Detailed information for compound 1590484

Basic information

Technical information
  • TDR Targets ID: 1590484
  • Name: 6a-(Tetrahydro-2H-pyran-2-yloxy)-6,6a,10b,10c -tetrahydrobenzo[3,4]cyclobuta[1,2-a]biphenyl en-4b(5H)-ol
  • MW: 348.435 | Formula: C23H24O3
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC12CCC3(C(C2c2c1cccc2)c1c3cccc1)OC1CCCCO1
  • InChi: 1S/C23H24O3/c24-22-12-13-23(26-19-11-5-6-14-25-19)18-10-4-2-8-16(18)21(23)20(22)15-7-1-3-9-17(15)22/h1-4,7-10,19-21,24H,5-6,11-14H2
  • InChiKey: GTAUFWQVNOOSHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-141001
  • AIDS141001
  • NSC655280
  • NCI60_019123

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0012 0.0103 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0291 0.0364
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0697 0.0918
Schistosoma mansoni hypothetical protein 0.0018 0.0243 0.0219
Loa Loa (eye worm) hypothetical protein 0.0014 0.0156 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.068 0.3058
Brugia malayi ecdysteroid receptor 0.0012 0.0102 0.0107
Onchocerca volvulus 0.0012 0.0102 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0102 0.0078
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0267 0.6071
Brugia malayi Melibiase family protein 0.0079 0.1546 0.2078
Echinococcus granulosus expressed protein 0.0039 0.068 0.0658
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0012 0.0103 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0102 0.0078
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0102 0.0107
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.1546 0.1526
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0102 0.0107
Trypanosoma brucei Aminopeptidase M1, putative 0.0014 0.0156 0.0607
Onchocerca volvulus 0.0028 0.044 0.0567
Toxoplasma gondii aminopeptidase n, putative 0.0361 0.7565 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1363 0.1342
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.1011 0.4577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.2195 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0014 0.0156 0.018
Brugia malayi AMP-binding enzyme family protein 0.0028 0.044 0.0567
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0028 0.0004
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0014 0.0156 0.018
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.068 0.0896
Schistosoma mansoni hypothetical protein 0.0475 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0102 0.0078
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0102 0.0107
Schistosoma mansoni hypothetical protein 0.0018 0.0243 0.0219
Echinococcus granulosus aminopeptidase N 0.0014 0.0156 0.0132
Entamoeba histolytica aminopeptidase, putative 0.0014 0.0156 0.0607
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0014 0.0156 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Trichomonas vaginalis rotamase, putative 0.0039 0.068 0.3058
Onchocerca volvulus 0.0014 0.0156 0.018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0243 0.0298
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.0365
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0211 0.0187
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0024 0.0546
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0102 0.0078
Trypanosoma cruzi aminopeptidase, putative 0.0014 0.0156 0.0607
Brugia malayi TATA binding protein associated factor 0.0014 0.0156 0.018
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0102 0.0107
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2393 0.2374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0102 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0102 0.0078
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0156 0.018
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0024 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0024 0.0546
Echinococcus granulosus GPCR family 2 0.0018 0.0243 0.0219
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0102 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.044 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0014 0.0156 0.0607
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0291 0.6617
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0014 0.0156 0.0607
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0156 0.0132
Brugia malayi nuclear receptor NHR-88 0.0012 0.0102 0.0107
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0156 0.0655
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1201 0.1561
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.2195 1
Brugia malayi steroid hormone receptor 0.0012 0.0102 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2393 0.2374
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.044 0.1914
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0102 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0102 0.0107
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.2195 1
Schistosoma mansoni cpg binding protein 0.0033 0.0564 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0102 0.0107
Brugia malayi AMP-binding enzyme family protein 0.0028 0.044 0.0567
Trypanosoma brucei polo-like protein kinase 0.011 0.2195 1
Onchocerca volvulus 0.0033 0.0564 0.0737
Trypanosoma brucei Aminopeptidase M1, putative 0.0014 0.0156 0.0607
Echinococcus multilocularis expressed protein 0.0039 0.068 0.0658
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0072 0.0048
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.0365
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0102 0.0078
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2393 0.2374
Brugia malayi AMP-binding enzyme family protein 0.0028 0.044 0.0567
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0564 0.0737
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0102 0.0078
Mycobacterium ulcerans aminopeptidase N PepN 0.0014 0.0156 0.3169
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0661 0.2932
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0361 0.7565 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0028 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0102 0.0078
Loa Loa (eye worm) histone methyltransferase 0.001 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Schistosoma mansoni cpg binding protein 0.0035 0.0604 0.0582
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0102 0.0078
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0014 0.0156 0.0607
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0102 0.0107
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1088 0.1453
Loa Loa (eye worm) peptidase family M1 containing protein 0.0014 0.0156 0.018
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0156 0.0655
Brugia malayi hypothetical protein 0.0014 0.0156 0.018
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0028 0.0004
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0014 0.0156 0.0132
Echinococcus multilocularis aminopeptidase N 0.0014 0.0156 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.044 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0102 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0102 0.0107
Schistosoma mansoni aminopeptidase A (M01 family) 0.0014 0.0156 0.0132
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.044 0.1914
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0102 0.0078
Schistosoma mansoni hypothetical protein 0.004 0.0697 0.0674
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.2195 0.2176
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0156 0.018
Trypanosoma cruzi aminopeptidase, putative 0.0014 0.0156 0.0607
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0267 0.6071
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0014 0.0156 0.0607
Loa Loa (eye worm) hypothetical protein 0.0021 0.0291 0.0364
Brugia malayi CXXC zinc finger family protein 0.0033 0.0564 0.0737
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0119 0.2393 0.2374
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0211 0.0248
Loa Loa (eye worm) hypothetical protein 0.0079 0.1546 0.2078
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0102 0.0078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0102 0.0078
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0661 0.2932
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0102 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0102 0.0078
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.2195 0.2964
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0012 0.0103 0.0365
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0102 0.0107
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0014 0.0156 0.0132
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.068 0.0896
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0014 0.0156 0.0607
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.044 1
Trichomonas vaginalis rotamase, putative 0.0038 0.0661 0.2968
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.044 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.044 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0243 0.0298
Loa Loa (eye worm) hypothetical protein 0.0028 0.044 0.0567
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0014 0.0156 0.0175
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1088 0.1453
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0102 0.0078
Brugia malayi hypothetical protein 0.0351 0.735 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0014 0.0156 0.0607
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0361 0.7565 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0156 0.0655
Loa Loa (eye worm) hypothetical protein 0.004 0.0697 0.0918
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0012 0.0103 0.0365
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0102 0.0107
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0028 0.0004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.011 0.2195 0.2176
Echinococcus multilocularis dnaJ subfamily B 0.0475 1 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0014 0.0156 0.0607
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0102 0.0078
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.1546 0.7026
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0102 0.0078
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0102 0.0078
Mycobacterium ulcerans aminopeptidase N PepN 0.0014 0.0156 0.3169
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0102 0.0078
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0243 0.0298
Loa Loa (eye worm) aminopeptidase N 0.0014 0.0156 0.018
Toxoplasma gondii melibiase subfamily protein 0.0119 0.2393 0.3141
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.044 0.1914
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1088 0.1453
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0291 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.2195 0.2176
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0028 0.044 0.0567
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0028 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.044 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Schistosoma mansoni coup transcription factor 0.0012 0.0102 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0102 0.0107
Echinococcus multilocularis GPCR, family 2 0.0018 0.0243 0.0219
Toxoplasma gondii aminopeptidase N protein 0.0361 0.7565 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0291 0.6421
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0024 0.0546
Mycobacterium ulcerans hypothetical protein 0.0028 0.044 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0102 0.0078
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0024 0.0546
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0014 0.0156 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0102 0.0107
Schistosoma mansoni hypothetical protein 0.0018 0.0243 0.0219
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0661 0.2932
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0291 0.0364
Onchocerca volvulus 0.0014 0.0156 0.018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0102 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0058 0.1088 0.1453
Echinococcus granulosus cpg binding protein 0.0035 0.0604 0.0582
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0243 0.0219
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.2195 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0102 0.0078
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0291 0.0354
Loa Loa (eye worm) hypothetical protein 0.0014 0.0156 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0102 0.0078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0243 0.0219
Loa Loa (eye worm) hypothetical protein 0.0351 0.735 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0014 0.0156 0.0175
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0014 0.0156 0.0607
Echinococcus multilocularis cpg binding protein 0.0035 0.0604 0.0582
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.044 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0267 0.6071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0267 0.6071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.2393 0.2374
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0661 0.2932
Schistosoma mansoni rotamase 0.0039 0.068 0.0658
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0291 0.0354
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0243 0.0219
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0156 0.018
Onchocerca volvulus 0.0351 0.735 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0661 0.2932
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0014 0.0156 0.0607
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0102 0.0078
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0243 0.0219
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.044 0.1914
Schistosoma mansoni kinase 0.0056 0.1042 0.1021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0291 0.0364
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.044 0.1914
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Brugia malayi nuclear hormone receptor 0.0012 0.0102 0.0107
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0069 0.0061
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0661 0.0844
Schistosoma mansoni hypothetical protein 0.0018 0.0243 0.0219
Trypanosoma brucei aminopeptidase, putative 0.0014 0.0156 0.0607
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0119 0.2393 0.2374
Schistosoma mansoni cpg binding protein 0.0035 0.0604 0.0582
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0102 0.0078
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.2195 0.2964
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0024 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.011 0.2195 1
Toxoplasma gondii aminopeptidase N, putative 0.0361 0.7565 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0014 0.0156 0.0607
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.044 0.1914
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0024 0.0052
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.1011 0.4577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0102 0.0107
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0014 0.0156 0.0132
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.044 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0024 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0102 0.0107
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0024 0.0546
Loa Loa (eye worm) hypothetical protein 0.0012 0.0102 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0102 0.0107
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0102 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0102 0.0107
Echinococcus granulosus leukotriene A 4 hydrolase 0.0014 0.0156 0.0132
Onchocerca volvulus 0.0014 0.0156 0.018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0243 0.0298
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0156 0.0132
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.1546 0.1526
Brugia malayi hypothetical protein 0.0014 0.0156 0.018
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0014 0.0156 0.0607
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0291 0.5
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0119 0.2393 0.2374
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.2195 0.2964
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0072 0.0048
Loa Loa (eye worm) hypothetical protein 0.0028 0.044 0.0567
Giardia lamblia Kinase, PLK 0.011 0.2195 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.044 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0102 0.0107
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0102 0.0078
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0102 0.0078
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.044 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0102 0.0078
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0102 0.0107
Loa Loa (eye worm) hypothetical protein 0.0014 0.0156 0.018

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.518 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.38 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.314 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.225 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.057 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.045 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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