Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cholecystokinin A receptor | Starlite/ChEMBL | No references |
Homo sapiens | cholecystokinin B receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0076 | 0.008 | 0.008 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0076 | 0.008 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2778 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0261 | 0.076 | 0.0686 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.1033 | 0.3594 | 0.3542 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2778 | 1 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2778 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1033 | 0.3594 | 0.3542 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0076 | 0.008 | 0.008 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2778 | 1 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.1033 | 0.3594 | 0.3542 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2778 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2778 | 1 | 1 |
Leishmania major | 0.2778 | 1 | 1 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2778 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.076 | 0.076 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0076 | 0.008 | 0.008 |
Brugia malayi | sulfakinin receptor protein | 0.0261 | 0.076 | 0.0686 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2778 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | Inhibitory activity against cholecystokinin-A (CCK-A) receptor in pancreas of guinea pig. | ChEMBL. | No reference |
IC50 (binding) | = 10 nM | Inhibitory activity against cholecystokinin-A (CCK-A) receptor in pancreas of guinea pig. | ChEMBL. | No reference |
IC50 (binding) | = 450 nM | Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig. | ChEMBL. | No reference |
IC50 (binding) | = 450 nM | Inhibitory activity against cholecystokinin-B (CCK-B) receptor in cortex of male hartley guinea pig. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.