Detailed information for compound 1611412

Basic information

Technical information
  • TDR Targets ID: 1611412
  • Name: 2,7-Diphenyl-1H,6H-diimidazo[1,5-b:1,5-e][1,2 ,4,5]tetraazine-1,3,6,8(2H,7H)-tetrone
  • MW: 374.31 | Formula: C18H10N6O4
  • H donors: 0 H acceptors: 6 LogP: 2.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n2nc3n(nc2c(=O)n1c1ccccc1)c(=O)n(c3=O)c1ccccc1
  • InChi: 1S/C18H10N6O4/c25-15-13-19-24-14(16(26)22(18(24)28)12-9-5-2-6-10-12)20-23(13)17(27)21(15)11-7-3-1-4-8-11/h1-10H
  • InChiKey: HIGIECWFVNHHFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS-145063
  • AIDS145063
  • NSC669039
  • NCI60_024065

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0316 0.1802 0.1687
Schistosoma mansoni hypothetical protein 0.0108 0.0542 0.0542
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0316 0.1802 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.1329 0.7931 0.7928
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0108 0.0542 0.0555
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0139 0.0139
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0108 0.0542 0.0409
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0542 0.0542
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0108 0.0542 0.0542
Trypanosoma brucei rac serine-threonine kinase, putative 0.0066 0.029 0.0153
Echinococcus granulosus serine threonine protein kinase nrc 0.0041 0.0139 0.0139
Loa Loa (eye worm) RNA binding protein 0.0073 0.0333 0.0333
Leishmania major hypothetical protein, conserved 0.0108 0.0542 0.0409
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0021 0.0018 0.0018
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0108 0.0542 0.0542
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0139 0.0139
Trypanosoma cruzi target of rapamycin kinase 3 0.133 0.794 0.7911
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0018
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0108 0.0542 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0043 0.0028
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0137 0.0137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0238 0.0238
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1671 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0409
Echinococcus granulosus serine:threonine protein kinase N2 0.0021 0.0018 0.0018
Brugia malayi TAR-binding protein 0.0073 0.0333 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0998 0.5931 0.5925
Leishmania major phosphatidylinositol 3-related kinase, putative 0.056 0.328 0.3186
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0108 0.0542 0.0409
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1671 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0108 0.0542 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.328 0.327
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.1329 0.7931 0.7928
Trypanosoma cruzi Protein kinase B 0.0045 0.0164 0.0026
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0108 0.0542 0.0542
Onchocerca volvulus 0.0108 0.0542 0.5
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.056 0.328 0.328
Brugia malayi p70 ribosomal S6 kinase beta 0.0062 0.0265 0.0265
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.056 0.328 0.3186
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0139 0.5
Loa Loa (eye worm) hypothetical protein 0.0108 0.0542 0.0542
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0108 0.0542 0.0542
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0542 0.0542
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0108 0.0542 0.0409
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0238 0.0238
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.1085 0.6453 0.6447
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.328 0.327
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0139 0.0121
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.328 0.327
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0179 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0041 0.0139 0.0139
Loa Loa (eye worm) phosphatidylinositol 3 0.1671 1 1
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0164 0.0164
Entamoeba histolytica protein kinase 2, putative 0.0041 0.0139 0.0121
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0542 0.0542
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.079 0.4671 0.4596
Trichomonas vaginalis PIKK family atypical protein kinase 0.1329 0.7931 0.7928
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0179 0.0179
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0164 0.0146
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0108 0.0542 0.0525
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0542 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1802 0.1789
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0108 0.0542 0.0527
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1671 1 1
Plasmodium vivax hypothetical protein 0.0108 0.0542 1
Giardia lamblia Hypothetical protein 0.0108 0.0542 0.0409
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0041 0.0139 0.0139
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.056 0.328 0.3186
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0316 0.1802 0.1687
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0139 0.0139
Leishmania major phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0409
Loa Loa (eye worm) hypothetical protein 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0902 0.5349 0.5342
Schistosoma mansoni fkbp-rapamycin associated protein 0.0316 0.1802 0.1802
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0525
Echinococcus granulosus tar DNA binding protein 0.0073 0.0333 0.0333
Entamoeba histolytica hypothetical protein 0.0108 0.0542 0.0525
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0179 0.0179
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0316 0.1802 0.1802
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Loa Loa (eye worm) AGC/NDR protein kinase 0.0021 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0108 0.0542 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0018 0.0003
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0108 0.0542 0.0527
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0316 0.1802 0.1802
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.056 0.328 0.3186
Echinococcus multilocularis protein kinase c epsilon type 0.0021 0.0018 0.0018
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5341 0.5333
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0018 0.0018
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0108 0.0542 0.0542
Brugia malayi RNA binding protein 0.0073 0.0333 0.0333
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0902 0.5349 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.1329 0.7931 0.7928
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0108 0.0542 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1802 0.1789
Brugia malayi FAT domain containing protein 0.0244 0.1368 0.1368
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0021 0.0018 0.0018
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0108 0.0542 0.0542
Echinococcus multilocularis serine threonine protein kinase 0.0021 0.0018 0.0018
Echinococcus multilocularis rac serine:threonine kinase 0.0045 0.0164 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0179 0.0179
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0108 0.0542 0.0542
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0137 0.0137
Brugia malayi Protein kinase domain containing protein 0.0066 0.029 0.029
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0128 0.0128
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Echinococcus granulosus nervana 2 0.0041 0.0137 0.0137
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0108 0.0542 0.0409
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0021 0.0018 0.0018
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0108 0.0542 0.0542
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0108 0.0542 0.0527
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0409
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0108 0.0542 0.0542
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0021 0.0018 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0139 0.5
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0108 0.0542 0.0542
Leishmania major phosphatidylinositol kinase, putative 0.0108 0.0542 0.0409
Schistosoma mansoni serine/threonine-protein kinase 0.0045 0.0164 0.0164
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0108 0.0542 0.0542
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0108 0.0542 1
Entamoeba histolytica protein kinase, putative 0.0062 0.0265 0.0247
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1671 1 1
Loa Loa (eye worm) hypothetical protein 0.0352 0.202 0.202
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0352 0.202 0.2588
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0123
Echinococcus granulosus NDR protein kinase 0.0021 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0108 0.0542 0.0409
Loa Loa (eye worm) hypothetical protein 0.0244 0.1368 0.1368
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0108 0.0542 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0108 0.0542 0.0542
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0409
Echinococcus granulosus serine protein kinase ATM 0.0316 0.1802 0.1802
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 1 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0108 0.0542 0.0542
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0244 0.1368 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1121 0.6671 0.6666
Toxoplasma gondii target of rapamycin (TOR), putative 0.1243 0.7409 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0409
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0333 0.0333
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0108 0.0542 0.0542
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0108 0.0542 0.0409
Entamoeba histolytica hypothetical protein 0.0108 0.0542 0.0525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0179 0.0179
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0137 0.0137
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0409
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0265 0.0265
Echinococcus multilocularis serine protein kinase ATM 0.0316 0.1802 0.1802
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0902 0.5349 0.5342
Echinococcus granulosus protein kinase c epsilon type 0.0021 0.0018 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0238 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0108 0.0542 0.0542
Echinococcus multilocularis serine:threonine protein kinase 38 0.0021 0.0018 0.0018
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1671 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0108 0.0542 0.0527
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.029 0.029
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0108 0.0542 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0988 0.5871 0.5865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5341 0.5333
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0108 0.0542 0.0542
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0525
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0542 0.5
Entamoeba histolytica protein kinase, putative 0.0066 0.029 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0998 0.5931 0.5925
Trichomonas vaginalis conserved hypothetical protein 0.0244 0.1368 0.1355
Loa Loa (eye worm) hypothetical protein 0.0208 0.115 0.115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0542 0.0527
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0021 0.0018 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0118 0.0118
Giardia lamblia Phosphatidylinositol 4-kinase 0.0108 0.0542 0.0409
Loa Loa (eye worm) hypothetical protein 0.0058 0.0238 0.0238
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0179 0.0179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0139 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0525
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0333 0.0333
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0137 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0018 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0352 0.202 0.2008
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.056 0.328 0.328
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.056 0.328 0.3186
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0045 0.0164 0.0026
Toxoplasma gondii FATC domain-containing protein 0.0316 0.1802 0.2288
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1671 1 1
Toxoplasma gondii AGC kinase 0.0062 0.0265 0.0174
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0316 0.1802 0.1802
Leishmania major phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0409
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.056 0.328 0.328
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0316 0.1802 0.1687
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0139 0.0139
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0108 0.0542 1
Schistosoma mansoni hypothetical protein 0.0244 0.1368 0.1368
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0103 0.0088
Schistosoma mansoni hypothetical protein 0.0039 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0448 0.2602 0.2591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0988 0.5871 0.5865
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0333 0.0333
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0139 0.0139
Brugia malayi Protein kinase domain containing protein 0.0021 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.034 0.195 0.195
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0108 0.0542 0.0542
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0208 0.115 0.1025
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0333 0.0333
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0139 0.0139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0108 0.0542 0.0525
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0018 0.0003
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0139
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0316 0.1802 0.1787
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0041 0.0139 0.0001
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0118 0.0118
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0108 0.0542 0.0527
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0108 0.0542 0.0527
Giardia lamblia GTOR 0.1671 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.056 0.328 0.3186
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0108 0.0542 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1426 0.8522 0.8519
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0108 0.0542 0.0409
Entamoeba histolytica protein kinase, putative 0.0066 0.029 0.0272
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0542 0.0542
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0108 0.0542 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0108 0.0542 0.0527
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0108 0.0542 0.0555
Schistosoma mansoni atypical protein kinase C 0.0021 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0316 0.1802 0.1787
Echinococcus granulosus protein kinase c iota type 0.0021 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0902 0.5349 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Onchocerca volvulus 0.0108 0.0542 0.5
Brugia malayi protein kinase C II. 0.0021 0.0018 0.0018
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0244 0.1368 0.1368
Trichomonas vaginalis PIKK family atypical protein kinase 0.1329 0.7931 0.7928
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0108 0.0542 0.0527
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0108 0.0542 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0128 0.0128
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0333 0.0333
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0108 0.0542 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0333 0.0333
Entamoeba histolytica hypothetical protein 0.0108 0.0542 0.0525
Loa Loa (eye worm) phosphatidylinositol kinase 0.0108 0.0542 0.0542
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0041 0.0139 0.0015
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0333 0.0333
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0108 0.0542 0.0542
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0021 0.0018 0.0018
Loa Loa (eye worm) phosphatidylinositol 3 0.056 0.328 0.328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.1802 0.1789
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0108 0.0542 0.0409
Leishmania major phosphatidylinositol kinase related protein, putative 0.0108 0.0542 0.0409
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1671 1 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0041 0.0139 0.0015
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0108 0.0542 0.0409
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0108 0.0542 1
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0139 0.0123
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0021 0.0018 0.0018
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0108 0.0542 0.0555
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0694 0.4089 0.4006
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.328 0.327
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0108 0.0542 0.0542
Entamoeba histolytica PH domain containing protein kinase, putative 0.0045 0.0164 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0542 0.0527
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1671 1 1
Echinococcus granulosus nervana 2 0.0041 0.0137 0.0137
Loa Loa (eye worm) phosphatidylinositol 3 0.0108 0.0542 0.0542
Echinococcus multilocularis nervana 2 0.0041 0.0137 0.0137
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0021 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.115 0.1136
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0118 0.0118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0179 0.0179
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.056 0.328 0.328
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1671 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0108 0.0542 0.0527
Echinococcus granulosus protein kinase C gamma type 0.0021 0.0018 0.0018
Echinococcus multilocularis protein kinase c iota type 0.0021 0.0018 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0103 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Schistosoma mansoni serine/threonine kinase 0.0021 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0998 0.5931 0.5925
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 0.5341 0.5333
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0108 0.0542 0.0542
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0108 0.0542 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1671 1 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0021 0.0018 0.0018
Entamoeba histolytica protein kinase rad3, putative 0.0316 0.1802 0.1787
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0108 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.056 0.328 0.327
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0108 0.0542 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0208 0.115 0.1136
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0316 0.1802 0.1802
Brugia malayi Protein kinase domain containing protein 0.0021 0.0018 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0179 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.133 0.794 0.7911
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0333 0.0333
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1671 1 1
Brugia malayi Hr1 repeat family protein 0.0021 0.0018 0.0018
Echinococcus granulosus Protein kinase C brain isozyme 0.0021 0.0018 0.0018
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0108 0.0542 1
Echinococcus granulosus serine/threonine protein kinase 0.0045 0.0164 0.0164
Echinococcus multilocularis 0.0108 0.0542 0.0542
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0108 0.0542 0.0555
Mycobacterium tuberculosis Conserved hypothetical protein 0.0108 0.0542 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1671 1 1
Echinococcus multilocularis nervana 2 0.0041 0.0137 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.1243 0.7409 0.7405
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0108 0.0542 0.0409
Trichomonas vaginalis AGC family protein kinase 0.0066 0.029 0.0275
Trypanosoma brucei target of rapamycin kinase 3, putative 0.133 0.794 0.7911
Leishmania major hypothetical protein, unknown function 0.0108 0.0542 0.0409
Loa Loa (eye worm) AGC/PKN protein kinase 0.0021 0.0018 0.0018
Giardia lamblia Kinase, AGC PKA 0.0041 0.0139 0.0001
Schistosoma mansoni ap endonuclease 0.0041 0.0139 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0316 0.1802 0.1802

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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