Detailed information for compound 1603065

Basic information

Technical information
  • TDR Targets ID: 1603065
  • Name: N-[(4-dimethylaminophenyl)methylideneamino]-N -methyl-1,1-dioxo-1,2-benzothiazol-3-amine
  • MW: 342.415 | Formula: C17H18N4O2S
  • H donors: 0 H acceptors: 2 LogP: 2.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C1=NS(=O)(=O)c2c1cccc2)/N=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C17H18N4O2S/c1-20(2)14-10-8-13(9-11-14)12-18-21(3)17-15-6-4-5-7-16(15)24(22,23)19-17/h4-12H,1-3H3/b18-12+
  • InChiKey: TZEJUXVSLJJQGJ-LDADJPATSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(4-dimethylaminophenyl)methyleneamino]-N-methyl-1,1-dioxo-1,2-benzothiazol-3-amine
  • (1,1-diketo-1,2-benzothiazol-3-yl)-[(4-dimethylaminobenzylidene)amino]-methyl-amine
  • STK133753

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens troponin T type 2 (cardiac) Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens troponin I type 3 (cardiac) Starlite/ChEMBL No references
Pseudomonas aeruginosa Beta Lactamase Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens troponin C type 1 (slow) Starlite/ChEMBL No references
Pseudomonas aeruginosa Beta-lactamase Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Troponin T, skeletal muscle homolog Get druggable targets OG5_129858 All targets in OG5_129858
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Troponin I 4, putative Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 Get druggable targets OG5_129858 All targets in OG5_129858
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) troponin Get druggable targets OG5_129858 All targets in OG5_129858
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus troponin i Get druggable targets OG5_132708 All targets in OG5_132708
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) troponin T Get druggable targets OG5_129858 All targets in OG5_129858
Brugia malayi Troponin family protein Get druggable targets OG5_132708 All targets in OG5_132708
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus oncosphere protein Tso22e Get druggable targets OG5_129858 All targets in OG5_129858
Onchocerca volvulus Troponin I homolog Get druggable targets OG5_132708 All targets in OG5_132708
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Troponin T, skeletal muscle, putative Get druggable targets OG5_129858 All targets in OG5_129858
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni troponin I Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma japonicum IPR001978,Troponin,domain-containing Get druggable targets OG5_132708 All targets in OG5_132708
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Class a beta-lactamase BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans class a beta-lactamase, BlaC Get druggable targets OG5_143180 All targets in OG5_143180
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni troponin t invertebrate Get druggable targets OG5_129858 All targets in OG5_129858
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_129858 All targets in OG5_129858
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum centrin-3 troponin C type 1 (slow) 161 aa 148 aa 33.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia GTOR 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.016 0.1315 1
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0076 0.0534 0.1655
Leishmania major importin beta-1 subunit, putative 0.0028 0.0083 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Schistosoma mansoni hypothetical protein 0.0372 0.3288 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0076 0.0529 0.0529
Schistosoma mansoni ran 0.0026 0.0059 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0145 0.2736
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1091 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Entamoeba histolytica hypothetical protein 0.0028 0.0083 0.1575
Entamoeba histolytica hypothetical protein 0.0043 0.022 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Loa Loa (eye worm) hypothetical protein 0.018 0.1503 0.4571
Echinococcus granulosus serine protein kinase ATM 0.0043 0.022 0.022
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0076 0.0529 0.0529
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0043 0.022 0.409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1023 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0048 0.0266 0.5019
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0076 0.0529 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Brugia malayi RNA, U transporter 1 0.0099 0.0744 0.2306
Entamoeba histolytica Ran family GTPase 0.0026 0.0059 0.1115
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0043 0.022 0.4156
Echinococcus granulosus muscleblind protein 0.018 0.1503 0.1503
Brugia malayi Troponin T 0.0076 0.0534 0.1655
Loa Loa (eye worm) hypothetical protein 0.0033 0.0129 0.0393
Loa Loa (eye worm) hypothetical protein 0.0076 0.0534 0.1623
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.0529 0.9843
Loa Loa (eye worm) hypothetical protein 0.0129 0.1023 0.3111
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0145 0.2693
Trichomonas vaginalis ran, putative 0.0026 0.0059 0.1115
Schistosoma mansoni troponin t invertebrate 0.016 0.1312 0.3992
Brugia malayi hypothetical protein 0.0076 0.0534 0.1655
Leishmania major phosphatidylinositol 3-kinase, putative 0.0076 0.0529 0.1505
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.022 0.0682
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0183
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0059 0.0059
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0076 0.0529 0.1565
Echinococcus multilocularis muscleblind protein 1 0.018 0.1503 0.1503
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0266 0.494
Schistosoma mansoni troponin I 0.0129 0.1023 0.3111
Schistosoma mansoni importin beta-1 0.0035 0.0145 0.044
Toxoplasma gondii target of rapamycin (TOR), putative 0.0076 0.0529 1
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0077 0.0538 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0076 0.0529 0.1565
Echinococcus granulosus snurportin 1 0.0372 0.3288 0.3288
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0083 0.1575
Schistosoma mansoni fkbp-rapamycin associated protein 0.0043 0.022 0.0669
Plasmodium vivax importin-beta 2, putative 0.0035 0.0145 1
Mycobacterium ulcerans lipoprotein LpqF 0.0077 0.0538 0.4088
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0529 0.1609
Brugia malayi Troponin I 0.0129 0.1023 0.3172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0083 0.0254
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.1115
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0077 0.0538 0.4088
Schistosoma mansoni hypothetical protein 0.0033 0.0129 0.0393
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0076 0.0529 0.9843
Echinococcus granulosus oncosphere protein Tso22e 0.016 0.1312 0.1312
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0043 0.022 0.0669
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0076 0.0529 0.1565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.244
Plasmodium falciparum importin beta, putative 0.0035 0.0145 1
Brugia malayi Muscleblind-like protein 0.018 0.1503 0.466
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0043 0.022 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Echinococcus multilocularis snurportin 1 0.0372 0.3288 0.3288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0048 0.0266 0.0808
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0083 0.0247
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.016 0.1315 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0145 0.0449
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3288 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0043 0.022 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Trypanosoma cruzi hypothetical protein, conserved 0.0382 0.338 1
Loa Loa (eye worm) troponin I 0.0129 0.1023 0.3111
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0145 0.2693
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0266 0.5019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Loa Loa (eye worm) troponin T 0.0076 0.0534 0.1623
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0076 0.0529 0.0529
Schistosoma mansoni troponin I 0.0129 0.1023 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0033 0.0129 0.0129
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0083 0.1575
Echinococcus granulosus geminin 0.0205 0.1729 0.1729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0076 0.0529 0.1505
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.0174
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0145 0.0145
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0076 0.0529 0.9843
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0076 0.0529 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0076 0.0529 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.4075
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0043 0.022 0.022
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0076 0.0529 0.0529
Brugia malayi FAT domain containing protein 0.0033 0.0129 0.04
Leishmania major hypothetical protein, conserved 0.0396 0.3517 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.022 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0083 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.0529 0.1565
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0076 0.0529 0.1565
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0019 0 0.5
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.016 0.1312 0.407
Trypanosoma brucei beta lactamase 0.0077 0.0538 1
Loa Loa (eye worm) troponin 0.0076 0.0534 0.1623
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Schistosoma mansoni ran 0.0026 0.0059 0.0179
Loa Loa (eye worm) hypothetical protein 0.0365 0.3225 0.9808
Loa Loa (eye worm) phosphatidylinositol 3 0.0076 0.0529 0.1609
Entamoeba histolytica protein kinase rad3, putative 0.0043 0.022 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.0529 0.1641
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0043 0.022 0.022
Brugia malayi Troponin T 0.0076 0.0534 0.1655
Echinococcus granulosus troponin i 0.0129 0.1023 0.1023
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0076 0.0529 0.1505
Echinococcus granulosus importin subunit beta 1 0.0035 0.0145 0.0145
Brugia malayi Troponin family protein 0.0129 0.1023 0.3172
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.0529 0.1505
Schistosoma mansoni troponin I 0.0129 0.1023 0.3111
Onchocerca volvulus Troponin I homolog 0.0129 0.1023 0.3172
Echinococcus multilocularis muscleblind protein 0.018 0.1503 0.1503
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0076 0.0529 0.9843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Treponema pallidum ribonuclease Z 0.0019 0 0.5
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.1097
Brugia malayi Troponin T 0.0076 0.0534 0.1655
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0076 0.0529 0.9843
Onchocerca volvulus 0.0365 0.3225 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Echinococcus multilocularis geminin 0.0205 0.1729 0.1729
Brugia malayi hypothetical protein 0.0365 0.3225 1
Echinococcus multilocularis serine protein kinase ATM 0.0043 0.022 0.022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.022 0.0682
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0083 0.0246
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0059 0.1115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0266 0.5019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0076 0.0529 0.1641
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0076 0.0529 0.1609
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0059 0.4075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1503 0.4571
Schistosoma mansoni hypothetical protein 0.0205 0.1729 0.5259
Schistosoma mansoni troponin I 0.0129 0.1023 0.3111
Chlamydia trachomatis ribonuclease Z 0.0019 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Schistosoma mansoni hypothetical protein 0.0129 0.1023 0.3111
Echinococcus multilocularis troponin i 0.0129 0.1023 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0083 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.022 0.4156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0529 1
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.016 0.1312 0.1312
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0083 0.1575
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0076 0.0529 0.1505
Leishmania major GTP-binding protein, putative 0.0026 0.0059 0.0168
Toxoplasma gondii FATC domain-containing protein 0.0043 0.022 0.4156
Schistosoma mansoni hypothetical protein 0.0205 0.1729 0.5259
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.044
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0033 0.0129 0.0129

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 4.497 uM PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383] ChEMBL. No reference
EC50 (functional) = 27.933 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 46.998 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
EC50 (functional) > 99 uM PUBCHEM_BIOASSAY: Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504720, AID504743] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
IC50 (binding) = 13.37 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 14.965 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 22.959 uM PubChem BioAssay. Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 0.3548 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.5911 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.1556 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 15.7578 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.6805 uM PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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