TDR Targets

Basic information

Technical information

TDR Targets ID: 1605735
Name: 2-methyl-5-nitro-N-[4-(5-thiophen-2-yl-4,5-di hydro-1,2-oxazol-3-yl)phenyl]benzenesulfonami de
MW: 443.496 | Formula: C20H17N3O5S2
H donors: 1 H acceptors: 4 LogP: 3.75 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1S(=O)(=O)Nc1ccc(cc1)C1=NOC(C1)c1cccs1)[N+](=O)[O-]
InChi: 1S/C20H17N3O5S2/c1-13-4-9-16(23(24)25)11-20(13)30(26,27)22-15-7-5-14(6-8-15)17-12-18(28-21-17)19-3-2-10-29-19/h2-11,18,22H,12H2,1H3
InChiKey: LVGBDUHSSXVCTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methyl-5-nitro-N-[4-[5-(2-thienyl)-4,5-dihydroisoxazol-3-yl]phenyl]benzenesulfonamide
NCI60_040186
NSC716272

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0048	0.0036
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0146	0.0527	0.0481
Trichomonas vaginalis	CAMK family protein kinase	0.0128	0.0448	0.1055
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.2319	1	1
Toxoplasma gondii	sugar transporter ST1	0.0059	0.0146	0.0098
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0676	0.2835	0.2801
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0125	0.0437	0.1138
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	major facilitator superfamily protein	0.0059	0.0146	0.0134
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Onchocerca volvulus		0.005	0.0108	0.6068
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0905	0.3837	1
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.2319	1	1
Onchocerca volvulus		0.0052	0.0118	0.7175
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0146	0.0527	0.0481
Leishmania major	myo-inositol/proton symporter (MIT)	0.0059	0.0146	0.0098
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Schistosoma mansoni	lamin	0.0052	0.0118	0.007
Brugia malayi	beta-lactamase family protein	0.0036	0.0048	0.0036
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0418	0.1713	0.4392
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.2319	1	1
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.2319	1	1
Schistosoma mansoni	hypothetical protein	0.0418	0.1713	0.1672
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.01	0.026
Echinococcus multilocularis	General substrate transporter	0.0359	0.1456	0.3795
Onchocerca volvulus		0.0059	0.0146	1
Loa Loa (eye worm)	sugar transporter	0.0059	0.0146	0.0852
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.01	0.0052
Brugia malayi	mbt repeat family protein	0.0048	0.01	0.0088
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0146	0.0527	0.0481
Schistosoma mansoni	dihydroorotate dehydrogenase	0.2319	1	1
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Brugia malayi	hypothetical protein	0.0059	0.0146	0.0134
Leishmania major	hypothetical protein, conserved	0.0059	0.0146	0.0098
Echinococcus multilocularis	lysyl tRNA synthetase	0.0093	0.0297	0.0773
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0128	0.0448	0.0307
Leishmania major	glucose transporter, lmgt2	0.013	0.0455	0.0409
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0146	0.0258
Plasmodium vivax	lysine--tRNA ligase, putative	0.0093	0.0297	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Brugia malayi	major facilitator superfamily protein	0.0059	0.0146	0.0134
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0146	0.0527	0.0481
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0125	0.0437	0.039
Plasmodium falciparum	protein kinase 6	0.1774	0.7627	0.7592
Giardia lamblia	Prolyl-tRNA synthetase	0.0125	0.0437	1
Schistosoma mansoni	sugar transporter	0.0059	0.0146	0.0098
Leishmania major	lysyl-tRNA synthetase, putative	0.0093	0.0297	0.0249
Plasmodium vivax	proline--tRNA ligase, putative	0.0146	0.0527	0.0481
Schistosoma mansoni	protein kinase	0.0128	0.0448	0.0402
Echinococcus granulosus	lamin dm0	0.0052	0.0118	0.0308
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Echinococcus granulosus	lysyl tRNA synthetase	0.0093	0.0297	0.0773
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0418	0.1713	0.4463
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0905	0.3837	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.01	0.5275
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0129	0.0117
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0059	0.0146	0.0098
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0905	0.3837	0.3808
Onchocerca volvulus		0.0052	0.0118	0.7175
Treponema pallidum	prolyl-tRNA synthetase	0.0044	0.0083	0.5
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0146	0.0258
Schistosoma mansoni	protein kinase	0.0128	0.0448	0.0402
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0128	0.0448	0.0307
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	Sugar transporter family protein	0.0059	0.0146	0.0134
Trypanosoma brucei	sugar transporter, putative	0.0059	0.0146	0.0098
Schistosoma mansoni	sugar transporter	0.0059	0.0146	0.0098
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.2319	1	1
Entamoeba histolytica	protein kinase, putative	0.0128	0.0448	0.0427
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0012	0.0071
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0128	0.0448	0.0402
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0128	0.0448	0.0307
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0128	0.0448	0.2615
Echinococcus granulosus	intermediate filament protein	0.0052	0.0118	0.0308
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Leishmania major	glucose transporter, lmgt1	0.013	0.0455	0.0409
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0905	0.3837	1
Plasmodium falciparum	proline--tRNA ligase	0.0146	0.0527	0.0387
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0125	0.0437	0.039
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trypanosoma cruzi	sugar transporter, putative	0.0059	0.0146	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0786	0.3317	0.8644
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	glucose transporter, putative	0.013	0.0455	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0455	0.1073
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0905	0.3837	1
Brugia malayi	mbt repeat family protein	0.0048	0.01	0.0088
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trypanosoma cruzi	glucose transporter, putative	0.0059	0.0146	0.0098
Toxoplasma gondii	transporter, major facilitator family protein	0.0059	0.0146	0.0098
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.01	0.026
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0059	0.0146	0.038
Onchocerca volvulus		0.0059	0.0146	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0128	0.0448	0.0436
Schistosoma mansoni	glucose transport protein	0.0418	0.1713	0.1672
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0194	0.0734	0.1913
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0128	0.0448	0.0402
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.01	0.026
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Echinococcus multilocularis	lamin dm0	0.0052	0.0118	0.0308
Schistosoma mansoni	serine/threonine protein kinase	0.0128	0.0448	0.0402
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0676	0.2835	0.2729
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Schistosoma mansoni	intermediate filament proteins	0.0052	0.0118	0.007
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Echinococcus multilocularis	tumor protein p63	0.0341	0.1378	0.3592
Echinococcus granulosus	solute carrier family 22	0.0059	0.0146	0.038
Onchocerca volvulus		0.0059	0.0146	1
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0146	0.0134
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0059	0.0146	0.0098
Loa Loa (eye worm)	sugar transporter	0.0418	0.1713	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Schistosoma mansoni	sugar transporter	0.0059	0.0146	0.0098
Trichomonas vaginalis	sugar transport protein, putative	0.0059	0.0146	0.0258
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0059	0.0146	0.0098
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	lysyl-tRNA synthetase	0.0093	0.0297	0.0285
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.01	0.0052
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0079	0.0235	0.0188
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0455	0.0409
Echinococcus granulosus	synaptic vesicle 2 protein	0.0059	0.0146	0.038
Plasmodium falciparum	lysine--tRNA ligase	0.0093	0.0297	0.0153
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0125	0.0437	0.1138
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Plasmodium vivax	hexose transporter	0.0418	0.1713	0.1672
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0146	0.0258
Echinococcus granulosus	General substrate transporter	0.0359	0.1456	0.3795
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0128	0.0448	0.0402
Echinococcus multilocularis	musashi	0.0052	0.0118	0.0308
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0905	0.3837	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0125	0.0437	0.039
Entamoeba histolytica	protein kinase, putative	0.0128	0.0448	0.0427
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0128	0.0448	0.1167
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0059	0.0146	0.0098
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0059	0.0146	0.0852
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0455	0.1073
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0125	0.0437	0.0425
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0128	0.0448	0.0402
Onchocerca volvulus		0.0048	0.01	0.5275
Plasmodium vivax	sugar transporter, putative	0.0059	0.0146	0.0098
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0059	0.0146	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0448	0.2615
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0437	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0118	0.0691
Brugia malayi	intermediate filament protein	0.0052	0.0118	0.0106
Toxoplasma gondii	sugar transporter ST2	0.0059	0.0146	0.0098
Schistosoma mansoni	glucose transport protein	0.0418	0.1713	0.1672
Trypanosoma cruzi	hexose transporter, putative	0.0071	0.0199	0.0151
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0146	0.0527	0.0481
Brugia malayi	hypothetical protein	0.0059	0.0146	0.0134
Schistosoma mansoni	lysyl-tRNA synthetase	0.0093	0.0297	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0114	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0048	0.01	0.0583
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Onchocerca volvulus		0.0059	0.0146	1
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0146	0.038
Onchocerca volvulus		0.0059	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0297	0.1731
Brugia malayi	hypothetical protein	0.0059	0.0146	0.0134
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0093	0.0297	0.0249
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0129	0.0336
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0128	0.0448	0.1167
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0129	0.0336
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0093	0.0297	0.0249
Echinococcus granulosus	solute carrier family 22	0.0059	0.0146	0.038
Trypanosoma cruzi	hexose transporter	0.013	0.0455	0.0409
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Toxoplasma gondii	protein kinase, putative	0.1181	0.504	0.5016
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0129	0.0336
Onchocerca volvulus		0.0059	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0334	0.195
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0905	0.3837	1
Onchocerca volvulus		0.0059	0.0146	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0052	0.0118	0.0106
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0128	0.0448	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0128	0.0448	0.0402
Giardia lamblia	Lysyl-tRNA synthetase	0.0093	0.0297	0.5182
Plasmodium falciparum	dihydroorotate dehydrogenase	0.2319	1	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0093	0.0297	0.0249
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0108	0.006
Toxoplasma gondii	lysine-tRNA ligase	0.0093	0.0297	0.0249
Brugia malayi	Zinc finger, C2H2 type family protein	0.0905	0.3837	0.383
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	glucose transporter, putative	0.013	0.0455	0.1073
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.2319	1	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0905	0.3837	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0129	0.0081
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.2319	1	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0455	0.0409
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0048	0.0282
Echinococcus multilocularis	calcium dependent protein kinase	0.012	0.0413	0.1077
Toxoplasma gondii	sugar transporter ST3	0.0059	0.0146	0.0098
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0059	0.0146	0.038
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trypanosoma brucei	glucose transporter 1E	0.013	0.0455	0.0409
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	beta-lactamase family protein	0.0036	0.0048	0.0036
Echinococcus granulosus	lamin	0.0052	0.0118	0.0308
Onchocerca volvulus		0.0059	0.0146	1
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0455	0.0409
Plasmodium falciparum	hexose transporter	0.0418	0.1713	0.159
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.01	0.026
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.2319	1	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.013	0.0455	0.0409
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0146	0.038
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0437	0.2549
Schistosoma mansoni	glucose transporter	0.0059	0.0146	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0455	0.1073
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.01	0.0052
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Schistosoma mansoni	lysyl-tRNA synthetase	0.0093	0.0297	0.0249
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0048	0.0126
Plasmodium falciparum	protein kinase 7	0.1181	0.504	0.4967
Trichomonas vaginalis	myo-inositol transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	Sugar transporter family protein	0.0418	0.1713	0.1703
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0125	0.0437	0.1025
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0194	0.0734	0.1913
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0418	0.1713	0.4463
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.01	0.0583
Brugia malayi	Cam kinase protein 1	0.0128	0.0448	0.0436
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0128	0.0448	0.0307
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0146	0.0258
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0676	0.2835	0.2801
Trypanosoma brucei	glucose transporter 2A	0.013	0.0455	0.0409
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0093	0.0297	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0079	0.0235	0.0188
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0905	0.3837	1
Echinococcus granulosus	tumor protein p63	0.0341	0.1378	0.3592
Onchocerca volvulus		0.0059	0.0146	1
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.2319	1	1
Echinococcus granulosus	solute carrier family 22	0.0059	0.0146	0.038
Onchocerca volvulus		0.0059	0.0146	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0905	0.3837	1
Onchocerca volvulus	Putative transporter	0.0059	0.0146	1
Leishmania major	dihydroorotate dehydrogenase	0.2319	1	1
Onchocerca volvulus		0.0059	0.0146	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0128	0.0448	0.0307
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0128	0.0448	0.2615
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0048	0.0282
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.2319	1	1
Trichomonas vaginalis	glucose transporter, putative	0.0059	0.0146	0.0258
Schistosoma mansoni	sugar transporter	0.0059	0.0146	0.0098
Onchocerca volvulus		0.0059	0.0146	1
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0146	0.0134
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.2319	1	1
Onchocerca volvulus		0.0059	0.0146	1
Echinococcus granulosus	calcium dependent protein kinase	0.012	0.0413	0.1077
Echinococcus granulosus	solute carrier family 22	0.0059	0.0146	0.038
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0044	0.0083	0.0035
Onchocerca volvulus		0.0059	0.0146	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0093	0.0297	0.0249
Chlamydia trachomatis	lysine--tRNA ligase	0.0093	0.0297	1
Schistosoma mansoni	lamin	0.0052	0.0118	0.007
Onchocerca volvulus		0.0059	0.0146	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0051	0.0114	0.0666
Loa Loa (eye worm)	intermediate filament protein	0.0052	0.0118	0.0691
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1774	0.7627	0.7615
Trypanosoma cruzi	hexose transporter, putative	0.0059	0.0146	0.0098
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0082	0.0246	0.0523
Leishmania major	glucose transporter, lmgt3	0.013	0.0455	0.0409
Echinococcus multilocularis	lamin	0.0052	0.0118	0.0308
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0052	0.0118	0.0691
Trypanosoma cruzi	hexose transporter, putative	0.013	0.0455	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0048	0.0282
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0146	0.0258
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Brugia malayi	Major Facilitator Superfamily protein	0.0059	0.0146	0.0134
Schistosoma mansoni	hypothetical protein	0.0297	0.1183	0.1141
Schistosoma mansoni	protein kinase	0.0128	0.0448	0.0402
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0455	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0129	0.0753
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0059	0.0146	0.0098
Onchocerca volvulus		0.0059	0.0146	1
Trypanosoma brucei	glucose transporter, putative	0.013	0.0455	0.0409
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0905	0.3837	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0125	0.0437	0.0425
Trichomonas vaginalis	sugar transporter, putative	0.013	0.0455	0.1073
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0079	0.0235	0.0188
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Brugia malayi	Sugar transporter family protein	0.0059	0.0146	0.0134
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0059	0.0146	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0905	0.3837	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.013	0.0455	0.0409
Mycobacterium ulcerans	sugar transporter	0.0059	0.0146	0.0098
Loa Loa (eye worm)	hypothetical protein	0.005	0.0108	0.0628
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0059	0.0146	0.038
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0048	0.0126
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0128	0.0448	0.0402
Mycobacterium ulcerans	integral membrane transport protein	0.0059	0.0146	0.0098
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0125	0.0437	0.0395
Brugia malayi	beta-lactamase	0.0036	0.0048	0.0036
Loa Loa (eye worm)	MBCTL1	0.0055	0.0129	0.0753
Toxoplasma gondii	facilitative glucose transporter GT1	0.0418	0.1713	0.1672
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Schistosoma mansoni	glucose transport protein	0.0418	0.1713	0.1672
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.0903	0.0859
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0093	0.0297	0.0655
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0059	0.0146	0.0258
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0128	0.0448	0.0402
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0146	0.0527	0.0481
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0146	0.038
Echinococcus multilocularis	solute carrier family 22	0.0059	0.0146	0.038
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0146	0.0852
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0129	0.0336
Leishmania major	protein kinase, putative	0.0128	0.0448	0.0402
Trichomonas vaginalis	conserved hypothetical protein	0.013	0.0455	0.1073

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.562	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.45	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.204	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.116	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.871	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.858	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.83	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.755	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.754	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.747	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.702	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1983730

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1605735