protein kinase domain containing protein	0.0072	0.0294	0.2254
Schistosoma mansoni	hypothetical protein	0.0054	0.0204	0.025
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0252	0.1193	0.1457
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0092	0.006
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0088	0.0374	0.0456
Toxoplasma gondii	protein kinase domain-containing protein	0.0017	0.0024	0.0305
Schistosoma mansoni	cyclins	0.0223	0.1045	0.1276
Leishmania major	cyclin 9, putative	0.0054	0.0204	0.1568
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.0808	0.0778
Plasmodium vivax	cyclin homologue, putative	0.0054	0.0204	0.2953
Plasmodium vivax	hypothetical protein, conserved	0.0054	0.0204	0.2953
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0203	0.0248
Brugia malayi	p70 ribosomal S6 kinase beta	0.0141	0.0639	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0593	0.0563
Trypanosoma cruzi	cyclin 6, putative	0.0275	0.1304	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.0783	0.0957
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0237	0.0205
Schistosoma mansoni	serine/threonine protein kinase	0.014	0.0636	0.0776
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0193	0.277
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0054	0.0204	0.0173
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0032	0.0039
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.014	0.0636	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0091	0.006
Entamoeba histolytica	cyclin family protein	0.0223	0.1045	0.801
Schistosoma mansoni	hypothetical protein	0.0019	0.0032	0.0039
Toxoplasma gondii	cyclin 4, putative	0.0054	0.0204	0.263
Trypanosoma cruzi	NIMA-related kinase, putative	0.0017	0.0024	0.0182
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0017	0.0024	0.0227
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0204	0.1162
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0017	0.0024	0.0182
Echinococcus granulosus	cyclin y	0.0054	0.0204	0.025
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0212	0.0259
Giardia lamblia	Cyclin B-like protein	0.0054	0.0204	0.0288
Echinococcus granulosus	serine threonine protein kinase nrc	0.0096	0.0416	0.0509
Echinococcus multilocularis	cyclin t1	0.0054	0.0204	0.025
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0096	0.0416	0.3193
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0054	0.0204	0.0173
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0017	0.0024	0.0182
Loa Loa (eye worm)	AGC/AKT protein kinase	0.015	0.0683	0.0653
Echinococcus multilocularis	roundabout 2	0.0031	0.0091	0.0112
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0203	0.115
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0117	0.0142
Echinococcus granulosus	cyclins	0.0223	0.1045	0.1276
Echinococcus granulosus	cyclin G2	0.0054	0.0204	0.025
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0212	0.0259
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0053	0.0203	0.0248
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0172	0.1645
Trichomonas vaginalis	CMGC family protein kinase	0.014	0.0636	0.3934
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0032	0.0039

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1887006

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1583619