Detailed information for compound 1623145

Basic information

Technical information
  • TDR Targets ID: 1623145
  • Name: 2-[3-(cyclohexylamino)-6-methylimidazo[1,2-a] pyridin-2-yl]phenol
  • MW: 321.416 | Formula: C20H23N3O
  • H donors: 2 H acceptors: 2 LogP: 5.56 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2n(c1)c(NC1CCCCC1)c(n2)c1ccccc1O
  • InChi: 1S/C20H23N3O/c1-14-11-12-18-22-19(16-9-5-6-10-17(16)24)20(23(18)13-14)21-15-7-3-2-4-8-15/h5-6,9-13,15,21,24H,2-4,7-8H2,1H3
  • InChiKey: XHXUSKGTMYPQMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(cyclohexylamino)-6-methyl-imidazo[1,2-a]pyridin-2-yl]phenol
  • 2-[3-(cyclohexylamino)-6-methyl-2-imidazo[1,2-a]pyridinyl]phenol
  • Oprea1_199293
  • 2-(3-Cyclohexylamino-6-methyl-imidazo[1,2-a]pyridin-2-yl)-phenol
  • ASN 03437539

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0578 0.1892 0.1892
Trypanosoma brucei target of rapamycin kinase 3, putative 0.212 0.792 0.7908
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2652 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0059 0.5
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0109 0.0059 0.0059
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0295 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0339 0.0955 0.0921
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.053 0.1704 0.1655
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0368 0.1071 0.1038
Entamoeba histolytica hypothetical protein 0.0181 0.0339 0.0282
Brugia malayi FAT domain containing protein 0.0397 0.1184 0.1132
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.7867
Echinococcus multilocularis Zinc finger, PHD finger 0.02 0.0415 0.0415
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0966 0.3409 0.3409
Toxoplasma gondii FATC domain-containing protein 0.052 0.1663 0.1879
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0181 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0181 0.0339 0.0303
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.02 0.0415 0.0358
Loa Loa (eye worm) phosphatidylinositol 3 0.2652 1 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0181 0.0339 0.0282
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.02 0.0415 0.0358
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.02 0.0415 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0181 0.0339 0.0339
Giardia lamblia Phosphatidylinositol 4-kinase 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.1449 0.5296 0.5279
Loa Loa (eye worm) hypothetical protein 0.0181 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.1586 0.5831 0.5816
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Schistosoma mansoni fkbp-rapamycin associated protein 0.052 0.1663 0.1663
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0111 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Trichomonas vaginalis PIKK family atypical protein kinase 0.1779 0.6588 0.6575
Leishmania major hypothetical protein, unknown function 0.0181 0.0339 0.0282
Trypanosoma cruzi target of rapamycin kinase 3 0.212 0.792 0.7908
Loa Loa (eye worm) hypothetical protein 0.052 0.1663 0.1663
Loa Loa (eye worm) FKBP5 protein 0.0109 0.0059 0.0059
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0181 0.0339 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0181 0.0339 0.7867
Toxoplasma gondii target of rapamycin (TOR), putative 0.1983 0.7384 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2652 1 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2652 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.03 0.0805 0.0805
Schistosoma mansoni immunophilin 0.0109 0.0059 0.0059
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0187 0.0363 0.0306
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.024 0.0569 0.0513
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0181 0.0339 0.7867
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0538 0.1735 0.1735
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0181 0.0339 0.0339
Loa Loa (eye worm) phosphatidylinositol 3 0.0181 0.0339 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0339 0.0955 0.0921
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.052 0.1663 0.1613
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0578 0.1892 0.2205
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0059 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.1451 0.5304 0.5287
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.7911 0.7904
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0059 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.0282
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0397 0.1184 0.1184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.0339 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.1449 0.5296 0.5279
Plasmodium vivax hypothetical protein 0.0181 0.0339 0.7867
Giardia lamblia GTOR 0.2652 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0928 0.3257 0.3232
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.052 0.1663 0.1613
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.0282
Leishmania major phosphatidylinositol kinase, putative 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.1663 0.1632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0917 0.3216 0.3191
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0181 0.0339 0.0282
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.02 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0368 0.1071 0.1018
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.052 0.1663 0.1663
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0111 0.0065 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.02 0.0415 0.0379
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0368 0.1071 0.1018
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0188 0.0188
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0268 0.068 0.0625
Entamoeba histolytica hypothetical protein 0.0181 0.0339 0.0282
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0059 0.0059
Trichomonas vaginalis immunophilin, putative 0.0109 0.0059 0.0022
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.03 0.0805 0.0805
Echinococcus granulosus serine:threonine protein kinase SMG1 0.052 0.1663 0.1663
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0181 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0096 0.0008 0.0008
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0059 0.0022
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.02 0.0415 0.0379
Onchocerca volvulus 0.0181 0.0339 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0917 0.3216 0.3191
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0397 0.1184 0.1184
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.02 0.0415 0.0358
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2652 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.024 0.0569 0.0513
Echinococcus multilocularis 0.0181 0.0339 0.0339
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.02 0.0415 0.0358
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0433 0.1325 0.1325
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0538 0.1735 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0917 0.3216 0.3191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0181 0.0339 0.0303
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1113 0.3981 0.3945
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.0834 0.0801
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0059 0.5
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.022 0.0493 0.0436
Trichomonas vaginalis PIKK family atypical protein kinase 0.2652 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.053 0.1704 0.1673
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2652 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0928 0.3257 0.3257
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.024 0.0569 0.0534
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0308 0.0834 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0917 0.3216 0.3191
Schistosoma mansoni lipoxygenase 0.0142 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0397 0.1184 0.1184
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0538 0.1735 0.1735
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0368 0.1071 0.1038
Trichomonas vaginalis PIKK family atypical protein kinase 0.1721 0.6358 0.6345
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0105 0.0105
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.02 0.0415 0.0379
Loa Loa (eye worm) phosphatidylinositol 3 0.0181 0.0339 0.0339
Echinococcus multilocularis fk506 binding protein 0.0109 0.0059 0.0059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0181 0.0339 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.1586 0.5831 0.5816
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.02 0.0415 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0713 0.2419 0.2391
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0181 0.0339 0.0282
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.024 0.0569 0.0534
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.02 0.0415 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.7911 0.7904
Trichomonas vaginalis PIKK family atypical protein kinase 0.1451 0.5304 0.5287
Echinococcus multilocularis serine protein kinase ATM 0.052 0.1663 0.1663
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.0282
Entamoeba histolytica hypothetical protein 0.052 0.1663 0.1613
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0928 0.3257 0.3217
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.024 0.0569 0.0513
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2652 1 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0181 0.0339 0.0339
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.02 0.0415 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.1451 0.5304 0.5287
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Trichomonas vaginalis conserved hypothetical protein 0.0397 0.1184 0.1152
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.052 0.1663 0.1613
Onchocerca volvulus 0.0181 0.0339 0.5
Loa Loa (eye worm) hypothetical protein 0.0532 0.1711 0.1711
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0181 0.0339 0.7867
Loa Loa (eye worm) hypothetical protein 0.03 0.0805 0.0805
Loa Loa (eye worm) phosphatidylinositol 3 0.0181 0.0339 0.0339
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0339 0.0955 0.0901
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.7911 0.7904
Mycobacterium leprae conserved hypothetical protein 0.0181 0.0339 0.5
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.02 0.0415 0.0415
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1247 0.4507 0.4475
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.02 0.0415 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.02 0.0415 0.0415
Leishmania major phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.0282
Schistosoma mansoni immunophilin 0.0109 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.2255 0.8447 0.8441
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.02 0.0415 0.0415
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0928 0.3257 0.3217
Leishmania major phosphatidylinositol 3-kinase, putative 0.02 0.0415 0.0358
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2652 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.212 0.792 0.7908
Loa Loa (eye worm) hypothetical protein 0.0339 0.0955 0.0955
Schistosoma mansoni hypothetical protein 0.0397 0.1184 0.1184
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.02 0.0415 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.1586 0.5831 0.5816
Loa Loa (eye worm) phosphatidylinositol 3 0.0499 0.1581 0.1581
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.02 0.0415 0.0415
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0109 0.0059 0.0059
Entamoeba histolytica hypothetical protein 0.0329 0.0917 0.0863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0368 0.1071 0.1018
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.1449 0.5296 0.5279
Trichomonas vaginalis PIKK family atypical protein kinase 0.1586 0.5831 0.5816
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0181 0.0339 0.0282
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0059 0.0059
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0181 0.0339 0.0282
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0111 0.0065 0.0065
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.024 0.0569 0.0569
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2652 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0329 0.0917 0.0863
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0181 0.0339 0.0282
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0109 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.1983 0.7384 0.7375
Schistosoma mansoni phosphatidylinositol 4-kinase 0.02 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.1451 0.5304 0.5287
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.1071 0.1018
Giardia lamblia Hypothetical protein 0.0181 0.0339 0.0282
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.052 0.1663 0.1663
Schistosoma mansoni hypothetical protein 0.0181 0.0339 0.0339
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0181 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.7911 0.7904
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0368 0.1071 0.1038
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.1663 0.1613
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.024 0.0569 0.0534
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0181 0.0339 0.7867
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0181 0.0339 0.0339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.052 0.1663 0.1613
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0966 0.3409 0.337
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0433 0.1325 0.1325
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0966 0.3409 0.3409
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0181 0.0339 0.7867
Leishmania major hypothetical protein, conserved 0.027 0.0688 0.0633
Plasmodium falciparum phosphatidylinositol 3-kinase 0.02 0.0415 1
Entamoeba histolytica protein kinase rad3, putative 0.052 0.1663 0.1613
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0966 0.3409 0.337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0181 0.0339 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.2118 0.7911 0.7904
Trichomonas vaginalis PIKK family atypical protein kinase 0.052 0.1663 0.1632
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.0339 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0917 0.3216 0.3176
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2652 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.024 0.0569 0.0513
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2652 1 1
Echinococcus granulosus serine protein kinase ATM 0.052 0.1663 0.1663
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.024 0.0569 0.0513
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0966 0.3409 0.337
Leishmania major phosphatidylinositol 3-kinase, putative 0.0917 0.3216 0.3176
Trichomonas vaginalis PIKK family atypical protein kinase 0.1586 0.5831 0.5816
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0966 0.3409 0.3409
Schistosoma mansoni lipoxygenase 0.01 0.002 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0105 0.0105
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0181 0.0339 0.0339
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2652 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0578 0.1892 0.1862
Loa Loa (eye worm) phosphatidylinositol 3 0.0181 0.0339 0.0339
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0111 0.0065 0.0065
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0261 0.0651 0.0595
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.03 0.0805 0.075

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 uM Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis ChEMBL. 22326163
IC50 (binding) = 1.9 uM Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis ChEMBL. 22326163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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