TDR Targets

Basic information

Technical information

TDR Targets ID: 159544
Name: 1,2,5,6-tetrahydropyrido[1,2-a]quinolin-3-one
MW: 199.248 | Formula: C13H13NO
H donors: 0 H acceptors: 1 LogP: 1.97 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCN2C(=C1)CCc1c2cccc1
InChi: 1S/C13H13NO/c15-12-7-8-14-11(9-12)6-5-10-3-1-2-4-13(10)14/h1-4,9H,5-8H2
InChiKey: OPJKPSOLCGGXEW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	Get druggable targets OG5_128852	All targets in OG5_128852
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_128852	All targets in OG5_128852
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	Get druggable targets OG5_128852	All targets in OG5_128852
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Entamoeba histolytica	steroid 5-alpha reductase, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	Get druggable targets OG5_128852	All targets in OG5_128852
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Trypanosoma brucei gambiense	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Leishmania donovani	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	Get druggable targets OG5_128852	All targets in OG5_128852
Leishmania mexicana	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	Get druggable targets OG5_128852	All targets in OG5_128852
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	Get druggable targets OG5_128852	All targets in OG5_128852
Leishmania infantum	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	Get druggable targets OG5_128852	All targets in OG5_128852
Leishmania braziliensis	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	Get druggable targets OG5_128852	All targets in OG5_128852
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128852	All targets in OG5_128852
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	Get druggable targets OG5_128852	All targets in OG5_128852

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	259 aa	254 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0399	0.041	0.4737
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Loa Loa (eye worm)	phosphatidylinositol 3	0.0124	0.008	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0418	0.0432	0.5727
Loa Loa (eye worm)	phosphatidylinositol 3	0.0139	0.0099	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0099	0.1308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.0717	0.9415
Onchocerca volvulus		0.0139	0.0099	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Giardia lamblia	GTOR	0.0687	0.0755	1
Entamoeba histolytica	protein kinase rad3, putative	0.0377	0.0383	0.4332
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0139	0.0099	0.0287
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0189	0.0158	0.2024
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0709	0.0781	0.0689
Mycobacterium leprae	conserved hypothetical protein	0.0139	0.0099	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0263	0.0247	0.3269
Loa Loa (eye worm)	cytochrome P450 family protein	0.012	0.0075	0.0998
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0377	0.0383	0.0287
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0263	0.0247	0.2256
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0428	0.0444	0.5883
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0194	0.0165	0.0478
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0377	0.0383	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0743	0.982
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0392	0.0402	0.4174
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0194	0.0165	0.1003
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0189	0.0158	0.0925
Echinococcus multilocularis	Zinc finger, PHD finger	0.0194	0.0165	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.0717	0.9415
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0709	0.0781	0.2269
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0387	0.0395	0.4515
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0159	0.0122	0.1621
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0655	0.0717	0.1986
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0561	0.0603	0.7722
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0194	0.0165	0.2107
Echinococcus multilocularis	serine protein kinase ATM	0.0392	0.0402	0.0306
Trichomonas vaginalis	conserved hypothetical protein	0.0279	0.0266	0.2545
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0149	0.0111	0.0179
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0667	0.073	0.2024
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0194	0.0165	0.1003
Leishmania major	hypothetical protein, conserved	0.3071	0.3609	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0208	0.0181	0.1253
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0189	0.0158	0.0438
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0368	0.0373	0.0277
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0139	0.0099	0.1308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0388	0.0397	0.4542
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0455	0.0477	0.5767
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0377	0.0383	0.4332
Brugia malayi	Cytochrome P450 family protein	0.012	0.0075	0.0964
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0561	0.0603	0.7688
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0709	0.0781	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0687	0.0755	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0743	0.982
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0139	0.0099	0.1308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0668	0.0731	0.9641
Trypanosoma cruzi	target of rapamycin kinase 3	0.0677	0.0743	0.2159
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0189	0.0158	0.0904
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0743	0.982
Entamoeba histolytica	hypothetical protein	0.0392	0.0402	0.4619
Loa Loa (eye worm)	hypothetical protein	0.0189	0.0158	0.2094
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0687	0.0755	0.2092
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0194	0.0165	0.1003
Loa Loa (eye worm)	phosphatidylinositol 3	0.0667	0.073	0.9674
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0194	0.0165	0.1003
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0687	0.0755	0.9664
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0155	0.0118	0.0326
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0194	0.0165	0.0456
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0194	0.0165	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0139	0.0099	0.0287
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0124	0.008	0.0233
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0687	0.0755	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0396	0.0407	0.4691
Loa Loa (eye worm)	phosphatidylinositol 3	0.0677	0.0743	0.9836
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0743	0.982
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.0099	0.1264
Echinococcus granulosus	serine protein kinase ATM	0.0392	0.0402	0.0306
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0687	0.0755	0.2193
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0561	0.0603	0.7688
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0155	0.0118	0.0342
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0368	0.0373	0.0277
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.0099	0.1264
Loa Loa (eye worm)	phosphatidylinositol 3	0.0139	0.0099	0.1308
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0392	0.0402	0.1167
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0561	0.0603	0.7688
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0709	0.0781	0.9399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0687	0.0755	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0709	0.0781	0.2269
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0263	0.0247	0.2039
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0189	0.0158	0.2094
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0263	0.0247	0.3159
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0139	0.0099	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0377	0.0383	0.5074
Brugia malayi	FAT domain containing protein	0.0279	0.0266	0.3402
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0139	0.0099	0.0287
Leishmania major	phosphatidylinositol kinase, putative	0.0139	0.0099	0.0274
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0237	0.0216	0.1794
Loa Loa (eye worm)	hypothetical protein	0.0368	0.0373	0.4939
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0687	0.0755	1
Loa Loa (eye worm)	hypothetical protein	0.0192	0.0163	0.2154
Toxoplasma gondii	FATC domain-containing protein	0.0392	0.0402	0.4725
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0194	0.0165	0.0907
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0392	0.0402	0.5323
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0677	0.0743	0.9844
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0687	0.0755	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.0099	0.1264
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0263	0.0247	0.2256
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0396	0.0407	0.4691
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0368	0.0373	0.4773
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0139	0.0099	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0409	0.0421	0.4917
Onchocerca volvulus		0.0139	0.0099	0.5
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0687	0.0755	0.0663
Loa Loa (eye worm)	hypothetical protein	0.0279	0.0266	0.3521
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0687	0.0755	0.0663
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0194	0.0165	0.1026
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0377	0.0383	0.3915
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0396	0.0407	0.4691
Trichomonas vaginalis	conserved hypothetical protein	0.0418	0.0432	0.5083
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0139	0.0099	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0189	0.0158	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.044	0.0459	0.5488
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0687	0.0755	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0746	0.0825	0.0733
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0655	0.0717	0.9492
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0667	0.073	0.9625
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0392	0.0402	0.5144
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0194	0.0165	0.0907
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0263	0.0247	0.2256
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0139	0.0099	0.1308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0561	0.0603	0.1752
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.841	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0263	0.0247	0.2256
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0189	0.0158	0.0904
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0279	0.0266	0.0169
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0253	0.0235	0.0684
Loa Loa (eye worm)	phosphatidylinositol 3	0.0687	0.0755	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0263	0.0247	0.0717
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0421	0.0437	0.515
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.0717	0.9415
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0677	0.0743	0.2059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0667	0.073	0.9674
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0709	0.0781	0.0689
Entamoeba histolytica	hypothetical protein	0.0492	0.0521	0.6435
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0263	0.0247	0.2256
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0194	0.0165	0.218
Trypanosoma cruzi	hypothetical protein, conserved	0.2932	0.3442	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0561	0.0603	0.7688
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0194	0.0165	0.218
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0279	0.0266	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.0717	0.9415
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0388	0.0397	0.4542
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0194	0.0165	0.1003
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0189	0.0158	0.0904
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0561	0.0603	0.1752
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0377	0.0383	0.4903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0677	0.0743	0.982
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0194	0.0165	0.0478
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0189	0.0158	0.0904
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0746	0.0825	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0235	0.3117
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0687	0.0755	0.2092
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0377	0.0383	0.1113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0675	0.074	0.9775
Mycobacterium ulcerans	hypothetical protein	0.0189	0.0158	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0492	0.0521	0.6435
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0455	0.0477	0.5767
Leishmania major	hypothetical protein, unknown function	0.0139	0.0099	0.0274
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0194	0.0165	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0687	0.0755	1
Trichomonas vaginalis	conserved hypothetical protein	0.0237	0.0216	0.1794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0392	0.0402	0.4619
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0675	0.074	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0418	0.0432	0.52
Loa Loa (eye worm)	phosphatidylinositol 3	0.0139	0.0099	0.1308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Loa Loa (eye worm)	phosphatidylinositol 3	0.0139	0.0099	0.1308
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0194	0.0165	0.0066
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0194	0.0165	0.0066
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0687	0.0755	0.9038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0665	0.0728	0.9595
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0194	0.0165	0.0066
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0746	0.0825	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0194	0.0165	0.1026
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0185	0.0154	0.1969
Schistosoma mansoni	hypothetical protein	0.0279	0.0266	0.23
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0299	0.0291	0.2924
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0687	0.0755	0.2193
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0189	0.0158	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0668	0.0731	0.9641
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0194	0.0165	0.0456

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -6.53	Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone.	ChEMBL.	15214782
IC50 (binding)	nM	Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 from human prostate homogenates.; No inhibition	ChEMBL.	9873639
IC50 (binding)	0 nM	Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2 from human prostate homogenates.; No inhibition	ChEMBL.	9873639
IC50 (binding)	= 298 nM	Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells	ChEMBL.	9873639
IC50 (binding)	= 298 nM	Inhibition of human Steroid 5-alpha-reductase type I	ChEMBL.	10714498
IC50 (binding)	= 298 nM	Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells	ChEMBL.	11020287
IC50 (binding)	= 298 nM	Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone.	ChEMBL.	15214782
IC50 (binding)	= 298 nM	Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 1 from recombinant CHO cells	ChEMBL.	9873639
IC50 (binding)	= 298 nM	Inhibition of human Steroid 5-alpha-reductase type I	ChEMBL.	10714498
IC50 (binding)	= 298 nM	Inhibition of recombinant steroid 5-alpha-reductase type I expressed in CHO cells	ChEMBL.	11020287
IC50 (binding)	= 298 nM	Inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone.	ChEMBL.	15214782
Log IC50 (binding)	= 6.53	Log of inhibitory concentration against human recombinant steroid 5-alpha-reductase type I in stably transfected chinese hamster ovary (CHO) 1827 cells using [3H]-testosterone.	ChEMBL.	15214782
logP (ADMET)	= 2.33	Partition coefficient (logP)	ChEMBL.	15214782

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL96006
PubChem: 10081476

Bibliographic References

4 literature references were collected for this gene.

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Detailed information for compound 159544