Detailed information for compound 1603071

Basic information

Technical information
  • TDR Targets ID: 1603071
  • Name: 4-methyl-2-phenyl-1,7-dihydropyrazolo[4,5-e]p yridine-3,6-dione
  • MW: 241.245 | Formula: C13H11N3O2
  • H donors: 2 H acceptors: 2 LogP: 1.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(C)c2c([nH]1)[nH]n(c2=O)c1ccccc1
  • InChi: 1S/C13H11N3O2/c1-8-7-10(17)14-12-11(8)13(18)16(15-12)9-5-3-2-4-6-9/h2-7H,1H3,(H2,14,15,17)
  • InChiKey: QKSMEUJDXLNQJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methyl-2-phenyl-1,7-dihydropyrazolo[4,5-e]pyridine-3,6-quinone
  • ZINC00106021
  • EU-0044740
  • ZINC00129648
  • 1H-Pyrazolo[3,4-b]pyridin-3(2H)-one, 6-hydroxy-4-methyl-2-phenyl-
  • 6-Hydroxy-4-methyl-2-phenyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
  • A3104/0131467
  • ZINC00190058
  • Oprea1_328074
  • TimTec1_004653
  • Oprea1_073877
  • A2544/0108258
  • STK011092
  • Oprea1_062275
  • ST038065

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Starlite/ChEMBL No references
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL No references
Homo sapiens leukocyte receptor tyrosine kinase Starlite/ChEMBL No references
Homo sapiens LIM domain kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) TK/ALK protein kinase Get druggable targets OG5_132231 All targets in OG5_132231
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K05743 LIM domain kinase 1, putative Get druggable targets OG5_131191 All targets in OG5_131191
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity testis-specific protein kinase Get druggable targets OG5_131191 All targets in OG5_131191
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132231 All targets in OG5_132231
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni protein kinase Get druggable targets OG5_131191 All targets in OG5_131191
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132231 All targets in OG5_132231
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni protein kinase Get druggable targets OG5_131191 All targets in OG5_131191
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity testis specific protein kinase Get druggable targets OG5_131191 All targets in OG5_131191
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0262 0.077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus multilocularis serotonin receptor 0.0159 0.0274 0.0274
Echinococcus multilocularis 0.0072 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0055 0.0689
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0172 0.0308 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0262 0.3288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0127 0.2219
Toxoplasma gondii FATC domain-containing protein 0.0155 0.0262 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Leishmania major protein kinase, putative 0.0074 0.0055 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0155 0.0262 0.0262
Schistosoma mansoni protein kinase 0.0191 0.0357 0.447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0191 0.0357 0.0357
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.012 0.0172 0.0172
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0155 0.0262 0.3288
Loa Loa (eye worm) hypothetical protein 0.0214 0.0416 0.5214
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0274 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0159 0.0274 0.3433
Plasmodium falciparum protein serine/threonine kinase-1 0.0074 0.0055 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0274 0.057 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Echinococcus granulosus dual specificity 0.0216 0.042 0.042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0274 0.057 0.1673
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0071 0.0046 0.0579
Echinococcus multilocularis dual specificity 0.0216 0.042 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0363 0.0798 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0274 0.057 1
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0172 0.3017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.012 0.0172 0.0172
Entamoeba histolytica protein kinase, putative 0.0216 0.042 0.7371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.057 0.7147
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0274 0.057 0.1673
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0274 0.057 0.1609
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0274 0.057 0.1609
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3938 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Loa Loa (eye worm) solute carrier family 6 member 4 0.0071 0.0046 0.0579
Entamoeba histolytica protein kinase rad3, putative 0.0155 0.0262 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0127 0.2219
Trypanosoma cruzi hypothetical protein, conserved 0.1377 0.3409 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0363 0.0798 1
Entamoeba histolytica protein kinase, putative 0.0216 0.042 0.7371
Trypanosoma cruzi target of rapamycin kinase 3 0.0274 0.057 0.1673
Brugia malayi FAT domain containing protein 0.012 0.0172 0.2156
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0262 0.3288
Loa Loa (eye worm) phosphatidylinositol 3 0.0274 0.057 0.7147
Echinococcus multilocularis serotonin receptor 0.0159 0.0274 0.0274
Echinococcus granulosus hypothetical protein 0.0072 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus multilocularis serine protein kinase ATM 0.0155 0.0262 0.0262
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0216 0.042 0.1233
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0274 0.057 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.057 0.7147
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0055 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0274 0.057 0.7147
Echinococcus granulosus dual specificity protein kinase clk2 0.0074 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0172 0.0308 0.5399
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0102 0.0127 0.0371
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0216 0.042 0.1233
Leishmania major phosphatidylinositol 3-kinase, putative 0.0274 0.057 0.1609
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0055 0.0161
Loa Loa (eye worm) hypothetical protein 0.0363 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.0579
Loa Loa (eye worm) hypothetical protein 0.012 0.0172 0.2156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Entamoeba histolytica protein kinase domain containing protein 0.0216 0.042 0.7371
Loa Loa (eye worm) hypothetical protein 0.0071 0.0046 0.0579
Brugia malayi Protein kinase domain containing protein 0.0216 0.042 0.5268
Onchocerca volvulus 0.0071 0.0046 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0155 0.0262 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Treponema pallidum sodium- and chloride- dependent transporter 0.0071 0.0046 0.5
Leishmania major protein kinase, putative 0.0074 0.0055 0.0155
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0274 0.057 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0074 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0051 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0274 0.057 0.057
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0074 0.0055 0.0161
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0074 0.0055 0.0161
Loa Loa (eye worm) hypothetical protein 0.0363 0.0798 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Schistosoma mansoni sodium/chloride dependent transporter 0.0071 0.0046 0.0579
Brugia malayi Protein kinase domain containing protein 0.0336 0.073 0.9149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0214 0.0416 0.5214
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0274 0.057 0.1673
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0216 0.042 0.5268
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0274 0.057 0.1673
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0074 0.0055 0.0964
Loa Loa (eye worm) hypothetical protein 0.0155 0.0262 0.3288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0191 0.0357 0.0357
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0074 0.0055 0.0964
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0155 0.0262 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Entamoeba histolytica hypothetical protein 0.0155 0.0262 0.4601
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.042 0.5268
Mycobacterium leprae conserved hypothetical protein 0.0053 0 0.5
Loa Loa (eye worm) norepinephrine transporter 0.0071 0.0046 0.0579
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0074 0.0055 0.0689
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0159 0.0274 0.3433
Schistosoma mansoni serine/threonine protein kinase 0.0074 0.0055 0.0689
Leishmania major hypothetical protein, conserved 0.143 0.3545 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0127 0.1586
Echinococcus multilocularis serotonin transporter 0.0071 0.0046 0.0046
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0216 0.042 0.7371
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0274 0.057 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0159 0.0274 0.0274
Trichomonas vaginalis CMGC family protein kinase 0.0074 0.0055 0.0964
Echinococcus granulosus serine protein kinase ATM 0.0155 0.0262 0.0262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0274 0.057 0.7147
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0274 0.057 1
Loa Loa (eye worm) hypothetical protein 0.032 0.0687 0.8604
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0274 0.057 0.057
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0262 0.077
Loa Loa (eye worm) hypothetical protein 0.0159 0.0274 0.3433
Entamoeba histolytica hypothetical protein 0.0216 0.042 0.7371
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0155 0.0262 0.0262
Loa Loa (eye worm) serotonin transporter b 0.0071 0.0046 0.0579
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0274 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0172 0.0308 0.3859
Brugia malayi Protein kinase domain containing protein 0.0074 0.0055 0.0689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0274 0.057 0.7147
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0 0.5
Echinococcus multilocularis dual specificity protein kinase clk2 0.0074 0.0055 0.0055
Giardia lamblia Kinase, CMGC CLK 0.0074 0.0055 0.0964
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0074 0.0055 0.0964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0274 0.057 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0071 0.0046 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Schistosoma mansoni protein kinase 0.0191 0.0357 0.447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Giardia lamblia GTOR 0.0274 0.057 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0172 0.0308 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0274 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0333 0.0722 0.9049
Echinococcus granulosus serotonin transporter 0.0071 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.012 0.0172 0.2156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0262 0.4601
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0216 0.042 0.1186
Schistosoma mansoni fkbp-rapamycin associated protein 0.0155 0.0262 0.3288
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.0308 0.5399
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0274 0.057 0.1609
Loa Loa (eye worm) TK/ALK protein kinase 0.0336 0.073 0.9145

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDGFRA ChEMBL. No reference
Ki (functional) = 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKAA1 ChEMBL. No reference
Ki (functional) = 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ACVR1 ChEMBL. No reference
Ki (functional) = 4.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKX ChEMBL. No reference
Ki (functional) = 4.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DAPK3 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IKBKE ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TBK1 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GPRK5 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK5 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TYRO3 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NEK2 ChEMBL. No reference
Ki (functional) = 4.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LRRK2 ChEMBL. No reference
Ki (functional) = 4.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1A1 ChEMBL. No reference
Ki (functional) = 4.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK8 ChEMBL. No reference
Ki (functional) = 4.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK9 ChEMBL. No reference
Ki (functional) = 4.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LTK ChEMBL. No reference
Ki (functional) = 4.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1A ChEMBL. No reference
Ki (functional) = 4.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LIMK1 ChEMBL. No reference
Ki (functional) = 4.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1B ChEMBL. No reference
Ki (functional) = 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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