TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.386 | Formula: C19H19N5O2
H donors: 2 H acceptors: 3 LogP: 1.66 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c2c(n1CC1CCOCC1)nc(cn2)c1ccc2c(c1)cc[nH]2
InChi: 1S/C19H19N5O2/c25-19-23-17-18(24(19)11-12-4-7-26-8-5-12)22-16(10-21-17)13-1-2-15-14(9-13)3-6-20-15/h1-3,6,9-10,12,20H,4-5,7-8,11H2,(H,21,23,25)
InChiKey: JPMOMDVUKVSFMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0477
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0577	1
Echinococcus granulosus	intermediate filament protein	0.0026	0.0172	0.0113
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0041
Schistosoma mansoni	lamin	0.0026	0.0172	0.0113
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0183	0.0124
Schistosoma mansoni	glycogen phosphorylase	0.0324	0.4422	0.4389
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0118
Echinococcus granulosus	glycogen phosphorylase	0.0324	0.4422	0.4389
Brugia malayi	hypothetical protein	0.0027	0.0183	0.0183
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0183	0.0283
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0183	0.0124
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0062	0.0002
Brugia malayi	hypothetical protein	0.0027	0.0183	0.0183
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0577	1
Schistosoma mansoni	glycogen phosphorylase	0.0324	0.4422	0.4389
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0845	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0027	0.0183	0.0124
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0845	0.079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.026	0.0568
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0172	0.0172
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Echinococcus multilocularis	glycogen phosphorylase	0.0324	0.4422	0.4389
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0845	0.079
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0183	0.2384
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0714	1	1
Echinococcus granulosus	lamin	0.0026	0.0172	0.0113
Echinococcus granulosus	acetylcholinesterase	0.0432	0.5973	0.5949
Entamoeba histolytica	glycogenphosphorylase, putative	0.014	0.18	0.3988
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0073	0.0845	0.079
Trichomonas vaginalis	pten, drome, putative	0.0027	0.0183	0.0392
Loa Loa (eye worm)	glycogen phosphorylase	0.0324	0.4422	0.4422
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0577	0.052
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0418	0.0926
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0324	0.4422	1
Echinococcus multilocularis	lamin	0.0026	0.0172	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0432	0.5973	0.5973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0265	0.0578
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0027	0.0183	0.0124
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0183	0.0124
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0027	0.0183	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0324	0.4422	0.4389
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0577	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Echinococcus multilocularis		0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.014	0.18	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0172	0.0172
Onchocerca volvulus		0.0027	0.0183	0.0027
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0577	0.0577
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0062	0.0002
Schistosoma mansoni	BC026374 protein (S09 family)	0.0073	0.0845	0.079
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0845	0.0845
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0577	0.052
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0265	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0172	0.0172
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	musashi	0.0026	0.0172	0.0113
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Carboxylesterase family protein	0.0432	0.5973	0.5973
Echinococcus granulosus	neuroligin	0.0073	0.0845	0.079
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0027	0.0183	0.0183
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0027	0.0183	0.0124
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Onchocerca volvulus		0.0027	0.0183	0.0027
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.0124	0.0531
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0305	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0027	0.0183	0.0183
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0577	0.4285
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.006	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0073	0.0845	0.1584
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0577	0.4285
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0432	0.5973	0.5949
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	carbohydrate phosphorylase	0.0324	0.4422	0.4422
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0477
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Trypanosoma brucei	RNA helicase, putative	0.0103	0.1267	1
Schistosoma mansoni	gliotactin	0.0073	0.0845	0.079
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0378	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0324	0.4422	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.006	0.5
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Brugia malayi	hypothetical protein	0.0027	0.0183	0.0183
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0183	0.0124
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0714	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.006	0.006
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.006	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.006	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0418	0.0926
Echinococcus granulosus	lamin dm0	0.0026	0.0172	0.0113
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0183	0.2384
Echinococcus granulosus	glycogen phosphorylase	0.0324	0.4422	0.4389
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Echinococcus multilocularis	lamin dm0	0.0026	0.0172	0.0113
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0183	0.2384
Onchocerca volvulus		0.0073	0.0845	0.1584
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0418	0.0926
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0041
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0073	0.0845	0.1892
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0027	0.0183	0.2384
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0183	0.0124
Brugia malayi	Carboxylesterase family protein	0.0073	0.0845	0.0845
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Echinococcus multilocularis	hypothetical protein	0.0027	0.0183	0.0124
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	Carboxylesterase family protein	0.0073	0.0845	0.0845
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0845	0.4512
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0418	0.0926
Giardia lamblia	GTOR	0.0054	0.0577	0.1186
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0845	0.4512
Echinococcus multilocularis	neuroligin	0.0073	0.0845	0.079
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.014	0.18	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.014	0.18	0.3988
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	acetylcholinesterase	0.0073	0.0845	0.079
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0577	0.1186
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0183	0.0124
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0027	0.0183	0.1022
Entamoeba histolytica	glycogen phosphorylase, putative	0.0324	0.4422	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0183	0.0124
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	Carboxylesterase family protein	0.0073	0.0845	0.0845
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0464	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Schistosoma mansoni	pcd6 interacting protein-related	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0265	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.026	0.0568
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0073	0.0845	0.079
Brugia malayi	Carboxylesterase family protein	0.0432	0.5973	0.5973
Echinococcus granulosus	Glycosyl transferase family 35	0.0324	0.4422	0.4389
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0419	0.6946
Onchocerca volvulus		0.0073	0.0845	0.1584
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0103	0.1267	0.1214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Brugia malayi	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0118
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0577	0.052
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0027	0.0183	0.0124
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0183	0.0124
Giardia lamblia	Protein tyrosine phosphatase	0.0027	0.0183	0.0283
Brugia malayi	Protein-tyrosine phosphatase 1	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Onchocerca volvulus		0.0027	0.0183	0.0027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Onchocerca volvulus	4.1 G protein, putative homolog	0.0027	0.0183	0.0027
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0714	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0577	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0714	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0118
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0183	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0172	0.0113
Giardia lamblia	Glycogen phosphorylase	0.0324	0.4422	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0118
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0027	0.0183	0.0183
Chlamydia trachomatis	glycogen phosphorylase	0.0324	0.4422	0.5
Echinococcus granulosus	para nitrobenzyl esterase	0.0073	0.0845	0.079
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0183	0.0124
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0062	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0183	0.0124
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0419	0.6946
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0073	0.0845	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	para nitrobenzyl esterase	0.0073	0.0845	0.079
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0577	0.0577
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.5973	0.5949
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0324	0.4422	1
Brugia malayi	hypothetical protein	0.0073	0.0845	0.0845
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0183	0.0124
Schistosoma mansoni	glycogen phosphorylase	0.014	0.18	0.175
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0027	0.0183	0.0124
Entamoeba histolytica	glycogen phosphorylase, putative	0.014	0.18	0.3988
Loa Loa (eye worm)	acetylcholinesterase 1	0.0432	0.5973	0.5973
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0577	0.1186
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0073	0.0845	0.079
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0577	0.1285
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0062	0.0118
Trichomonas vaginalis	spcc417.12 protein, putative	0.0073	0.0845	0.1892
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0027	0.0183	0.0124
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0419	0.2977
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0378	0.0835
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0027	0.0183	0.0183
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Leishmania major	tyrosine specific protein phosphatase, putative	0.0027	0.0183	0.2384
Loa Loa (eye worm)	carboxylesterase	0.0432	0.5973	0.5973
Onchocerca volvulus		0.0027	0.0183	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.022	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Schistosoma mansoni	lamin	0.0026	0.0172	0.0113
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.5973	0.5949
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0577	0.1285
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0027	0.0183	0.0283
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0183	0.0124
Brugia malayi	intermediate filament protein	0.0026	0.0172	0.0172
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0041
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.006	0.5
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0073	0.0845	0.079
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	carboxylesterase 5A	0.0432	0.5973	0.5949
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0062	0.0062
Onchocerca volvulus		0.0027	0.0183	0.0027
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0027	0.0183	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0322	0.0707
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0183	0.0124
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.006	0.0113
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Echinococcus granulosus	BC026374 protein S09 family	0.0073	0.0845	0.079
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0324	0.4422	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0845	0.079
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus granulosus	acetylcholinesterase	0.0432	0.5973	0.5949
Onchocerca volvulus		0.0027	0.0183	0.0027
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0183	0.0124
Onchocerca volvulus		0.0027	0.0183	0.0027
Echinococcus multilocularis	glycogen phosphorylase	0.0324	0.4422	0.4389
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0577	0.1285
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0062	0.0017
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0062	0.0062
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0062	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0432	0.5973	0.5973
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0183	0.0183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0418	0.0926
Onchocerca volvulus		0.0073	0.0845	0.1584
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0062	0.0041
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0183	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0845	0.0845
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0168	0.0901
Echinococcus granulosus	carboxylesterase 5A	0.0432	0.5973	0.5949
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0183	0.0124
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0027	0.0183	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0183	0.0183
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0073	0.0845	0.4512
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0183	0.0183
Brugia malayi	Carboxylesterase family protein	0.0073	0.0845	0.0845
Onchocerca volvulus		0.0027	0.0183	0.0027
Mycobacterium ulcerans	carboxylesterase, LipT	0.0073	0.0845	0.4512

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.021 uM	Inhibition of mTOR	ChEMBL.	21978683
IC50 (binding)	= 0.05 uM	Inhibition of mTOR-mediated Akt phosphorylation in human PC3 cells	ChEMBL.	21978683
IC50 (binding)	= 0.231 uM	Inhibition of mTOR-mediated S6 phosphorylation in human PC3 cells	ChEMBL.	21978683
IC50 (functional)	= 0.602 uM	Antiproliferative activity against human PC3 cells	ChEMBL.	21978683
IC50 (binding)	> 30 uM	Inhibition of PI3Kalpha	ChEMBL.	21978683

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21978683

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1946266

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1599520