Detailed information for compound 1588499

Basic information

Technical information
  • TDR Targets ID: 1588499
  • Name: [2-(3,5-dimethylpiperidin-1-yl)-2-oxoethyl] 4 -(methyl-phenylsulfamoyl)benzoate
  • MW: 444.544 | Formula: C23H28N2O5S
  • H donors: 0 H acceptors: 4 LogP: 3.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)C(=O)COC(=O)c1ccc(cc1)S(=O)(=O)N(c1ccccc1)C
  • InChi: 1S/C23H28N2O5S/c1-17-13-18(2)15-25(14-17)22(26)16-30-23(27)19-9-11-21(12-10-19)31(28,29)24(3)20-7-5-4-6-8-20/h4-12,17-18H,13-16H2,1-3H3
  • InChiKey: CNTLPEMYPXOVRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(3,5-dimethyl-1-piperidyl)-2-oxo-ethyl] 4-(methyl-phenyl-sulfamoyl)benzoate
  • 4-(methyl-phenylsulfamoyl)benzoic acid [2-(3,5-dimethyl-1-piperidinyl)-2-oxoethyl] ester
  • 4-(methyl-phenyl-sulfamoyl)benzoic acid [2-(3,5-dimethyl-1-piperidyl)-2-keto-ethyl] ester
  • [2-(3,5-dimethylpiperidin-1-yl)-2-oxo-ethyl] 4-(methyl-phenyl-sulfamoyl)benzoate
  • T5226680

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.3249 0.3242
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0419 0.1763 0.1687
Brugia malayi FAT domain containing protein 0.0324 0.1327 0.1327
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0143 0.0497 0.0672
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0063 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0143 0.0497 0.0497
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0921 0.4061 0.4055
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0371
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2218 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0143 0.0497 1
Leishmania major hypothetical protein, unknown function 0.0143 0.0497 0.0371
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0497 0.0497
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0744 0.3249 0.3249
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2218 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0487
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0143 0.0497 0.0487
Loa Loa (eye worm) hypothetical protein 0.0276 0.1108 0.1108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0118 0.0118
Leishmania major phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0371
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0063 0.0131 0.0131
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0143 0.0497 0.0487
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0063 0.0131 0.0101
Trichomonas vaginalis fk506-binding protein, putative 0.0063 0.0131 0.0121
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0143 0.0497 0.0497
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0143 0.0497 0.0487
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0143 0.0497 0.041
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0063 0.0131 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.1763 0.1755
Onchocerca volvulus 0.0143 0.0497 0.5
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0143 0.0497 1
Schistosoma mansoni hypothetical protein 0.0143 0.0497 0.0468
Schistosoma mansoni immunophilin 0.0063 0.0131 0.0101
Toxoplasma gondii FATC domain-containing protein 0.0419 0.1763 0.2384
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Entamoeba histolytica protein kinase rad3, putative 0.0419 0.1763 0.1763
Entamoeba histolytica hypothetical protein 0.0143 0.0497 0.0497
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0497
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0419 0.1763 0.1755
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0744 0.3249 0.3159
Entamoeba histolytica hypothetical protein 0.0143 0.0497 0.0497
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0744 0.3249 0.3159
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0143 0.0497 0.0487
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0143 0.0497 0.041
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0131 0.0121
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0143 0.0497 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5327 0.5322
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.7922 0.7919
Trichomonas vaginalis PIKK family atypical protein kinase 0.2218 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5319 0.5314
Leishmania major phosphatidylinositol kinase related protein, putative 0.0143 0.0497 0.0371
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0143 0.0497 0.0487
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0371
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0143 0.0497 0.041
Entamoeba histolytica hypothetical protein 0.0143 0.0497 0.0497
Echinococcus granulosus serine protein kinase ATM 0.0419 0.1763 0.1687
Schistosoma mansoni immunophilin 0.0063 0.0131 0.0101
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0467 0.1983 0.268
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2218 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0497
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0324 0.1327 0.1247
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2218 1 1
Giardia lamblia GTOR 0.2218 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0143 0.0497 0.0371
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0063 0.0131 0.0131
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0143 0.0497 0.0487
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0143 0.0497 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0487
Giardia lamblia Phosphatidylinositol 4-kinase 0.0143 0.0497 0.0371
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0143 0.0497 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0143 0.0497 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Trichomonas vaginalis PIKK family atypical protein kinase 0.1488 0.6656 0.6652
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0063 0.0131 0.0131
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0419 0.1763 0.1687
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0063 0.0131 0.0121
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1766 0.793 0.7928
Trichomonas vaginalis conserved hypothetical protein 0.0324 0.1327 0.1318
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0497
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0143 0.0497 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Trichomonas vaginalis PIKK family atypical protein kinase 0.1325 0.5912 0.5907
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Leishmania major phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0371
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0143 0.0497 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5319 0.5314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0497 0.0487
Loa Loa (eye worm) phosphatidylinositol 3 0.2218 1 1
Leishmania major hypothetical protein, conserved 0.0143 0.0497 0.0371
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0419 0.1763 0.1763
Toxoplasma gondii target of rapamycin (TOR), putative 0.165 0.7397 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0143 0.0497 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.3249 0.3242
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0497 0.0497
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Plasmodium vivax hypothetical protein 0.0143 0.0497 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0143 0.0497 0.0487
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0143 0.0497 0.041
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.1108 0.1099
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0143 0.0497 0.0371
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0143 0.0497 0.041
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0143 0.0497 0.0468
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0419 0.1763 0.1738
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2218 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1766 0.793 0.7902
Trichomonas vaginalis conserved hypothetical protein 0.0467 0.1983 0.1974
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0118 0.0118
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0131 0.004
Loa Loa (eye worm) hypothetical protein 0.0467 0.1983 0.1983
Brugia malayi Protein kinase domain containing protein 0.0037 0.001 0.001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2218 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0143 0.0497 0.041
Entamoeba histolytica protein kinase, putative 0.0037 0.001 0.001
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0143 0.0497 0.0497
Echinococcus multilocularis fk506 binding protein 0.0063 0.0131 0.004
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0143 0.0497 0.0487
Leishmania major phosphatidylinositol kinase, putative 0.0143 0.0497 0.0371
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.1763 0.1755
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2218 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0143 0.0497 0.0497
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0118 0.0118
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0063 0.0131 0.5
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0744 0.3249 0.3228
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0744 0.3249 0.3242
Trichomonas vaginalis PIKK family atypical protein kinase 0.1325 0.5912 0.5907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.3249 0.3242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.3249 0.3242
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0497
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0419 0.1763 0.1654
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2218 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0744 0.3249 0.3186
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0143 0.0497 0.0371
Schistosoma mansoni immunophilin 0.0054 0.0091 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.7922 0.7919
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0419 0.1763 0.1763
Schistosoma mansoni hypothetical protein 0.0324 0.1327 0.1301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.3249 0.3242
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0143 0.0497 0.0497
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0143 0.0497 0.0371
Loa Loa (eye worm) hypothetical protein 0.0143 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0744 0.3249 0.3242
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0497 0.0497
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0419 0.1763 0.1763
Echinococcus multilocularis 0.0143 0.0497 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.7922 0.7919
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0091
Giardia lamblia Hypothetical protein 0.0143 0.0497 0.0371
Entamoeba histolytica hypothetical protein 0.0143 0.0497 0.0497
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0419 0.1763 0.1654
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0143 0.0497 0.0468
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0143 0.0497 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Entamoeba histolytica protein kinase, putative 0.0037 0.001 0.001
Mycobacterium leprae conserved hypothetical protein 0.0143 0.0497 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0063 0.0131 0.0131
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0143 0.0497 0.041
Trichomonas vaginalis PIKK family atypical protein kinase 0.2218 1 1
Loa Loa (eye worm) hypothetical protein 0.0419 0.1763 0.1763
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0143 0.0497 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5327 0.5322
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0143 0.0497 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.1196 0.5319 0.5314
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0143 0.0497 0.041
Onchocerca volvulus 0.0143 0.0497 0.5
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0143 0.0497 0.041
Loa Loa (eye worm) hypothetical protein 0.006 0.0118 0.0118
Loa Loa (eye worm) phosphatidylinositol 3 0.0143 0.0497 0.0497
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0063 0.0131 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.1312 0.5852 0.5847
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0063 0.0131 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0371
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0143 0.0497 0.0497
Mycobacterium tuberculosis Conserved hypothetical protein 0.0143 0.0497 0.5
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1766 0.793 0.7902
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0324 0.1327 0.1247
Trichomonas vaginalis PIKK family atypical protein kinase 0.1325 0.5912 0.5907
Plasmodium vivax hypothetical protein, conserved 0.0143 0.0497 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0276 0.1108 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.1894 0.8515 0.8513
Loa Loa (eye worm) FKBP5 protein 0.0063 0.0131 0.0131
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0143 0.0497 0.041
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0143 0.0497 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0143 0.0497 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.2218 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0143 0.0497 0.0672
Leishmania major phosphatidylinositol 3-kinase, putative 0.0744 0.3249 0.3159
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0143 0.0497 0.0468
Echinococcus multilocularis Zinc finger, PHD finger 0.0143 0.0497 0.041
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0143 0.0497 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0497 0.0487
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1049 0.4646 0.464
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.7922 0.7919
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5327 0.5322
Trichomonas vaginalis PIKK family atypical protein kinase 0.165 0.7397 0.7394
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0143 0.0497 0.041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0143 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0143 0.0497 0.0487
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2218 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0143 0.0497 0.0487
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0143 0.0497 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0419 0.1763 0.1755
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0143 0.0497 0.0371
Schistosoma mansoni fkbp-rapamycin associated protein 0.0419 0.1763 0.1738
Trichomonas vaginalis PIKK family atypical protein kinase 0.1764 0.7922 0.7919
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0143 0.0497 0.0468
Loa Loa (eye worm) hypothetical protein 0.0324 0.1327 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.1198 0.5327 0.5322
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0143 0.0497 0.0487
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0143 0.0497 0.0672
Loa Loa (eye worm) phosphatidylinositol 3 0.0744 0.3249 0.3249
Echinococcus multilocularis serine protein kinase ATM 0.0419 0.1763 0.1687
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0143 0.0497 0.0497
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0063 0.0131 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0595 0.2567 0.256
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0143 0.0497 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.1312 0.5852 0.5847
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0143 0.0497 0.041
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0063 0.0131 0.004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0744 0.3249 0.3159
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0143 0.0497 0.041
Trichomonas vaginalis immunophilin, putative 0.0063 0.0131 0.0121
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0143 0.0497 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0037 0.001 0.001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0143 0.0497 0.0487
Loa Loa (eye worm) hypothetical protein 0.0452 0.1912 0.1912
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0143 0.0497 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.144 0.6436 0.6433
Trichomonas vaginalis conserved hypothetical protein 0.0276 0.1108 0.1099
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2218 1 1
Entamoeba histolytica hypothetical protein 0.0419 0.1763 0.1763
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0744 0.3249 0.3186
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0143 0.0497 0.0487
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2218 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0143 0.0497 0.0487

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.