TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 853.739 | Formula: C46H42Cl2N2O10
H donors: 8 H acceptors: 10 LogP: 9.99 Rotable bonds: 11
Rule of 5 violations (Lipinski): 3
SMILES: OC(=O)C(c1ccc(cc1)Cl)N/C=C/1\C(=O)C(=C(c2c1c(O)c(c(c2)C)c1c(C)cc2c(c1O)/C(=C/NC(c1ccc(cc1)Cl)C(=O)O)/C(=O)C(=C2C(C)C)O)C(C)C)O
InChi: 1S/C46H42Cl2N2O10/c1-19(2)31-27-15-21(5)33(41(53)35(27)29(39(51)43(31)55)17-49-37(45(57)58)23-7-11-25(47)12-8-23)34-22(6)16-28-32(20(3)4)44(56)40(52)30(36(28)42(34)54)18-50-38(46(59)60)24-9-13-26(48)14-10-24/h7-20,37-38,49-50,53-56H,1-6H3,(H,57,58)(H,59,60)/b29-17-,30-18-
InChiKey: LDEJXUOZPFOWCK-LZUTUTKMSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0631	0.507	0.507
Echinococcus multilocularis	smoothened	0.0257	0.2008	0.2008
Schistosoma mansoni	hypothetical protein	0.0012	0	0.0001
Brugia malayi	MH2 domain containing protein	0.0088	0.0625	0.1234
Schistosoma mansoni	endoplasmin	0.0035	0.0193	0.038
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.0193	0.0357
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0081	0.0572	0.1128
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.0424	0.0424
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0081	0.0572	0.1038
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0067	0.0109
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0035	0.0193	0.5
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0151	0.1143	0.2255
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0035	0.0193	0.0357
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0081	0.0572	0.0572
Brugia malayi	latrophilin 2 splice variant baaae	0.0025	0.0111	0.0219
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0035	0.0193	0.4382
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0193	0.6204
Toxoplasma gondii	LsmAD domain-containing protein	0.002	0.0067	0.0277
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0081	0.0572	0.1128
Brugia malayi	RNA binding protein	0.0068	0.0463	0.0912
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.065	0.1282
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0111	0.0219
Echinococcus granulosus	neuropeptide s receptor	0.0685	0.5513	1
Echinococcus granulosus	smoothened	0.0257	0.2008	0.3642
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0037	0.0206	0.0406
Echinococcus multilocularis	small conductance calcium activated potassium	0.0125	0.0928	0.0928
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0463	0.0912
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0035	0.0193	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0012	0	0.0001
Leishmania major	hypothetical protein, conserved	0.002	0.0067	0.0109
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0012	0.0024
Echinococcus multilocularis	heat shock protein	0.0035	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1964	0.3875
Loa Loa (eye worm)	heat shock protein 90	0.0035	0.0193	0.038
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.0424	0.0769
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0424	1
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0012	0	0.0001
Toxoplasma gondii	heat shock protein HSP90	0.0035	0.0193	0.0909
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0012	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0193	0.038
Schistosoma mansoni	hypothetical protein	0.0125	0.0928	0.1831
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0035	0.0193	0.4382
Plasmodium falciparum	DNA gyrase subunit B	0.0035	0.0193	0.7298
Brugia malayi	Probable DNA topoisomerase II	0.0035	0.0193	0.038
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0631	0.507	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0041	0.0242	0.0478
Trypanosoma cruzi	heat shock protein 90, putative	0.0035	0.0193	0.0357
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0035	0.0193	0.0357
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0064	0.043	0.043
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.002	0.0065	0.1283
Leishmania major	DNA topoisomerase ii	0.0035	0.0193	0.0357
Echinococcus granulosus	neuropeptide receptor	0.012	0.0887	0.1608
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0147	0.1109	0.2011
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.0424	1
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0035	0.0193	0.038
Brugia malayi	heat shock protein 90	0.0035	0.0193	0.038
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.0269	0.1296
Brugia malayi	Endoplasmin precursor	0.0035	0.0193	0.038
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0035	0.0193	0.4382
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0193	0.038
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0193	0.0357
Echinococcus multilocularis	heat shock protein 90	0.0035	0.0193	0.0193
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0035	0.0193	0.4382
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0065	0.0105
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0463	0.0912
Entamoeba histolytica	hypothetical protein	0.0064	0.043	1
Plasmodium vivax	endoplasmin, putative	0.0035	0.0193	0.6204
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0239	0.1961
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.0424	0.2074
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0418	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0424	0.0836
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0035	0.0193	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0091	0.065	0.1282
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0035	0.0193	1
Echinococcus granulosus	heat shock protein 90	0.0035	0.0193	0.0349
Plasmodium falciparum	heat shock protein 90	0.0035	0.0193	0.7298
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0463	0.0912
Schistosoma mansoni	hypothetical protein	0.0012	0	0.0001
Leishmania major	mitochondrial DNA topoisomerase II	0.0035	0.0193	0.0357
Echinococcus granulosus	heat shock protein	0.0035	0.0193	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0928	0.1831
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0035	0.0193	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0463	0.0463
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0239	1
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0035	0.0193	0.4382
Schistosoma mansoni	hypothetical protein	0.0025	0.0111	0.0219
Trypanosoma cruzi	heat shock protein 90, putative	0.0035	0.0193	0.0357
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Trypanosoma cruzi	PAB1-binding protein , putative	0.002	0.0067	0.0109
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0064	0.043	0.0779
Trypanosoma brucei	cytochrome P450, putative	0.002	0.0065	0.0105
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0035	0.0193	0.4382
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0065	0.0128
Loa Loa (eye worm)	TOPoisomerase family member	0.0035	0.0193	0.038
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0035	0.0193	0.4382
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0631	0.507	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0631	0.507	1
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0035	0.0193	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0463	0.0912
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0081	0.0572	0.1038
Echinococcus multilocularis		0.0013	0.0012	0.0012
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0035	0.0193	0.0193
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0035	0.0193	0.4382
Brugia malayi	hypothetical protein	0.002	0.0067	0.0132
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0035	0.0193	0.0357
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0221	0.1711	0.3359
Loa Loa (eye worm)	hypothetical protein	0.002	0.0067	0.0132
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.0269	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0151	0.1143	0.1143
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0463	0.0912
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.0221	0.1711	0.8553
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0035	0.0193	0.5
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Echinococcus granulosus	GPCR family 2	0.0012	0	0.0001
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0463	0.0912
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0081	0.0572	0.1128
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.0424	0.0814
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.0269	1
Leishmania major	cytochrome p450-like protein	0.002	0.0065	0.0105
Mycobacterium ulcerans	putative regultory protein	0.0035	0.0193	0.4382
Plasmodium falciparum	DNA topoisomerase 2	0.0035	0.0193	0.7298
Brugia malayi	hypothetical protein	0.0064	0.043	0.0847
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.0424	0.0836
Loa Loa (eye worm)	transcription factor SMAD2	0.0088	0.0625	0.1234
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0463	0.0912
Echinococcus granulosus	cytochrome P450 2K1	0.0013	0.0012	0.0022
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0035	0.0193	0.4382
Echinococcus granulosus	small conductance calcium activated potassium	0.0125	0.0928	0.1684
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0035	0.0193	0.0909
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0035	0.0193	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0091	0.065	0.1179
Trypanosoma brucei	PAB1-binding protein , putative	0.002	0.0067	0.0109
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0463	0.0912
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0035	0.0193	0.5
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0081	0.0572	0.1128
Loa Loa (eye worm)	hypothetical protein	0.0631	0.507	1
Trypanosoma brucei	Heat shock protein 83, putative	0.0035	0.0193	0.0357
Echinococcus granulosus	neuropeptide receptor A26	0.0685	0.5513	1
Brugia malayi	cytochrome P450	0.0013	0.0012	0.0024
Schistosoma mansoni	heat shock protein	0.0035	0.0193	0.038
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Schistosoma mansoni	pyruvate dehydrogenase	0.0631	0.507	1
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0035	0.0193	0.0357
Plasmodium vivax	heat shock protein 86, putative	0.0035	0.0193	0.6204
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0035	0.0193	1
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0087	0.0617	0.0617
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Trypanosoma cruzi	ion transport protein, putative	0.0106	0.0771	0.1501
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0424	1
Echinococcus multilocularis	G protein coupled receptor 139	0.012	0.0887	0.0887
Trypanosoma cruzi	Heat shock protein 83, putative	0.0035	0.0193	0.0357
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0239	1
Brugia malayi	Latrophilin receptor protein 2	0.0012	0	0.0001
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Brugia malayi	hypothetical protein	0.0013	0.001	0.0019
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0463	0.0912
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0012	0	0.0001
Plasmodium vivax	DNA gyrase subunit B, putative	0.0035	0.0193	0.6204
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0035	0.0193	0.4382
Brugia malayi	acetyltransferase, GNAT family protein	0.0151	0.1143	0.2255
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Loa Loa (eye worm)	MH2 domain-containing protein	0.0088	0.0625	0.1234
Schistosoma mansoni	DNA topoisomerase II	0.0035	0.0193	0.038
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Mycobacterium ulcerans	DNA gyrase subunit B	0.0035	0.0193	0.4382
Chlamydia trachomatis	DNA gyrase subunit B	0.0035	0.0193	0.5
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Echinococcus multilocularis	neuropeptide receptor A26	0.0685	0.5513	0.5513
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0193	0.4382
Trypanosoma brucei	DNA topoisomerase ii	0.0035	0.0193	0.0357
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0037	0.0206	0.0406
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.0424	1
Brugia malayi	Cytochrome P450 family protein	0.002	0.0065	0.0128
Plasmodium falciparum	endoplasmin, putative	0.0035	0.0193	0.7298
Schistosoma mansoni	hypothetical protein	0.0012	0	0.0001
Schistosoma mansoni	hypothetical protein	0.0064	0.043	0.0847
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0035	0.0193	0.0357
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0035	0.0193	0.0357
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0091	0.065	0.1282
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.0269	0.0489
Schistosoma mansoni	hypothetical protein	0.0012	0	0.0001
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0035	0.0193	0.4382
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0221	0.1711	0.3359
Echinococcus multilocularis	potassium voltage gated channel protein	0.0091	0.065	0.065
Schistosoma mansoni	neuropeptide receptor	0.012	0.0887	0.1749
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0463	0.0839
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Schistosoma mansoni	heat shock protein	0.0035	0.0193	0.038
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0035	0.0193	1
Schistosoma mansoni	pyruvate dehydrogenase	0.0596	0.4782	0.9433
Entamoeba histolytica	hypothetical protein	0.0064	0.043	1
Brugia malayi	Cytochrome P450 family protein	0.002	0.0065	0.0128
Schistosoma mansoni	calcium-activated potassium channel	0.0119	0.0879	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0206	0.0406
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0035	0.0193	0.4382
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0035	0.0193	0.0909
Loa Loa (eye worm)	CYP4Cod1	0.002	0.0065	0.0128
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0256	0.1998	1
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.0221	0.1711	0.3359
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Echinococcus multilocularis	neuropeptide s receptor	0.0685	0.5513	0.5513
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.0193	0.0357
Leishmania major	hypothetical protein, conserved	0.0035	0.0193	0.0357
Mycobacterium leprae	Probable two-component sensor kinase	0.0035	0.0193	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0081	0.0572	0.0572
Entamoeba histolytica	hypothetical protein	0.0064	0.043	1
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0035	0.0193	0.4382
Brugia malayi	kinase, mitochondrial precursor	0.0631	0.507	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.0269	1
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0035	0.0193	0.0357
Schistosoma mansoni	transcription factor LCR-F1	0.0064	0.043	0.0847
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0035	0.0193	0.4382
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0193	0.0357
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0631	0.507	0.507
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0035	0.0193	0.4382
Schistosoma mansoni	endoplasmin	0.0035	0.0193	0.038
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0035	0.0193	0.4382
Entamoeba histolytica	hypothetical protein	0.0064	0.043	1
Loa Loa (eye worm)	acetyltransferase	0.0151	0.1143	0.2255
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0631	0.507	0.9196
Loa Loa (eye worm)	endoplasmin	0.0035	0.0193	0.038
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0035	0.0193	0.4382
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0035	0.0193	0.4382
Loa Loa (eye worm)	cytochrome P450	0.0013	0.0012	0.0024
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0193	0.0357
Echinococcus granulosus	potassium voltage gated channel protein	0.0091	0.065	0.1179
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0035	0.0193	0.5
Plasmodium vivax	DNA topoisomerase II, putative	0.0035	0.0193	0.6204
Schistosoma mansoni	hypothetical protein	0.0013	0.0012	0.0024
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.0269	0.1296
Trypanosoma cruzi	ion transport protein, putative	0.0106	0.0771	0.1501
Chlamydia trachomatis	DNA gyrase subunit B	0.0035	0.0193	0.5
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0366	0.0721
Brugia malayi	TAR-binding protein	0.0068	0.0463	0.0912
Schistosoma mansoni	pyruvate dehydrogenase	0.0596	0.4782	0.9433
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0035	0.0193	0.5
Schistosoma mansoni	cytochrome P450	0.0013	0.0012	0.0024
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0035	0.0193	0.7298
Mycobacterium ulcerans	two component sensor kinase MprB	0.0035	0.0193	0.4382
Trypanosoma cruzi	cytochrome P450, putative	0.002	0.0065	0.0105
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0081	0.0572	0.1128
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0035	0.0193	0.0357
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Leishmania major	ion transport protein-like protein	0.0106	0.0771	0.1501
Leishmania major	heat shock protein 83-1	0.0035	0.0193	0.0357
Echinococcus multilocularis	neuropeptide receptor	0.012	0.0887	0.0887
Toxoplasma gondii	heat shock protein 90, putative	0.0035	0.0193	0.0909
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0035	0.0193	0.4382
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0193	0.0357
Schistosoma mansoni	calcium-activated potassium channel	0.0125	0.0928	0.1831
Loa Loa (eye worm)	cytochrome P450 family protein	0.002	0.0065	0.0128
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0035	0.0193	0.038
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0037	0.0206	0.0406
Brugia malayi	Cytochrome P450 family protein	0.0041	0.0242	0.0478
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0035	0.0193	0.4382
Schistosoma mansoni	voltage-gated potassium channel	0.0091	0.065	0.1282
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0035	0.0193	0.0909
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0035	0.0193	0.4382
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0035	0.0193	0.4382

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1962862

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1622250