TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.869 | Formula: C21H22ClN3O5
H donors: 2 H acceptors: 2 LogP: 3.93 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1c1n[nH]c(c1)C(=O)Nc1cc(OC)c(c(c1)OC)OC)Cl
InChi: 1S/C21H22ClN3O5/c1-5-30-17-7-6-12(22)8-14(17)15-11-16(25-24-15)21(26)23-13-9-18(27-2)20(29-4)19(10-13)28-3/h6-11H,5H2,1-4H3,(H,23,26)(H,24,25)
InChiKey: JVLGMFXBIVSTOU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0294	0.0264
Onchocerca volvulus		0.0067	0.0246	0.1938
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0082	0.0022
Echinococcus multilocularis	carbonic anhydrase II	0.191	0.978	1
Mycobacterium ulcerans	hypothetical protein	0.004	0.0106	0.0053
Schistosoma mansoni	carbonic anhydrase-related	0.0778	0.3924	0.3989
Mycobacterium ulcerans	carbonic anhydrase	0.1504	0.768	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0082	0.0027
Trypanosoma brucei	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0065	0.001
Toxoplasma gondii	ABC1 family protein	0.0036	0.0082	0.0079
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0082	0.0047
Schistosoma mansoni	carbonic anhydrase	0.0778	0.3924	0.3989
Brugia malayi	intermediate filament protein	0.0027	0.0037	0.0038
Schistosoma mansoni	hypothetical protein	0.0167	0.0765	0.0747
Entamoeba histolytica	acetyltransferase, putative	0.007	0.026	0.0244
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0056	0.1352
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0082	0.0047
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0106	0.0051
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.0967	0.0936
Entamoeba histolytica	ankyrin, putative	0.007	0.026	0.0244
Echinococcus granulosus	carbonic anhydrase	0.0778	0.3924	0.3989
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0046	0.0009
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0037	0.0003
Plasmodium falciparum	carbonic anhydrase	0.0778	0.3924	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0052	0.0015
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0082	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Onchocerca volvulus		0.0036	0.0082	0.0422
Toxoplasma gondii	inorganic anion transporter, sulfate permease (SulP) family protein	0.0032	0.0065	0.0036
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.191	0.978	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0082	0.0047
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0082	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0082	0.0022
Echinococcus multilocularis	carbonic anhydrase	0.0778	0.3924	0.3989
Plasmodium falciparum	inorganic anion exchanger, inorganic anion antiporter	0.0032	0.0065	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.1504	0.768	1
Brugia malayi	beta-lactamase	0.0036	0.0082	0.0084
Mycobacterium tuberculosis	Possible siderophore-binding protein	0.004	0.0106	0.0048
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0234	0.111	0.2135
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0294	0.0264
Onchocerca volvulus	Putative sulfate transporter	0.0203	0.0947	0.8445
Mycobacterium leprae	PROBABLE TRANSFERASE	0.0067	0.0246	0.0225
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0778	0.3924	0.3903
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0037	0.0003
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0082	0.0048
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0052	0.0015
Loa Loa (eye worm)	hypothetical protein	0.003	0.0052	0.0017
Brugia malayi	Pre-SET motif family protein	0.0207	0.0967	0.0989
Brugia malayi	hypothetical protein	0.0036	0.0082	0.0084
Entamoeba histolytica	carbonic anhydrase, putative	0.1437	0.7335	1
Trypanosoma brucei	carbonic anhydrase-like protein	0.191	0.978	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0082	0.0027
Onchocerca volvulus		0.0036	0.0082	0.0422
Mycobacterium ulcerans	transferase	0.0067	0.0246	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0037	0.0003
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0082	0.0022
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0056	0.0011
Echinococcus granulosus	dynactin 5 p25	0.007	0.026	0.0229
Echinococcus multilocularis	carbonic anhydrase	0.0778	0.3924	0.3989
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0082	0.0027
Brugia malayi	hypothetical protein	0.003	0.0056	0.0057
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.007	0.026	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0294	0.0264
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0065	0.001
Onchocerca volvulus		0.003	0.0052	0.0137
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0778	0.3924	0.4012
Schistosoma mansoni	hypothetical protein	0.0036	0.0082	0.0047
Leishmania major	hypothetical protein, conserved	0.0036	0.0082	0.0027
Schistosoma mansoni	carbonic anhydrase-related	0.0778	0.3924	0.3989
Trichomonas vaginalis	conserved hypothetical protein	0.1504	0.768	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0052	0.0015
Brugia malayi	beta-lactamase family protein	0.0036	0.0082	0.0084
Brugia malayi	follicle stimulating hormone receptor	0.023	0.1088	0.1112
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0294	0.0264
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0052	0.0015
Onchocerca volvulus		0.0203	0.0947	0.8445
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0778	0.3924	0.4012
Onchocerca volvulus		0.0036	0.0082	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Chlamydia trachomatis	sulfate transporter	0.0032	0.0065	0.5
Brugia malayi	TAR-binding protein	0.0076	0.0294	0.0301
Mycobacterium tuberculosis	Probable serine acetyltransferase CysE (sat)	0.007	0.026	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0082	0.0022
Wolbachia endosymbiont of Brugia malayi	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase	0.007	0.026	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0778	0.3924	0.4012
Toxoplasma gondii	hypothetical protein	0.0778	0.3924	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0082	0.0048
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0246	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0294	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0778	0.3924	0.3903
Mycobacterium tuberculosis	Beta-carbonic anhydrase	0.0966	0.4895	1
Mycobacterium tuberculosis	Beta-carbonic anhydrase CanB	0.0899	0.455	0.9284
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0052	0.0015
Echinococcus multilocularis	carbonic anhydrase	0.0778	0.3924	0.3989
Echinococcus granulosus	geminin	0.0167	0.0765	0.0747
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.191	0.978	1
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0778	0.3924	0.4012
Mycobacterium leprae	Probable transmembrane transport protein	0.0234	0.111	0.1417
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0294	0.0261
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0037	0.0038
Mycobacterium ulcerans	carbonic anhydrase	0.1437	0.7335	0.9547
Onchocerca volvulus		0.0235	0.1115	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0294	0.0301
Brugia malayi	RNA binding protein	0.0076	0.0294	0.0301
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0294	0.0261
Schistosoma mansoni	hypothetical protein	0.0167	0.0765	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0294	0.0264
Loa Loa (eye worm)	hypothetical protein	0.003	0.0056	0.0022
Plasmodium vivax	sulfate transporter, putative	0.0032	0.0065	0.4487
Brugia malayi	Pre-SET motif family protein	0.003	0.0052	0.0053
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.191	0.978	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0082	0.0084
Brugia malayi	beta-lactamase family protein	0.0036	0.0082	0.0084
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0082	0.0022
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.1074	0.2061
Schistosoma mansoni	carbonic anhydrase-related	0.0778	0.3924	0.3989
Mycobacterium leprae	CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE)	0.1437	0.7335	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0052	0.0015
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.191	0.978	1
Echinococcus granulosus	carbonic anhydrase	0.0778	0.3924	0.3989
Trypanosoma cruzi	Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative	0.0032	0.0065	0.001
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0067	0.0246	0.0215
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.023	0.1088	0.1057
Leishmania major	carbonic anhydrase family protein, putative	0.1437	0.7335	0.7486
Entamoeba histolytica	bacterial transferase hexapeptide family protein	0.004	0.0106	0.0032
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0106	0.0051
Schistosoma mansoni	hypothetical protein	0.0778	0.3924	0.3989
Loa Loa (eye worm)	hypothetical protein	0.0778	0.3924	0.3903
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.191	0.978	1
Mycobacterium tuberculosis	Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase)	0.0773	0.3895	0.7922
Echinococcus multilocularis	geminin	0.0167	0.0765	0.0747
Leishmania major	hypothetical protein, conserved	0.004	0.0106	0.0051
Echinococcus granulosus	carbonic anhydrase	0.0778	0.3924	0.3989
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0294	0.0264
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0082	0.0047
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.1115	0.1359
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.191	0.978	0.9779
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0778	0.3924	0.4012
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0106	0.0051
Schistosoma mansoni	carbonic anhydrase	0.1437	0.7335	0.7491
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0052	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0082	0.0048
Loa Loa (eye worm)	carbonic anhydrase 3	0.191	0.978	0.9779
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0082	0.0047
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0082	0.0047
Leishmania major	carbonic anhydrase-like protein	0.191	0.978	1
Echinococcus granulosus	carbonic anhydrase II	0.191	0.978	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0294	0.0261
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.191	0.978	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1888873

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1587768