Detailed information for compound 1608332

Basic information

Technical information
  • TDR Targets ID: 1608332
  • Name: 5-cyclohexyl-4-[(5-methylfuran-2-yl)methylide neamino]-2H-1,2,4-triazole-3-thione
  • MW: 290.384 | Formula: C14H18N4OS
  • H donors: 0 H acceptors: 2 LogP: 3.64 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(o1)/C=N/n1c(S)nnc1C1CCCCC1
  • InChi: 1S/C14H18N4OS/c1-10-7-8-12(19-10)9-15-18-13(16-17-14(18)20)11-5-3-2-4-6-11/h7-9,11H,2-6H2,1H3,(H,17,20)/b15-9+
  • InChiKey: CSMZUQKOOWVLMT-OQLLNIDSSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-cyclohexyl-4-[(5-methyl-2-furyl)methyleneamino]-2H-1,2,4-triazole-3-thione
  • 5-cyclohexyl-4-{[(5-methyl-2-furyl)methylene]amino}-4H-1,2,4-triazole-3-thiol
  • MLS000676840
  • SMR000271841
  • ZINC00028826
  • ST041464
  • ZINC01288435
  • Oprea1_148826
  • STOCK3S-01888

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1389 0.1389
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0015 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0015 0.0015
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0024 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0015 0.0015
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0003 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0015 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0015 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0426 0.0426
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0559 1 1
Onchocerca volvulus Alhambra homolog 0.0035 0.0435 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0015 0.0015
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0451 0.0451
Brugia malayi nuclear hormone receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.006 0.0895 0.0895
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0015 0.0015
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0333 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0435 0.9659
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0075 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0435 0.9659
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0559 1 1
Brugia malayi Pre-SET motif family protein 0.0251 0.4381 0.4381
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0024 0.0024
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0559 1 1
Brugia malayi ecdysteroid receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0435 0.0435
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Brugia malayi steroid hormone receptor 0.0012 0.0015 0.0015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0451 1
Mycobacterium tuberculosis Conserved protein 0.003 0.0333 0.5
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0146 0.3243
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0333 0.0333
Brugia malayi transcription factor E74 isoform 0.0013 0.0024 0.0024
Brugia malayi Ets-domain containing protein 0.0013 0.0024 0.0024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.4381 0.4381
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0024 0.0024
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0036 0.0451 0.0436
Echinococcus granulosus peregrin 0.0035 0.0435 0.0435
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0015 0.0015
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1389 0.1389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0015 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0015 0.0015
Mycobacterium ulcerans hypothetical protein 0.003 0.0333 0.5
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0003 0.0003
Schistosoma mansoni ets 0.0013 0.0024 0.0024
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0322 0.0322
Echinococcus granulosus lysosomal protective protein 0.0559 1 1
Echinococcus multilocularis ets variant gene 4 0.0013 0.0024 0.0024
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0333 0.0333
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0015 0.0015
Plasmodium falciparum phd finger protein, putative 0.0035 0.0435 1
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0451 0.0451
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0333 0.0333
Trypanosoma brucei polo-like protein kinase 0.0114 0.1875 0.1875
Plasmodium vivax SET domain protein, putative 0.0036 0.0451 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0015 0.0015
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0333 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1875 0.1875
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0003 0.0058
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0024 0.0024
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0015 0.0015
Brugia malayi Pre-SET motif family protein 0.0036 0.0451 0.0451
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0015 0.0015
Schistosoma mansoni coup transcription factor 0.0012 0.0015 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0011 0.0244
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0571 0.0571
Brugia malayi Ets-domain containing protein 0.0087 0.1389 0.1389
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Brugia malayi PHD-finger family protein 0.0035 0.0435 0.0435
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0011 0.0011
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0559 1 1
Onchocerca volvulus 0.0286 0.5015 0.5008
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0435 0.0435
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0015 0.0015
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0011 0.0011
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1389 0.1389
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0015 0.0015
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0333 0.5
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1875 0.1875
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0504 0.8991 0.8991
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0015 0.0015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1898 0.1898
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0015 0.0015
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0011 0.0011
Mycobacterium ulcerans hypothetical protein 0.003 0.0333 0.5
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0024 0.0024
Schistosoma mansoni gabp alpha 0.0087 0.1389 0.1389
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0571 0.0571
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0003 0.006
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0571 0.0571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0451 0.0451
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0015 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0027 0.0027
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0333 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0015 0.0015
Echinococcus multilocularis peregrin 0.0035 0.0435 0.0435
Giardia lamblia Kinase, PLK 0.0114 0.1875 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0015 0.0015
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0011 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0451 0.0451
Brugia malayi PHD-finger family protein 0.0012 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0015 0.0015
Giardia lamblia PHD finger protein 15 0.0035 0.0435 0.2276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0015 0.0015
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0322 0.0499
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0451 0.0451
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0015 0.0015
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1898 0.1898
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0322 0.0322
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0258 0.5916
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0333 0.0333
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1875 0.1875
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0013 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0451 0.0451
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0571 0.0571
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0003 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0015 0.0015
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0027 0.0027
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0687 0.0687
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.015 0.3337
Brugia malayi Ets-domain containing protein 0.0087 0.1389 0.1389
Schistosoma mansoni lysosomal protective protein precursor (cathepsin A) (carboxypeptidase 0.0055 0.0801 0.0801
Schistosoma mansoni kinase 0.0058 0.0851 0.0851
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0015 0.0015
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0559 1 1
Schistosoma mansoni elf1 0.0013 0.0024 0.0024
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0075 0.0075
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0024 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0015 0.0015
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0024 0.0024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0015 0.0015
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0024 0.0024
Echinococcus multilocularis lysosomal protective protein 0.0559 1 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1158 0.1158
Brugia malayi Fli-1 protein 0.0265 0.464 0.464
Leishmania major hypothetical protein, conserved 0.0257 0.4483 0.4483
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0024 0.0024
Schistosoma mansoni DNA helicase recq5 0.0012 0.0011 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1875 0.1875
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0043 0.0571 0.0571
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0687 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0015 0.0015
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0011 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1875 0.1875
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0024 0.0024
Schistosoma mansoni DNA helicase recq1 0.0012 0.0011 0.0011
Schistosoma mansoni ets-related 0.0265 0.464 0.464
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.4483 0.4483
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0571 0.0571
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1875 0.1875
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0146 0.2457 0.2457
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0559 1 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0011 0.0244
Trichomonas vaginalis set domain proteins, putative 0.0286 0.5015 1
Echinococcus granulosus protein C ets 2 0.0013 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0035 0.0435 0.0435
Loa Loa (eye worm) fli-1 protein 0.0265 0.464 0.464
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0451 0.0451
Schistosoma mansoni ets-related 0.0013 0.0024 0.0024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0015 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0015 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0015 0.0015
Echinococcus granulosus bloom syndrome protein 0.0029 0.0322 0.0322
Brugia malayi AF-10 protein 0.0012 0.0003 0.0003
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0075 0.0075
Brugia malayi nuclear receptor NHR-88 0.0012 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.4483 0.4483
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0015 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1465 0.1465
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0015 0.0015
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0015 0.0015
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0435 0.9659
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0333 0.0521
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0559 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Loa Loa (eye worm) RecQ helicase 0.0029 0.0322 0.0322
Echinococcus multilocularis protein C ets 2 0.0013 0.0024 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0015 0.0015
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0504 0.8991 0.8991
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0015 0.0015
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0559 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0824 0.1515
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0015 0.0015
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0559 1 1
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0559 1 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0024 0.0024
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0322 0.0499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0115 0.1898 0.1898
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0015 0.0015
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0435 0.0435
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.112 0.112
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0024 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1875 0.3644
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0559 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0435 0.0435
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1875 1
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.4483 0.4483
Brugia malayi Bromodomain containing protein 0.0035 0.0435 0.0435
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1875 0.1875
Loa Loa (eye worm) hypothetical protein 0.0559 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1875 0.1863
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0435 0.0435
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0824 0.1515
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0015 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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